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| 1 | Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing显示文摘We present a simple and customizable microneedle mold fabrication technique using a low-cost desktop SLA 3D printer.As opposed to conventional microneedle fabrication methods,this technique neither requires complex and expensive manufacturing facilities nor expertise in microfabrication.While most low-cost 3D-printed microneedles to date display low aspect ratios and poor tip sharpness,we show that by introducing a two-step“Print&Fill”mold fabrication method,it is possible to obtain high-aspect ratio sharp needles that are capable of penetrating tissue.Studying first the effect of varying design input parameters and print settings,it is shown that printed needles are always shorter than specified.With decreasing input height,needles also begin displaying an increasingly greater than specified needle base diameter.Both factors contribute to low aspect ratio needles when attempting to print submillimeter height needles.By setting input height tall enough,it is possible to print needles with high-aspect ratios and tip radii of 20–40μm.This tip sharpness is smaller than the specified printer resolution.Consequently,high-aspect ratio sharp needle arrays are printed in basins which are backfilled and cured in a second step,leaving sub-millimeter microneedles exposed resulting microneedle arrays which can be used as male masters.Silicone female master molds are then formed from the fabricated microneedle arrays.Using the molds,both carboxymethyl cellulose loaded with rhodamine B as well as polylactic acid microneedle arrays are produced and their quality examined.A skin insertion study is performed to demonstrate the functional capabilities of arrays made from the fabricated molds.This method can be easily adopted by the microneedle research community for in-house master mold fabrication and parametric optimization of microneedle arrays. | Kevin J.Krieger Nicky Bertollo Manita Dangol John T.Sheridan Madeleine M.Lowery Eoin D.O’Cearbhaill | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 2 | 糖尿病肾病患者的处理显示文摘 | Micahl Thorp D.O M.P.H 李井泉(编译) | 2005 | 中国全科医学2005，8，17： | 3 |
| 3 | Generalized I-Contractions and Pointwise R-Subweakly Commuting Maps显示文摘为点的普通的固定的点和不变的近似的存在明智 R-subweakly 变换并且兼容地图被建立。我们的结果统一并且概括各种各样的已知的结果到军士 muting 地图砰的一个更一般的班。 | D.O'REGAN N.HUSSAIN | 2007 | Acta Mathematica Sinica,English Series2007，23，8： | 2 |
| 4 | Green Functions with Pulsating Sources in A Two-Layer Fluid of Finite Depth显示文摘The derivation of Green function in a two-layer fluid model has been treated in different ways.In a two-layer fluid with the upper layer having a free surface,there exist two modes of waves propagating due to the free surface and the interface.This paper is concerned with the derivation of Green functions in the three dimensional case of a stationary source oscillating.The source point is located either in the upper or lower part of a two-layer fluid of finite depth.The derivation is carried out by the method of singularities.This method has an advantage in that it involves representing the potential as a sum of singularities or multipoles placed within any structures being present.Furthermore,experience shows that the systems of equations resulted from using a singularity method possess excellent convergence characteristics and only a few equations are needed to obtain accurate numerical results.Validation is done by showing that the derived two-layer Green function can be reduced to that of a single layer of finite depth or that the upper Green function coincides with that of the lower,for each case.The effect of the density on the internal waves is demonstrated.Also,it is shown how the surface and internal wave amplitudes are compared for both the wave modes.The fluid in this case is considered to be inviscid and incompressible and the flow is irrotational. | MANYANGA D.O 段文洋 | 2011 | China Ocean Engineering2011，25，4： | 2 |
| 5 | Bacterial strain‐specific induction of Foxp3<sup>+</sup> T regulatory cells is protective in murine allergy models显示文摘 | A.Lyons D.O'Mahony F.O'Brien J.MacSharry B.Sheil M.Ceddia W. M.Russell P.Forsythe J.Bienenstock B.Kiely F.Shanahan L.O'Mahony | 2010 | Clinical & Experimental Allergy2010，，5： | 2 |
| 6 | Real Exchange Rate Risk,Expectations and the Level of Direct Investment显示文摘 | Cushman D.O | | 0，，02： | 1 |
| 7 | Functional and morphological changes in the pancreatic remnant following pancreaticoduodenectomy with pancreaticogastric anastomosis显示文摘 | E.Lemaire D.O’Toole A.Sauvanet P.Hammel J.Belghiti P.Ruszniewski | 2002 | Br J Surg2002，，4： | 1 |
| 8 | Impacts of Climate Variability on Sustainable Agriculture in Imo State,Nigeria显示文摘Rainfall and Temperature are important factors in agriculture especially in Nigeria where rain-fed agriculture is practiced extensively and agriculture contributes to food security and provides employment for urban and rural dwellers.Therefore,climate variability represents a major danger to agriculture by modifying the rainfall and temperature pattern,thereby resulting to a big peril in the sustainability of agriculture.This is the reason all countries of the world are concerned about the effects of climate variability on agriculture.This work therefore,examined the impact of climate variability on rainfall and temperature in Imo State,South Eastern Nigeria.The rainfall and temperature data were gotten from Nigerian Meteorological Agency(NIMET)for a period of 30 years which was analyzed by using descriptive statistics,decadal distribution,trend graph anomalies and 5 year moving average.The analysis showed increasing trend pattern in yearly maximum,minimum temperature and decrease in annual rainfall,The third order polynomial trend shows a decrease in the anomaly of annual mean rainfall(y=-0.0002x4)and a persistent increase in the mean temperature anomaly especially in the second decade(1996-2007).The discoveries show that there is a notable variability in temperature and rainfall pattern which revealed an increase in temperature and decrease in annual rainfall.This calls for serious attention as people in this part of Nigeria critically depend on rainfall for agricultural practices.It is recommended that government should support the agricultural sector by providing mechanized farming systems such as irrigation and drilling of water borehole in farm sites for agriculture,especially for the rural farmers and create awareness to the farmers on recent trends in climate issues to achieve sustainable agriculture. | Ajiere S Diagi B.E Edokpa D.O | 2021 | Journal of Geographical Research2021，4，1： | 1 |
| 9 | A comparison of tracheal intubation using the Airtraq? or the Macintosh laryngoscope in routine airway management: a randomised, controlled clinical trial显示文摘 | C. H.Maharaj D.O’Croinin G.Curley B. H.Harte J. G.Laffey | 2006 | Anaesthesia2006，，11： | 1 |
| 10 | Purification and Characteri-zation of lysozyme from Hemolymph of Heliothis virescens Larvae显示文摘 | D.L Timothy D.O Donald | | 0，，： | 1 |
| 11 | Electrocatalytic characteristics of the metal hydride electrode for advanced Ni/MH batteries显示文摘 | Geng M Feng F Gamboa S.A Sebastian P.J Matchet A.J Nothowood D.O | | 0，，： | 1 |
| 12 | Anodic processes in plasma electrolytic oxidation of aluminium in alkaline solutions显示文摘 | L.O Snizhko A.L Yerokhin A Pilkington N.L Gurevina D.O Misnyankin A Leyland A Matthews | 2003 | Electrochimica Acta2003，，13： | 1 |
| 13 | Accommodative lag before and after the onset of myopia显示文摘 | Mutti D.O Mitchell G.L Hayes J.R | | 0，，3： | 1 |
| 14 | Otto Jespersen:Teacher and Linguist显示文摘 | Frederickson D.O | | 0，，02： | 1 |
| 15 | Macroeconomic conditions and capital structure adjustment speed显示文摘 | Cook D.O Tang T | | 0，，01： | 1 |
| 16 | Groin Hernia Repair by Laparoscopic Techniques: Current Status and Controversies显示文摘 | Maurice E. Arregui M.D. Susan B. Young D.O | 2005 | World Journal of Surgery2005，，8： | 1 |
| 17 | Asymptotical consensus of fractional-order multi-agent systems with current and delay states显示文摘In this paper,we study some new fractional-order multi-agent systems with current and delay states (FMASCD).Using the generalized Nyquist's stability criterion and Gerschgorin's circle theorem,we obtain the bounded input-bounded output (BIBO) stability and asymptotical consensus of the FMASCD under mild conditions.Moreover,we give some numerical examples to illustrate our main results. | Xuhui WANG Xuesong LI Nanjing HUANG D.O'REGAN | 2019 | Applied Mathematics and Mechanics(English Edition)2019，40，11： | 1 |
| 18 | Anodic processes in plasma electrolytic oxidation of aluminium in alkaline solutions显示文摘 | L.O Snizhko A.L Yerokhin A Pilkington N.L Gurevina D.O Misnyankin A Leyland A Matthews | 2003 | Electrochimica Acta2003，，13： | 1 |
| 19 | 查看详情显示文摘 | Lee H.S Oh W.K Kim B.Y Ahn S.C Kang D.O Shin D.I Kim J Mheen T.-I Ahn J.S | | 0，，： | 1 |
| 20 | Autotransfusion for ruptured ectopic pregnancy显示文摘 | D.O Selo-Ojeme J.L Onwude U Onwudiegwu | 2002 | International Journal of Gynecology and Obstetrics2002，，2： | 1 |
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