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| 1 | Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer显示文摘The estrogen receptor(ER) pathway plays a critical role in breast cancer development and progression. Endocrine therapy targeting estrogen action is the most important systemic therapy for ER positive breast cancer. However its efficacy is limited by intrinsic and acquired resistance. Mechanisms responsible for endocrine resistance include deregulation of the ER pathway itself, including loss of ER expression, posttranslational modification of ER, deregulation of ER coactivators; increased receptor tyrosine kinase signaling leading to activation of various intracellular pathways involved in signal transduction, proliferation and cell survival, including growth factor receptor tyrosine kinases human epidermal growth factor receptor-2, epidermal growth factor receptor, PI3K/AKT/mammalian target of rapamycin(m TOR), Mitogen activated kinase(MAPK)/ERK, fibroblast growth factor receptor, insulin-like growth factor-1 receptor; alterations in cell cycle and apoptotic machinery; Epigenetic modificationincluding dysregulation of DNA methylation, histone modification, and nucleosome remodeling; and altered expression of specific micro RNAs. Functional genomics has helped us identify a catalog of genetic and epigenetic alterations that may be exploited as potential therapeutic targets and biomarkers of response. New treatment combinations targeting ER and such oncogenic signaling pathways which block the crosstalk between these pathways have been proven effective in preclinical models. Results of recent clinical studies suggest that subsets of patients benefit from the combination of inhibitor targeting certain oncogenic signaling pathway with endocrine therapy. Especially, inhibition of the m TOR signaling pathway, a key component implicated in mediating multiple signaling cascades, offers a promising approach to restore sensitivity to endocrine therapy in breast cancer. We systematically reviewed important publications cited in Pub Med, recent abstracts from ASCO annual meetings and San Antonio Breast Cancer Symposium, and relevant trials registered at Clinical Trials.gov. We present the molecular mechanisms contributing to endocrine resistance, in particular focusing on the biological rationale for the clinical development of novel targeted agents in endocrine resistant breast cancer. We summarize clinical trials utilizing novel strategies to overcome therapeutic resistance, highlighting the need to better identify the appropriate patients whose diseases are most likely to benefit from these specific strategies. | Meng Zhao Bhuvaneswari Ramaswamy | 2014 | World Journal of Clinical Oncology2014，5，3： | 17 |
| 2 | Studies on the effect of weld defect on the fatigue behavior of welded structures显示文摘Structural integrity isstated as the science and technology of margin between safety and disaster. Systematic prediction of structural integrity of critical structures such ascombustion chambers,pressure vessels,nuclear reactor components,boilers etc.,ensures the human safety,environmental protection,and the economical considerations.The present work aims at prediction of fatigue behaviour of symmetric structures like pressure vessels in the presence of common welding defects such as lack of fusion( LOF),lack of penetration( LOP) and porosity.A ring type specimen which replicates the stress pattern in thepressure vessel is considered for the study of severity of weld imperfections. Initial dimensions of weld defects are arrived by performing NDT inspection.Crack growth analysis is carried out to determine the remaining life of the welded joint with defects. | Ramu Murugan Prabhu Raja Venugobal Thyla Pudukkarai Ramaswami Sathiskumar Jothi Somu Chinnusamy | 2018 | China Welding2018，27，1： | 12 |
| 3 | Embolization of liver tumors:Past,present and future显示文摘Curative therapies for hepatocellular carcinoma(HCC),such as resection and liver transplantation,can only be applied in selected patients with early tumors.More advanced stages require local or systemic therapies.Resection of HCC offers the only hope for cure.Even in patients undergoing resection,recurrences are common.Chemoembolization,a technique combining intraarterial chemotherapy with selective tumor ischemia,has been shown by randomized controlled trials to be efficacious in the palliative setting.There is now renewed interest in transarterial embolization/transarterial chemoembolization(TACE) with regards to its use as a palliative tool in a combined modality approach,as a neoadjuvant therapy,in bridging therapy before transplantation,for symptomatic indications,and even as an alternative to resection.There have also been rapid advances in the agents being embolized trans-arterially(genes,biological response modifiers,etc.).The current review provides an evidence-based overview of the past,present and future trends of TACE in patients with HCC. | Ashwin Rammohan Jeswanth Sathyanesan Sukumar Ramaswami Anand Lakshmanan Perumal Senthil-Kumar Ulagendra Perumal Srinivasan Ravi Ramasamy Palaniappan Ravichandran | 2012 | World Journal of Radiology2012，4，9： | 11 |
| 4 | Role of interventional radiology in the management of acute gastrointestinal bleeding显示文摘Acute gastrointestinal bleeding(GIB) can lead to significant morbidity and mortality without appropriate treatment. There are numerous causes of acute GIB including but not limited to infection, vascular anomalies, inflammatory diseases, trauma, and malignancy. The diagnostic and therapeutic approach of GIB depends on its location, severity, and etiology. The role of interventional radiology becomes vital in patients whose GIB remains resistant to medical and endoscopic treatment. Radiology offers diagnostic imaging studies and endovascular therapeutic interventions that can be performed promptly and effectively with successful outcomes. Computed tomography angiography and nuclear scintigraphy can localize the source of bleeding and provide essential information for the interventional radiologist to guide therapeutic management with endovascular angiography and transcatheter embolization. This review article provides insight into the essential role of Interventional Radiology in the management of acute GIB. | Raja S Ramaswamy Hyung Won Choi Hans C Mouser Kazim H Narsinh Kevin C McCammack Tharintorn Treesit Thomas B Kinney | 2014 | World Journal of Radiology2014，6，4： | 8 |
| 5 | Genome-wide analysis of NAC transcription factor family in rice显示文摘 | Mohammed Nuruzzaman Ramaswamy Manimekalai Akhter Most Sharoni Kouji Satoh Hiroaki Kondoh Hisako Ooka Shoshi Kikuchi | 2010 | Gene2010，，1： | 5 |
| 6 | Effect of fusion welding processes on tensile properties of armor grade, high thickness, non-heat treatable aluminium alloy joints显示文摘AA5059 is one of the high strength armor grade aluminium alloy that finds its applications in the military vehicles due to the higher resistance against the armor piercing (AP) threats. This study aimed at finding the best suitable process among the fusion welding processes such as gas tungsten arc welding (GTAW) and gas metal arc welding (GMAW) by evaluating the tensile properties of AA5059 aluminium alloy joints. The fracture path was identified by mapping the low hardness distribution profile (LHDP) across the weld cross section under tensile loading. Optical and scanning electron microscopies were used to characterize the microstructural features of the welded joints at various zones. It is evident from the results that GTAW joints showed superior tensile properties compared to GMAW joints and this is primarily owing to the presence of finer grains in the weld metal zone (WMZ) and narrow heat-affected zone (HAZ). The lower heat input associated with the GTAW process effectively reduced the size of the WMZ and HAZ compared to GMAW process. Lower heat input of GTAW process results in faster cooling rate which hinders the grain growth and reduces the evaporation of magnesium in weld metal compared to GMAW joints. The fracture surface of GTAW joint consists of more dimples than GMAW joints which is an indication that the GTAW joint possess improved ductility than GMAW joint. | K. Vasu H. Chelladurai Addanki Ramaswamy S. Malarvizhi V. Balasubramanian | 2019 | Defence Technology(防务技术)2019，15，3： | 4 |
| 7 | 表皮生长因子/HER2抑制剂在非小细胞肺癌患者治疗中的作用综述显示文摘晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)仍然是主要的全球健康问题。尽管可逆性表皮生长因子受体(epidermal growth factor receptor,EGFR)酪氨酸激酶抑制剂厄洛替尼可改善复发与再发NSCLC患者的生存期,但也存在明显的局限性,包括仅对少数患者亚群具有临床疗效、生存率较低及产生耐药性。EGFR和HER2的非可逆性抑制剂是临床开发的新型药物,有可能预防并克服第一代EGFR抑制剂的获得性耐药。 | Ramaswamy GOVINDAN 南娟 丁燕 | 2010 | 中国肺癌杂志2010，，4： | 4 |
| 8 | Proposed NIST standard for role-based access control显示文摘 | David F. Ferraiolo Ravi Sandhu Serban Gavrila D. Richard Kuhn Ramaswamy Chandramouli | 2001 | ACM Transactions on Information and System Security (TISSEC)2001，，3： | 4 |
| 9 | Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines显示文摘In the present study, total membrane proteins from tumor cell lines including HepG2, Hep3 B2,H226, Ovcar3 and N87 were extracted and digested with γLys C and trypsin. The resulting peptide lysate were pre-fractionated and subjected to untargeted quantitative proteomics analysis using a high resolution mass spectrometer. The mass spectra were processed by the Max Quant and the protein abundances were estimated using total peak area(TPA) method. A total of 6037 proteins were identified, and the analysis resulted in the identification of 2647 membrane proteins. Of those, tumor antigens and absorption,metabolism, disposition and elimination(ADME) proteins including UDP-glucuronosyltransferase,cytochrome P450, solute carriers and ATP-binding cassette transporters were detected and disclosed significant variations among the cell lines. The principal component analysis was performed for the cluster of cell lines. The results demonstrated that H226 is closely related with N87, while Hep3 B2 aligned with HepG2. The protein cluster of Ovcar3 was apart from that of other cell lines investigated. By providing for the first time quantitative untargeted proteomics analysis, the results delineated the expression profiles of membrane proteins. These findings provided a useful resource for selecting targets of choice for anticancer therapy through advancing data obtained from preclinical tumor cell line models to clinical outcomes. | Xiaomei Gu Qing Xiao Qian Ruan Yuezhong Shu Ashok Dongre Ramaswamy Iyer W.Griffith Humphreys Yurong Lai | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 3 |
| 10 | 特高压直流输电设备的设计显示文摘目前中国正在为各大水电站规划输电距离达2000km的大容量高压直流输电方案,800kV特高压直流是当前首选的方案。全球现有的高压直流输电系统的最高电压水平限制在500￣600 kV。因此,必须深入研究提高的稳态和暂态电压应力对特高压直流换流站主设备设计产生的影响。必须对现有技术水平和制造能力进行评估。将集中讨论特高压直流输电关键设备的特殊设计要求。 | HAEUSLER M KOELSCH H RAMASWAMI V | 2006 | 中国电力2006，39，2： | 3 |
| 11 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis显示文摘 | Jing Yang Sendurai A Mani Joana Liu Donaher Sridhar Ramaswamy Raphael A Itzykson Christophe Come Pierre Savagner Inna Gitelman Andrea Richardson Robert A Weinberg | 2004 | Cell2004，，7： | 3 |
| 12 | Effects of Brand Local and Nonlocal Origin on Consumer Attitudes in Developing Countries显示文摘 | Rajeev Batra Venkatram Ramaswamy Dana L. Alden Jan-Benedict E.M. Steenkamp S. Ramachander | 2000 | Journal of Consumer Psychology2000，，2： | 3 |
| 13 | Co-creation experiences: The next practice in value creation显示文摘 | C.K. Prahalad Venkat Ramaswamy | 2004 | Journal of Interactive Marketing2004，，3： | 3 |
| 14 | Carotenoid composition, distribution and degradation to flavour volatiles during black tea manufacture and the effect of carotenoid supplementation on tea quality and aroma显示文摘 | Ramaswamy Ravichandran | 2002 | Food Chemistry2002，，1： | 2 |
| 15 | 云南-广东±800 kV特高压直流输电工程基本设计显示文摘云南-广东±800 kV特高压直流输电项目目前正在建设中.这是中国很重要并极具技术含量的直流输电工程之一,它通过1 418 km长的直流输电线路将云南省的楚雄和广东省的穗东连接起来,设计输送容量为5 000 MW,是世界上最大的双极直流输电项目.文中介绍了云南-广东±800kV特高压直流输电项目的重点和难点,包括换流站整体设计原则以及增加的稳态和暂态电压应力对主设备设计提出的挑战,讨论了关键特高压直流设备的特殊设计概念. | Simon Balbierer Marcus Haeusler Ramaswami Velpanur 饶宏 尚春 尚涛 | 2007 | 电力系统装备2007，，8： | 2 |
| 16 | Co-creation experiences: The next practice in value creation显示文摘 | C.K. Prahalad Venkat Ramaswamy | 2004 | Journal of Interactive Marketing2004，，3： | 2 |
| 17 | Methodology for inventorying greenhouse gas emissions from global cities显示文摘 | Christopher Kennedy Julia Steinberger Barrie Gasson Yvonne Hansen Timothy Hillman Miroslav Havránek Diane Pataki Aumnad Phdungsilp Anu Ramaswami Gara Villalba Mendez | 2009 | Energy Policy2009，，9： | 2 |
| 18 | Mechanical properties of PP-LDPE blends with novel morphologies produced with a continuous chaotic advection blender显示文摘 | A. Dhoble B. Kulshreshtha S. Ramaswami D.A. Zumbrunnen | 2005 | Polymer2005，，7： | 2 |
| 19 | Changes in enzyme activities (polyphenol oxidase and phenylalanine ammonia lyase) with type of tea leaf and during black tea manufacture and the effect of enzyme supplementation of dhool on black tea quality显示文摘 | Ramaswamy Ravichandran Ramaswamy Parthiban | 1998 | Food Chemistry1998，，3： | 2 |
| 20 | Hematopoietic stem cell transplantation for auto immune rheumatic diseases显示文摘Stem cells have their origins in the embryo and during the process of organogenesis, these differentiate into specialized cells which mature to form tissues. In addition, stem cell are characterized by an ability to indefinitely self renew. Stem cells are broadly classified into embryonic stem cells and adult stem cells. Adult stem cells can be genetically reprogrammed to form pluripotent stem cells and exist in an embroyonic like state. In the early phase of embryogenesis, human embryonic stem cells only exist transiently. Adult stem cells are omnipresent in the body and function to regenerate during the process of apoptosis or tissue repair. Hematopoietic stem cells(HSC) are adult stem cells that form blood and immune cells. Autoimmune responses are sustained due to the perennial persistence of tissue self autoantigens and/or auto reactive lymphocytes. Immune reset is a process leading to generation of fresh self-tolerant lymphocytes after chemotherapy induced elimination of self or autoreactive lymphocytes. This forms the basis for autologous HSC transplantation(HSCT). In the beginning HSCT had been limited to refractory autoimmune rheumatic diseases(AIRD) due to concern about transplant related mortality and morbidity. However HSCT for AIRD has come a long way with better understanding of patient selection, conditioning regime and supportive care. In this narrative review we have examined the available literature regarding the HSCT use in AIRD. | Subramanian Ramaswamy Sandeep Jain Vinod Ravindran | 2016 | World Journal of Transplantation2016，6，1： | 2 |
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