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| 1 | Hemozoin triggers tumor necrosis factor alpha-mediated release of lysozyme by human adherent monocytes:new evidences on leukocyte degranulation in P.falciparum malaria显示文摘Objective:Avidly phagocytosed hemozoin(malarial pigment) alters several functions of human monocytes and stimulates generation of several cytokines.Recently,we showed that phagocytosis of hemozoin by human monocytes increases expression and activity of matrix metalloproteinase-9,a proteolytic enzyme available in specific gelatinase granules,which contain several enzymes including lysozyme.Present work investigated active lysozyme release after phagocytosis of hemozoin and its dependence on production of tumor necrosis factor alpha. Methods:After phagocytosis of hemozoin,hemozoin-containing trophozoites or control meals(opsonized nonparasitized red blood cells and latex particles),monocyte supematants were monitored for 2 hours,in presence of blocking anti-human tumor necrosis factor alpha antibodies or recombinant human tumor necrosis factor alpha cytokine in selected experiments.Lysozyme release was evaluated by a specific spectrometric assay measuring lysozyme activity after coincubation of cell supematants with suspensions of Mycrococcus Lysodeikticus,while levels of soluble tumor necrosis factor alpha were analyzed by specific enzyme-linked immunodsorbent assay. Results:Levels of lysozyme activity and soluble tumor necrosis factor alpha protein were increased in hemozoin in-or trophozoites-laden monocytes supematants.Phagocytosis per se(control meals) also increased lysozyme release,but levels were significantly lower than those obtained after phagocytosis of hemozoin or trophozoites. Interestingly,all effects on lysozyme release observed after phagocytosis were abrogated by blocking anti-human tumor necrosis factor alpha antibodies,while they were mimicked by recombinant human tumor necrosis factor alpha cytokine.Conclusions:Present work shows that phagocytosis of hemozoin promotes monocyte degranulation and enhances active lysozyme release.The effect requires tumor necrosis factor alpha mediation. | Mauro Prato Giribaldi G Arese P | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，3： | 3 |
| 2 | Type 2 diabetes mellitus and chronic hepatitis C: Which is worse? Results of a long-term retrospective cohort study显示文摘 | Chiara Giordanino Simone Ceretto Simona Bo Antonina Smedile Alessia Ciancio Elisabetta Bugianesi Rinaldo Pellicano Sharmila Fagoonee Elisabetta Versino Giuseppe Costa Daniele Arese Marco Sacco Mario Rizzetto Giorgio Saracco | 2011 | Digestive and Liver Disease2011，，5： | 3 |
| 3 | Solidification parameters during the columnar-to-equiaxed transition in lead-tin alloys显示文摘 | A. E. Ares C. E. Schvezov | 2000 | Metallurgical and Materials Transactions A2000，，6： | 2 |
| 4 | Influence of modified atmosphere packaging on sensory quality of shiitake mushrooms显示文摘 | Gabriela Antmann Gastón Ares Patricia Lema Claudia Lareo | 2008 | Postharvest Biology and Technology2008，，1： | 2 |
| 5 | Higher production of tumor necrosis factor alpha in hemozoin-fed human adherent monocytes is dependent on lipidic component of malarial pigment:new evidences on cytokine regulation in Plasmodium falciparum malaria显示文摘Objective:To investigate whether the increase of tumor necrosis factor alpha is dependent on lipidic component of malarial pigment.Methods:Adherent human monocytes were fed for 3 hours with different meals(native hemozoin;lipid free hemozoin;and control latex particles),then tumor necrosis factor alpha was monitored in cell supernatants up to 48 hours through western blotting or specific enzyme-linked immunoadsorbent assay.In selected experiments,unfed monocytes were treated with different doses of 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid or 4-hydroxynonenal instead of phagocytosis.Results:Hemozoin-fed monocytes produced higher levels of tumor necrosis factor alpha than unstimulated and latex-fed cells, while lipid-free hemozoin did not reproduce these results.Additionally,hemozoin effects were mimicked dose-dependently by 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid,but not by 4-hydroxynonenal.Conclusions:Present data suggest an essential role for lipids in hemozoindependent enhanced release of tumor necrosis factor alpha from monocytes,and 15(S,R)hydroxy -6,8,11,13-eicosatetraenoic acid could be one possible specific mediator. | Prato Mauro Gallo Valentina Arese Paolo | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 2 |
| 6 | Use of a reeombinant protein from BruceLla abortus for the diagnosis of brucel- losis in different animal species显示文摘 | Arese A Cravero S Bosehiroli M | 1998 | Rev Argent Mieroblol1998，31，： | 1 |
| 7 | Neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years显示文摘 | Susana Ares José Quero Jesus Diez Gabriella Morreale de Escobar | 2011 | Journal of Pediatric Endocrinology and Metabolism . 2011 (11-1)2011，，11： | 1 |
| 8 | Pahophysiology of hemolysis in glucose-6-phosphate dehydrogenase deficiency显示文摘 | Arese P | 1990 | Semin Hematol1990，27，： | 1 |
| 9 | Nitric oxide and the respiratory enzyme显示文摘 | Brunori M Forte E Arese M | 2006 | Biochim Biophys Acta2006，1757，： | 1 |
| 10 | Cloning of Brucella abortus gene and characterization of expressed 26-kilodalton periplasmic protein:potential use for diagnosis显示文摘 | Osvaldo L Rossetti Alicial 1 Arese Maria L Boschiroli | 1996 | J Clin Microbiol1996，34，1： | 1 |
| 11 | Expression of a fully functional cd 1 nitrite reductase from Pseudomonas aeruginosa in Pseudomonas stutzeri显示文摘 | Marzia Arese Walter G Zumft Francesca Cutruzzolà | 2002 | Protein Expression and Purification2002，，1： | 1 |
| 12 | Glutathione S-transferase M1,T1,P1 genotypes and risk for development of colorectal cancer显示文摘 | Ates NA Tamer L Ares C | | 0，，： | 1 |
| 13 | Protection against in?fection in mice vaccinated with a Brucella abortus mutant显示文摘 | Boschirol M Cravero S Arese A | 1997 | In?fee Immun1997，65，2： | 1 |
| 14 | Magnetic resonance imaging evaluation of patellar tendon graft remodelling after anterior cruciate ligament reconstruction with or without platelet-rich plasma显示文摘 | Seijas Roberto Ares Oscar Catala Jordi Alvarez-Diaz Pedro Cusco Xavier Cugat Ramon | 2013 | Journal of Orthopaedic Surgery2013，，1： | 1 |
| 15 | Differentiation ofconstrict tive pericarditis from restrictive cardiomyopathy:Assessment of Left ventricu]ar diastolic velcities in longitu-dinal axis by Doppler Tissueimaging显示文摘 | Carcia MJ Rodrlguez L Ares M | | 0，，01： | 1 |
| 16 | In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis显示文摘 | Follenzi A Arese M | 1995 | Arterioscler Thromb Vasc Biol1995，15，11： | 1 |
| 17 | Rupture of an aneurysm of the persistent trigeminal artery presenting as a carotid-cavernous sinnsfistula显示文摘 | Qian CX Ares C Codere F | | 0，，05： | 1 |
| 18 | 葡萄糖-6-磷酸脱氢酶缺乏症溶血的病理生理学显示文摘据估计,红细胞在其生存期中,行程约175英里,共经历约17万个循环周期,其间,要经受湍流、挤压及高渗的影响,并受到潜在杀伤细胞的威胁.同时,红细胞的内环境也由于其高氧载及内源性氧化物的产生而受到威胁.为对抗各种外在和内在危险因素.红细胞具有一种简单而有效的代谢途径以维护其功能.葡萄糖-6-磷酸脱氢酶(G6PD)为维持红细胞的抗氧化系统、保证红细胞的稳定性和活性起着极其主要的作用.本章着重讨论G6PD缺乏症患者摄入蚕豆后发生溶血所出现的一系列病理生理学改变,以阐明其发病机制.摄入蚕豆诱发的溶血蚕豆病的发生率及分布:蚕豆病主要发生于地中海沿岸和中东地区,如巴尔干半岛、希腊、塞浦路斯、土尔其、黎巴嫩、以色列、埃及、北非、伊朗、伊拉克等.在远东主要发生于台湾省和中国南部. | Arese P Flora AD 贾永前 | 1990 | 国外医学(输血及血液学分册)1990，13，5： | 1 |
| 19 | Comparison of oocyst shedding and the serum immune response to Cryptosporidium parvum in cattle and pigs显示文摘 | Quilez J Ares Mazas E Sanchez Acedo C | | 0，，： | 1 |
| 20 | Infiltration of plasmarich in growth factors for osteoarthritis of the knee short-term ef-fects on function and quality of life显示文摘 | Wang-Saegusa A Cugat R Ares O | | 0，，03： | 1 |
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