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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | 国家重点实验室在国家科技创新体系中的地位和作用显示文摘一、国家实验室对国家科技发展的作用
1.国家重点实验室对我国基础研究的发展发挥了不可替代的作用
改革开放以后,我国政府和科技界意识到基础研究的极端重要性和我国基础研究相对薄弱的状况,原国家计委决定集中一部分公共资源,有选择地在一些重要学科建设科学研究基地,称为国家重点实验室. | Department of Basic Research,MOST,Beijing 100862 | 2003 | 中国基础科学2003，，5： | 15 |
| 3 | 基于氢氧基平面激光诱导荧光法的稀释燃烧机理实验研究显示文摘为探讨反应物预热温度和稀释率对稀释燃烧机理的影响,该文以氮气稀释的甲烷–空气对冲扩散火焰为研究对象,采用氢氧基平面激光诱导荧光法(hydroxy radical planar laser induced fluorescence,OH-PLIF)进行实验研究。以OH基反应区厚度表征火焰厚度,实验结果表明,在反应物预热温度较低情况下,当预热温度一定时火焰厚度随反应物稀释率增大(或者浓度减小)而减小,当反应物稀释率一定时火焰厚度随预热温度升高而增大。但进一步分析表明,在反应物预热温度足够高时,火焰厚度将随反应物稀释率增加而增大。根据预热对化学反应速度的增大与稀释对化学反应速度的减小的共同作用,从火焰厚度随反应物预热温度与稀释率的变化情况可推断,在低预热温度稀释燃烧过程中,预热温度是影响火焰结构的主要因素;在预热温度足够高的稀释燃烧过程中,稀释率是火焰结构的主要影响因素,此时由于稀释引起化学反应速度大大降低,因此火焰厚度或体积显著增大。 | 刘玉英 Jean-Michel Most Philippe Bauer | 2008 | 中国电机工程学报2008，28，32： | 6 |
| 4 | Genome-wide analysis of NAC transcription factor family in rice显示文摘 | Mohammed Nuruzzaman Ramaswamy Manimekalai Akhter Most Sharoni Kouji Satoh Hiroaki Kondoh Hisako Ooka Shoshi Kikuchi | 2010 | Gene2010，，1： | 5 |
| 5 | Effects of supplementation of green tea extract on the milk performance of peripartal dairy cows and the expression of stress response genes in the liver显示文摘Background: We hypothesised that supplementation of green tea extract(GTE) in dairy cows during the transition period can attenuate proinflammatory conditions and prevent endoplasmic reticulum(ER) stress in the liver of these cows. Thirty Holstein cows with an average parity of 3.06(± 1.31, SD) were divided into a control group and a group that received a daily amount of 10 g of GTE from d 7 before the calving day and a daily amount of 20 g of GTE from the day of calving until d 7 of lactation.Results: Cows supplemented with GTE did not show differences in energy intake or milk yield in weeks 2–7 of lactation. However, these cows had a lower milk fat concentration and a lower energy corrected milk yield than the control cows and showed a trend of improved energy balance. The relative m RNA concentrations of proinflammatory genes, genes involved in the acute phase reaction and antioxidant genes in the liver in weeks 1, 4 and 7 of lactation were not different between the two groups of cows. The concentrations of α-tocopherol and the Trolox equivalent antioxidant capacity in plasma were not different between the two groups. However, the group supplemented with GTE showed significant reductions of some genes of the unfolded protein response(UPR) in week 1 and a trend of lower liver triacylglycerol(TAG) concentrations in the liver compared to the control group.Conclusions: This study shows that supplementation of GTE in dairy cows lowers the fat concentration in the milk but overall has no effect on the expression of inflammatory genes and the antioxidative status in dairy cows during early lactation. The finding of reduced m RNA levels of genes involved in the UPR at week 1, however, supports other results showing that supplementation of polyphenols could prevent the development of ER stress in the liver of cows during early lactation. The finding of a tendency towards a reduced TAG concentration in the liver of cows supplemented with GTE might be due to an improved energy balance in these cows. | Denise K.Gessner Corinna Brock Lena M.Hof Erika Most Christian Koch Klaus Eder | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 5 |
| 6 | Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L.in growing pigs by transcriptomics, metabolomics and lipidomics显示文摘Background:The hypothesis was tested that insect meal(IM)as protein source influences intermediary metabolism of growing pigs.To test this,30 male,5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights(BW)and fed isonitrogenous diets either without(CON)or with 5%IM(IM5)or 10%IM(IM10)from Tenebrio molitor L.for 4 weeks and key metabolic tissues(liver,muscle,plasma)were analyzed using omics-techniques.Results:Most performance parameters did not differ across the groups,whereas ileal digestibilities of most amino acids were 6.7 to 15.6%-units lower in IM10 than in CON(P<0.05).Transcriptomics of liver and skeletal muscle revealed a total of 166 and 198,respectively,transcripts differentially expressed between IM10 and CON(P<0.05).Plasma metabolomics revealed higher concentrations of alanine,citrulline,glutamate,proline,serine,tyrosine and valine and a lower concentration of asparagine in IM10 than in CON(P<0.05).Only one out of fourteen quantifiable amino acid metabolites,namely methionine sulfoxide(MetS),in plasma was elevated by 45%and 71%in IM5 and IM10,respectively,compared to CON(P<0.05).Plasma concentrations of both,major carnitine/acylcarnitine species and bile acids were not different across groups.Lipidomics of liver and plasma demonstrated no differences in the concentrations of triacylglycerols,cholesterol and the main phospholipids,lysophospholipids and sphingolipids between groups.The percentages of all individual phosphatidylcholine(PC)and phosphatidylethanolamine(PE)species in the liver showed no differences between groups,except those with 6 double bonds(PC 38:6,PC 40:6,PE 38:6,PE 40:6),which were markedly lower in IM10 than in CON(P<0.05).In line with this,the percentage of C22:6n-3 in hepatic total lipids was lower in IM10 than in the other groups(P<0.05).Conclusions:Comprehensive analyzes of the transcriptome,lipidome and metabolome of key metabolic tissues indicate that partial or complete replacement of a conventional protein source by IM in the diet has only a weak impact on the intermediary metabolism of growing pigs.Thus,it is concluded that IM from Tenebrio molitor L.can be used as a dietary source of protein in pigs without causing adverse effects on metabolism. | Sandra Meyer Denise K.Gessner Maria S.Braune Theresa Friedhoff Erika Most Marcus Höring Gerhard Liebisch Holger Zorn Klaus Eder Robert Ringseis | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 4 |
| 7 | 甲状腺乳头状腺癌颈淋巴结清扫术显示文摘我院在1952~1997年共治疗甲状腺癌2097例,其中乳头状腺癌1732例1954~1992年间乳头状腺癌1219例,男317,女902例,男女之比为1:2.85.年龄最小6岁,最大80岁,中位年龄37.68岁,S=12.72,行颈淋巴结清除术913例(71例行双颈清除术),共984例次。通过对913例(984例次)颈淋巴结清除术的分析及随访。预防性组淋巴结阳性率为66.32%,治疗性组为93.98%,预防性组10年以上无瘤生存率远高于治疗性组。治疗性组5年、10年无瘤生存率功能性组优于传统性组(P<0.01),预防性组10、15、20年无瘤生存率功能性组优于传统性组(P<0.005),说明功能性颈淋巴结清除术即保留功能又不降低生存率,是一种值得提倡的治疗方法。另外通过109例死亡原因回顾,死于复发和转移62例(56.88%),术后10年内死亡者占83.87%(52/62),术后10年以上复发机会明显减少。转移瘤多以肺转移为主,占71.4%。 | 徐本义 高明 张艳 张学忠 姜辉春. 72) . Most (913) of the patients were undergone neck dissection. 71 of the 913 patients underwent a bilateral nec | 1998 | 中国耳鼻咽喉头颈外科1998，9，S1： | 3 |
| 8 | 稀释燃烧的火焰稳定性显示文摘采用实验研究的方法探讨了反应物预热温度与稀释率两个因素对稀释燃烧火焰稳定性的影响.实验以氮气稀释的甲烷-空气对冲扩散火焰为研究对象,确定了不同反应物预热温度与氧化剂稀释率(氧气体积分数)时火焰的熄火极限,结果表明,增大反应物预热温度拓宽了火焰稳定燃烧区域,而增加氧化剂稀释率(降低氧气体积分数)会降低稀释火焰的稳定性,二者对火焰稳定性的影响作用相反.为了进一步分析反应物预热温度与稀释率对火焰稳定性的影响程度,引入了估算的Damk hler数,分析表明,在实验研究范围内,反应物预热温度对火焰稳定性的影响比稀释率的影响显著,是火焰稳定性的主要影响因素. | 刘玉英 MOST Jean-Michel BAUER Philippe 杨茂林 | 2009 | 燃烧科学与技术2009，15，2： | 2 |
| 9 | The Cosmic Dust in Suzhou Granite:Ablated Products of a Cometary Explosion | Hu Zhong-wei,Wang Er-kang,Wan Yu-qiuDepartement of Astronomy,Nanjing University,Nanjing 210093,China Department of Earth Sdence,Nanjing University,Nanjing 210093,China Cosmic dust has been collected in large number from deap-sea sediments,Greenland ice deposits,the stratosphere and space,of cosmic dust,some are the unmelted micrometeorite,and most are the ablated products of me-teoroids in the atmosphere.Cosmic dusts were recovered from two sites of the 1908 Tunguska explosion and the 1965 Revelstoks explosion Since 1987,a large number of microspherules have been extracted from Suzhou granite of China Their suface and section structures,mineral and chemical composition show that these microspherules are of the ablated cosmic dust.The microspherules occurred in the inner contact complex intrusion.It suggests that the microspherules may be products of the same event and were aggergated in some strata and then captured by the emplacement of granitic magma.Although the microspherules are similare to other ablated cosmic dusts,there are some diferences.Our calculated results of cometary motion through the atmosphere and explosion show that the microspherules may be the ablated dust of a comet with mass above 1015g at its explosion near the ground. | 1996 | 紫金山天文台台刊1996，15，3： | 2 |
| 10 | Proliferative hemangiomas:analysis of cytokine gene expression and angiogenesis 显示文摘 | Chang J Most D Bresnick S | 1999 | Plst Reconstr Surg1999，103，： | 2 |
| 11 | 关于《国家重点实验室评估规则》修订的说明显示文摘随着国家科技体制改革的不断深入和新颁布的《国家重点实验室建设与管理暂行办法》的贯彻实施,1999年制定的《国家重点实验室评估规则》已不能适应实验室进一步发展的需要。为此,我司组织对“国家重点实验室评估规则”进行了修订。 | Department of Basic Research, MOST, Beijing 100862 | 2003 | 中国基础科学2003，，4： | 2 |
| 12 | Gene expression of transforming growth factor beta-1 in rabbit zone Ⅱ flexor tendon wound healing:evidence for dual mechanisms of repair 显示文摘 | Chang J Most D Stelnicki E | 1997 | Plast Reconstr Surg1997，100，4： | 1 |
| 13 | Lineaweaver WCStudies in flexor tendon wound healing:neutra lizing antibody to TGF-betal increases postoperative range of motion显示文摘 | Chang J Thunder R Most D | 2000 | Plast Reconstr Surg2000，105，： | 1 |
| 14 | An Introduction to Stem Cell Biology 显示文摘 | Hemmat S Lieberman DM Most SP | 2010 | Facial Plastic Surgery2010，26，5： | 1 |
| 15 | Optimizing flexion after total knee osteoarthrotis: advavees in prosthetic design 显示文摘 | Sultan P G Most E Schule S | 2003 | Clin Orthop2003，416，11： | 1 |
| 16 | Spectrophotomettic characteristics of chloroohylls and their pheophytins in ethanol显示文摘 | WINTERMANS J F G M DE MOST D A | 1965 | Biochim Biophys Acta1965，109，： | 1 |
| 17 | Human ef-fector and memory CD8+T-cell responses to smallpox andyellow fever vaccines显示文摘 | Miller J D van der Most R G Akondy RS | 2008 | Immunity2008，28，5： | 1 |
| 18 | Rice bran oil,not fiber,lowers cholesterol in humans显示文摘 | Marlene M Most Richard Tulley Silvia Morales | 2005 | American Journal of Clinical Nutrition2005，1，： | 1 |
| 19 | Gene expression of transforming growth factor beta-1 in rabbit zone 显示文摘 | Chang J Most D Stelnicki E | 1997 | Plast Reconstr Surg1997，100，： | 1 |
| 20 | Proliferative hemangiomas: analysis of cytokine gene expression and angiogenesis显示文摘 | Chang J Most D Bresnick S | 1999 | Palst Reconstr Surg1999，103，1： | 1 |
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