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148篇 您的检索式:作者名="Dees D"
    题名 作者 年代 出处 被引量
1Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients.Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor 2016World Journal of Hypertension2016,6,1:3
2Predictors of complications after endoscopic retrograde cholangiopancreatography: a prognostic model for early discharge显示文摘Jeurnink S M Siersema P D Steyerberg E W Dees J Poley J W Haringsma J 2011Surg Endosc2011,25,:1
3Mal-aligning humeral offset may not effect shoulder:a biomechanical study显示文摘McMahon P J Dee D T Yang B Y 2003Med Sci Monit2003,9,8:1
4Immunocytochemical analysis of progesteronereceptors in breast Cancer显示文摘Masood S Dee S Jeffrey D 1991Am J clinpathol1991,96,1:1
5The ERA - Interim reanalysis: configuration and performance of the data assimilation system显示文摘Dee D P Uppala S M Simmons A J 2011Q J R Meteorol Soc2011,137,:1
6Simplification of the Kalman filter for meteorologicald ata assimilation显示文摘Dee D P 1991Quarterly Journal of the Royal Meteorological Society1991,117,:1
7Expression of defender against apoptotic death (DAD-1) in lr/s and Dianthus petals显示文摘Van Der Kop D A M Ruys G Dees D 2003Physiolo- gia Plantarum2003,117,2:1
8Exploring the international linkages of the euro area:A global VAR analysis显示文摘DEES S MAURO F D PESARAN M H 2007Journal of applied econometrics2007,22,1:1
9Data assimilation in the presence of forecast bias:The GEOS moisture analysis显示文摘Dee D P Todling R 2000Monthly Weather Review2000,128,9:1
10Transmission of PRRS virus from persistently infected sows to contact controls显示文摘Bierk M D Dee S A Rossow K D 2001Can J Vet Res2001,65,4:1
11Water-mlubie fluorescent carbon quantum dots and photocatalyst design 显示文摘Li H T He X D Kang Z H Huang H Liu Y Liu J Lian S Y Tsang C H A Yang X B Dee S T 2010Angezandte Chernie International Edition2010,49,26:1
12The ERA-Interim reanalysis: Configuration and performance of the data assimilation system 显示文摘DEE D P UPPALA S M SIMMONS A J 2011Q J R Meteo Soc2011,137,656:1
13The primate ovary contains a population of catecholaminergic neuron-like cells expressing nerve growth factor receptors 显示文摘Dees W L Hiney J K Schuhea T D 1995Endocrinology1995,136,:1
14Improved delay-range-dependent stability criteria for linear systems wiht time-varying delays 显示文摘Sun J Liu G P Chen J Dees D 2010Automatica2010,46,2:1
15Cytokines involved in interferon-gamma production by human macrophages显示文摘Robinson C M O'Dee D Hamilton T 0,,01:1
16Development of a high-power lithium-ion battery显示文摘JANSEN A N KAHAIAN A J KEPLER K D NELSON P A AMINE K DEES D W VISSERS D R THACKERAY M M 1999Journal of Power Sources1999,8182,:1
17The ERA-Interim reanalysis:configuration and performance of the data assimilation system显示文摘Dee D P Uppala S M Simmons A J 2011Quarterly Journal of the Royal Meteorological Society2011,137,656:1
18Structural and electrochemical studies of or-manganese dioxide (a-MnO2) 显示文摘JOHNSON C S DEE D W MANSUETTO M F 1997Journal of Power Sources1997,,68:1
19Conductivity of porous Ni/ZrO2-Y2O3 cermets显示文摘Dees D W Claar T D Easler T E 1987J Electrochem Soc1987,134,9:1
20Studies of Mg-substituted Li4-xMgxTi5O12 spinel electrodes (0≤x≤1) for lithium batteries显示文摘CHEN C H VAUGHEY J T JANSEN A N DEES D W KAHAIAN A J GOACHER T THACKERAY M M 2001Journal of the Electrochemical Society2001,148,1:1
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