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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Systematic review of nutrition screening and assessment in inflammatory bowel disease显示文摘BACKGROUND Malnutrition is prevalent in inflammatory bowel disease (IBD). Multiple nutrition screening (NST) and assessment tools (NAT) have been developed for general populations, but the evidence in patients with IBD remains unclear. AIM To systematically review the prevalence of abnormalities on NSTs and NATs, whether NSTs are associated with NATs, and whether they predict clinical outcomes in patients with IBD. METHODS Comprehensive searches performed in Medline, CINAHL Plus and PubMed. Included: English language studies correlating NSTs with NATs or NSTs/NATs with clinical outcomes in IBD. Excluded: Review articles/case studies;use of body mass index/laboratory values as sole NST/NAT;age<16. RESULTS Of 16 studies and 1618 patients were included, 72% Crohn’s disease and 28% ulcerative colitis. Four NSTs (the Malnutrition Universal Screening Tool, Malnutrition Inflammation Risk Tool (MIRT), Saskatchewan Inflammatory Bowel Disease Nutrition Risk Tool (SaskIBD-NRT) and Nutrition Risk Screening 2002 (NRS-2002) were significantly associated with nutritional assessment measures of sarcopenia and the Subjective Global Assessment (SGA). Three NSTs (MIRT, NRS-2002 and Nutritional Risk Index) were associated with clinical outcomes including hospitalizations, need for surgery, disease flares, and length of stay (LOS). Sarcopenia was the most commonly evaluated NAT associated with outcomes including the need for surgery and post-operative complications. The SGA was not associated with clinical outcomes aside from LOS. CONCLUSION There is limited evidence correlating NSTs, NATs and clinical outcomes in IBD. Although studies support the association of NSTs/NATs with relevant outcomes, the heterogeneity calls for further studies before an optimal tool can be recommended. The NRS-2002, measures of sarcopenia and developments of novel NSTs/NATs, such as the MIRT, represent key, clinically-relevant areas for future exploration. | Suqing Li Michael Ney Tannaz Eslamparast Ben Vandermeer Kathleen P Ismond Karen Kroeker Brendan Halloran Maitreyi Raman Puneeta Tandon | 2019 | World Journal of Gastroenterology2019，25，28： | 9 |
| 3 | Aluminium tolerance in barley (Hordeum vulgare L.): physiological mechanisms, genetics and screening methods显示文摘Aluminium (Al) toxicity is one of the major limiting factors for barley production on acid soils. It inhibits root cell division and elongation, thus reducing water and nutrient uptake, consequently resulting in poor plant growth and yield. Plants tolerate Al either through external resistance mechanisms, by which Al is excluded from plant tissues or internal tolerance mechanisms, conferring the ability of plants to tolerate Al ion in the plant symplasm where Al that has permeated the plas- malemma is sequestered or converted into an innocuous form. Barley is considered to be most sensitive to Al toxicity among cereal species. Al tolerance in barley has been assessed by several methods, such as nutrient solution culture, soil bioassay and field screening. Genetic and molecular mapping research has shown that Al tolerance in barley is controlled by a single locus which is located on chromosome 4H. Molecular markers linked with Al tolerance loci have been identified and validated in a range of diverse populations. This paper reviews the (1) screening methods for evaluating Al tolerance, (2) genetics and (3) mechanisms underlying Al tolerance in barley. | WANG Jun-ping RAMAN Harsh ZHANG Guo-ping MENDHAM Neville ZHOU Mei-xue | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 7 |
| 4 | Prevalence and Risk Factors of Atrial Fibrillation in Chinese Elderly: Results from the Chinese Longitudinal Healthy Longevity Survey显示文摘 | Choy-Lye Chei Prassanna Raman Chi Keong Chino Zhao-Xue Yin Xiao-Ming Shi Yi Zeng David B Matchar | 2015 | Chinese Medical Journal2015，，18： | 7 |
| 5 | Mammalian ALKBH1 serves as an N^6-mA demethylase of unpairing DNA显示文摘N^6-methyladenine(N^6-mA)of DNA is an emerging epigenetic mark in mammalian genome.Levels of N^6-mA undergo drastic fluctuation during early embryogenesis,indicative of active regulation.Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as a nuclear eraser of N^6-mA in unpairing regions(e.g.,SIDD,Stress-Induced DNA Double Helix Destabilization regions)of mammalian genomes.Enzymatic profiling studies revealed that ALKBH1 prefers bubbled or bulged DNAs as substrate,instead of single-stranded(ss-)or double-stranded(ds-)DNAs.Structural studies of ALKBH1 revealed an unexpected“stretch-out”conformation of its“Flip1”motif,a conserved element that usually bends over catalytic center to facilitate substrate base flipping in other DNA demethylases.Thus,lack of a bending“Flip1”explains the observed preference of ALKBH1 for unpairing substrates,in which the flipped N^6-mA is primed for catalysis.Co-crystal structural studies of ALKBH1 bound to a 21-mer bulged DNA explained the need of both flanking duplexes and a flipped base for recognition and catalysis.Key elements(e.g.,an ALKBH1-specificα1 helix)as well as residues contributing to structural integrity and catalytic activity were validated by structurebased mutagenesis studies.Furthermore,ssDNA-seq and DIP-seq analyses revealed significant co-occurrence of base unpairing regions with N^6-mA in mouse genome.Collectively,our biochemical,structural and genomic studies suggest that ALKBH1 is an important DNA demethylase that regulates genome N^6-mA turnover of unpairing regions associated with dynamic chromosome regulation. | Min Zhang Shumin Yang Raman Nelakanti Wentao Zhao Gaochao Liu Zheng Li Xiaohui Liu Tao Wu Andrew Xiao Haitao Li | 2020 | Cell Research2020，30，3： | 6 |
| 6 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 7 | Noni(Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats显示文摘Objective: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni(M. citrifolia) fruit juice(NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats.Methods: Lymphocytes isolated from axillary and inguinal lymph nodes of young(3–4 months) and old(18–21 months) rats were treated in vitro with different concentrations(0.0001%, 0.01%, and 1%) of NFJ for a period of 24 h. In the in vivo study, old(16–17 months) male F344 rats were treated with 5 mL/kg body weight of 5%, 10% and 20% of NFJ, twice a day, by oral gavage, and lymph node lymphocytes were isolated after 60 d. Concanavalin A(Con A)-induced lymphocyte proliferation, interleukin-2(IL-2)and interferon-γ(IFN-γ) production and expression of intracellular markers, such as phosphoextracellular signal-regulated kinase(p-ERK1/2), phospho-γ AMP response element-binding protein,phospho-protein kinase B(p-Akt), phospho-tyrosine hydroxylase(p-TH), phospho-nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor-α(p-IκB-α) and phospho-nuclear factor-κB(p-NF-κB p65 and p50) were examined in the lymphocytes of lymph nodes.Results: NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-γ production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-κB p65 and p50.Conclusion: These results suggest that the immunostimulatory properties of NFJ are facilitated through intracellular signaling pathways involving ERK1/2, Akt and NF-κB. | Uday P.Pratap Hannah P.Priyanka Karthik R.Ramanathan Vishak Raman Lalgi Hima Srinivasan Thyagarajan | 2018 | Journal of Integrative Medicine2018，16，3： | 5 |
| 8 | Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease显示文摘 | Maitreyi Raman Iftikhar Ahmed Patrick M. Gillevet Chris S. Probert Norman M. Ratcliffe Steve Smith Rosemary Greenwood Masoumeh Sikaroodi Victor Lam Pam Crotty Jennifer Bailey Robert P. Myers Kevin P. Rioux | 2013 | Clinical Gastroenterology and Hepatology2013，，7： | 5 |
| 9 | Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier显示文摘 | Jing-jing SUN Yi-chao CHEN Yi-xian HUANG Wen-chen ZHAO Yan-hua LIU Raman VENKATARAMANAN Bin-feng LU Song LI | 2017 | Acta Pharmacologica Sinica2017，38，6： | 5 |
| 10 | 基于HS光流法机器人避障策略优化显示文摘机器人的自主避障功能是其在未知环境中顺利行驶的必备功能,基于光流法的机器人避障系统是近几年研究的新热点,在光流场的计算方法中,被使用最多的是由Horn&Schunck提出的HS光流法。在传统HS光流法的基础上,提出了一种加快光流场计算的方法,并将两种算法应用到相同的避障系统中,通过比较机器人避障实验的结果可以得出,当使用改进算法计算光流场时,避障系统能更快地探测出机器人行驶前方的障碍物,提高了机器人躲避障碍物的效率。 | 曾凯 陈至坤 RAMAN Paranjape 钱俊磊 王福斌 | 2017 | 科学技术与工程2017，17，17： | 5 |
| 11 | Monteggia fracture dislocation equivalents analysis of eighteen cases treated by open reduction and internal fixation显示文摘 | Ajay Pal Singh Ish Kumar Dhammi Anil Kumar Jain Rajeev Raman Prashant Modi | 2011 | Chinese Journal of Traumatology2011，14，4： | 4 |
| 12 | 一种改进的HS光流法在机器人避障系统中的应用显示文摘机器人的自主避障功能是其在未知环境中顺利行驶的必备功能。基于光流法的机器人避障系统是近几年研究的新热点,在光流场的计算方法中,被使用最多的是由Horn&Schunck提出的HS光流法。在传统HS光流法的基础上,提出了一种加快光流场计算的方法;并将两种算法应用到相同的避障系统中。通过比较机器人避障实验的结果可以得出,当使用改进算法计算光流场时,避障系统能更快的探测出机器人行驶前方的障碍物,提高了机器人躲避障碍物的效率。 | 陈至坤 曾凯 RAMAN Paranjape 钱俊蕾 王福斌 | 2017 | 科学技术与工程2017，17，4： | 4 |
| 13 | Metamaterials for radiative sky cooling显示文摘From fundamental thermodynamic considerations,in order to convert heat to usable work,it is important to have a heat source with a temperature that is as high as possible,and to have a heat sink with a temperature that is as low as possible.The vast majority of energy conversion processes at the moment use our ambient surroundings on Earth itself,with | Shanhui Fan Aaswath Raman | 2018 | National Science Review2018，5，2： | 3 |
| 14 | Subcutaneous sarcoidosis of the upper and lower extremities: A case report and review of the literature显示文摘BACKGROUND Sarcoidosis is a granulomatous disease of unknown etiology that most often impacts the lungs.Cutaneous manifestations of sarcoidosis are seen among 9%- 37% of patients.Subcutaneous sarcoidosis is a rare presentation of cutaneous sarcoidosis with estimates of frequency ranging from 1.4%-16%.To date,very few articles and case reports have been written about this subject.In this paper,we describe a case of subcutaneous sarcoidosis and perform a review of the literature to determine if there are commonalities among patients who present with subcutaneous sarcoidosis.CASE SUMMARY A 38-year-old female,with a past medical history of arthritis and recurrent nephrolithiasis,presents with an 8-mo history of 4 firm,asymptomatic,skincolored nodules on her left and right upper extremities and neck.Needle biopsy and post-excisional pathology report both revealed well-formed,dense,noncaseating granulomas localized to the subcutaneous tissue.Chest computed tomography revealed mild mediastinal lymphadenopathy.A diagnosis of subcutaneous sarcoidosis was made,and the lesions were surgically removed.CONCLUSION Commonalities among patients presenting with subcutaneous sarcoidosis include: middle-aged female,lesions localizing to the upper or lower limbs,lymphadenopathy or pulmonary infiltration on chest imaging,elevated serum angiotensin-converting enzyme. | Raman Mehrzad Julia Festa Reena Bhatt | 2019 | World Journal of Clinical Cases2019，7，17： | 3 |
| 15 | 三轴矢量无人飞行器的创新设计与研究显示文摘为探索三轴及以上矢量动力无人飞行器的研究,基于多轴旋翼和二轴矢量飞行器的飞行原理基础,创新出一种不完全矢量动力驱动模式的三轴矢量无人飞行器。根据设计的尾部矢量动力系统,构建了机体三维模型,并实现了起降、俯仰、横滚、偏航等四种飞行姿态的平稳变换。通过对飞行器机臂连接管件的承载应力与变形分析:该部件正常工况下的最大承受应力为2.338e-1 MPa,小于使用材料的屈服应力;该部件最大形变量为3.714e-3 mm,材料变形远小于最大变形许可范围值。此外,又对飞行器PID控制策略及其稳定功能进行了可视化处理,依据图像调整飞行参数使得Strength数值保持在1.00附近且波动可控。外场飞行航测表明,三轴矢量飞行器能达到稳定飞行及摄像等预期目的。文中对三轴矢量无人飞行器的设计分析有助于矢量无人飞行器的结构创新及其工程应用研究。 | 胡瑞 许春霞 熊乐 盛敬 胡月 Roger Lewis Raman Maiti | 2020 | 机械设计与研究2020，36，5： | 3 |
| 16 | Elevation, Slope Aspect and Integrated Nutrient Management Effects on Crop Productivity and Soil Quality in North-west Himalayas, India显示文摘在农场简历资源上,再循环明确地与保存农业的介绍被给了更大的强调 withclimate 变化情形在西北 Himalaya 区域(NWHR ) 中间山。在这种变化情形,举起,斜坡方面和综合营养素下面,管理(INM ) 可以显著地影响土壤质量和庄稼生产率。研究处于一个 rainfed 条件在 NWHR 的 Ashti 分水岭在 20092010 ~ 20102011 期间被进行在土壤资源和庄稼生产率上检验举起,斜坡方面和综合滋养的管理(INM ) 的影响。二年农场示范试用显示庄稼生产率和土壤质量被举起,斜坡方面和 INM 显著地影响。结果证明改进技术的小麦等价物产量(WEY ) 与常规系统相比由 20%37% 增加了庄稼生产率。与豇豆和大豆玉米杂种由另一 8%17% 提高了产量。诺思方面和更高的举起与南方方面和低举起相比由 15%25% 增加了庄稼生产率(除了稻) 。与豇豆和大豆玉米杂种由另一 8%15% 提高了产量。不管斜坡,举起和收割系统, WEY 由于 INM 技术在这个区域增加了 30% 。举起,斜坡方面和 INM 的影响显著地影响了土壤资源(SQI ) 和土壤碳变化(SCC ) 。 SCC 显著地与 SQI 被相关为常规( R <啜class=“ a-plus-plus ”> 2 =0.65*), INM 技术( R <啜class=“ a-plus-plus ”> 2 =0.81*)并且为两种技术( R <啜class=“ a-plus-plus ”> 2 =0.73*)。它被推荐那在更高的举起。(除了稻土壤) 与面对斜坡的北方, INM 为更高的庄稼生产率被推荐;土壤资源的保存为 NWHR 的中间的山被推荐;并且 SCC 的单个价值作为为这个区域的 SQI 适当。 | Birendra Nath GHOSH Narinder Kumar SHARMA Nurnabi Meherul ALAM Raman Jeet SINGH Gopal Prasad JUYAL | 2014 | Journal of Mountain Science2014，11，5： | 3 |
| 17 | Gangrenous cholecystitis: A silent but potential fatal disease in patients with diabetic neuropathy. A case report显示文摘Gangrenous cholecystitis(GC) is a severe and potentially deadly complication of acute cholecystitis. We present a 83-year-old gentleman with a past medical history of type 2 diabetes mellitus with significant associated neuropathy, presenting to a community hospital in a major metropolitan area with 10 days nausea and vomiting and a benign abdominal exam. While the patient was admitted for hyperglycemia, he was subsequently found to have severe GC requiring urgent surgical intervention. | Melorin Mehrzad Charles C Jehle Lauren O Roussel Raman Mehrzad | 2018 | World Journal of Clinical Cases2018，6，15： | 3 |
| 18 | In vitro degradation and mechanical integrity of calcium-containing magnesium alloys in modified-simulated body fluid显示文摘 | M. Bobby Kannan R.K. Singh Raman | 2008 | Biomaterials2008，，15： | 2 |
| 19 | Influence of counterbody material on fretting wear behaviour of surface mechanical attrition treated Ti–6Al–4V显示文摘 | S. Anand Kumar S. Ganesh Sundara Raman T.S.N. Sankara Narayanan R. Gnanamoorthy | 2013 | Tribology International2013，，： | 2 |
| 20 | Recent advances in assessment of soil erosion vulnerability in a watershed显示文摘Soil erosion is one of the most critical hazards adversely affecting both environment and economy.Assessment of the annual soil erosion rate provides information on soil erosion risk zones indicating the areas with high,severe and low risks.Modelling and prediction of soil erosion has a long history of more than seven decades.It becomes imperative to be familiar with the quantum of studies conducted and methods employed across the world to assess vulnerability of ecosystems to soil erosion to plan strategies for their conservation.There are several methods based on various factors like land use,soil quality,topography etc.available to assess the susceptibility of a region to soil loss.With time the gap in understanding of such models and their use around the world has increased.Numerous models for assessing soil erosion exist but there is a lack of knowledge on spatial distribution of the methods being used.Academic papers related to assessment of soil erosion vulnerability published during the past three decades(1991—2019)were reviewed.Total 160 studies were reviewed to understand advances in the methods used to assess soil erosion vulnerability worldwide,identification of the most popular methods and proportion of studies conducted in the fragile region of Himalayas.The results show that 18 different methods have mainly been used to assess soil erosion risk in different regions.These methods include statistical,physical,process based and empirical models.The use of few physical methods like ANSWERS and SHE has decreased with time while that of physical and process methods like RUSLE,SWAT,WEPP and PESERA has increased with time.The review highlighted that various models being used worldwide are based on their suitability to the region.It also brings to attention that few models like PESERA,EUROSEM and WEPP are mostly being used concentrated in a particular region.Models like PESERA and EPM are mostly used in European region and may be encouraged to estimate soil erosion in Himalayan region.The review also highlights lack of studies with inclusion of water quality as an important parameter while assessing soil erosion vulnerability in the region.The review suggests that in case of lack of data,various statistical methods like PCA,CF,FUZZY etc can be preferred for qualitative assessment over quantitative assessment Considering availability of accurate input,researchers need to attempt more methods and perform comparative studies to attain accurate results for assessing soil erosion vulnerability leading to strategizing soil conservation in fragile regions. | Shachi Pandey Parmanand Kumar Miodrag Zlatic Raman Nautiyal Vijender Pal Panwar | 2021 | International Soil and Water Conservation Research2021，9，3： | 2 |
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