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| 1 | 新鲜水果可能降低男性吸烟人群中食管癌的长期死亡风险:林县营养干预试验30年随访研究显示文摘[目的]探讨新鲜水果摄入是否可以降低吸烟人群食管癌的长期死亡风险。[方法]选取年龄为40~69岁8862名男性吸烟人群为研究对象,开展基线人口学特征、生活习惯、疾病史及饮食习惯的调查,随后对该人群进行随访至今约30年。以食管癌死亡病例作为研究终点。利用Log-rank检验比较不同新鲜水果摄入频率受试人群中食管癌累积死亡率间的差异。风险比(HR)和95%可信区间(CI)则通过Cox等比例风险模型进行估计,用来表示受试者死于食管癌的相对风险。[结果]截至2015年12月31日,共计发生食管癌死亡病例891例。经过30年随访后,男性吸烟人群中,不同新鲜水果摄入频率受试人群中食管癌的30年累积死亡率分别为21.91%、16.48%、14.08%、11.03%和12.09%,且随着新鲜水果摄入频次的增加,食管癌30年累积死亡率呈下降趋势。与不食用新鲜水果受试人群相比,每月吃、1~3次/周、4~6次/周和每天吃的受试者食管癌的死亡风险分别降低27%(HR=0.73,95%CI:0.61~0.87)、39%(HR=0.61,95%CI:0.50~0.75)、49%(HR=0.51,95%CI:0.35~0.73)和49%(HR=0.51,95%CI:0.35~0.75)。在调整年龄、性别、地区、体重指数、教育水平、饮酒史和家族史、干预因素后,每周摄入新鲜水果1次以上仍可以降低食管癌的死亡风险(HR=0.87,95%CI:0.76~1.00),这种保护性效应在平原地区(HR=0.78,95%CI:0.63~0.96)和无饮酒史(HR=0.82,95%CI:0.68~1.00)的受试人群中尤为明显。[结论]新鲜水果的摄入可能降低男性吸烟人群中食管癌的长期死亡风险。 | 梁赫 王少明 杨召 于佩 Philip R.Taylor Christian C.Abnet 范金虎 乔友林 | 2017 | 中国肿瘤2017，26，12： | 5 |
| 2 | Ecologic study of serum selenium and upper gastrointestinal cancers in Iran显示文摘AIM: Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations.Recent cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provinces of Iran, namely Ardabil, Mazandaran, Golestan,and Kerman. The aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium deficiency.METHODS: We measured serum selenium in 300 healthy adults from ArdabU (n = 100), Mazandaran (n = 50), Golestan (n = 100), and Kerman (n = 50), using inductively coupled plasma, with dynamic reaction cell, mass spectrometry (ICP-DRC-MS) at the US Centers for Disease Control (Atlanta,Georgia).RESULTS: The median serum selenium concentrations were very different in the four Provinces. The medians (IQR) for selenium in Ardabil, Mazandarn, Golestan, and Kerman were 82 (75-94), 123 (111-132), 155 (141-173), and 119 (110-128) μg/L, respectively (P<0.001). The results of linear regression showed that the Province variable, by itself,explained 76% of the variance in log selenium (r^2 = 0.76).The proportion of the populations with a serum selenium more than 90μg/L (the concentration at which serum selenoproteins are saturated) was 100% in Golestan,Kerman, and Mazandaran but only 29% in ArdabU.CONCLUSION: Our findings suggest nat selenium defidency is not a major contributor to the high incidence of EC seen in northeastern Iran, but it may play a role in the high incidence of GC in Ardabil Province. | Mehdi Nouarie Akram Pourshams Farin Kamangar Masood Sotoudeh Mohammad Hossein Derakhshan Mobammad Reza Akbari Hafez Fakheri Mohammad Javad Zahedi Kathleen Caldwell Christian C.Abnet Philip R.Taylor Reza Malekzadeh Sanford M.Dawsey | 2004 | World Journal of Gastroenterology2004，10，17： | 2 |
| 3 | Frequent occurrence of esophageal cancer in young people in western Kenya显示文摘 | R. K.Parker S. M.Dawsey C. C.Abnet R. E.White | 2010 | Diseases of the Esophagus2010，，2： | 1 |
| 4 | No role for human papillomavirus in esophageal squamous cell carcinoma in China显示文摘 | JillKoshiol Wen‐QiangWei Aimee R.Kreimer WenChen PattiGravitt Jian‐SongRen Christian C.Abnet Jian‐BingWang FarinKamangar Dong‐MeiLin Magnusvon Knebel‐Doeberitz YuZhang RaphaelViscidi Guo‐QingWang Maura L.Gillison Mark J.Roth Zhi‐WeiDong EstherKim Philip R | 2010 | Int. J. Cancer2010，，1： | 1 |
| 5 | No role for human papillomavirus in esophageal squamous cell carcinoma in China显示文摘 | JillKoshiol Wen‐QiangWei Aimee R.Kreimer WenChen PattiGravitt Jian‐SongRen Christian C.Abnet Jian‐BingWang FarinKamangar Dong‐MeiLin Magnusvon Knebel‐Doeberitz YuZhang RaphaelViscidi Guo‐QingWang Maura L.Gillison Mark J.Roth Zhi‐WeiDong EstherKim Philip R | 2010 | Int J Cancer2010，，1： | 1 |
| 6 | Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China显示文摘 | Gina D.Tran Xiu‐DiSun Christian C.Abnet Jin‐HuFan Sanford M.Dawsey Zhi‐WeiDong Steven D.Mark You‐LinQiao Philip R.Taylor | 2004 | Int J Cancer2004，，3： | 1 |
| 7 | No role for human papillomavirus in esophageal squamous cell carcinoma in China显示文摘 | JillKoshiol Wen‐QiangWei Aimee R.Kreimer WenChen PattiGravitt Jian‐SongRen Christian C.Abnet Jian‐BingWang FarinKamangar Dong‐MeiLin Magnusvon Knebel‐Doeberitz YuZhang RaphaelViscidi Guo‐QingWang Maura L.Gillison Mark J.Roth Zhi‐WeiDong EstherKim Philip R | 2010 | Int J Cancer2010，，1： | 1 |
| 8 | Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China显示文摘 | Gina D.Tran Xiu‐DiSun Christian C.Abnet Jin‐HuFan Sanford M.Dawsey Zhi‐WeiDong Steven D.Mark You‐LinQiao Philip R.Taylor | 2004 | Cancer2004，，3： | 1 |
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