|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Optimum chemotherapy for the management of advanced biliary tract cancer显示文摘Biliary tract cancers(BTCs) are highly fatal malignancies, which are often diagnosed at an advanced stage and have relatively poor prognosis.The treatment of patients with advanced BTC is systemic, based on chemotherapy or best supportive care, depending on their performance status.Despite clinical trials studyingmany chemotherapeutic regimens and targeted therapies for the treatment of BTC, the standard of care for advanced BTC remains the combination of gemcitabine with cisplatin.Many new molecules targeting proliferation and survival pathways, the immune response and angiogenesis are currently undergoing phase Ⅰ and Ⅱ trials for the treatment of advanced BTC with promising results. | Marwan Ghosn Hampig Raphael Kourie Elie El Rassy Ralph Chebib Fadi El Karak Colette Hanna Dolly Nasr | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 2 | Two-point compression ultrasonography: Enough to rule out lower extremity deep venous thrombosis?显示文摘BACKGROUND: Deep venous thrombosis(DVT) is a major cause of morbidity and is a common presenting complaint to the emergency department(ED). Point-of-care two-point compression ultrasonography has evolved as a quick and effective way of diagnosing DVT. The purpose of this study is to validate the prevalence and distribution of venous thrombi isolated to proximal lower extremity veins, other than common femoral and popliteal veins in patients with DVT.METHODS: This is a single-center retrospective study that looked at patients presenting to the ED of a tertiary care hospital between January 2014 and August 2018. The clinical presentation and laboratory and imaging results were obtained using the hospital's electronic medical record.RESULTS: A total of 2,507 patients underwent a lower extremity duplex ultrasound during the study period. Among them, 379(15%) were included in the study. The percentages of isolated thrombi to the femoral vein and deep femoral vein were 7.92% and 0.53%, respectively. When the patients were stratified into the two groups of isolated DVT and two-point compression DVT, there were no statistically significant differences in the laboratory results between both groups. However, immobilized patients and patients with recent surgeries were more likely to have an isolated DVT.CONCLUSIONS: Thrombi isolated to proximal lower extremity veins other than the common femoral and popliteal veins make up 8.45% of DVTs. Given this significant number of missed DVTs, the authors recommend the addition of the femoral and deep femoral veins to the two-point compression exam. | Ralphe Bou Chebl Nader El Souki Mirabelle Geha Imad Majzoub Rima Kaddoura Hady Zgheib | 2021 | World Journal of Emergency Medicine2021，12，4： | 2 |
| 3 | Abrogation of the Rb/p16 tumor suppressive pathway in virtually all pancreatic carcinomas 显示文摘 | Mieke S Ralph H Joseph G et el | 1997 | Cancer Res1997，57，8： | 1 |
| 4 | Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproducitive toxicants显示文摘 | Ralph EL Lillian Fs & Valwei LS | 1992 | Rep Toxicol1992，6，： | 1 |
| 5 | Women's preferences for se- lective estrogen reuptake modulators : An investigation using pro- tection motivation theory显示文摘 | Ralph AF Ager B Bell ML el al | 2014 | Patient Educ Couns2014，96，1： | 1 |
| 6 | Changes in sphingomyelinases, ceramide, Bax, Bcl 2 , and caspase-3 during and after experimental status epilepticus显示文摘 | Mohamad A. Mikati Michele Zeinieh Ralph Abi Habib Jimmy El Hokayem Amal Rahmeh Marwan El Sabban Julnar Usta Ghassan Dbaibo | 2008 | Epilepsy Research2008，，2： | 1 |
| 7 | Process and case illustration ofconstruction innovation 显示文摘 | Abd El Halim A 0 Ralph Haas | 2004 | Journal of Construction Engineeringand Management2004，130，4： | 1 |
| 8 | DNA barcodes confirm the presence of a single member of the Anopheles maculipennis group in Morocco and Algeria: An. sicaulti is conspecific with An. labranchiae显示文摘 | Majda Laboudi Chafika Faraj Abderrahim Sadak Zoubir Harrat Said Chawki Boubidi Ralph E. Harbach Rajae El Aouad Yvonne-Marie Linton | 2010 | Acta Tropica2010，，1： | 1 |
| 9 | QT-GWAS:A novel method for unveiling biosynthetic loci affecting qualitative metabolic traits显示文摘Although the plant kingdom provides an enormous diversity of metabolites with potentially beneficial applications for humankind,a large fraction of these metabolites and their biosynthetic pathways remain unknown.Resolving metabolite structures and their biosynthetic pathways is key to gaining biological understanding andto allow metabolic engineering.In orderto retrieve novel biosynthetic genes involved in specialized metabolism,we developed a novel untargeted method designated as qualitative trait GWAs(QT-GWAS)that subjects qualitative metabolic traits to a genome-wide association study,while the conventional metabolite GWAS(mGWAS)mainly considers the quantitative variation of metabolites.As a proof of the validity of QT-GWAS,23 and 15of the retrieved associations identified in Arabidopsis thaliana by QTGWAS and mGWAS,respectively,were supported by previous research.Furthermore,seven genemetabolite associations retrieved by QT-GWAS were confirmed in this study through reverse genetics combined with metabolomics and/or in vitro enzyme assays.As such,we established that CYTOCHROME P450706A5(CYP706A5)is involved in the biosynthesis of chroman derivatives,UDP-GLYCOSYLTRANSFERASE 76C3(UGT76C3)is able tohexosylate guanine in vitro and in planta,and SULFOTRANSFERASE 202B1(SULT202B1)catalyzes the sulfation of neolignans in vitro.Collectively,our study demonstrates that the untargeted QT-GWAS method can retrieve valid gene-metabolite associations at the level of enzyme-encoding genes,even new associations that cannot be found by the conventional mGwAs,providing a new approach for dissecting qualitative metabolic traits. | Marlies Brouckaert Meng Peng RenéHofer lias El Houari Chiarina Darrah Veronique Storme Yvan Saeys Ruben Vanholme Geert Goeminne Vitaliy I.Timokhin John Ralph Kris Morreel Wout Boerjan | 2023 | Molecular Plant2023，16，7： | 0 |
| 10 | Comparing the demographic data and outcomes of septic shock patients presenting to teaching or non-teaching metropolitan hospitals in the United States显示文摘BACKGROUND:Studies looking at the effect of hospital teaching status on septic shock related in-hospital mortality are lacking.The aim of this study was to examine the effect of hospital teaching status on mortality in septic shock patients in the United States.METHODS:This was a retrospective observational study,using the Nationwide Emergency Department Sample Database(released in 2018).All patients with septic shock were included.Complex sample logistic regression was performed to assess the impact of hospital teaching status on patient mortality.RESULTS:A total of 388,552 septic shock patients were included in the study.The average age was 66.93 years and 51.7%were males.Most of the patients presented to metropolitan teaching hospitals(68.2%)and 31.8%presented to metropolitan non-teaching hospitals.Septic shock patients presenting to teaching hospitals were found to have a higher percentage of medical comorbidities,were more likely to be intubated and placed on mechanical ventilation(50.5%vs.46.9%)and had a longer average length of hospital stay(12.47 d vs.10.20 d).Septic shock patients presenting to teaching hospitals had greater odds of in-hospital mortality compared to those presenting to metropolitan non-teaching hospitals(adjusted odd ratio[OR]=1.295,95%confidence interval[CI]:1.256-1.335).CONCLUSION:Septic shock patients presenting to metropolitan teaching hospitals had significantly higher risks of mortality than those presenting to metropolitan non-teaching hospitals.They also had higher rates of intubation and mechanical ventilation as well as longer lengths of hospital stay than those in non-teaching hospitals. | Ralph Bou Chebl Nadim Kattouf Mohamad Assaf Saadeddine Haidar Gilbert Abou Dagher Sarah Abdul Nabi Rana Bachir Mazen El Sayed | 2022 | World Journal of Emergency Medicine2022，13，6： | 0 |
| 11 | Role of urine studies in asymptomatic febrile neutropenic patients presenting to the emergency department显示文摘BACKGROUND: The role of urine studies in the detection of urinary tract infection(UTI) in febrile neutropenic patients with urinary symptoms(having a urinary catheter or having a positive urine analysis) is inarguable. However, the evidence is scarce regarding the indication for urine studies in asymptomatic(i.e., without urinary symptoms) patients with febrile neutropenia(FN) presenting to the emergency department(ED). The aim of this study is to evaluate the need for obtaining urine studies in asymptomatic febrile neutropenic patients.METHODS: This was a retrospective cohort study conducted on adult cancer patients who presented to the ED with FN and had no urinary symptoms. We included all ED presentations of eligible patients between January 2013 and September 2018. Student's t-test and Wilcoxon rank-sum test were used for continuous data, while Chi-square and Fisher's exact tests were used for categorical data. Participants were divided into two groups based on their urine culture(UC) results: negative and positive UCs. Two cut-offs were used for positive UC results: ≥10~5 cfu/m L and ≥10~4 cfu/m L.RESULTS: We included 284 patients in our study. The age of our patient population was 48.5±18.5 years. More than two-thirds(68.7%) of patients had severe neutropenia, while only 3.9% and 9.9% of the patients had positive UCs at ≥10~5 cfu/m L and ≥10~4 cfu/m L, respectively. UCs were expectedly positive in most patients with urinalysis(UA) abnormalities. However, 27.3% and 32.1% of patients with positive UCs at ≥10~5 cfu/m L and ≥10~4 cfu/m L respectively had a normal UA. CONCLUSIONS: In our study, the incidence of UTI in adult febrile neutropenic cancer patients who present to the ED without urinary symptoms is low. Consequently, routine urine testing may not be warranted in this population, as it adds unnecessary financial burdens on the patients and delays timely management. | Hady Zgheib Aline El Zakhem Cynthia Wakil Mohamad Ali Cheaito Rola Cheaito Antoine Finianos Ralphe Bou Chebl Rima Kaddoura Nader Al Souky Imad El Majzoub | 2021 | World Journal of Emergency Medicine2021，12，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员