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35篇 您的检索式:作者名="Gilmar"
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1Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients显示文摘AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction(PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A-1498C>T(rs833031) and-634G>C(rs2010963) polymorphisms. Genotyping was validated for VEGF-A-1498C>T polymorphism in 129 patients and for VEGF-A-634G>C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association(OR = 0.32; P = 0.048) between genotype CC of the VEGF-A-1498C>T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A-1498C>T polymorphism and VEGF-A-634G>C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A-1498C>T polymorphism was significantly correlated with the 5-year survival(P = 0.032), but not significant difference(P = 0.27) was obtained with the VEGF-A-634G>C polymorphism with the 5-year survival in the univariate analysis. The genotype CT(HR = 2.79) and CC(HR = 4.67) of the polymorphism VEGF-A-1498C>T and the genotype CC(HR = 3.76) of the polymorphism VEGF-A-634C>G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A-1498C>T and the CC genotype of the VEGF-A-634C>G polymorphisms are prognostic factors of survival in Brazilians patients with sporadic colorectal carcinoma.Gilmar Ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino Damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael Dale Cotrim Guerreiro da Silva Jaques Waisberg 2017World Journal of Gastrointestinal Oncology2017,9,2:4
2Effect of high temperatures in the pre-blooming and blooming periods on ovule formation, pollen grains and yield of ‘Granada’ peach显示文摘Gilmar Ant?nio Nava Genei Ant?nio Dalmago Homero Bergamaschi Rafael Paniz Rinaldo Pires dos Santos Gilmar Arduino Bettio Marodin 2009Scientia Horticulturae2009,,1:2
3Antioxidant activity of( + )-bergenin-a phytoconstituent isolated from the bark of Sacoglottis uchi Huber ( Humi- reaceae) 显示文摘Heitor A De Abreu Izandina Aparecida dos S Lago Gilmar P Souza 2008Organ Biomol Chem2008,6,:1
4Seasonality of nutrients in leaves and fruit of apple tree显示文摘GILMAR R N ANTONIO R D 2006Scientia Agriculture2006,63,5:1
5Strong Coupling For Fluid Structure Interaction Problems显示文摘Nicolas C Gilmar M Hassan N J 2007European Journal of Computational Mechanics/Revue Européenne de Mécanique Numérique2007,16,34:1
6Seasonality of nutrients in leaves and fruit of apple tree显示文摘GILMAR R N ANTONIO R D 2006Scientia Agriculture2006,63,5:1
7Sol-gel silica film preparation from aqueous solutions for corrosion protection显示文摘Gilmar P T Mafia A S O Evandro D A O 2000Journal of Non-CrystallineSolids2000,273,:1
8China's quest for energy through FDI: new empir- ical evidence显示文摘Francisco Urdinez Gilmar Masiero and Mario Ogasa- vara 2014Journal of Chinese Economic and Busi- ness Studies2014,12,4:1
9Hormonal and histological studies related to in vitro banana bud formation显示文摘Gilmar R Z Gilberto B K Jane E K Elaine C R 2000Plant Cell Tissue and Organ Culture2000,63,:1
10Discussion on the verification of the overlap ratio intluenee on performance coefficients of a Savonius wind rotor using computational fluid dynamics 显示文摘JOAO VICENTE AKWA GILMAR ALVES DA SILVA JUNIOR ADRIANE PRISCO PETRY 2012Renewable Energy2012,38,:1
11Correlation between plasma 5-aminolevulinic acid concentrations and indicators of oxidative stress in lead-exposed workers显示文摘Cristine AC Gilmar CT Adriana MP 1997Clin Chem1997,43,7:1
12Discussion on the verification of the overlap ratio influence on performance Coefficients of a Savonius wind rotor using computational fluid dynamics显示文摘JO(A)O Vicente Akwa GILMAR Alres da Silva Júnior ADRIANE Prisco Petry 2012Renewable Energy2012,38,:1
13Hormonal and histological studies related to in vitro banana bud formalion显示文摘Gilmar R Zaffari Gilberto B Kerbany Jane E Kraus 2000Plant Cell Tissue and Organ Culture2000,63,:1
14Nitrogen and potas-sium fertilization affect apple fruit quality in Southern Brazil显示文摘GILBERTO N ANTONIO R D GILMAR R N 2008Communications in Soil Science and Plant Analysis2008,39,:1
15Novel cytotoxic oxygenated C29 sterols from the colombian marine sponge polymastia tenax 显示文摘Gilmar S Vanessa P Jaime R 2002J Nat Prod2002,65,:1
16Effects of interleukin-4 on the expression and activity of prostaglandin endoperoxide H synthase-2 in amnion-derived WISH cells显示文摘Gilmar JS Hansen WR Miller HC 1998J Mol Endocrinol1998,21,:1
17Sol-gel silica film preparation from aqueous solutions for c01 '1'osion protec- tion 显示文摘Gilmar P T Maia A S O Evandro D A O 2000Journal of Non-Crystalline Solids2000,273,:1
18Novel cytotoxic oxygenated C29 sterols from the colombian marine sponge Polymastia Tenax显示文摘GILMAR S VANESSA P JAIME R 2002J Nat Prod2002,65,:1
19Sol-gel silica film preparation from aqueous solutions for corrosion protection显示文摘Gilmar P T Maria A S O Evandro D A O 2000Journal of Non-Crystalline Solids2000,273,:1
20Sequential extraction and availability of copper in Cu fungicide-amended vineyard soils from Southern Brazil显示文摘Roberta Corrêa Nogueirol Luís Reynaldo Ferracciú Alleoni Gilmar Ribeiro Nachtigall George Wellington de Melo 2010Journal of Hazardous Materials2010,,1:1
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