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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Role of dehydration catalyst acid properties on one-step DME synthesis over physical mixtures显示文摘 | Ramos F S De Farias A M D Borges L E P | 2005 | Catal Today2005，101，1： | 1 |
| 3 | Adsorptive voltammetric study of thorium-alizarin complexon complex at a carbon paste electrode显示文摘 | Marcos F Teixeira S Luiz Ramos A | 2003 | Microchimica Acta2003，143，4： | 1 |
| 4 | Production of an Extracellular Polysaccharide with Emulsifier Properties by Penicillium citrinum 显示文摘 | CAMARGO-DE-MORAIS M M RAMOS S A F PIMENTEL M C B | 2003 | World J Microbiol &Biotechnol2003，19，2： | 1 |
| 5 | AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development显示文摘 | FUSARO A F BOCCA S N RAMOS R L | 2007 | Planta2007，225，5： | 1 |
| 6 | AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development显示文摘 | Fusaro A F Bocca S N Ramos R L B | 2007 | Planta2007，225，6： | 1 |
| 7 | Phase Ⅱ study of radiochemotherapy with UFT and low-dose oral leucovorin in patients with unresectable rectal cancer 显示文摘 | De La Torre A Ramos S Valca'rcel F | 1999 | Int J Radiat Oncol Biol Phys1999，45，3： | 1 |
| 8 | Analysis of the effect of pH on Cu^2+-fulvic acid complexation using a simple electrostatic model 显示文摘 | Ramos M A Fiol S Lopez R Antelo J M Arce F | 2002 | Environ Sci Technol2002，36，14： | 1 |
| 9 | General performance of density functionals显示文摘 | Sousa S F Fernandes P A Ramos M J | | 0，，42： | 1 |
| 10 | Thermal stability of nanocomposites based on polypropylene and bentonite显示文摘 | Ramos Filho F G M61o T J A Rabello M S | 2005 | Polymer Degradation and Stability2005，89，3： | 1 |
| 11 | Products of vegetable origin: a new alternative for the consumption of probiotic bacteria 显示文摘 | Martins E M F Ramos A M Vanzela E S L | 2013 | Food Research International2013，51，2： | 1 |
| 12 | Comparison of glyburide and insulin for the management of gestational diabetics with markedly elevated oral glucose challenge test and fasting hyperglycemia显示文摘 | Ramos G A Jacobson G F Kirby R S | 2007 | J Perinatol2007，27，5： | 1 |
| 13 | Dapagli flozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial显示文摘 | Ferrannini E Ramos S J Salsali A Tang W List J F | 2010 | Diabetes Care2010，33，： | 1 |
| 14 | Toxoplasma gondii Isolates From Free-Range Chickens From the Northeast Region of Brazil显示文摘 | de Oliveira L N Costa L M de Melo C F Silva J C Ramos Bevilaqua C M L Azevedo S S Muradian V Araújo D A F V Dubey J P Gennari S M | 2009 | The Journal of Parasitology2009，，1： | 1 |
| 15 | Assessing heavy metal contamination in Sado Estuary sediment:An index analysis approach显示文摘 | Caeiro S Costa M H Ramos T B Femandes F Silveira N Coimbra A Medeiros G Painho M | | 0，，02： | 1 |
| 16 | Comparison of recovery methods for the enumeration of injured Listeria innocua cells under isothermal and non-isothermal treatments 显示文摘 | Miller F A Ramos B BrandSo T R S | 2010 | Food Microbiology2010，27，8： | 1 |
| 17 | Phase II study of radioehemotherapy with UFT and low-dose oral leucovorin in patients with unresectable rectal cancer 显示文摘 | De la Torre A Ramos S Valcarcel F J | 1999 | Int J Radiat Oneol Biol Phys1999，45，3： | 1 |
| 18 | General Performance of Density Functionals 显示文摘 | Sousa S F Femandes P A Ramos M J | 2007 | Journal of Physical Chemistry A2007，111，10： | 1 |
| 19 | IST-LASAGNE:towards all-optical label swapping employing optical logic gates and optical flip-flops显示文摘 | Ramos F Kehayas E Martinez J M Clavero R Marti J Stampoulidis L Tsiokos D Avramopoulos H Zhang J Holm-Nielsen P V Chi N Jeppesen P Yan N Monroy I T Koonen A M J Hill M T Liu Y Dorren H J S Van Caenegem R Colle D Pickavet M Riposati B | | 0，，10： | 1 |
| 20 | Protein-ligand docking: Current status and future challenges 显示文摘 | Sousa S F Fernandes P A Ramos M J | 2006 | Proteins: Structure Function and Bioinformatics2006，65，1： | 1 |
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