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| 1 | Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome显示文摘AIM:To compare the utility of the Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA)and Asia-Pacific Association for the Study of Liver(APASL)definitions of acute-on-chronic liver failure(ACLF)in predicting short-term prognosis of patients with ACLF.METHODS:Consecutive patients of cirrhosis with acute decompensation were prospectively included.They were grouped into ACLF and no ACLF groups as per CLIF-SOFA and APASL criteria.Patients were followed up for 3 mo from inclusion or mortality whichever was earlier.Mortality at 28-d and 90-d was compared between no ACLF and ACLF groups as per both criteria.Mortality was also compared between different grades of ACLF as per CLIF-SOFA criteria.Prognostic scores like CLIF-SOFA,Acute Physiology and ChronicHealth Evaluation(APACHE)-Ⅱ,Child-Pugh and Model for End-Stage Liver Disease(MELD)scores were evaluated for their ability to predict 28-d mortality using area under receiver operating curves(AUROC).RESULTS:Of 50 patients,38 had ACLF as per CLIFSOFA and 19 as per APASL criteria.Males(86%)were predominant,alcoholic liver disease(68%)was the most common etiology of cirrhosis,sepsis(66%)was the most common cause of acute decompensation while infection(66%)was the most common precipitant of acute decompensation.The 28-d mortality in no ACLF and ACLF groups was 8.3%and 47.4%(P=0.018)as per CLIF-SOFA and 39%and 37%(P=0.895)as per APASL criteria.The 28-d mortality in patients with no ACLF(n=12),ACLF grade 1(n=11),ACLF grade 2(n=14)and ACLF grade 3(n=13)as per CLIF-SOFA criteria was 8.3%,18.2%,42.9%and76.9%(χ2 for trend,P=0.002)and 90-d mortality was 16.7%,27.3%,78.6%and 100%(χ2 for trend,P<0.0001)respectively.Patients with prior decompensation had similar 28-d and 90-d mortality(39.3%and 53.6%)as patients without prior decompensation(36.4%and 63.6%)(P=NS).AUROCs for 28-d mortality were 0.795,0.787,0.739 and 0.710 for CLIF-SOFA,APACHE-Ⅱ,Child-Pugh and MELD scores respectively.On multivariate analysis of these scores,CLIF-SOFA was the only significant independent predictor of mortality with an odds ratio 1.538(95%CI:1.078-2.194).CONCLUSION:CLIF-SOFA criteria is better than APASL criteria to classify patients into ACLF based on their prognosis.CLIF-SOFA score is the best predictor of short-term mortality. | Radha K Dhiman Swastik Agrawal Tarana Gupta Ajay Duseja Yogesh Chawla | 2014 | World Journal of Gastroenterology2014，20，40： | 26 |
| 2 | APACHE II score is superior to SOFA , CTP and MELD in predicting the short‐term mortality in patients with acute‐on‐chronic liver failure ( ACLF )显示文摘 | Ajay Duseja Narendra S Choudhary Sachin Gupta Radha Krishan Dhiman Yogesh Chawla | 2013 | Journal of Digestive Diseases2013，，9： | 2 |
| 3 | Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy显示文摘 | Ankur Gupta Radha K Dhiman Savita Kumari Satyavati Rana Ritesh Agarwal Ajay Duseja Yogesh Chawla | 2010 | Journal of Hepatology2010，，5： | 1 |
| 4 | Molecular imprinting in sol-gel matrix显示文摘 | RADHA Gupta ASHOK Kumar | 2008 | Bioteehnol Adv2008，26，6： | 1 |
| 5 | Impact of UV-B Radiation on Thylakoid Membrane and Fatty Acid Profile of Spirulina platensis显示文摘 | Radha Gupta Pratiksha Bhadauriya Vinay Singh Chauhan | 2007 | Current Microbiology2007，56，2： | 1 |
| 6 | 显示文摘 | Radha R Gupta U N Samuel V | 2008 | Ceram Int2008，34，6： | 1 |
| 7 | Biliary changes in extrahepatic portal venous obstruction: compression by collaterals or ischemic?显示文摘 | Radha K. Dhiman Pankaj Puri Yogesh Chawla Mukut Minz Jayapalli R. Bapuraj Sanjay Gupta Birendra Nagi Sudha Suri | 1999 | Gastrointestinal Endoscopy1999，，： | 1 |
| 8 | A co- pre- cipitation technique to prepare BiNbO4 Powders 显示文摘 | Radha R Gupta U N Samuel V | 2008 | Ceramics International2008，34，6： | 1 |
| 9 | Immunogenicity and safety of two schedules of Hepatitis B vaccination during pregnancy 显示文摘 | Gupta I Radha RK | 2003 | J Obstet Gynaecol Res2003，2，29： | 1 |
| 10 | A nuclear protein tyrosine phosphatase activates p53 and induces caspase - 1 - dependent ap- optosis 显示文摘 | Gupta S Radha V Sudhakar C | 2002 | FEBS Lett2002，532，： | 1 |
| 11 | Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy显示文摘 | Ankur Gupta Radha K Dhiman Savita Kumari Satyavati Rana Ritesh Agarwal Ajay Duseja Yogesh Chawla | 2010 | Journal of Hepatology2010，，5： | 1 |
| 12 | The guanine nucleotide ex- change factor, C3G regulates differentiation and survival of human neuro- blastoma cells显示文摘 | Radha V Rajanna A Gupta R K | 2008 | J Neurochem2008，107，5： | 1 |
| 13 | A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants显示文摘 | Chalasani ML Radha V Gupta V | 2007 | Invest Ophthalmol Vis Sci2007，48，： | 1 |
| 14 | Use of the fast Fourier transform in the frequency analysis of the second heart sound in normal man显示文摘 | Ajit P. Yoganathan Ramesh Gupta William H. Corcoran Firdaus E. Udwadia Radha Sarma M.D. Richard J. Bing M.D | 1976 | Medical & Biological Engineering1976，，4： | 1 |
| 15 | Use of the fast fourier transform for frequency analysis of the first heart sound in normal man显示文摘 | Ajit P. Yoganathan Ramesh Gupta Firdaus E. Udwadia J. Wayen Miller William H. Corcoran Radha Sarma John L. Johnson Richard J. Bing | 1976 | Medical & Biological Engineering1976，，1： | 1 |
| 16 | 乔德普尔莱士RAAS度假酒店显示文摘乔德普尔菜士RAAS酒店坐落于拉贾斯坦邦围墙城市焦特布尔中心地带,它是一个位于梅兰加尔城堡基地,占地1.5亩英亩(约6.07O平方米)的独特建筑群。该大庭院保留了来自17至18世纪三个年代久远的建造物。此次改建是希望在焦特布尔旧城区建立个拥有39间客房的豪华精品酒店。全新的设计让富有历史感的旧建筑和宽阔的庭院成为Raas酒店的特色体验。 | Ambrish Arora Rajiv Majumdar Arun Kullu Radha Muralidhara Anuja Gupta Ruchi Mehta Andr J.Fanthome Rajen Nandwana 蒋涛 | 2012 | 现代装饰2012，，10： | 0 |
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