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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Contemporary review of minimally invasive pancreaticoduodenectomy显示文摘AIM To assess the current literature describing various minimally invasive techniques for and to review short-term outcomes after minimally invasive pancreaticoduodenectomy(PD). METHODS PD remains the only potentially curative treatment for periampullary malignancies, including, most commonly, pancreatic adenocarcinoma. Minimally invasive approaches to this complex operation have begun to be increasingly reported in the literature and are purported by some to reduce the historically high morbidity of PD associated with the open technique. In this systematic review, we have searched the literature for high-quality publications describing minimally invasive techniques for PD-including laparoscopic, robotic, and laparoscopicassisted robotic approaches(hybrid approach). We have identified publications with the largest operative experiences from well-known centers of excellence for this complex procedure. We report primarily short term operative and perioperative results and some short term oncologic endpoints. RESULTS Minimal y invasive techniques include laparoscopic, robotic and hybrid approaches and each of these techniques has strong advocates. Consistently, across all minimally invasive modalities, these techniques are associated less intraoperative blood loss than traditional open PD(OPD), but in exchange for longer operating times. These techniques are relatively equivalent in terms of perioperative morbidity and short term oncologic outcomes. Importantly, pancreatic fistula rate appears to be comparable in most minimally invasive series compared to open technique. Impact of minimally invasive technique on length of stay is mixed compared to some traditional open series. A few series have suggestedthat initiation of and time to adjuvant therapy may be improved with minimally invasive techniques, however this assertion remains controversial. In terms of shortterms costs, minimally invasive PD is significantly higher than that of OPD. CONCLUSION Minimally invasive approaches to PD show great promise as a strategy to improve short-term outcomes in patients undergoing PD, but the best results remain isolated to high-volume centers of excellence. | Rui Dai Ryan S Turley Dan G Blazer | 2016 | World Journal of Gastrointestinal Surgery2016，8，12： | 5 |
| 3 | Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases显示文摘真核细胞的延伸因素 2 kinase (eEF2K ) 是由 phosphorylating 调整蛋白质合成的延伸阶段的不平常的蛋白质 kinase 并且禁止它的仅仅已知的底层, eEF2。延伸是一个高度消费精力的过程,并且 eEF2K 活动被几条发信号的小径紧调整。调整翻译延伸能调制细胞的精力需求并且可以也控制特定的蛋白质的表示。成长证据连接 eEF2K 到人的疾病的一个范围,包括心血管的条件(动脉粥样硬化,经由巨噬细胞幸存) 并且肺的动脉的高血压,以及稳固的肿瘤,在 eEF2K 看起来起取决于肿瘤的形成对照的作用的地方,打字并且上演。eEF2K 也涉及神经病学的混乱并且可以是在对待消沉和某些 neurodegenerative 疾病的一个珍贵目标。因为 eEF2K 没为哺乳动物的开发或房间生存能力被要求,禁止它的功能不能得到严肃的副作用,当时它是不正常的 kinase 的事实并且从绝大多数其它相当不同哺乳动物的 kinases 建议可能性开发它进没有影响另外的重要蛋白质 kinases ,禁止 eEF2K 的混合物。进一步的研究被需要探索这些可能性,有迫切需要识别并且描绘有势力和 eEF2K 的特定的小分子的禁止者。在这篇文章,我们在开发这酶的小分子的禁止者象进步一样在人的疾病有关 eEF2K 的角色考察最近的证据。 | Rui LIU Christopher G PROUD | 2016 | Acta Pharmacologica Sinica2016，37，3： | 5 |
| 4 | Caveolin-1mammary stem cells and estrogen-dependent breast cancers显示文摘 | Sotgia F Rui H Bonuccelli G | 2006 | Cancer Res2006，66，10： | 1 |
| 5 | Transfer matrix method for linear multibody system 显示文摘 | Rui X T Wang G P Lu Y Q | 2008 | Multibody System Dynamics2008，19，3： | 1 |
| 6 | Isolation and characterization of multipotent rat tendon-derived stem cells显示文摘 | Rui YF Lui PP Li G | 2010 | Tissue Eng Part A2010，16，： | 1 |
| 7 | Changes of Bt toxin in the rhizosphere of transgenic Bt cotton and its influence on soil functional bacteria显示文摘 | RUI Y K Yi G X Zhao J | 2005 | World Journal of Microbiology & Biotechnology2005，21，： | 1 |
| 8 | Validationof an improved method to estimate expressway travel time by the combination of detector and probe data显示文摘 | WANG Rui NAKAMURA H MAKOTO G | 2003 | Journal of the Eastern Asia Society for Transportation Studies2003，5，1： | 1 |
| 9 | Wind park reduced-order model using singular perturbations theory显示文摘 | Castro Rui M G Ferreira de Jesus J M | 1996 | IEEE Trans on Energy Conversion1996，11，4： | 1 |
| 10 | Population pharmacokinetics of propofol in Chinese patients显示文摘 | LI Y H RUI J Z ZHOU Y G | 2003 | Acta Pharmacol Sin2003，24，6： | 1 |
| 11 | The choice of a health care provider in Efitrea 显示文摘 | Habtom G Ruys P | 2007 | Health Policy2007，，80： | 1 |
| 12 | Foreign acquisitions by chinese firms: a strategic intent perspective显示文摘 | RUI H G S YIP | 2008 | Journal of World Business2008，43，2： | 1 |
| 13 | Synthesis and Characterization of Novel Fluorinated Aromatic Polyimides Derived from 1,1-Bis(4-amino-3,5-dimethylphenyl)-1-(3,5-ditrifluoromethylphenyl)-2,2,2-trifluoroethane and Various Aromatic Dianhydrides显示文摘 | Li H S Liu J G Rui J M | 2006 | Journal of Polymer Science Part A:Polymer Chemistry2006，44，8： | 1 |
| 14 | Probable risk factors for postoperative delirium in patients undergoing spinal surgery显示文摘 | Rui G Yang ZZ Li M | 2008 | Eur Spine J2008，17，11： | 1 |
| 15 | Have China's Enterprise Reforms Led to Improved Efficiency and Profitability? 显示文摘 | CHEN G M FIRTH M RUI O | 2006 | Emerging Markets Reviews2006，7，1： | 1 |
| 16 | The dynamic relation between stock returns, trading volume, and volatility 显示文摘 | CHEN G FIRTH M RUI O M | 2001 | The Financial Re- view2001，38，： | 1 |
| 17 | Foreign Ownership Restrictions and Market Segmentation in China's Stock Markets 显示文摘 | Chen G M Lee B S Rui O | 2001 | Journal of Financial Research2001，24，1： | 1 |
| 18 | A novel thermostable nitrile hydratase 显示文摘 | Rui A Dan G Fred A | 1998 | Extremophiles1998，2，2： | 1 |
| 19 | Integral Bifurcation Method and Its Application for Solving the Modified Equal Width Wave Equation and Its Variants显示文摘 | Rui W G Xie Sh L Long Y | 2007 | Rostock Math Kolloq2007，62，： | 1 |
| 20 | Expression of defender against apoptotic death (DAD-1) in lr/s and Dianthus petals显示文摘 | Van Der Kop D A M Ruys G Dees D | 2003 | Physiolo- gia Plantarum2003，117，2： | 1 |
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