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| 1 | Identification of some benproperine metabolites in humans and investigation of their antitussive effect显示文摘瞄准:识别 benproperine 的 4 未知代谢物,并且调查 monohydroxylate 代谢物的能止咳的效果(BPP, 1 ) 在在 po 剂量以后的人的尿。方法:通常认为的代谢物参考书用化学合成被准备。他们的结构用 1H 和 13C 被识别原子磁性的回声,和集体分光术。在人的尿的代谢物被分开,用液体层析离子的 assayed 套住集体分光术(LC/MS/MS ) ,并且推进综合参考物质与那些由他们的集体系列和色析法的保留时间的比较证实了。代谢物的能止咳的效果在 7.5% 枸橼酸在有意识的畿尼猪导致的咳嗽上被评估。结果:1-[1-Methyl-2-[2-( 苯基甲基) 含苯氧基]-ethyl]-4-piperidinol (2 ) , 1-[1-methyl-2-[2-( 苯基甲基) 含苯氧基] 乙醇]-3-piperidinol (3 ) 和他们的 glucuronides 4 和 5 从化学合成被获得。在人的尿的四尿代谢物在 LC/MS/MS 同样合成的物质与一样的色析法的保留时间和集体系列显示出山峰 2, 3, 4 和 5。混合物的磷酸盐 2 和 3 延长了咳嗽的潜伏并且在 3 min 期间减少了咳嗽的数字测试使用枸橼酸,但是没在有意识的畿尼猪的测试以后立即在 5 min 期间减少咳嗽的数字。结论:混合物 2, 3, 4,和 5 在人的尿作为 BPP 的代谢物被识别。在他们之中,加重 2 和 3 在能止咳的效果是不活跃的。 | Yan LI Da-fang ZHONG Si-wei CHEN Isamu MAEBA | 2005 | Acta Pharmacologica Sinica2005，26，12： | 4 |
| 2 | Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer显示文摘 | Minoru Oshima Keiichi Okano Shinobu Muraki Reiji Haba Takashi Maeba Yasuyuki Suzuki Shinichi Yachida | 2013 | Annals of Surgery2013，，2： | 4 |
| 3 | A patient with unresectable advanced pancreatic cancer achieving long-term survival with Gemcitabine chemotherapy显示文摘A 68-year-old female visited a local clinic with epigastralgia. A routine laboratory test revealed jaundice and liver dysfunction. She was referred to this hospital. Abdominal computed tomography (CT) and endoscopic retrograde cholangio-pancreatography (ERCP) revealed that the density of the entire pancreas had decreased,and showed dilatation of the common bile duct (CBD) and the main pancreatic duct (MPD). Pancreatic cancer was diagnosed by cytological examination analyzing the pancreatic juice obtained by ERCP. When jaundice had decreased the tumor was observed via laparotomy. No ascites,liver metastasis,or peritoneal dissemination was observed. The entire pancreas was a hard mass,and a needle biopsy was obtained from the head,body and tail of the pancreas. These biopsies diagnosed a poorly differentiated adenocarcinoma. Hepaticojejunostomy was thus performed,and postoperative progress was good. Chemotherapy with 1000 mg/body per week of gemcitabine was administered beginning 15 d postoperatively. However,the patient suffered relatively severe side effects,and it was necessary to change the dosing schedule of gemcitabine. Abdominal CT revealed a complete response (CR) after 3 treatments. Therefore,weekly chemotherapy was stopped and was changed to monthly administration. To date,for 4 years after chemotherapy,the tumor has not reappeared. | Yoshiki Okamoto Takashi Maeba Keitarou Kakinoki Keiichi Okano Kunihiko Izuishi Hisao Wakabayashi Hisashi Usuki Yasuyuki Suzuki | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 4 | Left atrial volume by real-time three-dimensional echocardiography: validation by 64- slice multidetector computed tomography 显示文摘 | Tsujimot0 S Maeba H | 2011 | J Am Soc Echocar- diogr2011，24，6： | 1 |
| 5 | Effect of montelukast on nuclear factor kappaB activation and proinflammatory molecules显示文摘 | Maeba S Ichiyama T Ueno Y | 2005 | Ann Allergy Asthma lmmunol2005，94，6： | 1 |
| 6 | Spherical carbon adsorbent (AST-120) protects deterioration of renal function in chronic kidney disease rats through inhibition ofreactive oxygen species production from mitochondria and reduction of serum lipid peroxidation显示文摘 | Owada S Maeba T Sugano Y | 2010 | Nephron Exp Nephrol2010，115，4： | 1 |
| 7 | Nasally administered cholera toxin A-subunit acts as a mueosal adjuvant显示文摘 | Campos EA Namikoshi J Maeba S | 2003 | J Oral Sci2003，45，1： | 1 |
| 8 | Characterization of factors involved in the production of 2 ( E ) - nonenal during mashing显示文摘 | Kuroda H Furusho S Maeba H Takashio M | 2003 | Biosci Biotechnol Biochem2003，67，： | 1 |
| 9 | Left atrial volume by real-time three-dimensional echocardiography:validation by 64-slice multidetector computed tomography显示文摘 | Miyasaka Y Tsujimoto S Maeba H | | 0，，06： | 1 |
| 10 | Hepatic resection for metastatic tumors from gastric cancer 显示文摘 | Okano K Maeba T Ishimura K | 2002 | Ann Surg2002，235，： | 1 |
| 11 | Hepatic resection for metastatic tumors from gastric cancer 显示文摘 | Okano K Maeba T Ishimura K | 2002 | Ann Surg2002，235，1： | 1 |
| 12 | Left atrial volume byreal-time three-dimensional echocardiography : validation by 64-slice multidetector computed tomography 显示文摘 | Miyasaka Y Tsujimoto S Maeba H | 2011 | J Am SocEchocardiogr2011，24，： | 1 |
| 13 | Lymphocytic infiltration surroundding liver metastases from colorectal cancer显示文摘 | Okano K Maeba T Modoguchi A | 2003 | J Surg Oncol2003，82，1： | 1 |
| 14 | Manually-powered continuous-flow maize-sheller显示文摘 | Nkakini S O Ayotamuno M J Ayotamuno Maeba G P D | 2007 | Applied Energy2007，84，12： | 1 |
| 15 | Choledochal cyst, pancreatobiliary malunion, and cancer显示文摘 | Takuji Todani Yasuhiro Watanabe Naoto Urushihara Yoshiki Morotomi Takashi Maeba | 1994 | Journal of Hepato - Biliary - Pancreatic Surgery1994，，3： | 1 |
| 16 | Hepatic resection for metastatic tumors from gastric cancer显示文摘 | Okano K Maeba T Ishimura K | 2002 | Ann Surg2002，235，1： | 1 |
| 17 | Hepatic resection for metastatic tumors from gastric cancer显示文摘 | Okano K Maeba T Ishimura K | 2002 | Ann Surg2002，235，1： | 1 |
| 18 | Hepatic resection for metastatic tumours from gastric cancer 显示文摘 | Okano k Maeba T Ishimura K | 2002 | Ann Surg2002，235，1： | 1 |
| 19 | Castleman disease of the pararenal retroperitoneum:report of a case显示文摘 | Okada S Maeta H Maeba T | 1999 | Surg Today1999，29，： | 1 |
| 20 | Castleman disease ff the pararenal retroperitonetan: report of a ease 显示文摘 | Okada S Maeta H Maeba T | 1999 | Surg Today1999，29，2： | 1 |
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