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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Seizure outcome after surgery for epilepsy due to focal cortical dysplastie lesions 显示文摘 | Alexandre V Jr Walz R Bianchin M M | 2006 | Seizure2006，15，6： | 1 |
| 3 | Poly(ethylene-co vinyl acetate)/clay Nanocomposites: Effect of Clay Nature and Organic Modifiers on Morphology,Mechanical and Thermal Properties显示文摘 | Peeterbroeck S Alexandre M Jerome R | 2005 | Polymer Degradation and Stability2005，，90： | 1 |
| 4 | Hard elastic carbon thin films form linking of carbon nanoparticles显示文摘 | Amaratunga G A J Chhowalla M Kiely C J Alexandrou I Aharonov R Devenish R M | 1996 | Nature (London)1996，383，： | 1 |
| 5 | The use of microRNAs as re{erence genes for quantitative polymerase chain reaction in soybean 显示文摘 | Franccli R K Francismar C M Alexandre L N | 2010 | Analytical Biochemistry2010，406，2： | 1 |
| 6 | Possible source of ancient carbon in phytolith concentrates from harvested gras ses显示文摘 | SANTOS G M ALEXANDRE A SOUTHON J R | 2012 | Biogeosciences2012，9，： | 1 |
| 7 | Stem protective tissue in Erytheoxylum tortuosum ( Erytheoxylaceae), Afire tolerant from cerrado 显示文摘 | Alexandre A A Silvia R M | 2008 | IA- WA Journal2008，29，1： | 1 |
| 8 | Molecular asymmetry in extraterrestrial chemistry:Insights from a pristine meteorite显示文摘 | Pizzarello S Huang Y Alexandre M R | 2008 | Proceedings of the National Academy of Sciences2008，105，： | 1 |
| 9 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
| 10 | Heart rate monitoring in soccer: interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bars Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength C ond Res2012，26，10： | 1 |
| 11 | Texture analysis using graphs generated by deterministic partially self-avoiding walks显示文摘 | Andre R Backes Alexandre S Martinez Odemir M Bruno | 2011 | Pattern Recognition2011，44，： | 1 |
| 12 | Partial purification of a virus inhibitor from Silene sehafta leaves 显示文摘 | Alexandre M A V Guzzo S D Harakava R | 1997 | Fitopatologia Brasileira1997，22，2： | 1 |
| 13 | One-pot synthesis of a chitosan-based hydrogel as a potential device for magnetic biomaterial 显示文摘 | Alexandre T Paulino Marcos R Guilherme Elisangela A M S deAlmeida | 2009 | Journal of Magnetism and Magnetic Materials2009，321，17： | 1 |
| 14 | Efficacyof non-thermal technologies and sanitizer solutionson microbial load reduction and quality retention ofstrawberries显示文摘 | Alexandre EMC Brandao T R S Silva C L M | 2012 | Journal of Food Engineering2012，108，3： | 1 |
| 15 | Molecular and compound-specific isotopic characterization of monocarboxylic acids in carbonaceous meteorites显示文摘 | Huang Y Wang Y Alexandre M R | 2005 | Geochimica et Cosmochimica Acta2005，69，： | 1 |
| 16 | Structure and isotopic ratios of aliphatic side chains in the insoluble organic matter of the Murchison carbonaceous chondrite显示文摘 | Huang Y Alexandre M R Wang Y | 2007 | Earth and Planetary Science Letters2007，259，： | 1 |
| 17 | One-pot synthesis of a chitosan-based hhdrogel as a potential device for magnetic biomaterial 显示文摘 | Alexandre T Mareos R Elisangela A M S | 2009 | Journal of Magnetism and Magnetie Materials2009，321，17： | 1 |
| 18 | Assessment of Lipid Compounds and Phosphorus in Mangrove Sedi- ments of Santa Catarina Island, SC, Brazil 显示文摘 | Mater L Alexandre M R Hansel F A | 2004 | Journal of the Brazilian Chemical Society2004，15，5： | 1 |
| 19 | Influence of the drying processes of yeasts on their volatile phenol sorption capacity inmodel wine显示文摘 | PRADELLE R vICHI M ALEXANDRE N | 2009 | International Journal of Food Microbiology2009，135，2： | 1 |
| 20 | An energy-shaping approach to the design of excitation control of synchronous generators显示文摘 | Galaz M Ortega R Alexandre S B | 2003 | Automatica2003，39，1： | 1 |
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