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| 1 | Portal hypertensive biliopathy: A single center experience and literature review显示文摘Portal hypertensive biliopathy (PHB) is characterized by anatomical and functional abnormalities of the intrahepatic, extrahepatic and pancreatic ducts, in patients with portal hypertension associated to extrahepatic portal vein obstruction and less frequently to cirrhosis. These morphological changes, consisting in dilatation and stenosis of the biliary tree, are due to extensive venous collaterals occurring in an attempt to decompress the portal venous blockage. It is usually asymptomatic until it progresses to more advanced stages with cholestasis, jaundice, biliary sludge, gallstones, cholangitis and finally biliary cirrhosis. Imaging mo-dalities of the biliary tree such as Doppler ultrasound, computed tomography, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography are essential to establish the diagnosis and the need of therapeutical interventions. Once the diagnosis is established, treatment with ursodesoxycholic acid seems to be beneficial. Decompression of the biliary tree to dilate, remove stones or implant biliary prosthesis by endoscopic or surgical procedures (hepato-yeyunostomy) usually resolves the cholestatic picture and prevents septic complications. The ideal treatment is the decompression of the portal system, with transjugular intrahepatic porto-systemic shunt or a surgical porto-systemic shunt. Unfortunately, few patients will be candidates for these procedures due to the extension of the thrombotic process. The purpose of this paper is to report the first 3 cases of PHB seen in a Colombian center and to review the literature. | Vanessa Suárez Andrés Puerta Luisa Fernanda Santos Juan Manuel Pérez Adriana Varón Rafael Claudino Botero | 2013 | World Journal of Hepatology2013，5，3： | 10 |
| 2 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 3 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 4 | Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?显示文摘AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality. | Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey Eli García-Ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria José María Remes-Troche | 2015 | World Journal of Hepatology2015，7，17： | 2 |
| 5 | A genomic explanation connecting 'Mediterranean diet',olive oil and cancer:Oleic acid,the main monounsaturated Fatty acid of olive oil,induces formation of inhibitory'PEA3 transcription factor-PEA3 DNA binding site' complexes at the Her-2/neu(erbB-2)oncogene promoter in breast,ovarian and stomach cancer cells显示文摘 | ADRIANA P LUCIANO V | 2006 | European Journal of Cancer2006，42，： | 1 |
| 6 | Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis 显示文摘 | JOHN P CHRISTOS M ADRIANA T | 2000 | Am J Cardiol2000，85，： | 1 |
| 7 | A new voltammetric method for the simultaneous determination of the antioxidants TBHQ and BHA in biodiesel using multi-walled carbon nanotube screen-printed electrodes显示文摘 | Ricardo P C Adriana G F A Luiz H V | 2013 | Fuel2013，105，： | 1 |
| 8 | Comprehensive analysis of major and minor chlorogenic acid and lactones in econo- mically relevant Brazilian coffee cultivars 显示文摘 | Daniel P Adriana F Carmen MD | 2008 | Food Chemistry2008，106，2： | 1 |
| 9 | Methanol removal efficiency and bacterial diversity of an activated carbon biofilter显示文摘 | Callie W B Adriana P Angela S Lindner | 2009 | Bioresour Techn2009，100，24： | 1 |
| 10 | Determination of selenium in nutritionally relevant foods by graphite atiomic absorption spectrometry using arsenic as internal standard显示文摘 | Adriana P O Jose A G N Joaquim A N | 2005 | Food Chemistry2005，93，2： | 1 |
| 11 | Effects of arsenite on estrogen receptor-a expression and activity in MCF-7 breast cancer cells显示文摘 | ADRIANA S EIlZABATH P MARY B M | 2000 | Endo2000，141，10： | 1 |
| 12 | Effect of l-arginine on arginase activity in male accessory sex glands of alloxan-treated rats 显示文摘 | JOSE D M ADRIANA S MARTIN P M | 2002 | Reproductive Toxicology2002，16，6： | 1 |
| 13 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Christos M Papamichael John P Lekakis Kimon S Stamatelopoulos Theodoros G Papaioannou Maria K Alevizaki Adriana T Cimponeriu John E Kanakakis Aggeliki Papapanagiotou Anastasios Th Kalofoutis Stamatios F Stamatelopoulos | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 14 | Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine显示文摘 | ELEAZAR L P RAFAEL C R ADRIANA J L | 2010 | J Nutr Biochem2010，11，： | 1 |
| 15 | Monitoring colloidal stability of polymer-coated magnetic nanoparticles using AC susceptibility measurements 显示文摘 | Adriana P Herrera Carola Barrera Yashira Zayas | 2010 | Journal of Colloid and Interface Science2010，342，： | 1 |
| 16 | Microvascular function regu- lates intestinal crypt response to radiation 显示文摘 | Jerzy G Franois P Adriana H | 2003 | Cancer Research2003，63，3： | 1 |
| 17 | A genomic explanation connecting Mediterranean diet', olive oil and cancer: Olive acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory ' PEA3 transcription factor-PEA3 DNA binding site' complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells 显示文摘 | Javier A M Adriana P Luciano V | 2006 | Cur J Cancer2006，34，42： | 1 |
| 18 | Synthesis of mixed alkylphosphites and alkylphos- phates显示文摘 | GHEORGHE I ADRIANA P SMARAANDA I | 2003 | Phosphorus Sulfur and Silicon and the Related Elements2003，178，7： | 1 |
| 19 | Synthesis of furo benzoxazin-3-ones, new psoralen isosters 显示文摘 | Adriana C Alessia C Giovanni P | 2002 | Eur J Org Chem2002，2002，12： | 1 |
| 20 | Hydraulic Breaker显示文摘 | ADRIANA P | 2000 | World Mining Equipment2000，28，5： | 1 |
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