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| 1 | 组蛋白去甲基化酶家族中组蛋白去甲基化酶4作用机制及其应用的研究进展显示文摘组蛋白甲基化是一种重要的表观遗传性修饰方式,是一个可逆的动态调节过程。组蛋白去甲基化酶家族中组蛋白去甲基化酶4能催化去除组蛋白赖氨酸残基甲基标记,调节染色质的结构,参与精细调控基因转录,维持染色质的活性和非活性平衡。组蛋白去甲基化酶4异常可能导致细胞增殖、分化、个体发育、能量代谢及肿瘤发生发展等多种生物进程异常。研究显示组蛋白去甲基化酶4可作为新的药物靶标。本文就组蛋白去甲基化酶4家族的结构、作用机制、在疾病发生发展进程中的生物学功能及特异性抑制剂开发的最新研究进展作一综述。 | 叶覃 Andreana HOLOWATYJ Roselyne M.LABBE 刘辉 ZengquanYANG | 2014 | 转化医学杂志2014，3，1： | 6 |
| 2 | 鹿角与鹿茸蛋白质鉴定显示文摘目的 鉴定鹿角与鹿茸蛋白质。方法 通过SDS-PAGE、2-DE分析鹿角与鹿茸蛋白质组成,比较两者电泳图谱,找出各自稳定的蛋白质条带或斑点及其差异。将两者SDS-PAGE蛋白质条带以胰蛋白酶进行胶内消化后,采用MALDI-TOF/TOF质谱分析,通过MASCOT检索匹配以鉴定蛋白质。结果 在SDS-PAGE图谱中,鹿角在约75、66.2 kD处呈现出2个清晰的蛋白质条带,而鹿茸则在约75、61、45、20 kD处呈出现4个蛋白质条带;2-DE分析显示,鹿角蛋白质斑点集中于Ⅰ区(pH5~7,M_(w) 45 kD)以及Ⅱ区(pH10,M_(w) 66.2 kD);鹿茸蛋白质斑点则主要分布在Ⅲ区(pH5~7,M_(w) 45 kD),另外,在pH5~6和M_(w) 20 kD的区域内存在3个稳定出现的蛋白质斑点。通过生物质谱分析,分别从鹿角与鹿茸中鉴定出2、4个蛋白质,评分高于100。结论 鹿角与鹿茸蛋白质电泳图谱存在明显差异,可为两者鉴别提供科学依据。 | 杨欢 Roselyn Tehzee Gblinwon 杨娅娅 王强 陈香 卢梦瑶 郑晗雪 吴沅臻 夏国华 沈玉萍 | 2022 | 中成药2022，44，6： | 2 |
| 3 | Modeling the role of public health education in Ebola virus disease outbreaks in Sudan显示文摘Public involvement in Ebola Virus Disease(EVD)prevention efforts is key to reducing disease outbreaks.Targeted education through practical health information to particular groups and sub-populations is crucial to controlling the disease.In this paper,we study the dynamics of Ebola virus disease in the presence of public health education with the aim of assessing the role of behavior change induced by health education to the dynamics of an outbreak.The power of behavior change is evident in two outbreaks of EVD that took place in Sudan only 3 years apart.The first occurrence was the first documented outbreak of EVD and produced a significant number of infections.The second outbreak produced far fewer cases,presumably because the population in the region learned from the first outbreak.We derive a system of ordinary differential equations to model these two contrasting behaviors.Since the population in Sudan learned from the first outbreak of EVD and changed their behavior prior to the second outbreak,we use data from these two instances of EVD to estimate parameters relevant to two contrasting behaviors.We then simulate a future outbreak of EVD in Sudan using our model that contains two susceptible populations,one being more informed about EVD.Our finding show how a more educated population results in fewer cases of EVD and highlights the importance of ongoing public health education. | Benjamin Levy Christina Edholm Orou Gaoue Roselyn Kaondera-Shava Moatlhodi Kgosimore Suzanne Lenhart Benjamin Lephodisa Edward Lungu Theresia Marijani Farai Nyabadza | 2017 | Infectious Disease Modelling2017，2，3： | 2 |
| 4 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 5 | Platinum,palladium and rhodium complexes as volatile pre-cursors for depositing materials显示文摘 | Jean-Cyrille Hierso Roselyne Feurer Philippe Kalck | 1998 | Coordination ChemstryReviews1998，178，： | 1 |
| 6 | A renewable copper electrode as an amperometric flow detector for nitrate determination in mineral water and soft drink samples显示文摘 | Juan C.M. Gamboa Roselyn C. Pe?a Thiago R.L.C. Paix?o Mauro Bertotti | 2009 | Talanta2009，，2： | 1 |
| 7 | Testing market efficiency in the EU carbon futures market显示文摘 | Joyeux Roselyne Milunovich George | 2010 | Applied Financial Eco- nomics2010，，20： | 1 |
| 8 | MOCVD of rhodium,palladium and platinum complexes onfluidized divided substrates:novel process for one-steppreparation of noble-metal catalysts显示文摘 | Jean-Cyrille Hierso Roselyne Feurer Philippe Kalck | 1998 | Applide Organo-metallic Chemistry1998，12，： | 1 |
| 9 | Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig显示文摘 | David I. Bernstein Julie D. Earwood Fernando J. Bravo Gary H. Cohen Roselyn J. Eisenberg Jennifer R. Clark Jeffrey Fairman Rhonda D. Cardin | 2011 | Vaccine2011，，11： | 1 |
| 10 | Consumer willingness to pay for food safety in Tanzania: an incentive‐aligned conjoint analysis显示文摘 | Roselyne Alphonce Frode Alfnes | 2012 | International Journal of Consumer Studies2012，，4： | 1 |
| 11 | The importance of sediment phosphorus release in the restoration of very shallow lakes (The Norfolk Broads, England) and implications for biomanipulation显示文摘 | Geoffrey Phillips Roselyn Jackson Claire Bennett Alison Chilvers | 1994 | Hydrobiologia1994，，1： | 1 |
| 12 | Lung ultrasound findings in meconium aspiration syndrome显示文摘 | Marco Piastra Nadya Yousef Roselyne Brat Paolo Manzoni Mostafa Mokhtari Daniele De Luca | 2014 | Early Human Development2014，，： | 1 |
| 13 | Explaining Housing Prices in Australia: 1970 - 2003 显示文摘 | Peter A Roselyne J George M Demi C | 2005 | Eco- nomic Record2005，8，： | 1 |
| 14 | Gamma-Glutamyl transpeptidase substrate specificity and catalytic 显示文摘 | Jeffrey W K Roselyne C Christian L | 2005 | Mechanism methods in Enzymology2005，，401： | 1 |
| 15 | Analysis of Chicken Mucosal Immune Response to Eimeria tenella and Eimeria maxima Infection by Quantitative Reverse Transcription-PCR显示文摘 | FABFICE LAURENT ROSELYNE MANCASSOLA SONLA LACROIX | 2001 | Infection and lmmuity2001，69，4： | 1 |
| 16 | HPLC determination of ketamine,norketamine and dehynorketamine in plasma with a high-purity reversed-pHase serbent显示文摘 | Sebastien B O Roselyne B O | | 0，，03： | 1 |
| 17 | Y-autosome translocation and infertility: usefulness of molecular, cytogenetic and meiotic studies显示文摘 | Bruno Delobel Ratib Djlelati Odette Gabriel-Robez Marie-Fran?oise Croquette Roselyne Rousseaux-Prévost Jean Rousseaux Jean-Marc Rigot Y. Rumpler | 1998 | Human Genetics1998，，1： | 1 |
| 18 | Easy cloning of Mini-Tn10 insertion from the Bacillus subtilis chromosome显示文摘 | MICHEL S ROSELYNE | 1994 | Journal of Bacteriology1994，，3： | 1 |
| 19 | Probing non-enzymatic glycation of type I collagen:A novel approach using Raman and infrared biophotonic methods显示文摘 | Said M Happillon T Untereiner V Marie G Georges S Teddy H Valérie U Roselyne G Pierre J Ganesh D | 2013 | 1830(6):3525-35312013，1830，6： | 1 |
| 20 | Plant species diversity and polyploidy in islands of natural vegetation isolated in extensive cultivated lands显示文摘 | Roselyne Lumaret Jean-Louis Guillerm Jacques Maillet Regine Verlaque | 1997 | Biodiversity and Conservation1997，，4： | 1 |
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