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| 1 | The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13显示文摘Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases. | Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter | 2021 | Cellular & Molecular Immunology2021，18，6： | 4 |
| 2 | Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches显示文摘 | Romina Lomonaco Nishanth E. Sunny Fernando Bril Kenneth Cusi | 2013 | Drugs2013，，1： | 2 |
| 3 | Does elec- tive re-siting of intravenous cannulae decrease peripheral thrombophlebitis? A randomized controlled study显示文摘 | Nishanth S Sivaram G Kalayarasanr R | 2009 | Natl Med J India2009，22，2： | 1 |
| 4 | Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old rats显示文摘 | K. Mallikarjuna K.R. Shanmugam K. Nishanth Ming-Chieh Wu Chien-Wen Hou Chia-Hua Kuo K. Sathyavelu Reddy | 2010 | Alcohol2010，，： | 1 |
| 5 | A Property Based Approach for Simultaneous Process and Molecular Design显示文摘在这个工作,性质聚类技术和组贡献方法被联合启用过程表演要求和分子性质限制的同时的考虑。用这方法论,过程设计问题被解决识别相应于发达方法论的重要优点是为问题,那能被仅仅三个性质令人满意地描述的需要的过程 performance.A 的性质目标,进程和分子设计问题能同时在一个三元图解,不管多少,分子的碎片在搜索空间被包括上视觉上被解决。在第三的簇图上,如果作为分离的值或作为一个区域给,如果作为间隔给,目标性质作为单个点被代表。候选人部件的结构和身份然后被联合或“混合”分子的碎片直到产生性质匹配目标识别。 | Fadwa Tahra Eljack Charles Conrad Solvason Nishanth Chemmangattuvalappil Mario Richard Eden | 2008 | Chinese Journal of Chemical Engineering2008，16，3： | 1 |
| 6 | Protein ki-nase C-θcritically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis显示文摘 | Sakowicz-Burkiewicz M Nishanth G Helmuth U | 2008 | J Immunol2008，180，8： | 1 |
| 7 | A Theory of Window-based Unicast Congestion Control显示文摘 | NISHANTH R SIMON S | 2001 | Department of Computer Science2001，，5： | 1 |
| 8 | Treatment of in-trabony de- feet with platelet rich fibrin: a ease report 显示文摘 | Pavan B Nishanth SIR Esha A et at | 2011 | Archives of Oral Sci- ences & Research AOSR2011，1，2： | 1 |
| 9 | Kinetics of phosphorus and potassium release from rock phosphate and waste mica enriched compost and their effect on yield and nutrient uptake by wheat (Triticum aestivum)显示文摘 | Nishanth D Biswas D R | 2008 | Biore- source Technology2008，，99： | 1 |
| 10 | A survey of mobility ininformation-centric networks显示文摘 | BY G T NISHANTH S RUBEN C | 2013 | Communications of the ACM2013，56，12： | 1 |
| 11 | Differential gene expression in embryogenic, non-embryogenic and desiccation induced cultures of sugarcane显示文摘 | Suprasanna P Desai N S Nishanth G | 2004 | Sugar Technol2004，6，4： | 1 |
| 12 | Analysis of flow-field in a dual mode ramjet combustor with boundary layer bleed in isolator显示文摘A two-dimensional Reynolds averaged Navier Stokes(RANS)simulation of a dual mode ramjet(DMRJ)combustor is performed,modeling the University of Michigan dual-mode combustor experimental setup operating in reacting mode with different equivalence ratios(4).The simulations are carried out using a k-u SST turbulence model and a steady diffusion flamelet model for non-premixed combustion.Air enters the isolator at Mach 2.2,stagnation pressure and temperature of 549.2 kPa and 1400 K respectively.Hydrogen is injected transverse to the flow direction and upstream of the cavity flame holder to simulate ramjet(4 Z 0.29)and scramjet(4 Z 0.19)modes of operation.Wall static pressure plots are used to validate numerical results against experimental data.Analysis of flow separation in ramjet mode due to the presence of a shock train in the isolator is carried out by means of numerical Schlieren images overlapped with contours of negative axial velocity,showing the effects of shock wave boundary layer interaction(SWBLI).Active control through wall normal boundary layer bleed in the separated flow region is implemented,which weakens the shock train and moves it downstream closer to the cavity.Bleed results in an improved stagnation pressure recovery in ramjet mode,with a marginal increase in combustion efficiency. | Nishanth Thillai Amit Thakur Srikrishnateja K. Dharani J. | 2021 | Propulsion and Power Research2021，10，1： | 1 |
| 13 | Protective Effect of Dietary Ginger on Antioxidant Enzymes and Oxidative Damage in Experimental Diabetic Rat Tissues显示文摘 | Shanmugam K R Mallikarjuna K Nishanth K | 2011 | Food Chemistry2011，124，4： | 1 |
| 14 | Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular design framework显示文摘Direct application of bio-oil from fast pyrolysis as a fuel has remained a challenge due to its undesirable attributes such as low heating value,high viscosity,high corrosiveness and storage instability.Solvent addition is a simple method for circumventing these disadvantages to allow further processing and storage.In this work,computer-aided molecular design tools were developed to design optimal solvents to upgrade bio-oil whilst having low environmental impact.Firstly,target solvent requirements were translated into measurable physical properties.As different property prediction models consist different levels of structural information,molecular signature descriptor was used as a common platform to formulate the design problem.Because of the differences in the required structural information of different property prediction models,signatures of different heights were needed in formulating the design problem.Due to the combinatorial nature of higher-order signatures,the complexity of a computer-aided molecular design problem increases with the height of signatures.Thus,a multi-stage framework was developed by developing consistency rules that restrict the number of higher-order signatures.Finally,phase stability analysis was conducted to evaluate the stability of the solvent-oil blend.As a result,optimal solvents that improve the solvent-oil blend properties while displaying low environmental impact were identified. | Jia Wen Chong Suchithra Thangalazhy-Gopakumar Kasturi Muthoosamy Nishanth G.Chemmangattuvalappil | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 1 |
| 15 | Protein ki- nase C-thera critically regulates the proliferation and survival of pathogen-specific T cells in murine listefiosis 显示文摘 | Sakowicz-Burkiewicz M Nishanth G Helmuth U | 2008 | J Immunol2008，180，8： | 1 |
| 16 | Analytical solution of gaseous slip flow in long microchannels 显示文摘 | Nishanth Dongari Abhishek Agrawal Amit Agrawal | 2007 | Interna- tional Journal of Heat and Mass Transfer2007，50，1718： | 1 |
| 17 | Stem cells in the adult CNS revealed:examining their regulation by myelin basic protein显示文摘Neural stem cells(NSCs)are found along the entire neuraxis,through development and into adulthood and old age(Sachewsky et al.,2014;Xu et al.,2016).There are two neurogenic niches in the adult CNS.One is the subgranular zone in the hippocampus and the other is found in the periventricular region throughout the extent of the neuraxis(Barnabé-Heider et al.,2010;Mirzadeh et al.,2010).Herein we focus on the periventricular region where we recently re- | Wenjun Xu Nishanth Lakshman Cindi M.Morshead | 2016 | Neural Regeneration Research2016，11，12： | 1 |
| 18 | Kinetics of phosphorus and potassium release from rock phosphate and waste mica enrichedcompost and their effect on yield and nutrient uptake by wheat(Triticum aestivum)显示文摘 | Nishanth D Biswas D R | 2008 | Bioresource Technology2008，99，： | 1 |
| 19 | Local drug delivery of alendronate gel for the treatment of chronic periodontitis subjects with diabetes mellitus: A double masked controlled clinical trial 显示文摘 | AR Pradeep Anuj Sharma Nishanth S Rao | 2012 | Journal of Periodontology2012，83，10： | 1 |
| 20 | Variations inSurface Ozone and NOx at Kannur:A Tropical,Coastal Site in India显示文摘 | NISHANTH T KUMAR M K S VALSARAJ K T | 2012 | Journal of Atmospheric Chemistry2012，69，2： | 1 |
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