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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Trans on Power Delivery1993，8，4： | 1 |
| 3 | A versatile rhodium catalyst for acetalization reactions under mild conditions显示文摘 | Ott G M Ramos T Grand D | 1989 | Tetrahedron Letters1989，30，45： | 1 |
| 4 | Avian reovirus polypeptides:analysis of intracellular virus-specified products,virions,top component,and cores显示文摘 | SCHNITZER T J RAMOS T GOUVEA V | 1982 | J Virol1982，43，3： | 1 |
| 5 | A study on the char- acteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Transactions on Power Deliv- ery1993，8，18： | 1 |
| 6 | Role of cortical cell type and morphology in sub- and su- prathreshold uniform electric field stimulation in vitro 显示文摘 | Radman T Ramos R L Brumberg J C | 2009 | Brain Stimulation2009，2，4： | 1 |
| 7 | Current use of pressurized liquid extraction and subcritical water extraction in environmental analysis显示文摘 | Ramos L Kristenson E M Brinkman U A T | 2002 | Journal of Chromatography A2002，975，1： | 1 |
| 8 | Leakage detection and location in gas pipelines through an LPV identification approach显示文摘 | Lopes S P Azevedo T P Ramos J A | 2011 | C in Nonlinear Science and Numerical Simulation2011，12，16： | 1 |
| 9 | HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra - 1 pathway 显示文摘 | Ramos - Nino ME Blumen SR Sabo - Attwood T | 2008 | Am J Respir Cell Mol Biol2008，38，2： | 1 |
| 10 | Familial hyperc- holesterolemia: Molecular characterization of possible cases from the Azores Islands (Portugal) 显示文摘 | Cymbron T Mendes P Ramos A | 2014 | Meta Gene2014，14，2： | 1 |
| 11 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 12 | Ilizarov externalfixation or locked intramedullary nailing in diaphyseal tib-ial fractures:a randomized,prospective study of 58con-secutive patients显示文摘 | Ramos T Eriksson BI Karlsson J | 2014 | Arch Orthop Trauma Surg2014，134，6： | 1 |
| 13 | A study On the characteristics of various conductive contaminants accumulated on high voltage in- sulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Transactions on Power Delivery1993，8，4： | 1 |
| 14 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G CampiUo R M T Naito K | 1993 | IEEE Transactions on Power Delivery1993，8，4： | 1 |
| 15 | Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions显示文摘 | Ramos M A Kuzuya M Esaki T | 1998 | Arterioscler Thromb Vasc Biol1998，18，7： | 1 |
| 16 | Curve reconstruction:Connecting dots with good reason显示文摘 | Dey T K Mehlhorn K Ramos E A | 2000 | Computational Geometry Theory and Applications2000，15，4： | 1 |
| 17 | Assessing heavy metal contamination in Sado Estuary sediment:an index analysis approach 显示文摘 | Caeiro S Costa M H Ramos T B et cd | 2005 | Ecological Indicators2005，，5： | 1 |
| 18 | Current use of pressurised liquid extraction and subcritical water extraction in environmental analysis显示文摘 | Ramos L Kristenson E M Brinkman U A T | 2002 | Journal of Chromatography A2002，975，1： | 1 |
| 19 | Hemodynamic benefits of left ventricular pacing in two pacemakers syndromes with refractory heart failure显示文摘 | Alberca T Ramos M Vinas J | 2000 | Rev Esp Cardiol2000，53，8： | 1 |
| 20 | Mutual in fluence of Cu and a cationic herbicide on their adsorption desorp tion processes on two selected soils显示文摘 | Undabeytia T Morillo E Ramos A B Maqueda C | 2002 | Water Air and Soil Pollution2002，137，14： | 1 |
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