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| 1 | Comparison of Wirsung-jejunal duct-tomucosa and dunking technique for pancreatojejunostomy after pancreatoduodenectomy显示文摘Pancreato-enteric reconstruction after pancreatoduodenectomy (PD) is still a source of debate because of the high incidence of complications. Among the various types of pancreato-jejunostomies we don’t know yet which is the best in terms of anastomotic failure and related complications rates. Wirsung-jejunal duct-to-mucosa anastomosis (WJ) and 'dunking' pancreato-jejunal anastomosis (DPJ) are the two most used ones worldwide but conflicting results are reported. To determine which is the safer anastomosis and to define when an anastomosis should be preferred, we retrospectively reviewed two groups of patients who underwent WJ or DPJ. METHODS:Twenty-three patients underwent PD with WJ (n=17) with dilated (WJD) (n=9) or not-dilated Wirsung’s duct (WJND) (n=8) or with a DPJ (n=6) over a 3-year period at a single institution. RESULTS: The complications rate was high in all groups of patients (33.3% in WJD, 37.5% in WJND and 66.7% in DPJ). A pancreatic fistula developed in one patient in each group (11. 1% in WJD, 12. 5% in WJND and 16. 7% in DPJ). All these patients were managed conservatively. Anastomotic disruption took place in the WJ patients especially in the WJND group (n=2) compared to the WJD (n=1) (25% vs 11.1%) or DPJ groups (0%) : these three patients required a re-operation. Overall, the anastomotic defects were higher in patients who underwent WJND (37.5%), compared to WJD (22.2%) and to DPJ (16.7%). However, no statistical differences were found among the groups. Delayed gastric emptying (DGE) and total parenteral nutrition (TPN) along with anastomotic defects were responsible for a prolonged hospital stay. CONCLUSIONS:Our results were not able to demonstrate any statistical difference between the two different techniques in preventing anastomotic failure. WJ can represent a valid choice in case of a dilated duct and a firm, fibrotic enlarged gland that could not be properly invaginated in a small jejunal loop. DGE may occur in those patients who experienced an anastomotic failure and required a TPN regimen with a prolonged hospital stay. | Unita di Chirurgia, Dipartimento di Fisiopatologia Clinica (Batignani G, Fratini G, Zuckermann M and Tonelli F) and Dipartimento di Statistica (Bianchini E), Universitd degli Studi di Firenze, Flo rence, Italy | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 2 | Upper aerodigestive tract disorders and gastro-oesophageal reflux disease显示文摘A wide variety of symptoms and diseases of the upper aerodigestive tract are associated to gastro-oesophageal reflux disease(GORD). These disorders comprise a large variety of conditions such as asthma, chronic otitis media and sinusitis, chronic cough, and laryngeal disorders including paroxysmal laryngospasm. Laryngopharyngeal reflux disease is an extraoesophageal variant of GORD that can affect the larynx and pharynx. Despite numerous research efforts, the diagnosis of laryngopharyngeal reflux often remains elusive,unproven and controversial, and its treatment is then still empiric. Aim of this paper is to review the current literature on upper aerodigestive tract disorders in relation to pathologic gastro-oesophageal reflux, focusing in particular on the pathophysiology base and results of the surgical treatment of GORD. | Andrea Ciorba Chiara Bianchini Michele Zuolo Carlo Vittorio Feo | 2015 | World Journal of Clinical Cases2015，3，2： | 4 |
| 3 | Thromboelastographic reference ranges for a cirrhotic patient population undergoing liver transplantation显示文摘AIM To describe the thromboelastography(TEG) 'reference' values within a population of liver transplant(LT) candidates that underline the differences from healthy patients.METHODS Between 2000 and 2013, 261 liver transplant patients with a model for end-stage liver disease(MELD) score between 15 and 40 were studied. In particular the adult patients(aged 18-70 years) underwent to a first LT with a MELD score between 15 and 40 were included, while all patients with acute liver failure, congenital bleeding disorders, and anticoagulant and/or antiplatelet drug use were excluded. In this population of cirrhotic patients, preoperative haematological and coagulation laboratory tests were collected, and the pretransplant thromboelastographic parameters were studied and compared with the parameters measured in a previously studied population of 40 healthy subjects. The basal TEG parameters analysed in the cirrhotic population of liver candidates were as follows: Reaction time(r), coagulation time(k), Angle-Rate of polymerization of clot(α Angle), Maximum strenght of clot(MA), Amplitudes of the TEG tracing at 30 min and 60 min after MA is measured(A30 and A60), and Fibrinolysis at 30 and 60 min after MA(Ly30 and Ly60). The possible correlation between the distribution of the reference range and the gender, age, MELD score(higher or lower than 20) and indications for transplantation(liver pathology) were also investigated. In particular, a MELD cut-off value of 20 was chosen to verify the possible correlation between the thromboelastographic reference range and MELD score. RESULTS Most of the TEG reference values from patients with end-stage liver disease were significantly different from those measured in the healthy population and were outside the suggested normal ranges in up to 79.3% of subjects. Wide differences were found among all TEG variables, including r(41.5% of the values), k(48.6%), α(43.7%), MA(79.3%), A30(74.4%) and A60(80.9%), indicating a prevailing trend to hypocoagulability. The differences between the mean TEG values obtained from healthy subjects and the cirrhotic population were statistically significant for r(P = 0.039), k(P < 0.001), MA(P < 0.001), A30(P < 0.001), A60(P < 0.001) and Ly60(P = 0.038), indicating slower and less stable clot formation in the cirrhotic patients. In the cirrhotic population, 9.5% of patients had an r value shorter than normal, indicating a tendency for faster clot formation. Within the cirrhotic patient population, gender, age and the presence of hepatocellular carcinoma or alcoholic cirrhosis were not significantly associated with greater clot firmness or enhanced whole blood clot formation, whereas greater clot strength was associated with a MELD score < 20, hepatitis C virus and cholestaticrelated cirrhosis(P < 0.001; P = 0.013; P < 0.001).CONCLUSION The range and distribution of TEG values in cirrhotic patients differ from those of healthy subjects, suggesting that a specific thromboelastographic reference range is required for liver transplant candidates. | Lesley De Pietri Marcello Bianchini Gianluca Rompianesi Elisabetta Bertellini Bruno Begliomini | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 4 | Facial nerve paralysis in children显示文摘Facial nerve palsy is a condition with several implications, particularly when occurring in childhood. It represents a serious clinical problem as it causes significant concerns in doctors because of its etiology, its treatment options and its outcome, as well as in little patients and their parents, because of functional and aesthetic outcomes. There are several described causes of facial nerve paralysis in children, as it can be congenital(due to delivery traumas and genetic or malformative diseases) or acquired(due to infective,inflammatory, neoplastic, traumatic or iatrogenic causes). Nonetheless, in approximately 40%-75% of the cases, the cause of unilateral facial paralysis still remains idiopathic. A careful diagnostic workout and differential diagnosis are particularly recommended in case of pediatric facial nerve palsy, in order to establish the most appropriate treatment, as the therapeutic approach differs in relation to the etiology. | Andrea Ciorba Virginia Corazzi Veronica Conz Chiara Bianchini Claudia Aimoni | 2015 | World Journal of Clinical Cases2015，3，12： | 3 |
| 5 | 国际癌症研究机构工作组乳腺癌筛查简报显示文摘乳腺癌是导致全球女性死亡最常见的恶性肿瘤之一,而且超过一半发生在低至中等收入的国家。近年来在我国,特别是大中城市及沿海经济发展较快地区,乳腺癌已排在女性恶性肿瘤的第一位,是危害妇女健康的主要疾病。如何在早期筛查乳腺癌,以提高防癌效果,对社区及临床有重要意义。本期世界全科医学工作嘹望对2015—06-03在线发表于《新英格兰杂志》的《国际癌症研究机构(IARC)工作组乳腺癌筛查简报》进行了部分翻译,IARC对经乳腺钼靶X线摄影检查筛查乳腺癌的利弊进行了细致评估后,推荐50~69岁女性接受筛查利大于弊。同时,简报还对一般人群及乳腺癌高危人群采取不同方法进行乳腺癌筛查的利弊相关证据评价进行了总结,对全科医生和临床医师筛查工作提供了借鉴。 | Béatrice Lauby-Secretan Chiara Scoccianti Dana Loomis Lamia Benbrahim-Tallaa Véronique Bouvard Franca Bianchini Kurt Straif | 2015 | 中国全科医学2015，18，27： | 2 |
| 6 | Overweight, obesity, and cancer risk显示文摘 | Franca Bianchini Rudolf Kaaks Harri Vainio | 2002 | Lancet Oncology2002，，： | 2 |
| 7 | A Clinical Outcome-Based Prospective Study on Venous Thromboembolism After Cancer Surgery: The @RISTOS Project显示文摘 | Giancarlo Agnelli Giorgio Bolis Lorenzo Capussotti Roberto Mario Scarpa Francesco Tonelli Erminio Bonizzoni Marco Moia Fabio Parazzini Romina Rossi Francesco Sonaglia Bettina Valarani Carlo Bianchini Gualberto Gussoni | 2006 | Annals of Surgery2006，，1： | 2 |
| 8 | Cracks, bifurcation and shear bands propagation in saturated clays显示文摘 | Saada A S Bianchini G F Liang L Q | 1994 | Geotechnique1994，44，1： | 1 |
| 9 | Gill Na^+,K^+-ATPase and osmoregulation in the estuarine crab,Chasm agnathus granulate Dana,1851 (Decapoda,Grapsidae)显示文摘 | CASTIHO P C MARTINS I A BIANCHINI A | 2001 | J Exp Mar Ecol2001，256，： | 1 |
| 10 | Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features 显示文摘 | Papini E Guglielmi R Bianchini A | 2002 | J Clin Endocrinol Metab2002，87，5： | 1 |
| 11 | Learning from students, inquiry into practice, and participation in professional communities: Beginning teachers' uneven progress toward equitable science teaching 显示文摘 | Bianchini J A & Cavazos L M | 2007 | Journal of Research in Science Teaching2007，，4： | 1 |
| 12 | Salinity effects on osmoregulation and growth of the euryhaline flounder Paralichthys orbignyanus 显示文摘 | SAMPAIO L A BIANCHINI A | 2002 | Journal of Experimental Marine Biology and Ecology2002，269，2： | 1 |
| 13 | Differential induction of 3-hydroxy-3-methylglutaryl CoA reductase in two cotton species following inoculation with Verticillium 显示文摘 | JOOST O Bianchini G Bell A A | 1995 | Molecular Plant-Microbe Interactions1995，8，6： | 1 |
| 14 | Learning without Local Minima in Radial Basis Function Networks显示文摘 | Monica Bianchini | 1995 | IEEE Transaction Neural Networks1995，6，3： | 1 |
| 15 | Percutaneous Laser Ablation in the Treatment of Hepatocellular Carcinoma with Small Tumors: Analysis of Factors Affecting the Achievement of Tumor Necrosis显示文摘 | Claudio Maurizio Pacella Giancarlo Bizzarri Giampiero Francica Antonio Bianchini Stefano De Nuntis Sara Pacella Anna Crescenzi Silvia Taccogna Giuseppe Forlini Zaccaria Rossi John Osborn Roberto Stasi | 2005 | Journal of Vascular and Interventional Radiology2005，，11： | 1 |
| 16 | Inside PageRank 显示文摘 | M Bianchini M Gori F Scarselli | 2005 | ACM Transactions on Internet Technology2005，5，1： | 1 |
| 17 | Heat-expandable microspheres for car protection production 显示文摘 | Massimo Tomalino Giovanni Bianchini | 1997 | Progress in Organic Coatings1997，32，： | 1 |
| 18 | Could Design Leadership Be Personal? Forecasting New Forms of “Indie Capitalism”显示文摘 | Massimo Bianchini Stefano Maffei | 2012 | Design Management Journal2012，，1： | 1 |
| 19 | EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchyrnal to amoeboid-like motility style显示文摘 | Parri M Taddei ML Bianchini F | 2009 | Cancer Res2009，69，5： | 1 |
| 20 | Learning without local minima in radial basis function networks显示文摘 | BIANCHINI M FRASCONI P GORI M | 1995 | IEEE Trans on Neural Networks1995，6，3： | 1 |
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