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| 1 | New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting. | Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj | 2015 | World Journal of Gastroenterology2015，21，3： | 14 |
| 2 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 3 | Speckle tracking echocardiography to assess regional ventricular function in patients with apical hypertrophic cardiomyopathy显示文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM. | María Cristina Saccheri Tomás Francisco Cianciulli Luis Alberto Morita Ricardo JoséMéndez Martín Alejandro Beck Juan Enrique Guerra Alberto Cozzarin Luciana Jimena Puente Lorena Romina Balletti Jorge Alberto Lax | 2017 | World Journal of Cardiology2017，9，4： | 7 |
| 4 | 网状Meta分析结论形成的方法:最小背景化框架显示文摘网状Meta分析的最大优势在于可量化比较针对同一疾病的不同干预措施,并按某一指标对其优劣进行排序。多种干预措施的纳入增加了网状Meta分析结果解读的复杂性,仅基于排序结果进行解读可能会存在误导性。目前,对网状Meta分析结果的解读尚无公认的标准。2020年11月,GRADE工作组基于网状Meta分析的GRADE分级结果,提出了2种网状Meta分析结论形成的方法:部分背景化框架(partially contextualised framework)和最小背景化框架(minimally contextualised framework)。本文结合具体实例,旨在对最小背景化框架的方法、原理和步骤进行介绍,以期为网状Meta分析制作者采用该方法呈现和解读结果提供指导。 | 栗梦婷 朱鸿飞 后亮瑛 王琪 田金徽 陈耀龙 杨克虎 邓宏勇 曾力楠 张伶俐 Romina Brignardello-Petersen 葛龙 | 2021 | 中国循证医学杂志2021，21，9： | 6 |
| 5 | Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis显示文摘Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct.The absorption,distribution and elimination of drugs are impaired during this pathology.Prolonged cholestasis may alter both liver and kidney function.Lactam antibiotics,diuretics,non-steroidal anti-inflammatory drugs,several antiviral drugs as well as endogenous compounds are classified as organic anions.The hepatic and renal organic anion transport pathways play a key role in the pharmacokinetics of these compounds.It has been demonstrated that acute extrahepatic cholestasis is associated with increased renal elimination of organic anions.The present work describes the molecular mechanisms involved in the regulation of the expression and function of the renal and hepatic organic anion transporters in extrahepatic cholestasis,such as multidrug resistanceassociated protein 2,organic anion transporting polypeptide 1,organic anion transporter 3,bilitranslocase,bromosulfophthalein/bilirubin binding protein,organic anion transporter 1 and sodium dependent bile salt transporter.The modulation in the expression of renal organic anion transporters constitutes a compensatory mechanism to overcome the hepatic dysfunction in the elimination of organic anions. | Anabel Brandoni María Herminia Hazelhoff Romina Paula Bulacio Adriana Mónica Torres | 2012 | World Journal of Gastroenterology2012，18，44： | 5 |
| 6 | Fundamental aspects of postharvest heat treatments显示文摘Heat treatments have been investigated for use in many aspects of postharvest storage.They have been developed for insect control,prevention of fungal development and prevention of postharvest storage disorders including chilling injury.The treatment times and temperature range vary widely,from days at 356C to 396C in hot air,to up to 636C for less than a minute in hot water.Much of the research has been performed to develop solutions to a particular problem,and less investigation has been conducted on the responses of the commodity to the treatment.However,since the turn of the century,a number of groups have been active in examining the molecular responses and changes that occur in commodities during and after the heat treatment.This review examines the changes at the level of transcriptome,proteome and metabolome that occur in response to the different heat treatments. | Susan Lurie Romina Pedreschi | 2014 | Horticulture Research2014，1，1： | 4 |
| 7 | 网状Meta分析结论形成的方法:部分背景化框架显示文摘目前网状Meta分析已得到飞速发展和广泛应用,具有可量化比较相同主题的2种以上不同处理措施的相对优势的特点。但由于存在多个干预措施的比较,增加了其结果解读的复杂性,解读时对证据可信度的忽略也导致了结论存在误导性。近期,GRADE工作组提出了2种网状Meta分析结论形成的方法,即部分背景化框架与最小背景化框架。本文聚焦于部分背景化框架,当使用该框架时,作者必须确定效应阈值,以区分无效、较小效应、中等效应和较大效应。部分背景化框架的指导原则包括根据效应大小与利弊对干预措施进行分类,及分类时考虑效应的点估计值和干预措施排序,综合考虑证据可信度(证据质量)以得出结论。本文结合实例,对部分背景化框架的原理步骤进行描述和阐释,以期为该方法在网状Meta分析结果解读与结论形成环节的应用提供指导。 | 朱鸿飞 栗梦婷 后亮瑛 王琪 田金徽 陈耀龙 杨克虎 邓宏勇 曾力楠 张伶俐 Romina Brignardello-Petersen 葛龙 | 2021 | 中国循证医学杂志2021，21，9： | 3 |
| 8 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 9 | Differential expression of the fractalkine chemokine receptor (CX3CR 1) in human rnonocytes during differentiation显示文摘传播单核白血球(瞬间) 可以连续地使人重新住入巨噬细胞(MAC ) 或树枝状的房间(DC ) 维持动态平衡的人口。MAC 和 DC 是玩不同、互补的免疫学的功能的专业化房间。因此,他们现在的不同迁移的性质。明确地,而 MAC 大部分留在纸巾, DC 能够从外部纸巾移居到淋巴的机关。这个工作的目的是分析 fractalkine 受体的表达式(CX 3 CR1 ) 在 monocytic 区别进程期间。两 CX 3 CR1 mRNA 和蛋白质。在瞬间区别过程期间, CX 3 CR1 是在 DC 和 MAC 的 downregulated。然而, MAC 显示出显著地更高的 CX 3 CR1 表示层次比 DC。我们也观察了对抗 CX 3 由干扰素(IFN ) 的 CR1 规定 -γ并且 interleukin (IL )-4 在通过古典、其他的 MAC 小径的 MAC 激活期间分别地。IFN-γ禁止了 CX 3 CR1,而是 IL-4 导致了它。另外,我们表明了在 CX 3 由可溶的 fractalkine 的 CR1 表示和 apoptosis 预防(sCX 3 CL1 ) 在瞬间, DC 和 MAC。这是表明顺序、微分的 CX 3 CR1 调整在瞬间区别期间。最重要地,我们表明了在 CX 3 CR1 表示和房间幸存面对 sCX 3 CL1。 | Cecilia Analia Panek Maria Victoria Ramos Maria Pilar Mejias Maria Iimena Abrey-Recalde Romina Iimena Fernandez-Brando Maria Soledad Gori Gabriela Veronica Salamone2 Marina Sandra Palermo | 2015 | Cellular & Molecular Immunology2015，12，6： | 3 |
| 10 | 奥兰-伊托概念车显示文摘在与雪铁龙公司合作数年,进行车饰设计后,法国时尚设计师奥兰·伊托回归本色,设计出一款体现"遗传突变"的概念车,为400年的交通工具发展史绘制出一幅不寻常的图解。 | Thomas Gerbeaux Romina Shama(摄影) Ting(编译) | 2011 | 汽车生活2011，，3： | 3 |
| 11 | Role of sex hormones in the modulation of cholangiocyte function显示文摘Over the last years,cholangiocytes,the cells that line the biliary tree,have been considered an important object of study for their biological properties which involves bile formation,proliferation,injury repair,fibrosis and angiogenesis.Cholangiocyte proliferation occurs in all pathologic conditions of liver injury where it is associated with inflammation and regeneration.During these processes,biliary cells start to secrete different cytokines,growth factors,neuropeptides and hormones which represent potential mechanisms for cross talk with other liver cells.Several studies suggest that hormones,and in particular,sex hormones,play a fundamental role in the modulation of the growth of this compartment in the injured liver which functionally conditions the progression of liver disease.Understanding the mechanisms of action and the intracellular pathways of these compounds on cholangiocyte pathophysiology will provide new potential strategies for the management of chronic liver diseases.The purpose of this review is to summarize the recent findings on the role of sex hormones in cholangiocyte proliferation and biology. | Romina Mancinelli Paolo Onori Sharon DeMorrow Heather Francis Shannon Glaser Antonio Franchitto Guido Carpino Gianfranco Alpini Eugenio Gaudio | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 3 |
| 12 | Potential Use of a Poultry Manure Digestate as a Biofertiliser:Evaluation of Soil Properties and Lactuca sativa Growth显示文摘Anaerobic digestion is a process that is widely used for the treatment of organic wastes. The digestate can be used as a soil amendment or crop fertiliser. The aims of our work were to evaluate 1) the physicochemical composition and pathogen content in a digestate from poultry manure, according to international regulations, and 2) the effect of its soil application on the major chemical and biological soil properties and on the growth of Lactuca sativa. The experiment consisted of two groups of pots(with and without crop). Treatments applied to each group were as follows: low and high doses of digestate and inorganic fertiliser, and no application(control)(low dose: 70 kg nitrogen(N) ha^(-1) and 21 kg phosphorus(P) ha^(-1); high dose: 210 kg N ha^(-1) and 63 kg P ha^(-1)). Soil samples were taken 7 and 34 d(harvest) after treatment applications. Heavy metal and pathogen contents in the digestate were below the upper limit values. Despite the high pH and electrical conductivity values of the digestate, both soil parameters presented acceptable values for crop growth. Although there were no initial increases in total inorganic N and available P in soil with digestate application, an increase in the fresh weight of crop was observed with the high dose application. This is probably associated with the slow nutrient release from the digestate during the development of the crop. Changes in the microbial community were temporary and occurred at the initial sampling stage of the experiment. | Natalia MóRTOLA Romina ROMANIUK Vanina COSENTINO Maximiliano EIZA Patricia CARFAGNO Pedro RIZZO Patricia BRES Nicolás RIERA Marcos ROBA Mariano BUTTI Daiana SAINZ Lucrecia BRUTTI | 2019 | Pedosphere2019，29，1： | 2 |
| 13 | The role of the microbiota in inflammation, carcinogenesis, and cancer therapy显示文摘 | Amiran Dzutsev Romina S. Goldszmid Sophie Viaud Laurence Zitvogel Giorgio Trinchieri | 2015 | Eur. J. Immunol2015，，1： | 2 |
| 14 | COVID-19 and liver injury:Pathophysiology,risk factors,outcome and management in special populations显示文摘The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2 is an ongoing health concern.In addition to affecting the respiratory system,COVID-19 can potentially damage other systems in the body,leading to extra-pulmonary manifestations.Hepatic manifestations are among the common consequences of COVID-19.Although the precise mechanism of liver injury is still questionable,several mechanisms have been hypothesized,including direct viral effect,cytokine storm,hypoxic-ischemic injury,hypoxiareperfusion injury,ferroptosis,and hepatotoxic medications.Risk factors of COVID-19-induced liver injury include severe COVID-19 infection,male gender,advanced age,obesity,and underlying diseases.The presentations of liver involvement comprise abnormalities in liver enzymes and radiologic findings,which can be utilized to predict the prognosis.Increased gamma-glutamyltransferase,aspartate aminotransferase,and alanine aminotransferase levels with hypoalbuminemia can indicate severe liver injury and anticipate the need for intensive care units’hospitalization.In imaging,a lower liver-to-spleen ratio and liver computed tomography attenuation may indicate a more severe illness.Furthermore,chronic liver disease patients are at a higher risk for severe disease and death from COVID-19.Nonalcoholic fatty liver disease had the highest risk of advanced COVID-19 disease and death,followed by metabolic-associated fatty liver disease and cirrhosis.In addition to COVID-19-induced liver injury,the pandemic has also altered the epidemiology and pattern of some hepatic diseases,such as alcoholic liver disease and hepatitis B.Therefore,it warrants special vigilance and awareness by healthcare professionals to screen and treat COVID-19-associated liver injury accordingly. | Romina Roshanshad Amirhossein Roshanshad Reza Fereidooni Mahnaz Hosseini-Bensenjan | 2023 | World Journal of Hepatology2023，15，4： | 2 |
| 15 | Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens显示文摘Dear Editor,Infectious bursal disease virus(IBDV)causes infectious bursal disease,a highly contagious immunosuppressive disease that affects young chickens and causes economic losses in the poultry industry worldwide.IBDV replicates mainly in actively dividing B lymphocytes within the bursa of Fabricius(BF),leading to immunosuppression in affected flocks(Mahgoub et al.,2012).Viral protein 2(VP2),the only structural component of the | Flavia Adriana Zanetti Romina Cardona Carlos Rodolfo Federico Silvina Chimeno-Zoth Gabriela Calamante | 2016 | Virologica Sinica2016，31，3： | 2 |
| 16 | Adjustable Intragastric Balloon vs Non-Adjustable Intragastric Balloon: Case–Control Study on Complications, Tolerance, and Efficacy显示文摘 | Alfredo Genco Daniela Dellepiane Giovanni Baglio Fulvio Cappelletti Francesca Frangella Roberta Maselli Maria Chiara Dante Romina Camoirano Michele Lorenzo Nicola Basso | 2013 | Obesity Surgery2013，，7： | 2 |
| 17 | Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT 2A serotonin receptors显示文摘 | Cécile Vindis Romina D’Angelo Elodie Mucher Anne Nègre-Salvayre Angelo Parini Jeanne Mialet-Perez | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 2 |
| 18 | A Clinical Outcome-Based Prospective Study on Venous Thromboembolism After Cancer Surgery: The @RISTOS Project显示文摘 | Giancarlo Agnelli Giorgio Bolis Lorenzo Capussotti Roberto Mario Scarpa Francesco Tonelli Erminio Bonizzoni Marco Moia Fabio Parazzini Romina Rossi Francesco Sonaglia Bettina Valarani Carlo Bianchini Gualberto Gussoni | 2006 | Annals of Surgery2006，，1： | 2 |
| 19 | Analysis of Liver Repair Mechanisms in Alagille Syndrome and Biliary Atresia Reveals a Role for Notch Signaling显示文摘 | Luca Fabris Massimiliano Cadamuro Maria Guido Carlo Spirli Romina Fiorotto Michele Colledan Giuliano Torre Daniele Alberti Aurelio Sonzogni Lajos Okolicsanyi Mario Strazzabosco | 2007 | The American Journal of Pathology2007，，： | 2 |
| 20 | Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches显示文摘 | Romina Lomonaco Nishanth E. Sunny Fernando Bril Kenneth Cusi | 2013 | Drugs2013，，1： | 2 |
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