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| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Frequency transfer function of dispersive and nonlinear single-mode optical fibers in microwave optical systems显示文摘 | Ramos F Marti J | 2000 | IEEE Photon Technol Lett2000，12，5： | 2 |
| 4 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez Ramos J Song S Cardozo Pelaez F | | 0，，： | 2 |
| 5 | Determination of the furaltadone metabolite 5-methylmorpholino-3-amino -9 oxazolidinone (AMOZ) using liquid chromatography coupled to electrospray tandem mass spectrometry during the nitrofuran crisis in Portugal显示文摘 | Barbosa J Ferreira M L Ramos F | 2007 | Accred Qual Assur2007，12，： | 1 |
| 6 | Characteristics of the heterotrophic population in hypersaline environments of different salt concentration显示文摘 | RODRIGUEZ V F RUIZ B F RAMOS C A | 1981 | Microbiol Ecol1981，7，： | 1 |
| 7 | Optimization of millimeter-wave signal generation through FM-IM conversion in chirped fiber gratings 显示文摘 | Marti J Fuster J M Ramos F | 2000 | Microwave and Optical Technology Letters2000，27，6： | 1 |
| 8 | Feasibility of occipital condyle smvw placement for occipitocervical fixation: a cadaveric study and description of a novel technique显示文摘 | Uribe JS Ramos E Vale F | 2008 | J Spinal Dis- ord Tech2008，21，8： | 1 |
| 9 | Software- defined networking: A comprehensive survey显示文摘 | KREUTZ D RAMOS F M V VERISSIMO P E | 2015 | Proceedings of the IEEE2015，103，1： | 1 |
| 10 | Adult bone marrow stromal cells differentiate into neural cells in vivo显示文摘 | Sanchez - Ramos J Song S Cardozo - Pelaez F | 2000 | Exp Neurol2000，164，： | 1 |
| 11 | Stereotactic targeting of the globus pallidus internus in Parkinson's disease:imaging versus electrophysiological mapping显示文摘 | GURIDI F GOROSPE A RAMOS E | 1999 | Neurosurgery1999，45，： | 1 |
| 12 | Biological nitrogenand phenol removal from saline industrial wastewater bysubmerged fixed-film reactor显示文摘 | Ramos A F Gomez M A Hontoria E | 2007 | Journal of Hazardous Materials2007，142，1： | 1 |
| 13 | Wave-Based Slewing and Vibration Control of a Flexible Arm显示文摘 | Yang Tangwen O'Connor W J Ramos F | | 0，，02： | 1 |
| 14 | Thermo- and pH-sensitive IPN hydrogels based on PNIPAAm and PVA-Ma networks with LCST tailored close to human body temperature 显示文摘 | WENCESLAU A C SANTOS F G RAMOS E R F NAKAMURA C V RUBlRA A F MUNIZ E C | 2012 | Materials Science and Engineering C2012，32，5： | 1 |
| 15 | Scheimpflug - based tomography and biomechanical assessment in pressure - induced stromal keratopathy 显示文摘 | Faria - Correia F Ramos I Valbon B | 2013 | J Refract Surg2013，29，5： | 1 |
| 16 | Chases in volatiles with the application of progressive freeze-concentration to Andes berry(Rubus glaucus Benth)显示文摘 | RAMOS F A DELGADO J L BAUTISTAE MORALES A L DUQUEC | 2005 | Journal of Food Engineering2005，，69： | 1 |
| 17 | Reduced- dimension blind space - time 2 - D Rank receivers for DS - CDMA communication systems 显示文摘 | CHEN Y F ZOLTOWSKI M D RAMOS J | 2000 | IEEE Trans on Signal Process2000，48，： | 1 |
| 18 | Influence of skimmed milk concentrate replacement by dry dairy products in a low fat set-type yoghurt model system显示文摘 | Guzaman-Gonzalez M Morals F Ramos M | 1999 | Journal of Science Food and Agriculture1999，，79： | 1 |
| 19 | Mitigation of chromatic dispersion effects employing electro absorption modula- tor-based transmitters显示文摘 | Polo V Mart'l J Ramos F | 1999 | IEEE Photonics Technology Letters1999，11，7： | 1 |
| 20 | Renal function and outcome of PTRA and stenting for atherosclerotic renal artery stenosis 显示文摘 | RAMOS F KOTLIAR C ALVAREZ D | 2003 | Kidney Int2003，63，1： | 1 |
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