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| 1 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 2 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 3 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 4 | 云南德钦白马雪山岩体热历史及其对青藏高原三江地区构造地貌演化的指示意义显示文摘青藏高原三江地区高程缓降、河流及深切峡谷发育,重建其构造-热年代时空演化为把握该地区地形地貌发育演化的内在驱动力提供科学依据。本研究以云南德钦白马雪山岩体为研究对象,开展磷灰石(U-Th)/He及裂变径迹年代学分析,结合已发表的U-Pb和Ar-Ar年代学结果来重塑该地区的构造-热演化历史和地形演化。研究表明,该地区经历了多期快速冷却事件:三叠世的岩浆侵位活动,早白垩世和中-晚始新世的快速冷却,以及中新世和上新世以来的快速剥蚀。青藏高原隆升致使全球气候变化的同时也导致其周缘地区经受强烈侵蚀:中新世以来(21~11Ma)快速冷却速率为10℃/Myr,而上新世以来(ca.5Ma)冷却速率从10℃/Myr增至15℃/Myr。假定区域现今地温梯度为25~35℃/km,河谷剖面不同位置的侵蚀速率及剥蚀量的空间分布特征进一步表明(靠近澜沧江主干道处侵蚀速率远高于其支流,且对应的年龄相对年轻),河流下切及溯源侵蚀的多重效应导致该地区快速剥蚀、剥露,地形起伏加大的瞬态地貌演化规律。 | 肖萍 刘静 王伟 曾令森 谢克家 Raphaёl PIK 钟宁 | 2015 | 岩石学报2015，31，5： | 3 |
| 5 | Fluctuation Relations for Diffusion Processes显示文摘 | Rapha?l Chetrite Krzysztof Gawe?dzki | 2008 | Communications in Mathematical Physics2008，，2： | 2 |
| 6 | Active learning of deep surrogates for PDEs:application to metasurface design显示文摘Surrogate models for partial differential equations are widely used in the design of metamaterials to rapidly evaluate the behavior of composable components.However,the training cost of accurate surrogates by machine learning can rapidly increase with the number of variables.For photonic-device models,we find that this training becomes especially challenging as design regions grow larger than the optical wavelength.We present an active-learning algorithm that reduces the number of simulations required by more than an order of magnitude for an NN surrogate model of optical-surface components compared to uniform random samples.Results show that the surrogate evaluation is over two orders of magnitude faster than a direct solve,and we demonstrate how this can be exploited to accelerate large-scale engineering optimization. | Raphaël Pestourie Youssef Mroueh Thanh V.Nguyen Payel Das Steven G.Johnson | 2020 | npj Computational Materials2020，，1： | 2 |
| 7 | Improved parallel interference cancellation for CDMA 显示文摘 | Divsalar D Simon M K Raphaeli D | 1998 | IEEE Trans on Communications1998，46，2： | 1 |
| 8 | Long‐term results of tension‐free vaginal tape for female urinary incontinence: Follow up over 6?years显示文摘 | XavierDeffieux Anne ClaireDonnadieu Rapha?lPorcher AmelieGervaise ReneFrydman HerveFernandez | 2007 | International Journal of Urology2007，，6： | 1 |
| 9 | A mathematical model for induction heating of thixoformable aluminum billets 显示文摘 | Raphae C Willem L | 1998 | Light Metals1998，，： | 1 |
| 10 | Adverse effects of propranolol when used in the treatment of hemangiomas:a case series of 28 infants显示文摘 | De Graaf M Breur JM Raphaěl MF | | 0，，02： | 1 |
| 11 | Non-invasive pulmonary aerosol delivery in mice by the endotracheal route显示文摘 | Maytal Bivas-Benita Rapha?l Zwier Hans E. Junginger Gerrit Borchard | 2005 | European Journal of Pharmaceutics and Biopharmaceutics2005，，3： | 1 |
| 12 | Optimization of oil yield and oil total phenolic content during grape seed cold screw pressing显示文摘 | Natacha R Raphaёlle S Brigitte T | 2015 | Industrial Crops and Products2015，63，： | 1 |
| 13 | IgE-binding epitopic peptide mapping on a three-dimensional model built for the 13S globulin allergen of buckwheat (Fagopyrum esculentum)显示文摘 | CAMILLE S RAPHAE C CLAUDE G | 2009 | Peptides2009，30，6： | 1 |
| 14 | Improved parallel interference canc ellation for CDMA 显示文摘 | Marvin K Simon Dan Raphaeli | 1998 | IEEE Transactions on communications1998，46，2： | 1 |
| 15 | IgE-binding epitopic peptide mapping on a three dimensional model built for the 13S globulin allergen of buckwheat (Fagopyrum esculentum)显示文摘 | CAMILLE S RAPHAE C CLAUDE G | 2009 | Peptides2009，30，6： | 1 |
| 16 | J Phys France显示文摘 | Ondarcuhu T Fabre P Rapha l E Veyssi M | 1990 | 51:1 5271990，51，： | 1 |
| 17 | Historical evolution of soil organic matter concepts and their relationships with the fertility and sustainability of cropping systems显示文摘 | Rapha?l J. Manlay Christian Feller M.J. Swift | 2006 | Agriculture Ecosystems and Environment2006，，3： | 1 |
| 18 | Semiblind Turbo equalization scheme for LTE uplink receiver 显示文摘 | KUTZ G BAR-OR A RAPHAELI D | 2012 | IEEE transactions on vehicular technology2012，61，9： | 1 |
| 19 | The Effects of Prolonged Ambulation on Labor with Epidural Analgesia显示文摘 | Stéphane Frenea Christine Chirossel Rapha?l Rodriguez Jean-Philippe Baguet Claude Racinet Jean-Francois Payen | 2004 | Anesthesia & Analgesia2004，，1： | 1 |
| 20 | Intravenous immunoglobulin for Guillain-Barr syndrome显示文摘 | Hughes RA Rapha 1 JC Swan AV | 2001 | Cochrane Database Syst Rev2001，，00： | 1 |
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