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| 1 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 2 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 3 | Survey of clustering algorithms显示文摘 | XU Rui WUNSCH D I I | 2005 | IEEE Trans on Neural Networks2005，16，3： | 1 |
| 4 | Survery of clustering algorithms显示文摘 | Xu Rui Wunseh D | 2005 | IEEE Trans on Neural Networks2005，16，3： | 1 |
| 5 | SOCS-I and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2显示文摘 | Rui LY Yuan MS Frantz D | 2002 | J Biol Chem2002，277，44： | 1 |
| 6 | Characterization of NMDA induced depression in rat hippocampus: involvement of AMPA and NMDA receptors显示文摘 | RUI L MIKHAIL D FREDRIK H | 2004 | Neuroscience Letters2004，，357： | 1 |
| 7 | Survey of clustering algorithm 显示文摘 | Xu Rui Wunsch D | 2005 | IEEE Trans on Neural Network2005，16，3： | 1 |
| 8 | Countermeasure for frost heave of concrete L-type retaining wall backfill with granular wastes显示文摘 | RUI D H SUZUKI T YAMASHITA S HYASHI K | 2006 | Journal of Geotechnical Engineering for JSCE2006，62，3： | 1 |
| 9 | Elemene for the treatment of lung cancer 显示文摘 | Rui D Chen X Y Wu T X | 2007 | Cochrane Database Syst Rev2007，17，00： | 1 |
| 10 | SOCS-1 and SOCS-3 block insulinsignaling by ubiquitin-mediated degradation of IRS1 and IRS2 显示文摘 | Rui L Yuan M Frantz D | 2002 | J Biol Chem2002，277，42： | 1 |
| 11 | Frost heave force of natural ground and countermeasure for damage of structures显示文摘 | RUI D H SUZUKI T KIM YONGSU | 2007 | Journal of the Korean Geotechnical Society2007，23，5： | 1 |
| 12 | Urinary trypsin inhibitor attenuatesseawater induced acute lung injury by influencing theactivities of nuclear factor κB and its related inflammatory mediators显示文摘 | Rui M Yunyou D Xinhong Z | 2012 | Respiration2012，83，： | 1 |
| 13 | SOCS-1 and SOCS-3 block insulin signaling by ubiquitin mediated degradation of IRS1 andIRS2显示文摘 | Rui L Yuan M Frantz D | 2002 | J Biol Chem2002，277，44： | 1 |
| 14 | Survey of clustering algorithms显示文摘 | Rui Xu Wunsch D | 2005 | IEEE Trans on Neural Network2005，16，3： | 1 |
| 15 | Expression of defender against apoptotic death (DAD-1) in lr/s and Dianthus petals显示文摘 | Van Der Kop D A M Ruys G Dees D | 2003 | Physiolo- gia Plantarum2003，117，2： | 1 |
| 16 | Vegetation cover reduces erosion and enhances soil organic carbon in a vineyard in the central spain显示文摘 | Rui~Colmenero M Bienes R Eldridge D J | 2013 | Catena2013，104，： | 1 |
| 17 | Survey of clustering algorithms 显示文摘 | Xu Rui Wunsch D | 2005 | IEEE Transactions on Neural Networks2005，16，3： | 1 |
| 18 | Sparse transfer learning for interac- tive video search reranking 显示文摘 | Tian X Tao D Rui Y | 2011 | ACM Transactions on Multi- media Computing Communications & Applications2011，8，3： | 1 |
| 19 | A mathematical model for predic- tion of compressive strength in cement-silica fume blends 显示文摘 | Zeli J Rui D Krstulovi R | 2004 | Cement and Concrete Research2004，34，12： | 1 |
| 20 | Mutual information:a measure of dependency for nonlineartime series 显示文摘 | Andreia D Rui M Diana A M | 2004 | Physica A2004，344，2： | 1 |
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