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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Characteristics of the heterotrophic population in hypersaline environments of different salt concentration显示文摘 | RODRIGUEZ V F RUIZ B F RAMOS C A | 1981 | Microbiol Ecol1981，7，： | 1 |
| 3 | Stereotactic targeting of the globus pallidus internus in Parkinson's disease:imaging versus electrophysiological mapping显示文摘 | GURIDI F GOROSPE A RAMOS E | 1999 | Neurosurgery1999，45，： | 1 |
| 4 | Biological nitrogenand phenol removal from saline industrial wastewater bysubmerged fixed-film reactor显示文摘 | Ramos A F Gomez M A Hontoria E | 2007 | Journal of Hazardous Materials2007，142，1： | 1 |
| 5 | Thermo- and pH-sensitive IPN hydrogels based on PNIPAAm and PVA-Ma networks with LCST tailored close to human body temperature 显示文摘 | WENCESLAU A C SANTOS F G RAMOS E R F NAKAMURA C V RUBlRA A F MUNIZ E C | 2012 | Materials Science and Engineering C2012，32，5： | 1 |
| 6 | Chases in volatiles with the application of progressive freeze-concentration to Andes berry(Rubus glaucus Benth)显示文摘 | RAMOS F A DELGADO J L BAUTISTAE MORALES A L DUQUEC | 2005 | Journal of Food Engineering2005，，69： | 1 |
| 7 | Char- acterization and dehydrogenation activity of Pt/Nb2 05 catalysts显示文摘 | Aranda D A G Ramos A L D Passos F B | 1996 | Catalysis Today1996，28，12： | 1 |
| 8 | Probabilistic midterm transmission planning in a liberalized market 显示文摘 | Sanchez-Martin P Ramos A Alonso J F | 2005 | IEEE Transactions on Power Systems2005，20，4： | 1 |
| 9 | A new methodology for the coordinated design of robust decentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
| 10 | A newmethodology for the coordinated design of robustdecentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEETransactions on Power Systems2004，19，1： | 1 |
| 11 | Study of the slow batch pyrolysis of mixtures of plastics, tyres and forestry biomass wastes显示文摘 | PARADELA F PINTO F RAMOS A M | 2009 | Journal of Analytical and Applied Pyrolysis2009，85，12： | 1 |
| 12 | Acute sensory neuropathy associated with a varicella-zoster infection显示文摘 | Ramos F Monforte C Luengo A | 1999 | Rev Neurol1999，28，： | 1 |
| 13 | Role of dehydration catalyst acid properties on one-step DME synthesis over physical mixtures显示文摘 | Ramos F S De Farias A M D Borges L E P | 2005 | Catal Today2005，101，1： | 1 |
| 14 | Cerebellar anatomy as applied to cerebellar microsurgical resections显示文摘 | Ramos A Chaddad-Neto F Doria-Netto HL | 2012 | Arq Neuropsiquiatr2012，70，6： | 1 |
| 15 | Adsorptive voltammetric study of thorium-alizarin complexon complex at a carbon paste electrode显示文摘 | Marcos F Teixeira S Luiz Ramos A | 2003 | Microchimica Acta2003，143，4： | 1 |
| 16 | Production of an Extracellular Polysaccharide with Emulsifier Properties by Penicillium citrinum 显示文摘 | CAMARGO-DE-MORAIS M M RAMOS S A F PIMENTEL M C B | 2003 | World J Microbiol &Biotechnol2003，19，2： | 1 |
| 17 | Computational analysis of ligand recognition sites of homo-and heteropentameric5-HT3 receptors显示文摘 | Moura Barbosa A J De Rienzo F Ramos M J | 2010 | Eur J Med Chem2010，45，11： | 1 |
| 18 | AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development显示文摘 | FUSARO A F BOCCA S N RAMOS R L | 2007 | Planta2007，225，5： | 1 |
| 19 | AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development显示文摘 | Fusaro A F Bocca S N Ramos R L B | 2007 | Planta2007，225，6： | 1 |
| 20 | DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis显示文摘 | Lorenz-Depiereux B Bastepe M Benet-Pages A Amyere M Wagenstaller J Muller-Barth U Badenhoop K Kaiser SM Rittmaster RS Shlossberg AH Olivares JL Loris C Ramos FJ Glorieux F Vikkula M Juppner H Strom TM | | 0，，11： | 1 |
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