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| 1 | 抗原修复技术研究进展显示文摘自从应用抗原修复技术的文章于1991年发表后,抗原修复技术(煮沸石蜡切片于水溶液中)迅速、广泛应用于常规甲醛固定、石蜡包埋组织切片的免疫组织化学染色,从而打开了从传统形态学迈向分子形态学的大门。抗原修复技术被誉为免疫组织化学技术的革命性突破旧。Gown在评价抗原修复技术所取得的成就时,指出“在过去十多年里,抗原修复技术在诊断性免疫组织化学分析方面造成了如此深远的影响,使得这方面的文献分为2个时代:抗原修复技术前与抗原修复技术后时代。20世纪90年代初抗原修复技术的问世就是这两个阶段的分水岭”。 | 石善溶 石砚 Clive R.Taylor | 2007 | 中华病理学杂志2007，36，1： | 14 |
| 2 | 新鲜水果可能降低男性吸烟人群中食管癌的长期死亡风险:林县营养干预试验30年随访研究显示文摘[目的]探讨新鲜水果摄入是否可以降低吸烟人群食管癌的长期死亡风险。[方法]选取年龄为40~69岁8862名男性吸烟人群为研究对象,开展基线人口学特征、生活习惯、疾病史及饮食习惯的调查,随后对该人群进行随访至今约30年。以食管癌死亡病例作为研究终点。利用Log-rank检验比较不同新鲜水果摄入频率受试人群中食管癌累积死亡率间的差异。风险比(HR)和95%可信区间(CI)则通过Cox等比例风险模型进行估计,用来表示受试者死于食管癌的相对风险。[结果]截至2015年12月31日,共计发生食管癌死亡病例891例。经过30年随访后,男性吸烟人群中,不同新鲜水果摄入频率受试人群中食管癌的30年累积死亡率分别为21.91%、16.48%、14.08%、11.03%和12.09%,且随着新鲜水果摄入频次的增加,食管癌30年累积死亡率呈下降趋势。与不食用新鲜水果受试人群相比,每月吃、1~3次/周、4~6次/周和每天吃的受试者食管癌的死亡风险分别降低27%(HR=0.73,95%CI:0.61~0.87)、39%(HR=0.61,95%CI:0.50~0.75)、49%(HR=0.51,95%CI:0.35~0.73)和49%(HR=0.51,95%CI:0.35~0.75)。在调整年龄、性别、地区、体重指数、教育水平、饮酒史和家族史、干预因素后,每周摄入新鲜水果1次以上仍可以降低食管癌的死亡风险(HR=0.87,95%CI:0.76~1.00),这种保护性效应在平原地区(HR=0.78,95%CI:0.63~0.96)和无饮酒史(HR=0.82,95%CI:0.68~1.00)的受试人群中尤为明显。[结论]新鲜水果的摄入可能降低男性吸烟人群中食管癌的长期死亡风险。 | 梁赫 王少明 杨召 于佩 Philip R.Taylor Christian C.Abnet 范金虎 乔友林 | 2017 | 中国肿瘤2017，26，12： | 5 |
| 3 | The Xa7 resistance gene guards the rice susceptibility gene SWEET14 against exploitation by the bacterial blight pathogen显示文摘Many plant disease resistance(R)genes function specifically in reaction to the presence of cognate effectors from a pathogen.Xanthomonas oryzae pathovar oryzae(Xoo)uses transcription activator-like effectors(TALes)to target specific rice genes for expression,thereby promoting host susceptibility to bacterial blight.Here,we report the molecular characterization of Xa7,the cognate R gene to the TALes AvrXa7 and PthXo3,which target the rice major susceptibility gene SWEET14.Xa7 was mapped to a unique 74-kb region.Gene expression analysis of the region revealed a candidate gene that contained a putative AvrXa7 effector binding element(EBE)in its promoter and encoded a 113-amino-acid peptide of unknown function.Genome editing at the Xa7 locus rendered the plants susceptible to avrXa7-carrying Xoo strains.Both AvrXa7 and PthXo3 activated a GUS reporter gene fused with the EBE-containing Xa7 promoter in Nicotiana benthamiana.The EBE of Xa7 is a close mimic of the EBE of SWEET14 for TALe-induced disease susceptibility.Ectopic expression of Xa7 triggers cell death in N.benthamiana.Xa7 is prevalent in indica rice accessions from 3000 rice genomes.Xa7 appears to be an adaptation that protects against pathogen exploitation of SWEET14 and disease susceptibility. | Dangping Luo Jose C.Huguet-Tapia R.Taylor Raborn Frank F.White Volker P.Brendel Bing Yang | 2021 | Plant Communications2021，2，3： | 5 |
| 4 | 蔬菜与云锡矿工肺癌的队列研究显示文摘目的 为了解蔬菜与云锡 (YTC)矿工肺癌危险性的关系。方法 研究食物频率问卷(FFQ)资料中蔬菜摄入频率的重复性和有效性 ,在此基础上用 χ2 检验、单因素、多因素cox回归分析了云锡矿工肺癌高危人群不同蔬菜摄入频率、总蔬菜摄入量与其发生肺癌相对危险性的关系。结果 冬瓜、黄瓜、菠菜、芹菜、鲜辣椒、鲜黄豆、四季豆、红薯、芦笋、嫩竹笋、青玉米等 11种蔬菜摄入频率的重复性和有效性较好 (r=0 .2 0~ 0 .33,P <0 .0 5 ) ;在这 11种蔬菜中有冬瓜、黄瓜、芹菜、鲜辣椒4种蔬菜在不同摄入频率和总蔬菜不同摄入量时云锡矿工肺癌发病率差异有显著性 (χ2 =8.83~30 .6 4,P <0 .0 5 ) ;与肺癌相对危险性呈负相关 (RR <1,P <0 .0 5 ) ;经调整年龄、工龄、吸烟后 ,冬瓜、芹菜 2种蔬菜仍然显示与矿工肺癌危险性呈负相关 (P <0 .0 5 )。结论 本研究表明蔬菜尤其是芹菜和冬瓜对云锡矿工肺癌确有保护作用 ,但作用较弱。 | 吕全军 姚树祥 黄承钰 兰亚佳 仓绍义 Phillip R.Taylor 乔友林 王瑞淑 | 2000 | 中华流行病学杂志2000，21，3： | 3 |
| 5 | Improving foot care for people with diabetes mellitus – a randomized controlled trial of an integrated care approach显示文摘 | M. E.Donohoe J. A.Fletton A.Hook R.Powell I.Robinson J. W.Stead K.Sweeney R.Taylor J. E.Tooke | 2001 | Diabetic Medicine2001，，： | 2 |
| 6 | PRELIMINARY REPORT ON THE RESULTS OF NUTRITION PREVENTION TRIALS OF CANCER AND OTHER COMMON DISEASES AMONG RESIDENTS IN LINXIAN,CHINA显示文摘To examine whether vitamin / mineral supplementation may lower mortality and incidence for human cancer and mortality from other diseases as well as to provide the scientific basis and feasible approach for human cancer prevention and control,from 1982 to 1991 scientists from China and USA conducted two randomized, double-blind,placebo-controlled nutrition intervention trials in Linxian,China,where the mortality rates of esophageal and gastric cardia cancer are among the highest in the world and there is suspicion that the population’s chronic deficiencies of | 黎钧耀 李冰 William J.Blot Philip R.Taylor | 1995 | Chinese Medical Journal1995，，10： | 2 |
| 7 | Ecologic study of serum selenium and upper gastrointestinal cancers in Iran显示文摘AIM: Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations.Recent cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provinces of Iran, namely Ardabil, Mazandaran, Golestan,and Kerman. The aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium deficiency.METHODS: We measured serum selenium in 300 healthy adults from ArdabU (n = 100), Mazandaran (n = 50), Golestan (n = 100), and Kerman (n = 50), using inductively coupled plasma, with dynamic reaction cell, mass spectrometry (ICP-DRC-MS) at the US Centers for Disease Control (Atlanta,Georgia).RESULTS: The median serum selenium concentrations were very different in the four Provinces. The medians (IQR) for selenium in Ardabil, Mazandarn, Golestan, and Kerman were 82 (75-94), 123 (111-132), 155 (141-173), and 119 (110-128) μg/L, respectively (P<0.001). The results of linear regression showed that the Province variable, by itself,explained 76% of the variance in log selenium (r^2 = 0.76).The proportion of the populations with a serum selenium more than 90μg/L (the concentration at which serum selenoproteins are saturated) was 100% in Golestan,Kerman, and Mazandaran but only 29% in ArdabU.CONCLUSION: Our findings suggest nat selenium defidency is not a major contributor to the high incidence of EC seen in northeastern Iran, but it may play a role in the high incidence of GC in Ardabil Province. | Mehdi Nouarie Akram Pourshams Farin Kamangar Masood Sotoudeh Mohammad Hossein Derakhshan Mobammad Reza Akbari Hafez Fakheri Mohammad Javad Zahedi Kathleen Caldwell Christian C.Abnet Philip R.Taylor Reza Malekzadeh Sanford M.Dawsey | 2004 | World Journal of Gastroenterology2004，10，17： | 2 |
| 8 | Political Science and the Three New Institutionalisms*显示文摘 | Peter A.Hall Rosemary C. R.Taylor | 2006 | Political Studies2006，，5： | 1 |
| 9 | Political Science and the Three New Institutionalisms*显示文摘 | Peter A.Hall Rosemary C. R.Taylor | 2006 | Political Studies2006，，5： | 1 |
| 10 | Degradation of thermal-barrier coatings at very high temperatures显示文摘 | F.H.Stott D.J.Wet R.Taylor | | 0，，： | 1 |
| 11 | Political Science and the Three New Institutionalisms*显示文摘 | Peter A.Hall Rosemary C. R.Taylor | 2006 | Political Studies2006，，5： | 1 |
| 12 | A comparison of the nursing competence of graduates and diplomates from UK nursing programmes[INFORMATIO]显示文摘 | Helen P.Bartlett VanessaSimonite ElizabethWestcott Heidi R.Taylor | 2001 | Journal of Clinical Nursing2001，，3： | 1 |
| 13 | Motoneuron programmed cell death in response to proBDNF显示文摘 | Anna R.Taylor David J.Gifondorwa Mac B.Robinson Jane L.Strupe DavidPrevette James E.Johnson BarbaraHempstead Ronald W.Oppenheim Carolanne E.Milligan | 2012 | Devel Neurobio2012，，5： | 1 |
| 14 | Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China显示文摘 | Gina D.Tran Xiu‐DiSun Christian C.Abnet Jin‐HuFan Sanford M.Dawsey Zhi‐WeiDong Steven D.Mark You‐LinQiao Philip R.Taylor | 2004 | Int J Cancer2004，，3： | 1 |
| 15 | A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals显示文摘 | Michael J.Dooley Karen M.Allen Christopher J.Doecke Kirsten J.Galbraith George R.Taylor JenniferBright Dianne L.Carey | 2004 | British Journal of Clinical Pharmacology2004，，4： | 1 |
| 16 | Political Science and the Three New Institutionalisms*显示文摘 | Peter A.Hall Rosemary C. R.Taylor | 2006 | Political Studies2006，，5： | 1 |
| 17 | A framework for testing meso‐mediational relationships in Organizational Behavior显示文摘 | John E.Mathieu Scott R.Taylor | 2007 | J. Organiz. Behav2007，，2： | 1 |
| 18 | Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China显示文摘 | Gina D.Tran Xiu‐DiSun Christian C.Abnet Jin‐HuFan Sanford M.Dawsey Zhi‐WeiDong Steven D.Mark You‐LinQiao Philip R.Taylor | 2004 | Cancer2004，，3： | 1 |
| 19 | Ammonium, nitrate, and proton fluxes along the maize root显示文摘 | A. R.Taylor A. J.Bloom | 2002 | Plant Cell & Environment2002，，12： | 1 |
| 20 | 数字广告的6个核心原则显示文摘过去几年中。社交网站(例如,FACEBOOK,人人网)和其他用户生成内容网站(例如,土豆,YOUTUBE,FLICKER)纷纷建立。并且它们被运用成为一种广告媒介,这引起了大家广泛的关注。一开始由于人们知识的匮乏,不知道怎样有效地利用因特网使其成为广告媒介,在美国因特网用了好几年的时间才成为了主流广告媒体,现在很值得我们来查看一下人们在提高广告在数字媒介运用的过程中学习到了哪些东西。我通过数字广告的6点核心原则来探讨我们在数字广告中学到了什么。 | Charles R.Taylor | 2010 | 中国广告2010，，11： | 1 |
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