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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Hematoma enlargement in spontaneous intracerebral hemorrhage显示文摘 | Fujii Y Tanaka R Takeuchi S | 1994 | J Neurosurg1994，80，： | 1 |
| 5 | Ante- cedents and Consequences of the Perceived Adjust ment of Japanese Expatriates in the USA 显示文摘 | TAKEUCHI R YUN S RUSSELL J E A | 2001 | Inter- national Journal of Human Resource Management2001，13，8： | 1 |
| 6 | The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0显示文摘 | Suzuki R Ohtake S Takeuchi J | | 0，，02： | 1 |
| 7 | Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid ceils显示文摘 | Okuda S Tsutsui H Shiina K Sprunck S Takeuchi H Yui R Kasahara R D HamamuraY Mizukami A S usaki D Kawano N Sakakibara T Namiki S Itoh K Otsuka K Matsuzaki M Nozaki H Kuroiwa T Nakano A Kanaoka M M Dresselhaus T Sasaki N Higashiyama T | | 0，，7236： | 1 |
| 8 | Top management team functional diversity and organizational innovation in china: the moderating effects of environment显示文摘 | QIAN C CAO Q TAKEUCHI R | 2013 | Strategic Management Journal2013，34，1： | 1 |
| 9 | The core and complementary sequence responsible for biological activity of the diapause hormone of the silkworm, Bombyxmori显示文摘 | SATIO H TAKEUCHI Y TAKEDA R | 1994 | JPeptides1994，15，7： | 1 |
| 10 | Extranodal NK/T-cell lymphoma: diagnosis and treatment cues显示文摘 | Suzuki R Takeuchi K Ohshima K | 2008 | Hematol Oncol2008，26，： | 1 |
| 11 | Fluoxetine-induced cortical adult neurogenesis显示文摘 | Ohira K Takeuchi R Shoji H | 2013 | Neuropsychopharmacology2013，38，： | 1 |
| 12 | Molecular process in acute liver iniury and regeneration induced by carbon tetrachloride显示文摘 | Taniguchi M Takeuchi T Nakatsuka R | 2004 | Life Sci2004，75，13： | 1 |
| 13 | Local recurrence of large squamous-cell carcinoma of the esophagus after endoscopic resection显示文摘 | Ishihara R Iishi H Takeuchi Y | 2008 | Gastointes Endosc2008，67，6： | 1 |
| 14 | Thermal fracture mechanisms in ceramic thermal barrier coatings 显示文摘 | Kk ini K Choules B D Takeuchi Y R | 1997 | journal of Thermal Spray Teehno logy1997，6，1： | 1 |
| 15 | Hematoma enlargement in spontaneous intracebral hemorrhage显示文摘 | Fujii Y Tanaka R Takeuchi S | 1994 | J Neurosurg1994，80，1： | 1 |
| 16 | Hematoma enlargement in spontaneous intracerebral hemorrhage 显示文摘 | Fujii Y Tanaka R Takeuchi S | 1994 | J Neurosurg1994，80，： | 1 |
| 17 | Hematom enlargement in spontaneous intracerebral hemorrhage显示文摘 | Fujii Y Tanaka R Takeuchi S | 1994 | J Neurosurg1994，80，： | 1 |
| 18 | Strong convergence theorems by hybrid methods for families of nonexpansive mappings in Hilbert space显示文摘 | Takahashi W Takeuchi Y Kubota R | 2008 | Journal of Mathematical Analysis and Applications2008，341，1： | 1 |
| 19 | Low-intensity pulsed ultra sound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study显示文摘 | Takeuchi R Ryo A Komitsu N | 2008 | Arthritis Res Ther2008，10，4： | 1 |
| 20 | A1- and N-polar A1N layers grown on c-plane sapphire substrates by modified flow-modulation MOCVD 显示文摘 | TAKEUCHI M SHIMIZU H KAJITANI R | 2007 | J Cryst Growth2007，305，2： | 1 |
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