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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Solid phase microextraction capillary gas chromatography combined with furnace atomization plasma emission spectrometry for speciation of mercury in fish tissues显示文摘 | Patricia G Reinaldo C C Zoltan M | 2003 | Spectrochimica Acta Part B2003，，58： | 1 |
| 3 | Fracture detection in a carbonate reservoir using a variety of seismic methods显示文摘 | Maria A P Vladimir G Reinaldo J M | 1999 | Geophysics1999，64，4： | 1 |
| 4 | Device-associated infec-tion rates in intensive care units of Brazilian hospitals:findingsof the international nosocomial infection control consortium显示文摘 | Reinaldo S Victor R Gorki G | 2008 | Pan Am J Public Health2008，24，3： | 1 |
| 5 | Semi -batch emulsion copolymerization of styrene and butyl acrylate for production of high solids content latexes:Experiments and mathematical model 显示文摘 | Giovane M Wilson H Reinaldo G | 2011 | Chemical Engineering Science2011，66，23： | 1 |
| 6 | Heat shock reduces browning of fresh-cut celery petioles显示文摘 | Julio G L V Mary E Mangrich Reinaldo Campos-Vargas | 2003 | Postharvest Biology and Technology2003，，27： | 1 |
| 7 | Computational evaluation of effective material properties of composites reinforced by randomly distributed spherical particles 显示文摘 | Sreedhar K Harald B Reinaldo R Ulrich G | 2007 | Composite Structures2007，77，2： | 1 |
| 8 | Device-associated infection rates in intensive care units of Brazilian hospitals:findings of the international nosocomial infection control consortium 显示文摘 | Reinaldo S Victor R Gorki G | 2008 | Pan Am Public Health2008，24，3： | 1 |
| 9 | Generatingcapacity reliability evaluation based on Monte Carlo simulationand cross-entropy methods显示文摘 | Armando M Leite da Silva Reinaldo A G | 2010 | IEEE Transactions on PowerSystems2010，25，1： | 1 |
| 10 | A GARCH forecasting model to predict day-ahead electricity prices显示文摘 | Reinaldo C G Contreras J | 2005 | IEEE Transactions on Power Systems2005，20，2： | 1 |
| 11 | Device-associated infection rates in intensive care units of brazlian hospitals:findings of the international nosocomial infection control consortium显示文摘 | Reinaldo S Victor R Gorki G | 2008 | Pan Am J Public Health2008，24，3： | 1 |
| 12 | A note on solutions to the maximal expected covering location prohlem显示文摘 | Fernando Y C Roberto D G Reinaldo M D | 2002 | Computers & Operations Research2002，30，1： | 1 |
| 13 | Electrochemical evidence of caffeine adsorption on zinc surface in ethanol显示文摘 | Fabiana G Reinaldo G | 2008 | Corros Sci2008，50，1： | 1 |
| 14 | Factors influencing algae-clay aggregation显示文摘 | MARIANA G REINALDO B | 2004 | Hydrobiologia2004，523，： | 1 |
| 15 | Computational evaluation of effective material properties of composites reinforced by randomly distributed spherical particles显示文摘 | Sreedhar K Harald B Reinaldo R Ulrich G | | 0，，02： | 1 |
| 16 | Heat shock reduces browning of fresh-cut celery petioles显示文摘 | Julio G Loaiza-Velarde Mary E Mangrich Reinaldo Campos- Vargas | 2003 | Postharvest Biology and Technology2003，27，3： | 1 |
| 17 | Butyl acrylate and vinyl acetate semicontious emulsion copolymerizations: Study of stabilization performance 显示文摘 | Pedro H H A Reinaldo G Claudia S | 2004 | Macromol Symp2004，206，1： | 1 |
| 18 | Evaluation of maize core collection for drought tolerance 显示文摘 | Flavia F T Reinaldo L G Paulo E P | 2010 | Crop Breeding and Applied Biotechnology2010，10，： | 1 |
| 19 | Emergency Peripartum hystereetomy:experience at a community teaching hospital显示文摘 | Elana SK Reinaldo F David G | | 0，，06： | 1 |
| 20 | Substitution of Y2O3 by a rare earth oxide mixture as sintering additive of Si3N4 ceramics显示文摘 | Kurt S Reinaldo G Sebastiao R | 2000 | Materials Letters2000，45，： | 1 |
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