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| 1 | Advanced casting technologies for lightweight automotive applications显示文摘This paper provides an overview of alloy and process developments in aluminum and magnesium castings for lightweight automotive applications. Wear-resistant aluminum alloys, creep-resistant and high strength/ductility magnesium alloys have been developed for automotive applications. On the process front, vacuumassisted die casting and high vacuum die casting technologies have been developed for high-integrity body and chassis applications. Thin-wall and hollow casting components are being produced by low-pressure die casting processes for structural applications. Overcasting technology is gaining traction and has enabled mixed material designs for automotive sub-systems such as engine cradles and instrument panel beams. Simulation tools developed to predict the interfacial interactions of the dissimilar components and the structural integrity of the overcast systems are being validated in the casting trials. | Alan A.Luo Anil K.Sachdev Bob R.Powell | 2010 | China Foundry2010，7，4： | 29 |
| 2 | Improving foot care for people with diabetes mellitus – a randomized controlled trial of an integrated care approach显示文摘 | M. E.Donohoe J. A.Fletton A.Hook R.Powell I.Robinson J. W.Stead K.Sweeney R.Taylor J. E.Tooke | 2001 | Diabetic Medicine2001，，： | 2 |
| 3 | NOTUM inhibition increases endocortical bone formation and bone strength显示文摘The disability,mortality and costs caused by non-vertebral osteoporotic fractures are enormous.Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures.Cortical bone is a major determinant of non-vertebral bone strength.To identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable genes.Cortical bone thickness was substantially elevated in Notum?/?mice.NOTUM is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not osteoclasts.Three orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were developed.They increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone formation.Thus,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures. | Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu | 2019 | Bone Research2019，7，1： | 2 |
| 4 | 以现代和古老实例论大陆扩张过程中地壳深部的变质作用显示文摘 | M.Sandifor R.Powell 甘盛飞 | 1988 | 地质地球化学1988，，01： | 1 |
| 5 | The effects of strategic counting instruction,with and without deliberate practice,on number combination skill among students with mathematics difficulties显示文摘 | Lynn S Fuchs Sarah R.Powell Pamela M.Seethaler Paul T.Cirino Jack M.Fletcher Douglas Fuchs | | 0，，： | 1 |
| 6 | The pressure dependence of the zirconium‐in‐rutile thermometer显示文摘 | H. S.TOMKINS R.POWELL D. J.Ellis | 2007 | Journal of Metamorphic Geology2007，，6： | 1 |
| 7 | 东南极Bunger山的变质作用演化:元古造山事件中主变质期后伴随有限冷却的增压作用的证据显示文摘东南极的Bunger山在元古代期间经历了一次低压麻粒岩相造山事件。含石英的泥质片麻岩中,S_1叶理平行干M_1组合,石榴石-堇青石-尖晶石-铁铁矿和石榴石-矽线石-尖晶石-钛铁矿-金红石的稳定共存是M_1期间主期变质压力(大约为4Kb),温度(大约在800℃)的证据。在M_2期间,石榴石反应边的生长和围绕铁尖晶石及铁钛氧化物的堇青石是增压期间M_1组合不稳定的证据。M_2组合的热动力学计算表明,其形成压力为6~7Kb,温度为750℃左右。因此,来自Bunger山的片麻岩表明了在有限的冷却期间,大约有2Kb或更多一些的增压作用。这样的P-T轨迹不同于具有等压冷却或减压特征的其它元古代地体。未变形的大的紫苏花岗岩体在增压作用的末期,在950℃左右的温度下向上侵入。由于变质作用是因为软流圈下的热扰动,在其上厚岩石圈中较薄大陆地壳的中等地壳深度上发生的,这就能较好地解释了M1期间的低压变质作用。我们提出冷却期间的增压作用,是相邻的正常厚度地壳和Bunger山薄地壳之间体积力的作用通过热扰动″接通″而发生重力回流的结果。在这样的模式内,出露于Bunger山的紫苏花岗岩侵入作用的时间与下地壳变质最大值期间部分熔融作用一致。 | K.Stuwe R.Powell 王天武 | 1991 | 世界地质1991，10，2： | 0 |
| 8 | 变质岩平衡热力学的理论框架显示文摘变质岩石学研究定量化是近来变质地质学研究的一个重要方面,变质作用PTt轨迹研究就是这方面的突出例子。所有这些定量研究都涉及到平衡热力学的一些基本概念和理论方法。我们按照平衡热力学逻辑发展纲要,结合变质岩石学的研究现状,建立了变质岩石学中平衡热力学框架。在这一理论框架中不仅对一些重要基本概念和方法作了介绍,更侧重阐述了不均匀体系中独立组分变量和独立体系变量的特点和相互关系,以及这些变量在变质岩定量研究至关重要部分。在此基础上,简单介绍了近来发展的热力学数据库、平均温度压力计算、成因格子建立和环带矿物推算PT轨迹的基本思路和所涉及的方法,这对了解和应用这些知识有着重要意义。 | 徐国伟 梅华林 R.Powell | 1993 | 国外前寒武纪地质1993，，2： | 0 |
| 9 | Skeletal phenotypes in secreted frizzled-related protein 4 gene knockout mice mimic skeletal architectural abnormalities in subjects with Pyle's disease from SFRP4 mutations显示文摘Mutations in SFRP4 cause Pyle’s bone disease with wide metaphyses and increased skeletal fragility.The WNT signaling pathway plays important roles in determining skeletal architecture and SFRP4 is a secreted Frizzled decoy receptor that inhibits WNT signaling.Seven cohorts of male and female Sfrp4 gene knockout mice,examined through 2 years of age,had a normal lifespan but showed cortical and trabecular bone phenotypes.Mimicking human Erlenmeyer flask deformities,bone cross-sectional areas were elevated 2-fold in the distal femur and proximal tibia but only 30%in femur and tibia shafts.Reduced cortical bone thickness was observed in the vertebral body,midshaft femur and distal tibia.Elevated trabecular bone mass and numbers were observed in the vertebral body,distal femur metaphysis and proximal tibia metaphysis.Midshaft femurs retained extensive trabecular bone through 2 years of age.Vertebral bodies had increased compressive strength,but femur shafts had reduced bending strength.Trabecular,but not cortical,bone parameters in heterozygous Sfrp4mice were modestly affected.Ovariectomy resulted in similar declines in both cortical and trabecular bone mass in wild-type and Sfrp4 KO mice.SFRP4 is critical for metaphyseal bone modeling involved in determining bone width.Sfrp4 KO mice show similar skeletal architecture and bone fragility deficits observed in patients with Pyle’s disease with SFRP4 mutations. | Robert Brommage Jeff Liu David R.Powell | 2023 | Bone Research2023，11，1： | 0 |
| 10 | 金省之共性显示文摘许多太古代绿岩金矿、维特瓦特斯兰德金矿、板岩带金矿及浅成热液金矿的形成与低盐度、高温(>200℃)还原流体有关。这种含金流体出现在不同时空、岩石序列及构造背景中,是镁铁质岩和/或杂砂岩变质去挥发分作用的产物。绿泥石-钠长石-方解石-石英组合(如镁铁质岩或杂砂岩),在绿片岩-角闪岩相边界发生的变质作用(约480℃±20°,3~5kbar)产生大量低盐度H_2O-CO_2流体,其成分与许多金矿床已查明的流体相似。流体含还原硫(由黄铁矿溶解提供),具备Au呈Au-S络合分子搬运的理想条件。金的沉淀可以因温度、硫活度降低及氧活度变化实现。变质去挥发分流体模式解释了主要金省之共性(如高地热梯度、低盐度以及与变质作用大致同时),也说明了容矿岩石与构造、具体时序关系、蚀交组合以及不同矿床地质年龄之多变性。相似性是由深部过程产生,而差异性则是由沉淀位置或其附近的作用造成。 | G.N.Phillips R.Powell 胡雄伟 | 1994 | 国外花岗岩类地质与矿产1994，，2： | 0 |
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