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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Determination of the furaltadone metabolite 5-methylmorpholino-3-amino -9 oxazolidinone (AMOZ) using liquid chromatography coupled to electrospray tandem mass spectrometry during the nitrofuran crisis in Portugal显示文摘 | Barbosa J Ferreira M L Ramos F | 2007 | Accred Qual Assur2007，12，： | 1 |
| 3 | Optimization of millimeter-wave signal generation through FM-IM conversion in chirped fiber gratings 显示文摘 | Marti J Fuster J M Ramos F | 2000 | Microwave and Optical Technology Letters2000，27，6： | 1 |
| 4 | Reduced- dimension blind space - time 2 - D Rank receivers for DS - CDMA communication systems 显示文摘 | CHEN Y F ZOLTOWSKI M D RAMOS J | 2000 | IEEE Trans on Signal Process2000，48，： | 1 |
| 5 | Computational analysis of ligand recognition sites of homo-and heteropentameric5-HT3 receptors显示文摘 | Moura Barbosa A J De Rienzo F Ramos M J | 2010 | Eur J Med Chem2010，45，11： | 1 |
| 6 | Heart-lung interactions with different ventilatory settings during acute lung in- jury and hypovolaemia: an experimental study显示文摘 | da Silva Ramos F J de Oliveira E M Park M | 2011 | Br J Anaesth2011，106，3： | 1 |
| 7 | DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis显示文摘 | Lorenz-Depiereux B Bastepe M Benet-Pages A Amyere M Wagenstaller J Muller-Barth U Badenhoop K Kaiser SM Rittmaster RS Shlossberg AH Olivares JL Loris C Ramos FJ Glorieux F Vikkula M Juppner H Strom TM | | 0，，11： | 1 |
| 8 | Hydrocarbon selective catalytic reduction of NO over Cu/Fe-pillared clays: Diffuse refectance infrared spectroscopy studies显示文摘 | DORADO F GARCFA P B LUCAS A D RAMOS M J ROMERO A | 2010 | J Mol Catal A2010，332，12： | 1 |
| 9 | Analysis of the effect of pH on Cu^2+-fulvic acid complexation using a simple electrostatic model 显示文摘 | Ramos M A Fiol S Lopez R Antelo J M Arce F | 2002 | Environ Sci Technol2002，36，14： | 1 |
| 10 | General performance of density functionals显示文摘 | Sousa S F Fernandes P A Ramos M J | | 0，，42： | 1 |
| 11 | Qm/Mm studies on the β-galactosidase catalytic mechanism: Hydroly- sis and transglycosylation reactions显示文摘 | Bras N F Femandes P A Ramos M J | 2010 | Journal of Chemical Theory & Computation2010，6，2： | 1 |
| 12 | The minnesota impedance cardiograph- theory and applications 显示文摘 | Kubicek W G Lottke F J Ramos M U | 1974 | Biomed Eng1974，9，： | 1 |
| 13 | Gyro-based attitude reference systems for communications satellites 显示文摘 | Hsing J C Ramos A Barrentt M F | 1980 | Journal of Guidance and Control1980，3，3： | 1 |
| 14 | The blood-brain barrier:Structure,function and therapeutic approaches to cross it显示文摘 | Tajes M Ramos F E Weng J X | 2014 | Mol Membr Biol2014，31，5： | 1 |
| 15 | Ultrsound Enhanced Reactions Involving Activated Carbons As Catalysts:Synthesis of Unsaturated Nitriles显示文摘 | SILVA I F VITAL J RAMOS A M | 1998 | Carbon1998，36，： | 1 |
| 16 | Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis显示文摘 | Moura L M Ramos S F Zamorano J I | 2007 | J Am Coll Cardiol2007，49，5： | 1 |
| 17 | All-optical packet header processor based on cascaded SOA-MZIs显示文摘 | MARTINEZ J M RAMOS F MARTI J | 2004 | Elect Lett2004，40，14： | 1 |
| 18 | Thermal stability of nanocomposites based on polypropylene and bentonite显示文摘 | Ramos Filho F G M61o T J A Rabello M S | 2005 | Polymer Degradation and Stability2005，89，3： | 1 |
| 19 | Antimony quartz and antimony-gold quartz veins from northern Portugal 显示文摘 | Neiva A M t~ Andr~ P Ramos J M F | 2008 | Ore geology Reviews2008，，： | 1 |
| 20 | Oxydehydrogenation of cyclohexanol over carbon catalysts显示文摘 | Silva I F Vital J Ramos A M | 1998 | Carbon1998，36，： | 1 |
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