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| 1 | Infections with Helicobacter pylori and challenges encountered in Africa显示文摘Helicobacter pylori(H.pylori)is the causative agent of gastritis,peptic ulcer disease,mucosa associated lymphoid tissue lymphoma and gastric cancer(GC).While this bacterium infects 50%of the world’s population,in Africa its prevalence reach as high as 80%as the infection is acquired during childhood.Risk factors for H.pylori acquisition have been reported to be mainly due to overcrowding,to have infected siblings or parent and to unsafe water sources.Despite this high H.pylori prevalence there still does not exist an African guideline,equivalent to the Maastricht V/Florence Consensus Report of the European Helicobacter and Microbiota Study Group for the management of this infection.In this continent,although there is a paucity of epidemiologic data,a contrast between the high prevalence of H.pylori infection and the low incidence of GC has been reported.This phenomenon is the so-called“African Enigma”and it has been hypothesized that it could be explained by environmental,dietary and genetic factors.A heterogeneity of data both on diagnosis and on therapy have been published.In this context,it is evident that in several African countries the increasing rate of bacterial resistance,mainly to metronidazole and clarithromycin,requires continental guidelines to recommend the appropriate management of H.pylori.The aim of this manuscript is to review current literature on H.pylori infection in Africa,in terms of prevalence,risk factors,impact on human health,treatment and challenges encountered so as to proffer possible solutions to reduce H.pylori transmission in this continent. | Stella Smith Muinah Fowora Rinaldo Pellicano | 2019 | World Journal of Gastroenterology2019，25，25： | 8 |
| 2 | Inflammatory bowel disease: Traditional knowledge holds the seeds for the future显示文摘Despite the level of sophistication they have reached nowadays, the available tools for treatment of inflammatory bowel disease(IBD) can at best chronicize the disease but not cure it. Chances to make leap forward from this hold-back may include designs to reach personalized treatment strategies taking advantage of modern genome associated studies, and shift resources towards unfolding inciting pathogenetic steps rather than continuing to develop drugs that address down-stream phenomena. We have arbitrarily chosen to scrutinize a few projects that may make their way in 2015 and mark the history of IBD research. The list includes: the role of appendix as a regulating factor in pathogenesis of ulcerative colitis/proctitis; the reappraisal of(auto)immune phenomena in the era of microbiome; projects to treat IBD by stem cell infusion; recognition of the crucial pathogenetic role of gut microbiome, and attempts to modify it to treat enteric diseases, from clostridium difficile infection to IBD. | Giovanni C Actis Rinaldo Pellicano Floriano Rosina | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，2： | 6 |
| 3 | Plasma erythropoietin levels in anaemic and non-anaemic patients with chronic liver diseases显示文摘AIM: To investigate the serum erythropoietin (Epo) levels in patients with chronic liver diseases and to compare to subjects with iron-deficiency anaemia and healthy controls.METHODS: We examined 31 anaemic (ALC) and 22 non-anaemic (NALC) cirrhotic patients, 21 non-anaemic subjects with chronic active hepatitis (CAH), 24 patients with iron-deficiency anaemia (ID) and 15 healthy controls. Circulating Epo levels (ELISA; R&D Systems, Europe Ltd, Abingdon,UK) and haemoglobin (Hb) concentration were determined in all subjects.RESULTS: Mean±SD of Epo values was 26.9±10.8 mU/mL in ALC patients, 12.5±8.0 mU/mL in NALC subjects,11.6±6.3 mU/mL in CAH patients, 56.4±12.7 mU/mL in the cases of ID and 9.3±2.6 mU/mL in controls. No significant difference (P>0.05) was found in Epo levels between controls, CAH and NALC patients. ALC individuals had higher Epo levels (P<0.01) than these groups whereas ID subjects had even higher levels (P<0.001) than patients suffering from ALC.CONCLUSION: Increased Epo values in cirrhotics, are only detectable when haemoglobin was lesser than 12 g/dL.Nevertheless, this rise in value is lower than that observed in anaemic patients with iron-deficiency and appears blunted and inadequate in comparison to the degree of anaemia. | Cosimo MarcelloBruno Sergio Neri ClaudioSciacca Gaetano Bertino Pietro DiPrima Danila Cilio Luciano Caruso Raffaello Cristaldi Rinaldo Pellicano | 2004 | World Journal of Gastroenterology2004，10，9： | 5 |
| 4 | Plasma-Lyte 148: A clinical review显示文摘AIM To outline the physiochemical properties and specific clinical uses of Plasma-Lyte 148 as choice of solution for fluid intervention in critical illness, surgery and perioperative medicine.METHODS We performed an electronic literature search from Medline and Pub Med(via Ovid), anesthesia and pharmacology textbooks, and online sources including studies that compared Plasma-Lyte 148 to other crystalloid solutions. The following keywords were used: 'surgery', 'anaesthesia', 'anesthesia', 'anesthesiology', 'anaesthesiology', 'fluids', 'fluid therapy', 'crystalloid', 'saline', 'plasma-Lyte', 'plasmalyte', 'hartmann's', 'ringers' 'acetate', 'gluconate', 'malate', 'lactate'. All relevant articles were accessed in full. We summarized the data and reported the data in tables and text. RESULTS We retrieved 104 articles relevant to the choice of Plasma-Lyte 148 for fluid intervention in critical illness, surgery and perioperative medicine. We analyzed the data and reported the results in tables and text.CONCLUSION Plasma-Lyte 148 is an isotonic, buffered intravenous crystalloid solution with a physiochemical composition that closely reflects human plasma. Emerging data supports the use of buffered crystalloid solutions in preference to saline in improving physicochemical outcomes. Further large randomized controlled trials assessing the comparative effectiveness of PlasmaLyte 148 and other crystalloid solutions in measuring clinically important outcomes such as morbidity and mortality are needed. | Laurence Weinberg Neil Collins Kiara Van Mourik Chong Tan Rinaldo Bellomo | 2016 | World Journal of Critical Care Medicine2016，5，4： | 5 |
| 5 | Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy显示文摘AIM: To investigate the seroprevalence of Helicobacter pylori(H pylorri) infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for gastric cancer (GC).METHODS: Samples from 317 (184 males, 133females, mean age 69±3.4 years) consecutive patients who had undergone surgery for gastric non-cardia adenocarcinoma were included in the study. Five hundred and fifty-five (294 males, 261 females, mean age 57.3±4.1 years) patients consecutively admitted to the Emergency Care Unit served as control. Histological examination of tumor, lymph nodes and other tissues obtained at the time of surgery represented the diagnostic 'gold standard'. An enzyme immunosorbent assay was used to detect serum anti-H pylori(IgG)antibodies and Western blotting technique was utilized to search for anti-CagA protein (IgG).RESULTS: Two hundred and sixty-one of three hundred and seventeen (82.3%) GC patients and 314/555 (56.5%)controls were seropositive for anti-H pylori (P<0.0001;OR, 3.58; 95%CI, 2.53-5.07). Out of the 317 cases, 267(84.2%) were seropositive for anti-CagA antibody vs 100 out of 555 (18%) controls (P<0.0001; OR, 24.30;95%CI, 16.5-35.9). There was no difference between the frequency of H pyloriin intestinal type carcinoma (76.2%) and diffuse type cancer (78.8%). Intestinal metaplasia (IM) was more frequent but not significant in the intestinal type cancer (83.4% vs 75.2% in diffuse type and 72.5% in mixed type). Among the patients examined for IM, 39.8% had IM type Ⅰ, 8.3% type Ⅱ and 51.9% type Ⅲ (type Ⅲ vs others, P = 0.4).CONCLUSION; This study confirms a high seroprevalence of H pyloriinfection in patients suffering from gastric adenocarcinoma and provides further evidence that searching for CagA status over H pylori infection might confer additional benefit in identifying populations at greater risk for this tumor. | Giorgio Palestro Rinaldo Pellicano Gian Ruggero Fronda Guido Valente Marco De Giuli Tito Soldati Agostino Pugliese Stefano Taraglio Mauro Garino Donata Campra Miguel Angel Cutufia Elena Margaria Giancarlo Spinzi Aldo Ferrara Giorgio Marenco Mario Rizzetto Antonio Ponzetto | 2005 | World Journal of Gastroenterology2005，11，45： | 5 |
| 6 | Cardiorenal Syndrome显示文摘 | Claudio Ronco Mikko Haapio Andrew A. House Nagesh Anavekar Rinaldo Bellomo | 2008 | Journal of the American College of Cardiology2008，，19： | 5 |
| 7 | Lack of association between seroprevalence of Helicobacterpylori infection and primary biliary cirrhosis显示文摘AIM: To determine the association between seroprevalence of Helicobacter pylori(Hpylon) infection and primary biliary cirrhosis (PBC).METHODS: In this case-control study, 149 consecutive patients (10 males, 139 females, mean age 58.2+11 years, range 26-82 years) suffering from PBC and 619 consecutive healthy volunteer blood donors (523 males, 96 females, mean age 47±5.3 years, range 18-65 years) attending the Hospital Blood Bank and residing in the same area were recruited. A commercial enzyme linked immunosorbent assay was used to detect anti-Hpylori(IgG) antibodies in serum.RESULTS: Antibodies to Hpyloriwere present in 78 (52.3%) out of 149 PBC-patients and in 291 (47%) out of 619 volunteers (P= 0.24, OR 1.24, 95% CI 0.85-1.80). In the subjects less than 60 years old, the prevalence of Hpylori infection among PBC-patients (40/79) was slightly higher than in controls (50.6% vs46.2%) P= 0.46, OR = 1.19, 95% CI: 0.72-1.95). In those over 60 years, the prevalence of H pyloriinfection was similar between PBC-patients and controls (54.2% vs57.8%, P= 0.7, OR 0.86, 95% CI 0.36-2.07). CONCLUSION: There is no association between seroprevalence of Hpyloriinfection and primary biliary cirrhosis. | Marilena Durazzo Floriano Rosina Alberto Premoli Enrico Morello Sharmila Fagoonee Rosaria Innarella Enrico Solerio Rinaldo Pellicano Mario Rizzetto | 2004 | World Journal of Gastroenterology2004，10，21： | 4 |
| 8 | Direct carotid puncture in acute ischaemic stroke intervention显示文摘Endovascular intervention for acute ischaemic stroke care is mostly performed in older patients,often with unfavourable aortic and supra-aortic anatomy,as well as cardiovascular comorbidities.A significant subset of them may benefit from transcervical access as the initial approach for mechanical thrombectomy.In fact,direct carotid artery puncture in these cases has the advantage to bypass the anatomical obstacles and achieve faster reperfusion.Caution is advised when common carotid artery access is pursued in order to avoid adverse events,including haematoma formation,iatrogenic arterial dissection and sheath kinking.In spite of potential complications,direct carotid puncture in acute ischaemic stroke intervention overcomes challenging angioarchitecture and may reduce the rate of poor clinical outcomes associated with delayed revascularisation in certain cases. | Elisa Colombo Lorenzo Rinaldo Giuseppe Lanzino | 2020 | Stroke & Vascular Neurology2020，5，1： | 4 |
| 9 | Cardiorenal Syndrome显示文摘 | Claudio Ronco Mikko Haapio Andrew A. House Nagesh Anavekar Rinaldo Bellomo | 2008 | Journal of the American College of Cardiology2008，，19： | 3 |
| 10 | Inflammatory bowel diseases: Current problems and future tasks显示文摘Current knowledge on inflammatory bowel disease(IBD)is mainly endorsed by controlled trials and epidemiologic studies. Yet,we seldom look at the messages from real-world practice. Among a patient population followed since2008,we looked at an unselected sample of 64 IBD patients [26 Crohn's disease(CD) and 38 ulcerative colitis(UC)] who had been seen as out-patients in the last year.Inducing remission,mesalamines(86% for UC/69% for CD/33%-16% as MMX formulation) prevailed as prescrip-tions; steroids(55%/19% for UC/CD) ranked second.Prescription of third-party drugs(antibiotics,NSAIDs,biologics) and adherence,were issues in the maintenance.34% of CD,and 23% of UC patients showed accompany-ing immunologic diseases: CD-associated familiar psoriasis(4:9) ranked first. Main Message. The association between IBD(CD mainly) and psoriasis,now found in our practice,matches current basic science gathering IBD together with psoriasis(and perhaps chronic respiratory disease) under the comprehensive term 'barrier organ disease' wherein an epithelial surface with sensor system srules contacts between outer antigens and a reactive underneath tissue,with the balance between inflammation and quiescence kept at any time by mucosal permeability.IBD is thus viewed as a polyfactorial/polygenic/syndromic disorder,embedded into a galaxy of immune conditions offering multiple points of attack. This mindset of splitting the IBDs into pathogenic categories may allow overcoming the uniformly targeting of a single cytokine by biological drugs,in favor of demarcating the boundaries between different disease-subtype-specific indications,and paving the way to future personalized strategies. | Giovanni C Actis Floriano Rosina Rinaldo Pellicano | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 3 |
| 11 | Type 2 diabetes mellitus and chronic hepatitis C: Which is worse? Results of a long-term retrospective cohort study显示文摘 | Chiara Giordanino Simone Ceretto Simona Bo Antonina Smedile Alessia Ciancio Elisabetta Bugianesi Rinaldo Pellicano Sharmila Fagoonee Elisabetta Versino Giuseppe Costa Daniele Arese Marco Sacco Mario Rizzetto Giorgio Saracco | 2011 | Digestive and Liver Disease2011，，5： | 3 |
| 12 | Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014显示文摘AIM To assess the etiology of chronic liver diseases(CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology.METHODS A random sample of charts of patients referred to for increased liver enzymes between January 1998 and December 2006, and between January 2012 and December 2014 were reviewed. Etiology search included testing for hepatitis B virus(HBV), hepatitis C virus(HCV), autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease and hereditary hemocromatosis. A risky alcohol consumption was also considered. Nonalcoholic fatty liver disease(NAFLD) was diagnosed in patients with histological and/or ultrasound evidence of steatosis/steatohepatitis, and without other causes of CLD.RESULTS The number of patients included was 1163. Of them, 528(45%) had positivity for HCV and 85(7%) for HBV. Among the virus-free patients, 417(36%) had metabolic disorders whereas the remaining had history of alcohol abuse, less prevalent causes of CLD or concomitant conditions. In comparison to 1998-2000(41%), a reduction of HCV alone-related cases was detected during the periods 2001-2003(35%, OR = 0.75, 95%CI: 0.53-1.06), 2004-2006(33%, OR = 0.70, 95%CI: 0.50-0.97) and 2012-2014(31%, OR = 0.64, 95%CI: 0.46-0.91). On the contrary, in comparison to 1998-2000(31%), metabolic-alone disorders increased in the period 2004-2006(39%, OR = 1.37, 95%CI: 0.99-1.91) and 2012-2014(41%, OR = 1.53, 95%CI: 1.09-2.16). The other etiologies remained stable. The increase of incidence of metabolic-alone etiology during the period 2004-2006 and 2012-2014 tended to be higher in older patients(≥ 50 years) compared to younger(P = 0.058).CONCLUSION In the Northwest of Italy, during this study period, the prevalence of HCV infection decreased notably whereas that of NAFLD increased. | Giorgio Maria Saracco Andrea Evangelista Sharmila Fagoonee Giovannino Ciccone Elisabetta Bugianesi Gian Paolo Caviglia Maria Lorena Abate Mario Rizzetto Rinaldo Pellicano Antonina Smedile | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 13 | 超声内镜在胰腺癌中的应用现状与展望显示文摘胰腺疾病的诊治在临床上一直是一个难点。在过去的几年中我们见证了放射学和核医学成像的技术进步。考虑到这一点,我们尝试描述超声内镜(EUS)在胰腺癌(PC)诊断及分期的过程中新的角色。到目前为止对于PC最准确的成像技术是对比增强计算机断层扫描(CT)和EUS。后者在检测微小病灶及评估肿瘤大小和淋巴结情况时具有最高的精度,但对于一个可疑的胰腺病变的患者而言,螺旋CT或最新的磁共振成像(MRI)仍是首要的选择。如在CT、MRI扫描为阴性结果而临床上高度怀疑PC,或是CT/MRI扫描后可疑病变需细胞组织学确认时,可应用EUS。相信在不久的将来用于诊断和治疗胰腺疾病的EUS将有更大的发展空间,并且病理结果将为其提供最好的应用证据。 | Claudio De Angelis Rosario Francesco Brizzi Rinaldo Pellicano 冯铁成 李新营 | 2014 | 中国普通外科杂志2014，23，3： | 2 |
| 14 | Effect of high temperatures in the pre-blooming and blooming periods on ovule formation, pollen grains and yield of ‘Granada’ peach显示文摘 | Gilmar Ant?nio Nava Genei Ant?nio Dalmago Homero Bergamaschi Rafael Paniz Rinaldo Pires dos Santos Gilmar Arduino Bettio Marodin | 2009 | Scientia Horticulturae2009，，1： | 2 |
| 15 | Is Helicobacter pylori the Infectious Trigger for Headache?: A Review显示文摘 | Lidia Savi Davide G. Ribaldone Sharmila Fagoonee Rinaldo Pellicano | 2013 | Infectious Disorders - Drug Targets2013，，5： | 2 |
| 16 | Early Goal-Directed Sedation Versus Standard Sedation in Mechanically Ventilated Critically Ill Patients: A Pilot Study*显示文摘 | Yahya Shehabi Rinaldo Bellomo Michael C. Reade Michael Bailey Frances Bass Belinda Howe Colin McArthur Lynne Murray Ian M. Seppelt Steve Webb Leonie Weisbrodt | 2013 | Critical Care Medicine2013，，： | 2 |
| 17 | Self-organized fractal river basin geometry 显示文摘 | RINALDO A RODRIGUEZ-ITURBE I RIGON R | 1993 | Physical Review Letters1993，70，6： | 1 |
| 18 | Current trends in initial management of laryngeal cancer: the declining use of open surgery显示文摘 | Carl E. Silver Jonathan J. Beitler Ashok R. Shaha Alessandra Rinaldo Alfio Ferlito | 2009 | European Archives of Oto - Rhino - Laryngology2009，，9： | 1 |
| 19 | Clinical review: Anticoagulation for continuous renal replacement therapy - heparin or citrate显示文摘 | Heleen M Oudemans- van Straaten John A Kellum Rinaldo Bello- nan | 2011 | Crit Care2011，15，1： | 1 |
| 20 | Esthesioneuroblastoma and cervical lymph node metastases: clinical and therapeutic implications 显示文摘 | Rinaldo A Ferlito A Shaha A R | 2002 | Acta Otolaryngol2002，122，： | 1 |
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