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| 1 | Is breast conservative surgery a reasonable option in multifocal or multicentric tumors?显示文摘The incidence of multifocal(MF) and multicentric(MC) carcinomas varies widely among clinical studies,depending on definitions and methods for pathological sampling.Magnetic resonance imaging is increasingly used because it can help identify additional and conventionally occult tumors with high sensitivity.However,false positive lesions might incorrectly influence treatment decisions.Therefore,preoperative biopsies must be performed to avoid unnecessary surgery.Most studies have shown higher lymph node involvement rates in MF/MC tumors than in unifocal tumors.However,the rate of local recurrences is usually low after breast conservative treatment(BCT) of MC/MF tumors.It has been suggested that BCT is a reasonable option for MC/MF tumors in women aged 50-69 years,with small tumors and absence of extensive ductal carcinoma in situ.A metaanalysis showed an apparent decreased overall survival in MC/MF tumors but data are controversial.Surgery should achieve both acceptable cosmetic results and negative margins,which requires thorough preoperative radiological workup and localization of lesions.Boost radiotherapy techniques must be evaluated since double boosts might result in increased toxicity,namely fibrosis.In conclusion,BCT is feasible in selected patients with MC/MF but the choice of surgery must be discussed in a multidisciplinary team comprising at least radiologists,surgeons and radiotherapists. | Gilles Houvenaeghel Agnès Tallet Aurélie Jalaguier-Coudray Monique Cohen Marie Bannier Camille Jauffret-Fara Eric Lambaudie | 2016 | World Journal of Clinical Oncology2016，7，2： | 4 |
| 2 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 3 | Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits 显示文摘 | Camille S Bowen Forbes Yanjun Zhang Muraleedharan G Nair | 2009 | Journal of Food Composition and Analysis2009，23，6： | 1 |
| 4 | IgE-binding epitopic peptide mapping on a three-dimensional model built for the 13S globulin allergen of buckwheat (Fagopyrum esculentum)显示文摘 | CAMILLE S RAPHAE C CLAUDE G | 2009 | Peptides2009，30，6： | 1 |
| 5 | Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD显示文摘 | Camille D Mona B Salman S | 2010 | Chest2010，138，5： | 1 |
| 6 | IgE-binding epitopic peptide mapping on a three dimensional model built for the 13S globulin allergen of buckwheat (Fagopyrum esculentum)显示文摘 | CAMILLE S RAPHAE C CLAUDE G | 2009 | Peptides2009，30，6： | 1 |
| 7 | Sediment - magnetic signature of land - use and drought as recorded in lake sediment from south - central Minnesota, USA 显示文摘 | Geiss C E Banerjee S K Camill P | 2004 | Quaternary Research2004，62，2： | 1 |
| 8 | Anthocyanin content, antiox-idant, anti-inflammatory and anticancer properties of blackberry and raspberry fi'uits显示文摘 | CAMILLE S BOWEN F ZHANG Y | 2010 | J Food Corala Anal2010，23，6： | 1 |
| 9 | Manual rota- tion in occiput posterior or transverse positions: risk factors and consequences on the cesarean delivery rate 显示文摘 | CAMILLE L R PAULINE S THOMAS S | 2007 | Obstet Gynecol2007，110，4： | 1 |
| 10 | Anthocyanin content, antioxidant, anti-inflammatory and antieancer properties of blackberry and raspberry fruits显示文摘 | CAMILLE S BOWEN-FORBES ZHANG Y | 2010 | Journal of Food Composition and Analysis2010，23，6： | 1 |
| 11 | Climate change disequilibrium of boreal permafrost petlands caused by local processes显示文摘 | Camill P Clark G S | 1989 | The American Naturalist1989，151，3： | 1 |
| 12 | Stigma in HIV- positive women 显示文摘 | Margarete S Camille L Julie B | 2004 | Journal of Nursing Scholarship2004，36，2： | 1 |
| 13 | Epidemic of end-stage renal Disease in peoplewith diabetes in the United States population: Do we knowthe cause显示文摘 | Camille A J Andrzej S K John R | 2005 | Kidney Int2005，67，5： | 1 |
| 14 | Evolving Towards the Hypercycle: A Spatial Model of Molecular Evolution 显示文摘 | CAMILLE S O A PETER F S | 2006 | Physica D2006，217，2： | 1 |
| 15 | Interpreting recruitment limi- tation in forests显示文摘 | Clerk J S Beckage B Camill P | 1999 | American Journal of Botany1999，84，1： | 1 |
| 16 | Antiinflammatoryproperties of cholinergic up-regulation: a new role for ace-tylcholinesterase inhibitors显示文摘 | Eran N Yasmine HA Camille S | 2006 | Neuropharmacol2006，50，5： | 1 |
| 17 | Liver transplantation for hepatopulmonary syndrome: A ten-year experience in Paris, France显示文摘 | Camille Taille Jacquès Cadranel Agnes Bellocq Gabriel Thabut Olivier Soubrane Fran?ois Durand Philippe Icha? Christophe Duvoux Jacques Belghiti Yvon Calmus Hervé Mal | 2003 | Transplantation2003，，9： | 1 |
| 18 | 小鼠白念珠菌抗原特异性T细胞系的建立和TH1、TH2细胞因子的产生显示文摘在念珠菌感染时,TH1细胞分泌IL-12、IFN-γ,可激活或提高中性粒细胞和巨噬细胞抗念珠菌的能力,而TH2细胞分泌的IL-4和IL-10对机体的抗念珠菌有抑制作用。T细胞产生的这些细胞因子对宿主抗念珠菌有重要意义。动物实验证实小鼠对全身和皮肤-黏膜念珠菌感染的敏感程度与其自身的TH1和TH2细胞因子的平衡密切相关。但是,鉴于这些研究之间尚存在着很多矛盾或争议的观点,例如,在小鼠实验中发现,给已感染念珠菌的小鼠注射重组IFN-γ能提高小鼠的生存能力和巨噬细胞在体外的杀念珠菌的能力。但也有实验表明,小鼠在接受了IFN-γ后,对白念珠菌的敏感性增加。我们在细胞因子研究方面仍有大量的工作要做。 | 胡雁 章小缓 Camile S Farah Robert B Ashman | 2007 | 中华微生物学和免疫学杂志2007，27，1： | 1 |
| 19 | Ursolic acid analogues: non-phenolic functional food components in Ja- maican raspberry fruits 显示文摘 | Camille S Bowen-Forbes Vanisree Mulabagal | 2009 | Food Chem2009，116，3： | 1 |
| 20 | Homology modelling and conformational analysis of IgE-binding epitopes of Ara h 3 and other legumin allergens with a cupin fold from tree nuts显示文摘 | Annick B Geraldine J Camille S | 2007 | Molecular Im- munology2007，44，： | 1 |
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