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| 1 | Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats显示文摘The aim of this study was to evaluate the effect of naringin on experimentally induced inflammatory bowel disease in rats.Naringin(20,40 and 80 mg/kg) was given orally for 7 days to Wistar rats before induction of colitis by intrarectal instillation of 2 mL of 4%(v/v) acetic acid solution.The degree of colonic mucosal damage was analyzed by examining mucosal damage,ulcer area,ulcer index and stool consistency.Intrarectal administration of 4%acetic acid resulted in significant modulation of serum alkaline phosphatase,lactate dehydrogenase,superoxide dismutase(SOD),glutathione(GSH),malondialdehyde(MDA) and myeloperoxidase(MPO) content along with colonic nitric oxide(NO),xanthine oxidase(XO) level and protein carbonyl content in the colonic tissue as well as in blood.Naringin(40 and 80 mg/kg) exerted a dose dependent(P < 0.05) ameliorative effect,as it significantly increased hematological parameter as well as colonic SOD and GSH.There was a significant(P < 0.05)and dose dependant inhibition of macroscopical score,ulcer area along with colonic MDA,MPO activity by the7 days of pretreatment of naringin(40 and 80 mg/kg).Biochemical studies revealed a significant(P < 0.05) dose dependant inhibition in serum alkaline phosphatase(ALP) and lactate dehydrogenase(LDH) levels by pretreatment of naringin.Increased levels of colonic NO,XO,protein carbonyl content and DNA damage were also significantly decreased by naringin pretreatment.The findings of the present investigation propose that naringin has an anti-inflammatory,anti-oxidant and anti-apoptotic potential effect at colorectal sites as it modulates the production and expression of oxidative mediators such as MDA,MPO,NO and XO,thus reducing DNA damage. | Venkatashivam Shiva Kumar Anuchandra Ramchandra Rajmane Mohammad Adil Amit Dattatraya Kandhare Pinaki Ghosh Subhash Laxman Bodhankar | 2014 | The Journal of Biomedical Research2014，28，2： | 8 |
| 2 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 3 | Predictive distribution modeling for rare Himalayan medicinal plant Ber- beris aristata DC 显示文摘 | Kiranmayi M U Gururaja K V Ramchandra T V | 2011 | Journal of Environmental Biology2011，32，6： | 1 |
| 4 | Catalytic characteristics of MnO<SUB>2</SUB> nanostructures for the O<SUB>2</SUB> reduction process显示文摘 | Ramchandra S Kalubarme Min-Seung Cho Kwi-Sub Yun Tae-Sin Kim Chan-Jin Park | 2011 | Nanotechnology2011，，39： | 1 |
| 5 | Blind trampyloric nasojejunal versus nusogastric tube intubation in severe head injuries:a preliminary report显示文摘 | Ramchandra P Nathoo N | 2005 | J Clin Neurosci2005，12，4： | 1 |
| 6 | Imaging and pathological fea- tures of primary hepatic neuroendocrine carcinoma:An analysis of nine cases and review of the literature 显示文摘 | Chen Z Xiao HE Ramchandra P | 2014 | Oncol Lett2014，7，4： | 1 |
| 7 | Transition Metal Ion Impregnated Mesoporous TiO2 for Photocatalytic Degradation of Organic Contaminants in Water显示文摘 | Rajesh J T Ramchandra G K Raksh V J | 2006 | Ind Eng Chem Res2006，45，15： | 1 |
| 8 | Central angioten- sin type 1 receptor blockade decreases cardiac but not renal sym- pathetic nerve activity in heart failure 显示文摘 | Ramchandra R Hood S G Watson A M | 2012 | Hypertension2012，59，3： | 1 |
| 9 | Role of renal sympathetic nerve activity in hypertension induced by chronic nitric oxide inhibition 显示文摘 | Ramchandra R Barrett C J Guild SJ | 2007 | Am J Physiol Regul Integr Comp Physiol2007，292，4： | 1 |
| 10 | Problems in preparation of FeZSM-5 catalysts显示文摘 | W. Keith Hall Xiaobing Feng James Dumesic Ramchandra Watwe | 1998 | Catalysis Letters (-)1998，，1： | 1 |
| 11 | Hypertonic sodium resuscitation after hemorrhage improves hemodynamic function by stimulating cardiac,but not renal,sympathetic nerve activity显示文摘 | Frithiof R Ramchandra R Hood SG | 2011 | Am J Physiol Heart Circ Physiol2011，300，2： | 1 |
| 12 | What sets the long-term level of renal sympathetic nerve activity: a role for an giotensing II and baroreflexes 显示文摘 | Barrett CJ Ramchandra R Guild SJ | 2003 | Circ Res2003，92，12： | 1 |
| 13 | Hypertonic sodium resuscitation after hemorrhage improves modynamic function by stimulating cardiac, but not renal, sympathetic nerve activity显示文摘 | Frithiof R Ramchandra R Hood SG | 2011 | Am J Physiol Heart Circ Physiol2011，300，2： | 1 |
| 14 | Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure显示文摘 | Ramchandra R Hood SG Watson AM | | 0，，03： | 1 |
| 15 | Anti-Arthritic Activity of Bartogenic Acid Isolated from Fruits of Barringtonia racemosa Roxb. (Lecythidaceae)显示文摘 | Kalpesh Ramdas Patil Chandragouda Raosaheb Patil Ramchandra Baburao Jadhav Vallabh Krishnalal Mahajan Prabhakar Raosaheb Patil Pradeep Sampatrao Gaikwad | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 16 | Effects of boron defieciecy and recovery on water relation and photosynthesis in cauliflower显示文摘 | Sharma P N Tanuja Ramchandra | 1991 | Indian J of Exper Biology1991，29，10： | 1 |
| 17 | Role of prostaglm:- dins in determining the increased cardiac sympathetic nerve activi- ty in ovinesepsis显示文摘 | Booth LC Ramchandra R Calzavacca P | 2014 | Am J Physiol Regul Integr Comp Physiol2014，307，1： | 1 |
| 18 | Albumin microspheres as carriers for the antiarthritic drug celecoxib显示文摘 | Hetal Thakkar Rakesh Kumar Sharma Anil Kumar Mishra Krishna Chuttani Rayasa Ramchandra Murthy | 2005 | AAPS PharmSciTech2005，，1： | 1 |
| 19 | Hypertonic sodium resus- citation after hemorrhage improves hemodynamic function by stimulating cardiac, but not renal, sympathetic nerve activity 显示文摘 | Frithiof R Ramchandra R Hood S G | 2011 | Am J Physiol Heart Circ Physiol2011，300，2： | 1 |
| 20 | Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure 显示文摘 | RAMCHANDRA R HOOD S G WATSON A M | 2012 | Hypertension2012，59，3： | 1 |
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