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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Mental health of parents of children with autism spectrum disorder during COVID-19 pandemic: A systematic review显示文摘BACKGROUND Children diagnosed with autism spectrum disorder(ASD)may have great difficulties when their routines change,and this may affect the psychological wellbeing of their parents.For this reason,it is important to examine studies that address the mental health of parents in order to adapt to the coronavirus disease 2019(COVID-19)pandemic.AIM To determine the mental health status of parents with children diagnosed with ASD in the COVID-19 pandemic.METHODS The study,which is a systematic review,was conducted between December 15,2020 and December 30,2020 by scanning articles in English.The Scopus,Science Direct,PubMed,Cochrane,Web of Science,and Google Scholar databases were used for scanning.The keywords COVID-19 AND(“autism”OR“autistic”OR“autism spectrum disorder”)AND parent AND(“mental health”OR“anxiety”OR“stress”)were used in the search process.The inclusion criteria in the study were findings regarding the mental health of parents with children diagnosed with ASD in the COVID-19 pandemic,addressing their anxiety and stress situations,being a research article,and accessing the full text of the article.RESULTS In the study,a total of 6389 articles were reached,and the full texts of 173 articles were evaluated for eligibility.After the articles excluded by the full-text search were eliminated,12 studies involving 7105 parents were included in the analysis.The findings obtained from the articles containing data on mental health in the COVID-19 pandemic of parents with children with autism spectrum disorder were discussed in three groups.These were findings on the experiences of parents with children with ASD in the COVID-19 pandemic regarding the areas where parents with children with ASD need support in the COVID-19 pandemic and methods of coping with the COVID-19 pandemic for parents with children with ASD.In the systematic review,it was determined that the anxiety and stress of the parents increased,they needed more support compared to the pre-pandemic period,and they had difficulty coping.CONCLUSION In this systematic review,it was concluded that the COVID-19 pandemic negatively affected the mental health of the parents of children with ASD. | Büşra Yılmaz Merve Azak NevinŞahin | 2021 | World Journal of Psychiatry2021，11，7： | 2 |
| 5 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 6 | Hydrogen Peroxide stimulates extracellular signal-- regulated protein kinases in pulmonary arterial smooth muscle cells显示文摘 | Jin N Liu Y Rhoades RA | 1998 | AmJ RespirCell Mol Biol1998，19，2： | 1 |
| 7 | Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type显示文摘 | Miyazaki Y DeFronzo RA | 2009 | Cardiovase Diabetol2009，8，： | 1 |
| 8 | Metallothionein-Ⅰ/Ⅱ null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals显示文摘 | Liu J Liu Y Goyer RA | 2000 | Toxicol Sci2000，55，2： | 1 |
| 9 | Toll-like receptor 2 is re-quired for innate, butnot acquired, host defense to Borrelia buzgdoifen显示文摘 | WootenRM Ma Y Yoder RA | 2002 | Immunol2002，168，1： | 1 |
| 10 | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding proteinlc (SREBP-lc) gene by antagonizing ligand-dependent activation of the LXR显示文摘 | Ou J Tu H Shan B Luk A DeBose-Boyd RA Bashmakov Y Goldstein JL Brown MS | | 0，，11： | 1 |
| 11 | Is airway smooth muscle the ' missing link' modulating airway inflammation in asthma? 显示文摘 | Tliba 0 Amrani Y Panettieri RA Jr | 2008 | Chest2008，133，1： | 1 |
| 12 | Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores : a potential therapy for treatment of lipofuscin-based retinal diseases显示文摘 | Radu RA Han Y Bui TV | 2005 | Invest Ophthalmol Vis Sci2005，46，12： | 1 |
| 13 | Astrocytes and brain injury 显示文摘 | Chen Y Swanson RA | 2003 | J Cereb Blood Flow Metab2003，23，2： | 1 |
| 14 | Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress 显示文摘 | Teshima Y Akao M Li RA | 2003 | S roke2003，34，7： | 1 |
| 15 | Intrafamilial correlation of clinical manifestations in neurofibromatosis 2显示文摘 | Zhao Y Kumar RA Baser ME | 2002 | Genet Epidemiol2002，23，3： | 1 |
| 16 | Airway smooth muscle: contraction and beyond显示文摘 | Amrani Y Panettieri RA | 2003 | Int J Biochem Cell Biol2003，35，3： | 1 |
| 17 | Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin phar- macokinetics显示文摘 | Shu Y Brown C Castro RA | 2008 | Clin Pharmacol Ther2008，83，2： | 1 |
| 18 | Structure of the human activatingnatural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6显示文摘 | Li Y Wang Q Mariuzza RA | 2011 | J Exp Med2011，208，4： | 1 |
| 19 | Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neoartery 显示文摘 | WU W ALLEN RA WANG Y | 2012 | Nat Med2012，18，7： | 1 |
| 20 | Serum thyroid hormone levels may not accurately reflect thyroid tissue levels and cardiac function in mild hypothyroidism显示文摘 | Liu Y Redetzke RA Said S | 2008 | Am J Physiol Heart Circ Physiol2008，294，5： | 1 |
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