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| 1 | A Robust CRISPR/Cas9 System for Convenient, High-Efficiency Multiplex Genome Editing in Monocot and Dicot Plants显示文摘CRISPR/Cas9 染色体指向系统被用于许多种类。然而,为植物报导的 mostCRISPR/Cas9 系统能仅仅修改一个或一些指向地点。这里,我们报导一个柔韧的 CRISPR/Cas9 向量系统,利用植物 codon 优化了 Cas9 基因,为方便、高效率的复合染色体在 monocot 和 dicot 植物编辑。我们设计了基于 PCR 的过程很快产生多重 sgRNA 表达式盒子,它能在一个轮由金门结扎或吉布森汇编克隆被装配进二进制 CRISPR/Cas9 向量。与这个系统,我们与 85.4% 变化评估的一般水准在米饭编辑了 46 个目标地点,主要在 biallelic 和同型结合的地位。我们推想在米饭的大约 16% 同型结合的变化通过相应基于再结合的修理跟随的非相应的加入结束的机制被产生。我们也获得了一致 biallelic,在 Arabidopsis T 1 植物的异质接合、同型结合、妄想的变化。在米饭和 Arabidopsis 的指向的变化是可继承的。我们在 T 0 米饭和 T 1 由同时的指向的 Arabidopsis 植物多重(多达八) 一个基因家庭,在一条 biosynthetic 小径的多重基因,或在单个基因的多重地点的成员。这个系统为为基本研究和基因改进在植物学习多重基因和基因家庭的功能提供了一个万用的工具箱。 | Xingliang Ma Qunyu Zhang Qinlong Zhu Wei Liu Yan Chen Rong Qiu Bin Wang Zhongfang Yang Heying Li Yuru Lin Yongyao Xie Rongxin Shen Shuifu Chen Zhi Wang Yuanling Chen Jingxin Guo Letian Chen Xiucai Zhao Zhicheng Dong Yao-Guang Liu | 2015 | Molecular Plant2015，8，8： | 272 |
| 2 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 3 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 4 | A General Description for Chinese Medicine in Treating Premature Ovarian Failure显示文摘Premature ovarian failure(POF) is a kind of gynecological disease that causes amenorrhea, infertility, menopause and urogenital symptoms. Currently hormone replacement therapy(HRT) is the most popular choice for women with POF to get rid of menopausal syndrome. However, as the popularization of Chinese herbs made Chinese medicine(CM) shine new lights, physicians are able to treat POF with both meno-herbs and integrated therapy. HRT has its own indications and contraindications. For example, unexplained vaginal bleeding, acute liver damage, liver dysfunction, vascular embolization, and breast cancer are all contraindications of HRT, and CM is taken by more physicians as an adjuvant therapy. This review, including a range of common Chinese herbs and formulations according to the existing literature, provides a general description of CM treating POF from the aspects of mechanisms and clinical application. It also highlights acupuncture as a unique physiotherapy for POF. Although the validity of CM has been supported by the evidence of many preclinical trials, clinical trials and meta-analysis, the adverse events with CM therapy still exist and no guarantee has been made for its safety. This review concludes the updated information for CM treating POF contributing to further studies. | LIN Jing LI Xue-lian SONG Hui LI Qian WANG Ming-yan QIU Xue-min LI Da-jin WANG Ling | 2017 | Chinese Journal of Integrative Medicine2017，23，2： | 37 |
| 5 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 6 | The control of syndepositional faulting on the Eogene sedimentary basin fills of the Dongying and Zhanhua sags, Bohai Bay Basin显示文摘The Dongying and Zhanhua sags are the major hydrocarbon exploration and produc- tion subbasins in the Bohai Bay Basin. Integrated analysis of the sedimentary basin fills has shown that the syndepositional faults and their arrangement styles exerted an important influ- ence on the development and distribution of the Eogene depositional systems. The sedimentary filling evolution of the subbasins reflects the general control of the episodic rifting process. The major long-term active normal faults formed a series of paleogeomorphic accident or slopebreak zones that commonly delineated the subsidiary palaeostructural units and the depositional facies tracts and constrained the general distribution of sedimentary facies zones. The central sag boundary fault slopebreak zones usually determined the distribution of the depocenters of ter- restrial clastic depositional systems, particularly the lowstand fans or deltaic depositional sys- tems, and have proven to be the economically important targets for the exploration of subtle sandstone reservoirs. A variety of syndepositional fault arrangement patterns, including the par- allel, en echelon, combo-like, broom-like fault systems and the fault overlap or transfer zones, have been recognized in the subbasins. They generated distinctive geomorphic features and exerted a direct influence on sediment dispersal and sandbody distribution during the Eogene synrift stage. It is the key for the prediction of depositional systems tracts and reservoir sand- stones to investigate the activity and distribution of the fault slopebreak zones and reconstruct the structural paleogeomorphy in different basin filling stages of the basin evolution. | LIN Changsong1, ZHENG Herong2, REN Jianye1, LIU Jingyan1 & Qiu Yigang1 1. Department of Energy Geology, China University of Geosciences, Beijing 100083, China 2. Petroleum Exploration and Production Institute, Sino-Petroleum and Chemistry Cooperation, Beijing 100083, China | 2004 | Science China Earth Sciences2004，47，9： | 33 |
| 7 | Generation of neural progenitor cells by chemical cocktails and hypoxia显示文摘神经祖先房间(NPC ) 能被定义因素从体的房间导致。这里,我们报导 NPC 能从老鼠被产生由化学鸡尾酒的胚胎的成纤维细胞,也就是 VCR (V, VPA, HDAC 的一个禁止者;C, CHIR99021, GSK-3 kinases 和 R 的一个禁止者, Repsox, TGF-β 的一个禁止者;小径) ,在一个生理的 hypoxic 条件下面。这些导致化学药品的 NPC (ciNPCs ) 类似于鼠标关于他们为在 vitro 并且在 vivo 的不同 neuroectodermal 系的 proliferative 和自我更新的能力,基因表达式侧面,和 multipotency 的导出大脑的 NPC。进一步的实验揭示那种选择有 histone deacetylation,肝糖 synthase kinase,和 TGF-β 的禁止者的鸡尾酒;小径为 ciNPC 正式就职显示出类似的功效。而且, ciNPCs 能也与一样的化学鸡尾酒 VCR 从老鼠尾巴尖端成纤维细胞和人的尿房间被导致。因此,我们的学习证明没有介绍外长的因素,到 NPC 的体的房间的那系特定的变换能被化学鸡尾酒完成。 | Lin Cheng Wenxlang Hu Binlong Qiu Jian Zhao Yongchun Yu Wuqiang Guan Min Wang Wuzhou Yang Gang Pei | 2014 | Cell Research2014，24，6： | 32 |
| 8 | The role of magmatism in the thinning and breakup of the South China Sea continental margin显示文摘INTRODUCTION Magmatism plays a key role in the process of continental margin breakup and ocean formation.Even in the extremely magma-poor Iberia and Newfoundland margin,studies of field outcrops have shown that syn-rift magmatism had participated in rifting from a very early stage and contributed directly to the rifting process.The final transition from exhumed continental mantle to the ocean formation is also triggered by the accumulation and eruption of magma[1]. | Zhen Sun Jian Lin Ning Qiu Zhimin Jian PinXian Wang Xiong Pang Jinyun Zheng Benduo Zhu | 2019 | National Science Review2019，6，5： | 34 |
| 9 | Controlling N-doping type in carbon to boost single-atom site Cu catalyzed transfer hydrogenation of quinoline显示文摘Single-atom site(SA)catalysts on N-doped carbon(CN)materials exhibit prominent performance for their active sites being M-Nx.Due to the commonly random doping behaviors of N species in these CN,it is a tough issue to finely regulate their doping types and clarify their effect on the catalytic property of such catalysts.Herein,we report that the N-doping type in CN can be dominated as pyrrolic-N and pyridinic-N respectively through compounding with different metal oxides.It is found that the proportion of distinct doped N species in CN depends on the acidity and basicity of compounded metal oxide host.Owing to the coordination by pyrrolic-N,the SA Cu catalyst displays an enhanced activity(two-fold)for transfer hydrogenation of quinoline to access the valuable molecule tetrahydroquinoline with a good selectivity(99%)under mild conditions.The higher electron density of SA Cu species induced by the predominate pyrrolic-N coordination benefits the hydrogen transfer process and reduces the energy barrier of the hydrogenation pathway,which accounts for the improved catalytic effeciency. | Jian Zhang Caiyan Zheng Maolin Zhang Yajun Qiu Qi Xu Weng-Chon Cheong Wenxing Chen Lirong Zheng Lin Gu Zhengpeng Hu Dingsheng Wang Yadong Li | 2020 | Nano Research2020，13，11： | 29 |
| 10 | Randomized comparison of intracoronary tirofiban versus urokinase as an adjunct to primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: results of the ICTUS-AMI trial显示文摘 | ZHU Tian-qi ZHANG Qi DING Feng-hua QIU Jian-ping JIN Hui-geng JIANG Li LU Lin ZHANG Rui-yan HU Jian YANG Zhen-kun SHEN Ying SHEN Wei-feng | 2013 | Chinese Medical Journal2013，，16： | 27 |
| 11 | The General Design and Technology Innovations of CAP1400显示文摘行波堆为一次通过式燃料循环反应堆,其利用堆芯自增殖大大降低了对浓缩和后处理的需求。自增殖将次临界换料燃料转化为新的临界燃料,从而使增殖燃烧波得以扩散。该理念建立在增殖燃烧波和燃料的相对移动的基础上。因此,燃料或增殖燃烧波相对于固定的观察器而言是移动的。行波堆最实用的体现就是能够在将核反应保持在同一位置的同时移动燃料——有时行波堆也被称为'驻波堆'。行波堆能够使用换料铀燃料运行,换料铀燃料包括完全贫化铀、天然铀和低浓缩铀燃料(即235U含量为5.5%或更低的燃料),这些燃料通常在快谱中达不到临界状态。轻水反应堆卸出的乏燃料也可以作为行波堆的换料燃料。上述情况均无需后处理即可实现极高的燃料利用率和燃料废物量的显著降低。当换料燃料为贫化铀时,行波堆的最大优势得以实现,即在启动后,无需浓缩设施,就可维持最先启动的反应堆和一连串后续的反应堆的运行。自2006年起,泰拉能源公司(Terra Power)与50多个机构高度协作,开展了概念设计、工程设计和相关技术开发活动,力争到2026年实现将第一个机组投入使用。本文总结了行波堆技术,包括它的发展计划及其进展,分析了行波堆的社会和经济效益。 | Mingguang Zheng Jinquan Yan Jun Shenttu Lin Tian Xujia Wang Zhongming Qiu | 2016 | Engineering2016，2，1： | 27 |
| 12 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 13 | Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy显示文摘AIM To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota(GM),and how ketogenic diet(KD) alters GM.METHODS A total of 14 epileptic and 30 healthy infants were recruited and seizure frequencies were recorded. Stool samples were collected for 16 S r DNA sequencing using the Illumina Miseq platform. The composition of GM in each sample was analyzed with MOTHUR,and intergroup comparison was conducted by R software.RESULTS After being on KD treatment for a week,64% of epileptic infants showed an obvious improvement,with a 50% decrease in seizure frequency. GM structure in epileptic infants(P1 group) differed dramatically from that in healthy infants(Health group). Proteobacteria,which had accumulated significantly in the P1 group,decreased dramatically after KD treatment(P2 group). Cronobacter predominated in the P1 group and remained at a low level both in the Health and P2 groups. Bacteroides increased significantly in the P2 group,in which Prevotella and Bifidobacterium also grew in numbers and kept increasing.CONCLUSION GM pattern in healthy infants differed dramatically from that of the epileptic group. KD could significantly modify symptoms of epilepsy and reshape the GM of epileptic infants. | Gan Xie Qian Zhou Chuang-Zhao Qiu Wen-Kui Dai He-Ping Wang Yin-Hu Li Jian-Xiang Liao Xin-Guo Lu Su-Fang Lin Jing-Hua Ye Zhuo-Ya Ma Wen-Jian Wang | 2017 | World Journal of Gastroenterology2017，23，33： | 25 |
| 14 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 15 | HYDRAULICS OF COMPOUND CHANNEL WITH VEGETATED FLOODPLAINS显示文摘Experimental researches were conducted on flood carrying capacity of compound open channels with wide and narrow floodplains as well as hydrodynamic behavior of overbank flow across vegetated floodplains. Results show that hydrodynamic behavior of compound channels with narrow floodplains is different from that of the wide floodplains. In such compound channels with narrow vegetated floodplains as in the Pearl River delta nework, it has been found that vegetated domains become really impenetra ble when the length of vegetated domain is larger than Lm, the length of f low in floodplain coming into the main channel, and that the influence of vegeta ted floodplains upon flood stages of a channel is not very significant. | Huang Ben-sheng, Lai Guan-wen, Qiu Jing, Lin Shu-zhong (Guangdong Research Institute of Water Conservancy & Hydro-Power, Guangzhou 510610, China | 2002 | Journal of Hydrodynamics2002，14，1： | 21 |
| 16 | A broadband achromatic metalens array for integral imaging in the visible显示文摘Integral imaging is a promising three-dimensional(3D)imaging technique that captures and reconstructs light field information.Microlens arrays are usually used for the reconstruction process to display 3D scenes to the viewer.However,the inherent chromatic aberration of the microlens array reduces the viewing quality,and thus,broadband achromatic imaging remains a challenge for integral imaging.Here,we realize a silicon nitride metalens array in the visible region that can be used to reconstruct 3D optical scenes in the achromatic integral imaging for white light.The metalens array contains 60×60 polarization-insensitive metalenses with nearly diffraction-limited focusing.The nanoposts in each high-efficiency(measured as 47%on average)metalens are delicately designed with zero effective material dispersion and an effective achromatic refractive index distribution from 430 to 780 nm.In addition,such an achromatic metalens array is composed of only a single silicon nitride layer with an ultrathin thickness of 400 nm,making the array suitable for on-chip hybrid-CMOS integration and the parallel manipulation of optoelectronic information.We expect these findings to provide possibilities for full-color and aberration-free integral imaging,and we envision that the proposed approach may be potentially applicable in the fields of high-power microlithography,high-precision wavefront sensors,virtual/augmented reality and 3D imaging. | Zhi-Bin Fan Hao-Yang Qiu Han-Le Zhang Xiao-Ning Pang Li-Dan Zhou Lin Liu Hui Ren Qiong-Hua Wang Jian-Wen Dong | 2019 | Light(Science & Applications)2019，8，1： | 21 |
| 17 | Loss of heterozygosity on long arm of chromosome 22 in sporadic colorectal carcinoma显示文摘AIM: The loss of heterozygosity (LOH) on tumorsuppressor genes is believed to play a key role incarcinogenesis of colorectal cancer, In this study, weanalyzed the LOH at 5 loci on the long arm ofchromosome 22 in sporadic colorectal cancer to identifyadditional loci involved in colorectal tumorigenesis.METHODS: Five polymorphic microsatellite markerswere analyzed in 83 cases of colorectal and normal DNAby PCR. PCR products were eletrophoresed on an ABI377 DNA sequencer; Genescan 3.1 and Genotype 2.1software were used for LOH scanning and analysisComparison between LOH frequency andclinicopathological data were performed by x2 test. P<0.05 was considered as statistically significant.RESULTS: The average LOH frequency on chromosome22q was 28.38 %. The region between markersD22S280 and D22S274 (22q12.2-q13.33) exhibitedrelatively high LOH frequency. The two highest LOH lociwith frequencies of 35.09 % and 34.04 % wasidentified on D22S280 (22q12.2-12.3) and D22S274(22q13.32-13.33). 8 cases showed LOH at allinformative loci, suggesting that one chromosome 22qhad been completely lost. On D22S274 locus, LOHfrequency of rectal cancer was 50 % (9/18), which washigher than that of proximal colon cancer (12 %, 2/17) (P=0.018). The frequency of distal colon cancer was42 % (5/12), also higher than that of proximal coloncancer. But there was no statistical significance. Puttingboth the tumors in distal colon and rectum togetherinto consideration, the frequency, 47 % (14/30), washigher than that of proximal colon cancer (P=0.015),suggesting the mechanism of carcinogenisis wasdifferent in both groups.CONCLUSIONS: This study provided evidence for theinvolvement of putative tumor suppressor genes relatedto the sporadic colorectal carcinoma on chromosome22q. The tumor-suppressor-gene(s) might locate on the22q12.2-12.3 and/or 22q13.32-13.33. | Chong-Zhi Zhou Zhi-Hai Peng Fang Zhang Guo-Qiang Qiu Department of General Surgery,Shanghai First People Hospital,Shanghai 200080,China Lin He Shanghai Institutes for Biological Science,Chinese Academy of Science,Shanghai 200031,China | 2002 | World Journal of Gastroenterology2002，8，4： | 21 |
| 18 | Functional Variant in microRNA-196a2 Contributes to the Susceptibility of Congenital Heart Disease in a Chinese Population显示文摘 | XU , J. Hu, Z.B. Xu, Z.F. Gu, H.Y Yi, L. Cao, H. L. Chen, J. P. Tian, T. Liang, J. Lin, Y. Qiu, W. S. Ma, H.X. Shen, H. B Chen, Y. J. | 2009 | 南京医科大学学报(自然科学版)2009，29，11： | 20 |
| 19 | Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern显示文摘Dear Editor,As of October,2021,SARS-CoV-2 has infected more than 230 million people;promoting roll-out vaccinations could help build herd immunity for the pandemic.However,the waning of antibody in magnitude and decreased protective efficacy in multiple types of vaccines have been reported. | Jingwen Ai Haocheng Zhang Qiran Zhang Yi Zhang Ke Lin Zhangfan Fu Jieyu Song Yuanhan Zhao Mingxiang Fan Hongyu Wang Chao Qiu Yang Zhou Wenhong Zhang | 2022 | Cell Research2022，32，1： | 19 |
| 20 | Dynamic and Static Recrystallization Behavior of Low Carbon High Niobium Microalloyed Steel显示文摘The recrystallization behavior of a low carbon high niobium microalloyed steel was investigated using continuous and interrupted hot compression tests.The results showed that the initiation of dynamic recrystallization(DRX)could be detected from inflection in the plot of the strain hardening rate against stress regardless of the stress peak appearance.According to the Zener-Hollomon parameter equation,the activity energy of DRX(Qdef)was obtained and a new modified expression calculating Qdef was proposed in consideration of the chemical composition of experimental steel.Applying the 2% offset method,the static softening fraction was determined.The graphic representation of the softening fraction vs interruption time gave the information about the non-static recrystallization temperature(about 1000 ℃)and the relationship of precipitation-time-temperature.Static recrystallization kinetics followed the Avrami's law at high deformation temperature,and different values of the exponent m were given to illustrate the effect of niobium element on static recrystallization at different deformation temperatures. | LAN Liang yun QIU Chun lin ZHAO De-wen GAO Xiu hua DU Lin-xiu | 2011 | Journal of Iron and Steel Research(International)2011，18，1： | 16 |
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