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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Temporal variability of denitrification in estuarine sediments显示文摘 | LAW C S REES A P OWENS N J P | 1991 | Estuarine Coastal and Shelf Science1991，33，1： | 1 |
| 3 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 4 | One-pot synthesis of tetrasubstituted pyrazoles-proof of regiochemistry 显示文摘 | HANEFELD U REES C W WHITE A J P | 1996 | J Chem Soc Perkin Trans 11996，13，： | 1 |
| 5 | Nitrous oxide: Estuarine sources and atmospheric flux 显示文摘 | LAW C S REES A P OWENS N J P | 1992 | Estuarine Coastal and Shelf Science1992，35，3： | 1 |
| 6 | Design,simulation and implementation of networked predictive control systems显示文摘 | Liu G P Rees D Chai S C | 2005 | Measurementand Control2005，38，1： | 1 |
| 7 | A field guide to the insects and mites infesting cured fish显示文摘 | Haines C P Rees D P | 1998 | FAO Fisheries Technical Paper1998，，： | 1 |
| 8 | New threshold and confidence estimates for terminal restriction fragment length polymorphism analysis of complex bacterial communities 显示文摘 | OSBRONE C A REES G N JANSSEN P H | 2006 | Applied and Environmental Microbiology2006，72，2： | 1 |
| 9 | Design and stability analysis of networked control systems with random communication time delay using the modified MPC显示文摘 | Liu G P Mu J X Rees D Chai S C | 2006 | International Journal of Control2006，79，4： | 1 |
| 10 | The liverpool telescope: performance and first results显示文摘 | Steele I A Smith R J Rees P C | 2004 | SPIE2004，5489，： | 1 |
| 11 | Design and practical implementation of networked predictive control systems显示文摘 | Rees D Chai S C | 2005 | Network Sensing and Control2005，19，3： | 1 |
| 12 | Solid-phans organic reactions: a review of the recent literature显示文摘 | Hermkens P H H Ottenheijm H C J Rees D | 1996 | Tetrahedron1996，52，： | 1 |
| 13 | Bacteriophage applications:Where are we now?显示文摘 | Monk A B Rees C D Barrow P | 2010 | Letters in Applied Microbiology2010，51，： | 1 |
| 14 | Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli显示文摘 | Lowman M A Rees P H Benyon R C | 1988 | J Allergy Clin Immunol1988，81，： | 1 |
| 15 | Nitrous oxide in the Bellingshausen Sea and Drake Passage显示文摘 | Rees A P Owens N J P Upstill-Goddard R C | 1997 | Journal of Geophysical Research1997，102，2： | 1 |
| 16 | Genome-Wide SNP detection,validation,and development of an 8K SNP array for apple显示文摘 | Chagne D Crowhurst R N Troggio M Davey M W Gilmore B Lawley C Vanderzande S Hellens R P Kumar S CestaroA Velasco R Main D Rees J D Iezzoni A Mockler T Wilhelm L Van de Weg E Gardiner S E Bassil N Peace C | | 0，，： | 1 |
| 17 | Temporal variability of denitrification in estuarine sediments显示文摘 | Law C S Rees A P Owens N J P | 1991 | Estuarine Coastal and Shelf Science1991，33，1： | 1 |
| 18 | Design and stability analysis of networked control systems with random communication time delay using the modified MPC显示文摘 | Liu G P Mu J X Rees D Chai S C | | 0，，04： | 1 |
| 19 | Defining soil buffer power: Implications for ion diffuseion and nutrient uptake modeling显示文摘 | van Rees K C J Comerford N B Rao P S C | 1990 | Soil Sci Soc Am J1990，54，8： | 1 |
| 20 | The liver- pool telescope: performance and first results 显示文摘 | STEELE I A SMITH R J REES P C | 2004 | SPIE2004，5489，： | 1 |
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