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| 1 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017,6,1: | 4 |
| 2 | Zinc oxide nano-enabled microfluidic reactor for water purification and its applicability to volatile organic compounds显示文摘This paper reports fast and efficient chemical decontamination of water within a tree-branched centimeter-scale microfluidic reactor.The microreactor integrates Zinc oxide nanowires(ZnO NWs)in situ grown acting as an efficient photocatalytic nanomaterial layer.Direct growth of ZnO NWs within the microfluidic chamber brings this photocatalytic medium at the very close vicinity of the water flow path,hence minimizing the required interaction time to produce efficient purification performance.We demonstrate a degradation efficiency of 95%in o5 s of residence time in one-pass only.According to our estimates,it becomes attainable using microfluidic reactors to produce decontamination of merely 1 l of water per day,typical of the human daily drinking water needs.To conduct our experiments,we have chosen a laboratory-scale case study as a seed for addressing the health concern of water contamination by volatile organic compounds(VOCs),which remain difficult to remove using alternative decontamination techniques,especially those involving water evaporation.The contaminated water sample contains mixture of five pollutants:Benzene;Toluene;Ethylbenzene;m–p Xylenes;and o-Xylene(BTEX)diluted in water at 10 p.p.m.concentration of each.Degradation was analytically monitored in a selective manner until it falls below 1 p.p.m.for each of the five pollutants,corresponding to the maximum contaminant level(MCL)established by the US Environmental Protection Agency(EPA).We also report on a preliminary study,investigating the nature of the chemical by-products after the photocatalytic VOCs degradation process. | Imadeddine Azzouz Yamina Ghozlane Habba Martine Capochichi-Gnambodoe Frédéric Marty Jérôme Vial Yamin Leprince-Wang Tarik Bourouina | 2018 | Microsystems & Nanoengineering2018,4,1: | 4 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017,17,27: | 3 |
| 4 | Frequency transfer function of dispersive and nonlinear single-mode optical fibers in microwave optical systems显示文摘 | Ramos F Marti J | 2000 | IEEE Photon Technol Lett2000,12,5: | 2 |
| 5 | Proton motive force generation by citro- lactic fermentation in leuconostoc and mesenteroides显示文摘 | MARTY TEYSSET C POSTHUMA C LOLKEMAS J S | 1996 | J Bacteriol1996,178,: | 2 |
| 6 | Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice显示文摘 | Marti A Novo F J Martinez-Anso E | 1998 | Biochem Biophys Res Commun1998,246,: | 2 |
| 7 | Effects of diazepam and midazolam on baroreflex control of heart rate and sympathetic activity in human显示文摘 | Marty J Gauzit R Lefervre P | 1986 | Anesth Analg1986,65,: | 1 |
| 8 | Proton shock acceleration in laser-plasma interactions显示文摘 | Silva L O Marti M Davies J R | 2004 | Phys Rev Lett2004,92,01: | 1 |
| 9 | Optimization of millimeter-wave signal generation through FM-IM conversion in chirped fiber gratings 显示文摘 | Marti J Fuster J M Ramos F | 2000 | Microwave and Optical Technology Letters2000,27,6: | 1 |
| 10 | A confocal microscopy analysis of the spindle and chromosome configurations of human oocytes cryopreserved at the germinal vesicle and metaphase Ⅱ stage 显示文摘 | Boiso I Marti M Santalo J | 2002 | Hum Reprod2002,17,7: | 1 |
| 11 | Hypoxia-induced vascular endotheliad growth factor expression precedes neovasculariZation after cerebral ischemia显示文摘 | Marti H J Bemaudin M Bellail A | 2000 | J AM J Pathol2000,156,3: | 1 |
| 12 | Hypoxia and cobaltstimulate lactate dehydrogenase(LDH)activity in vascularsmooth muscle cells显示文摘 | Marti HH Jung HH Pfeilschifter J | 1994 | Pflugers Arch1994,429,: | 1 |
| 13 | Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia显示文摘 | Marti H J Bernaudin M Bellail A | 2000 | Am J Pathol2000,156,3: | 1 |
| 14 | Swine torque teno virus detection in pig commercial vaccines, enzymes for laboratory use and human drugs containing components of porcine origin显示文摘 | KEKARAINEN T MARTI'NEZ-GUINO' L SEGALE' S J | 2009 | J Gen Virol2009,90,3: | 1 |
| 15 | Expression of caspases and their substrates in the rat model of foeal cerebral ischemia显示文摘 | Lopoz E Marti E | 2000 | Neurobiol Dis2000,7,4: | 1 |
| 16 | Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii显示文摘 | Vila J Marti S Samchez-Cespedes J | 2007 | J Antimicrob Chemother2007,59,6: | 1 |
| 17 | Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii 显示文摘 | VILA J MARTI S SANCHEZ-CESPEDES J | 2007 | J Antimicrob Chemother2007,59,6: | 1 |
| 18 | Detection of paraoxon by continuous flow system based enzyme sensor显示文摘 | Eanty G Marty J L | 1998 | Biosensor & Bioelectronics1998,13,2: | 1 |
| 19 | Strictly aerobic and anaerobic associated with sinking particulate matter and zooplankton fecal pellets显示文摘 | Bianchi M Marty D Teyssie J L | 1992 | Marine Ecology Progress Series1992,88,1: | 1 |
| 20 | Aging increases pharmacodynamic sensitivity to the hypnotic effects of midazolam显示文摘 | Jacobs JR Reves JG Marty J | 1995 | Anesth Analg1995,80,1: | 1 |