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| 1 | A Robust CRISPR/Cas9 System for Convenient, High-Efficiency Multiplex Genome Editing in Monocot and Dicot Plants显示文摘CRISPR/Cas9 染色体指向系统被用于许多种类。然而,为植物报导的 mostCRISPR/Cas9 系统能仅仅修改一个或一些指向地点。这里,我们报导一个柔韧的 CRISPR/Cas9 向量系统,利用植物 codon 优化了 Cas9 基因,为方便、高效率的复合染色体在 monocot 和 dicot 植物编辑。我们设计了基于 PCR 的过程很快产生多重 sgRNA 表达式盒子,它能在一个轮由金门结扎或吉布森汇编克隆被装配进二进制 CRISPR/Cas9 向量。与这个系统,我们与 85.4% 变化评估的一般水准在米饭编辑了 46 个目标地点,主要在 biallelic 和同型结合的地位。我们推想在米饭的大约 16% 同型结合的变化通过相应基于再结合的修理跟随的非相应的加入结束的机制被产生。我们也获得了一致 biallelic,在 Arabidopsis T 1 植物的异质接合、同型结合、妄想的变化。在米饭和 Arabidopsis 的指向的变化是可继承的。我们在 T 0 米饭和 T 1 由同时的指向的 Arabidopsis 植物多重(多达八) 一个基因家庭,在一条 biosynthetic 小径的多重基因,或在单个基因的多重地点的成员。这个系统为为基本研究和基因改进在植物学习多重基因和基因家庭的功能提供了一个万用的工具箱。 | Xingliang Ma Qunyu Zhang Qinlong Zhu Wei Liu Yan Chen Rong Qiu Bin Wang Zhongfang Yang Heying Li Yuru Lin Yongyao Xie Rongxin Shen Shuifu Chen Zhi Wang Yuanling Chen Jingxin Guo Letian Chen Xiucai Zhao Zhicheng Dong Yao-Guang Liu | 2015 | Molecular Plant2015，8，8： | 272 |
| 2 | Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase显示文摘背景 Berberine 是 Coptidis 根茎(CR ) 和外皮 phellodendri 的主要成分之一,在这研究,我们与糖尿病的 nephropathy (DN ) 在老鼠在肾的功能和它的可能的机制上调查了 berberine 的有益的效果。方法男 Wistar 老鼠被划分成三个组:正常,糖尿病的模型,和 berberine 处理组。在糖尿病的模型和 berberine 治疗组的老鼠被 intraperitonal 注射与 streptozotocin (STZ ) 导致到糖尿病。Glomerular 区域, glomerular 体积, fasting 血葡萄糖(FBG ) ,血脲氮(甜面包) ,浆液 creatinine (Cr ) 和为 24 个小时(UP24h ) 的尿蛋白质用商业地可得到的工具包被测量。同时, superoxide dismutase (草皮) 的活动,在浆液的 malondialdehyde (MDA ) 的内容, aldose reductase (AR ) 的活动和在肾的 AR mRNA 和蛋白质的表示被不同方法检测。结果显示出的结果 berberine 的那个口头的政府(200mg 牲汥瑡摥 ? ぐ?? | LIU Wei-hua HEI Zi-qing NIE Hong TANG Fu-tian HUANG He-qing LI Xue-juan DENG Yan-hui CHEN Shao-rui GUO Fen-fen HUANG Wen-ge CHEN Feng-ying LIU Pei-qing | 2008 | Chinese Medical Journal2008，，8： | 41 |
| 3 | Development of "Purple Endosperm Rice" by Engineering Anthocyanin Biosynthesis in the Endosperm with a High-Efficiency Transgene Stacking System显示文摘Anthocyanins 在主食庄稼的 anthocyanin 生合成的高抗氧化剂活动,和工程例如米饭(Oryza sativa L.) ,能为改进人的健康提供支持健康的食物。然而,为 biofortification 设计新陈代谢的小径仍然保持困难,并且因为它的 biosynthetic 小径的复杂基因规章的网络,在米饭内乳设计 anthocyanin 生产的以前的尝试失败了。在这研究,我们为叠的 transgene 开发了一个高效率的向量系统并且使用了它在米饭内乳设计 anthocyanin 生合成。我们做了包含内乳特定的倡导者驾驶的八 anthocyanin 相关的基因(从从薄荷科植物的玉米和六结构的基因 ?的二规章的基因) 的构造,加为标记切除的一个可选的标记和基因。有这构造的米饭的转变产生了新奇 biofortified germplasm 紫色内乳瑞斯(用汉语的叫的 Zijingmi ) ,它在内乳有高 anthocyanin 内容和抗氧化剂活动。这 anthocyanin 生产源于 transgenes 和产生激活的表示(或改进) 13 内长的 anthocyanin 生合成基因的表示,那是 silenced 或在野类型的米饭内乳在底层表示。这研究为叠的 transgene 提供一个有效、万用的工具箱并且为一条复杂生物小径的成功的工程表明它的使用,建议为在工厂的农学的特点的合成生物学和改进的这个工具箱的潜在的用途。 | Qinlong Zhu Suize Yu Dongchang Zeng Hongmei Liu Huicong Wang Zhongtang Yang Xianrong Xie Rongxin Shen Jiantao Tan Heying Li Xiucai Zhao Qunyu Zhang Yuanling Chen Jingxing Guo Letian Chen Yao-Guang Liu | 2017 | Molecular Plant2017，10，7： | 47 |
| 4 | From Golden Rice to aSTARice:Bioengineering Astaxanthin Biosynthesis in Rice Endosperm显示文摘Carotenoids are important phytonutrients with antioxidant properties,and are widely used in foods and feedstuffs as Supplements.Astaxanthin,a red-colored ketocarotenoid,has strong antioxidant activity and thus can benefit human health.However,astaxanthin is not produced in most higher plants.Here we report the bioengineering of astaxanthin biosynthesis in rice endosperm by introducing four synthetic genes,sZmPSY1,sPaCrtl,sCrBKT,and sHpBHY,which encode the enzymes phytoene synthase,phytoene desaturase,β-carotene ketolase,and β-carotene hydroxylase,respectively.Transgneic overexpression of two (sZmPSY1 and sPaCrtl),three (sZmPSY1,sPaCrtl and sCrBKT),and all these four genes driven by rice endosperm-specific promoters established the Carotenoid/ketocarotenoid/astaxanthin biosynthetic pathways in the endosperm and thus resulted in various types of germplasm,from the yellow-grained β-caro- tene-enriched Golden Rice to orange-red-grained Canthaxanthin Rice and Astaxanthin Rice,respectively. Grains Of Astaxanthin Rice were enriched with astaxanthin in the endosperm and had higher antioxidant activity.These results proved that introduction of a minimal set of four transgenes enables de novo biosynthesis of astaxanthin in therice endosperm.This work provides a Successful example for synthetic biology in plants and biofortification in crops;the biofortified rice products generated by this study could be consumed as health-promoting foods and processed tO produce dietary supplements. | Qinlong Zhu Dongchang Zeng Suize Yu Chaojun Cui Jiamin Li Heying Li Junyu Chen Runzhao Zhang Xiucai Zhao Letian Chen Yao-Guang Liu | 2018 | Molecular Plant2018，11，12： | 35 |
| 5 | Prognostic values of serum cystatin C and β2 microglobulin, urinary β2 microglobulin and N-acetyl-β-D-glucosaminidase in early acute renal failure after liver transplantation显示文摘在肝移植以后的背景尖锐肾的失败(ARF ) 与高死亡和病态被联系。早治疗学或预防的干预被早有效的预示的因素的缺乏妨碍。最近的研究显示那浆液 cystatin 铺平 C 和 2-microglobulin (132 MG ) 象一样尿 2 MG 和 N 乙酰 --D- glucosaminidase (唠叨) 将与早、温和的肾的缺陷在病人增加。在这研究,这些因素在接受了 orthotopic 肝移植( OLT )的病人在不同阶段期间被检测,并且他们在 OLT 以后预言早 ARF 的可行性也是 analyzed.Methods 没有,接待了的有正常的血脲氮(甜面包)和浆液 creatinine ( SCr )的六十个病人修改了骑在背肩上的肝移植veno静脉绕过有希望地被学习。血样品为浆液 2 MG (n=60 ) 的决心从病人被拉, SCr (n=60 ) 和在跟随 5 间隔的浆液 Cystatin C (n=39 ) :在操作前(到) ,在 anhepatic 阶段(T1 ) 前的 20 分钟,在 anhepatic (T2 ) 的 25 分钟,在 repeffusion (T3 ) 以后并且在操作(T4 ) 的结束的 60 分钟。尿 2 MG (n=-60 ) 并且唠叨(n=60 ) 也在跟随 3 间隔被检验:在操作前(到) ,在灌注(T3 ) 以后并且在操作(T4 ) 的结束的 60 分钟。根据 Rimola 在在操作以后的 24 个小时的 ARF 的 A 标准,所有病人被划分成二个组:ARF 组和 non-ARF 组。数据统计上被分析评估在六十个盒子中的十个显示出的 operation.Results 前与正常 SCr 和甜面包在病人在肝移植以后为早 ARF 认为这些因素是预示的因素的 feasibiliy ARF (16.7%) 。逻辑回归分析证明浆液的层次并且尿在操作前的 2 MG 以及浆液 cystatin C 在肝移植以后与早 ARF 被相关( P < 0.05 ),当仅仅浆液 cystatin 铺平时,在操作的结束的 C 和 Cr 与早 ARF 相关( P < 0.05 , P < 0.01 )在肝移植以后。浆液 2 MG, Cystatin C, SCr 并且尿在 ARF 组的 2 个 MG 层次在 non-ARF 组比那更多高(P < 0.05, P < 0.01 ) 。浆液 cystatin C 的正确、假的预兆的积极比率之间有重要差别,浆液并且尿在操作前的 2 个 MG 层次( P < 0.05 , P < 0.01 ),当仅仅 SCr 在手术的结束显示出这些组之间的重要差别时( P < 0.01 )结果揭示了的 .Conclusions 在在手术,和那肝移植前表明了正常 SCr 和甜面包的那些病人之中有潜在的肾的损坏,这能加重这损坏并且引起 ARF 。这里,我们提供了浆液 Cystatin C 的预示的价值, 2 MG,尿 2 MG 并且在肝移植以后与早尖锐的肾的失败在病人唠叨。 | HEI Zi-qing LI Xiao-yun SHEN Ning PANG Hong-yu ZHOU Shao-li GUAN Jian-qiang | 2008 | Chinese Medical Journal2008，，14： | 26 |
| 6 | A Novel Rice bHLH Transcription Factor, DTD, Acts Coordinately with TDR in Controlling Tapetum Function and Pollen Development显示文摘Dear Editor, Male reproductive development is an essential biological process for flowering plants and crucial for crop seed production.Formation of the male reproductive organ,the anther,involves a number of developmental events,including stamen meristem specification,generation of sporogenous cells and their differentiation into microspore mother cells (MMCs),meiosis,microspore (pollen) maturation,and pollination (Ma,2005).The formation of microspores and their development into mature pollen grains require cooperative interactions between gametophytic (microspores) and sporophytic (anther wall) cells,with the innermost cell layer,the tapetum,playing the most crucial role (Ma,2005).Tapetal cells undergo degeneration by programmed cell death (PCD). | Chonghui Ji Heying Li Libin Chen Min Xie Fengping Wang Yuanling Chen Yao-Guang Liu | 2013 | Molecular Plant2013，6，5： | 14 |
| 7 | Effect of Astragalus membranaceus injection on the activity of the intestinal mucosal mast cells after hemorrhagic shock-reperfusion in rats显示文摘Background The mechanism of mucosal damage induced by ischemia-reperfusion (IR) after hemorrhagic shock is complex; mast cells (MC) degranulation is associated with the mucosal damage. Astragalus membranaceus can protect intestinal mucosa against intestinal oxidative damage after hemorrhagic shock, and some antioxidant agents could prevent MC against degranulation. This study aimed to observe the effects of astragalus membranaceus injection on the activity of intestinal mucosal mast cells (IMMC) after hemorrhage shock-reperfusion in rats Methods Thirty-two Wistar rats were randomly divided into the normal group, model group, low dosage group, (treated with Astragalus membranacaus injection, 10 g crude medication/kg) and high dosage group (treated with Astragalus membranacaus injection, 20 g crude medication/kg). The rat model of hemorrhagic shock-reperfusion was induced by hemorrhage for 60 minutes followed by 90 minutes of reperfusion. The animals were administrated with 3 ml of the test drug solution before reperfusion. At the end of study, intestinal pathology, ultrastructure of IMMC, and expression of tryptase were assayed. The levels of malondisldehyde (MDA), TNF-α, histamine, and superoxide dismutase (SOD) activity in intestine were detected, and the number of IMMC was counted. Results The Chiu’s score of the rats in the model group was higher than in other groups (P<0.01). The Chiu’s score in the high dosage group was higher than that in the low dosage group (P<0.05). Hemorrhage-reperfusion induced IMMC degranulation: Astragalus membranaceus injection attenuated this degranulation. Expression of tryptase and the number of IMMC in the model group increased compared with the other groups (P<0.01) and was significantly reduced by the treatments of Astragalus membranaceus injection at both doses. There was no significant difference between the two treatment groups (P>0.05). MDA content and concentration of TNF-α in the model group were higher than that in the other three groups (P<0.05), and the concentration of TNF-α in the low dosage group was higher than that in the high dosage group (P<0.05). SOD activity and the concentration of histamine in the model group were lower than the other three groups (P<0.05). There was a negative correlation betweenthe Chiu’s score and the concentration of histamine and a positive correlation between the Chiu’s score and the concentration of TNF-α and between the SOD activity and the concentration of histamine in the four groups (P<0.05). Conclusion Astragalus membranaceus injection may reduce the damage to small intestine mucosa by inhibiting the activated IMMC after hemorrhagic shock. | GAN Xiao-liang HEI Zi-qing Huang He-qing CHEN Li-xin LI Shang-rong CAI Jun | 2006 | Chinese Medical Journal2006，，22： | 13 |
| 8 | Kai Xin San ameliorates scopolamine-induced cognitive dysfunction显示文摘Kai Xin San(KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this study, 72 specific-pathogen-free male Kunming mice aged 8 weeks were randomly divided into a vehicle control group, scopolamine group, low-dose KXS group, moderate-dose KXS group, high-dose KXS group, and positive control group. Except for the vehicle control group and scopolamine groups(which received physiological saline), the doses of KXS(0.7, 1.4 and 2.8 g/kg per day) and donepezil(3 mg/kg per day) were gastrointestinally administered once daily for 2 weeks. On day 8 after intragastric treatment, the behavioral tests were carried out. Scopolamine group and intervention groups received scopolamine 3 mg/kg per day through intraperitoneal injection. The effects of KXS on spatial learning and memory, pathological changes of brain tissue, expression of apoptosis factors, oxidative stress injury factors, synapse-associated protein, and cholinergic neurotransmitter were measured. The results confirmed the following.(1) KXS shortened the escape latency and increased residence time in the target quadrant and the number of platform crossings in the Morris water maze.(2) KXS increased the percentage of alternations between the labyrinth arms in the mice of KXS groups in the Y-maze.(3) Nissl and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining revealed that KXS promoted the production of Nissl bodies and inhibited the formation of apoptotic bodies.(4) Western blot assay showed that KXS up-regulated the expression of anti-apoptotic protein Bcl-2 and inhibited the expression of pro-apoptotic protein Bax. KXS up-regulated the expression of postsynaptic density 95, synaptophysin, and brain-derived neurotrophic factor in the cerebral cortex and hippocampus.(5) KXS increased the level and activity of choline acetyltransferase, acetylcholine, superoxide dismutase, and glutathione peroxidase, and reduced the level and activity of acetyl cholinesterase, reactive oxygen species, and malondialdehyde through acting on the cholinergic system and reducing oxidative stress damage. These results indicate that KXS plays a neuroprotective role and improves cognitive function through reducing apoptosis and oxidative stress, and regulating synapse-associated protein and cholinergic neurotransmitters. | Yu-Min Xu Xin-Chen Wang Ting-Ting Xu Hong-Ying Li Shang-Yan Hei Na-Chuan Luo Hong Wang Wei Zhao Shu-Huan Fang Yun-Bo Chen Li Guan Yong-Qi Fang Shi-Jie Zhang Qi Wang Wei-Xiong Liang | 2019 | Neural Regeneration Research2019，14，5： | 11 |
| 9 | Perioperative changes of ventricular function and three indicators of myocardial injury during orthotopic liver transplantation显示文摘 | HEI Zi-qing LIU De-zhao LUO Chen-fang LI Shang-rong MA Wu-hua LUO Gang-jian | 2006 | Chinese Medical Journal2006，，11： | 9 |
| 10 | Protective effect of Astragalus membranaceus on intestinal mucosa reperfusion injury after hemorrhagic shock in rats显示文摘AIM: To study the protective effect of Astragalus membranaceus on intestinal mucosa reperfusion injury and its mechanism after hemorrhagic shock in rats.METHODS: A total of 32 SD rats were randomly divided into four groups (n = 8, each group): normal group,model group, low dosage group (treated with 10 g/kg Astragalus membranaceus) and high dosage group (treated with 20 g/kg Astragalus membranaceus). The model of hemorrhagic shock for 60 min and reperfusion for 90 min was established. Therapeutic solution (3 mL)was administrated before reperfusion. At the end of the study, the observed intestinal pathology was analyzed. The blood concentrations of lactic acid (LD), nitric oxide (NO),endothelin-1 (ET-1), malondialdehyde (MDA) and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) in intestinal mucosa were determined.RESULTS: The intestinal mucosa pathology showed severe damage in model group and low dosage group,slight damage in high dosage group and no obvious damage in normal group. The Chiu's score in low dose group and high dose group was significantly lower than that in model group. The content of MDA in model group was higher than that in low and high dose groups, while that in high dose group was almost the same as in normal group. The activity of SOD and GSH-PX was the lowest in model group and significantly higher in high dose group than in normal and low dose groups. The concentrations of LD and ET-1 in model group were the highest. The concentrations of NO in model group and low dose group were significantly lower than those in high dose group and normal group.CONCLUSION: High dose Astragalus membranaeus has much better protective effect on hemorrhagic shockreperfusion injury of intestinal mucosa than low dose Astragalus membranaceus. The mechanism may be that Astragalus membranaceus can improve antioxidative effect and regulate NO/ET level during hemorrhagic reperfusion. | Zi-Qing Hei He-Qing Huang Jing-Jun Zhang Bing-Xue Chen Xiao-Yun Li | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 11 | Relationship between the expression of Toll-like receptor 2 and 4 in mononuclear cells and postoperative acute lung injury in orthotopic liver transplantation显示文摘这研究的目的是调查在像使用费的受体的动态表示之间的潜在的关系的背景 2 和 4 ( TLR2/4 )在象在在在 orthotopic 肝移植( OLT )以后的病人的煽动性的因素和尖锐的肺损害(所有)的浆液集中的变化一样的外部血 mononuclear 房间外部血 27 个病人取样的 .Methods (有 ASA 到的 23 个男人和 4 个女人)收到了 OLT 的人,在 T1 为 TLR2/4 的测量被收集(在正式就职以后一在 mononuclear 房间的 TLR2/4 的表示被流动 cytometry 测量。肿瘤的浆液集中坏死因素(TNF )-a, intedeukin (IL )-113 和 IL-8 被连接酶的 irnmunosorbent 试金(ELISA ) 测量。27 个病人根据 ALI 的诊断标准被分到 ALI 组(n=9 ) 和 non-ALI 组(n=18 ) 。 TLR2/4 在的表达式所有组或 non-ALI 组是比作 non-ALI 组,血损失的卷,腹水,全部的输出和血房间是的输的红的 analyzed.Results 在 ALI 组,和更长持续的 anhepallc 阶段更高( P < 0.05 , P < 0.01 )。在房间在 T3 和 T4 显著地增加了的 mononuclear 的 TLR2/4 的表示,和 TNF- , IL-1 和 IL-8 的浆液集中也显著地增加了。在在 ALI 组和非所有组之间的 Child-Turcotte-Pugh (CTP ) 分数没有重要差别(P > 0.05 ) 。在 mononuclear 房间的 TLR2/4 的表示在 T3 显著地增加了并且 14 在 ALI 组织(P < 0.05, P < 0.01 ) 。积极关联在 mononuclear 房间和 TNF- 的浆液集中在 TLR4 的表示之间被注意, IL-1 (P=0.041, P=0.046 ) 在里面所有组。在 non-ALI 组,统计结果证明在 mononuclear 房间的 TLR2/4 的表示水平不在 OLT 的仙子起作用的时期期间是显著地不同的(除在 T4 的 TLR4 表示以外) 。比作 non-ALI 组,在 mononuclear 房间的 TLR2/4 表示的增加的振幅在 ALI 组是更重要的。在 mononuclear 房间的表示其 TLR2/4 到一次在 T1 超过了那的病人是更可能的受不了 ALI (P=0.013 ) ,与 16 的相对风险。 | CHI Xin-jin CAI Jun LUO Chen-fang CHENG Nan HEI Zi-qing LI Shang-rong LUO Gang-jian | 2009 | Chinese Medical Journal2009，，8： | 9 |
| 12 | UBSS and blind parameters estimation algorithms for synchronous orthogonal FH signals显示文摘By using the sparsity of frequency hopping(FH) signals,an underdetermined blind source separation(UBSS) algorithm is presented. Firstly, the short time Fourier transform(STFT) is performed on the mixed signals. Then, the mixing matrix, hopping frequencies, hopping instants and the hooping rate can be estimated by the K-means clustering algorithm. With the estimated mixing matrix, the directions of arrival(DOA) of source signals can be obtained. Then, the FH signals are sorted and the FH pattern is obtained. Finally, the shortest path algorithm is adopted to recover the time domain signals. Simulation results show that the correlation coefficient between the estimated FH signal and the source signal is above 0.9 when the signal-to-noise ratio(SNR) is higher than 0 d B and hopping parameters of multiple FH signals in the synchronous orthogonal FH network can be accurately estimated and sorted under the underdetermined conditions. | Weihong Fu Yongqiang Hei Xiaohui Li | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 9 |
| 13 | Genome-wide identification and analysis of the DREB genes and their expression profiles under abiotic stresses in Chinese jujube(Ziziphus jujuba Mill.)显示文摘CBF/DREB proteins play a critical role in abiotic stress-mediated gene expression and represent attractive regulons for plant breeding programs.However,no study has been conducted for CBF/DREB protein-related genes in jujube(Ziziphus jujuba Mill.).In this study,twenty-five ZjDREB genes were identified and annotated from the jujube(Z.jujuba‘Dongzao’)genome.Detailed analysis,including gene classification,annotation,phylogenetic evaluation,conserved motif determination and expression profiling were performed on all genes.Phylogenetic analysis showed that ZjDREB proteins were divided into five subgroups(A1–A5),but lacking a subgroup A6 corresponding to AtDREBs.The ZjDREB genes were distributed in nine of twelve chromosomes in the genome.Additionally,the expression patterns of the DREB genes under different abiotic stresses were investigated using q RT-PCR.Nineteen ZjDREB genes were down-regulated under low temperature,in contrast six ZjDREB genes(01,03,05,11,23 and 24)were up-regulated.Under drought,salinity and high temperature conditions,expression of ZjDREB03,09,10,14,15,17 and 20 genes were induced and showed similar expression patterns,suggesting that various stress conditions share common elements in the signaling pathway.The results suggest that the family of DREB genes play an important role in abiotic stresses in jujube,and provide a foundation for further functional studies of this important class of transcriptional regulators. | Heying Zhou Jiping Jia Decang Kong Zhendong Zhang Shuang Song Yingyue Li Xiaoming Pang | 2019 | Journal of Forestry Research2019，30，4： | 8 |
| 14 | Changes of nitric oxide and endothelin, thromboxane A2 and prostaglandin in cirrhotic patients undergoing liver transplantation显示文摘瞄准:为了调查起作用的仙子,氮的氧化物变化(没有) 并且 endothelin (et ) , thromboxane A2 (TXA2 ) 和在在结束阶段肝疾病病人的肝移植期间的前列腺素(PGI2 ) 。方法:有经历肝移植的结束阶段肝硬化的 27 个病人在这未来的研究被注册。血样品在五个不同外科的阶段从优异静脉被获得。硝酸盐和亚硝酸根的血浆集中决心反映血浆没有层次。ET-1,6-keto-PGF1 高山的血浆层次哈并且 thromboxane B2 (TXB2 ) ,后者二分别地是 PGI2 和 TXA2 的稳定的代谢物,被测量。结果:没有水平在脉管的跨 clamping 以后显著地减少了并且在灌注以后在 30 min 显著地增加了。当在在夹钳以后并且在灌注以后的 30 min 的 ET 层次显著地被提高时。NO/ET 的比率在脉管的跨 clamping 以后并且在外科的结束在 30 min 显著地减少了。PGI2 水平和 TXA2 在肝移植期间比基线水平显著地高,但是 TXA2/PGI2 的比率在夹钳以后在 30 min 显著地减少了。结论:NO/ET 和 TXA2/PGI2 在肝移植期间变化。尽管精确机制仍然保持未知,他们可以在许多肝的病理学起一个作用移植, 移植物, 移植片相关的过程。 | Zi-Qing Hei He-Qing Huang Chen-Fang Luo Shang-Rong Li Gang-Jian Luo | 2006 | World Journal of Gastroenterology2006，12，25： | 6 |
| 15 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 16 | Comparison of α particle detectors based on single-crystal diamond films grown in two types of gas atmospheres by microwave plasma-assisted chemical vapor deposition显示文摘Chemical vapor deposition(CVD)-grown diamond films have been developed as irradiation-resistant materials to replace or upgrade current detectors for use in extreme radiation environments. However, their sensitivity in practical applications has been inhibited by space charge stability issues caused by defects and impurities in pure diamond crystal materials. In this study, two high-quality CVD-grown single-crystal diamond(SCD) detectors with low content of nitrogen impurities were fabricated and characterized. The intrinsic properties of the SCD samples were characterized using Raman spectroscopy, stereomicroscopy, and X-ray diffraction with the rocking curve mode, cathode luminescence(CL), and infrared and ultraviolet-visible-near infrared spectroscopies. After packaging the detectors, the dark current and energy resolution under α particle irradiation were investigated. Dark currents of less than 5 pA at 100 V were obtained after annealing the electrodes, which is comparable with the optimal value previously reported. The detector that uses a diamond film with higher nitrogen content showed poor energy resolution, whereas the detector with more dislocations showed poor charge collection efficiency(CCE). This demonstrates that the nitrogen content in diamond has a significant effect on the energy resolution of detectors, while the dislocations in diamond largely contribute to the poor CCE of detectors. | Yan-zhao Guo Jin-long Liu Jiang-wei Liu Yu-ting Zheng Yun Zhao Xiao-lu Yuan Zi-hao Guo Li-fu Hei Liang-xian Chen Jun-jun Wei Jian-peng Xing Cheng-ming Li | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，5： | 5 |
| 17 | Existence and Stability of Positive Solutions for an Elliptic Cooperative System显示文摘由讨论一个线性合作系统的性质,为一个椭圆形的合作系统的积极解决方案的存在的必要、足够的条件以联系线性系统的主要特征值被建立,并且某本地稳定性结果因为积极解决方案也被获得。 | Li Jun HEI Jian Hua WU | 2005 | Acta Mathematica Sinica,English Series2005，21，5： | 4 |
| 18 | A High-throughput Genomic Tool: Diversity Array Technology Complementary for Rice Genotyping显示文摘差异数组技术(DArTTM ) 是胶化无关的描绘的一个 genotyping 工具和高产量。现在的学习的主要目的是为米饭(Oryza sativa L.) 验证飞镖以一种高产量方式的 genotyping。技术上,主要目的是产生米饭通用的基因分享,并且优化这个 genomic 工具以便评估米饭 germplasm 基因差异。为了完成这,第一,一个通用飞镖数组被开发。从 24 个变化的十个代表是有通用数组的 hybridized 决定在数组上打印的克隆的增进知识。增进知识 1 152 克隆在一个幻灯片上被重新穿并且过去常采指纹 24 germplasms 中的 17 个。从是到 DNA 数组的 assayed 的 germplasm 准备的 Hybridizing 目标给了 germplasms 的 DNA 指纹。未加工的数据被使正常化并且转变了成二进制数据,它然后被使用 NTSYSpc 分析(为簇和分类分析的数字分类系统, v。2.02j ) 软件包裹。图形地显示的 dendrogram 源于数组试验性的数据与简单顺序重复 genotyping 轮廓和变化不同变化的家谱偏差被匹配。考虑到飞镖是一条顺序无关的 genotyping 途径,它将在印射的基因差异和基因的研究被使用有机体多样,特别为有开发更少的分子的标记的那些庄稼。 | Yong Xie Kenneth McNally Cheng-Yun Li Hei Leung You-Yong Zhu | 2006 | Journal of Integrative Plant Biology2006，48，9： | 4 |
| 19 | A Joint Learning Framework for the CCKS-2020 Financial Event Extraction Task显示文摘This paper presents a winning solution for the CCKS-2020 financial event extraction task, where the goal is to identify event types, triggers and arguments in sentences across multiple event types. In this task, we focus on resolving two challenging problems(i.e., low resources and element overlapping) by proposing a joint learning framework, named SaltyFishes. We first formulate the event extraction task as a joint probability model. By sharing parameters in the model across different types, we can learn to adapt to low-resource events based on high-resource events. We further address the element overlapping problems by a mechanism of Conditional Layer Normalization, achieving even better extraction accuracy. The overall approach achieves an F1-score of 87.8% which ranks the first place in the competition. | Jiawei Sheng Qian Li Yiming Hei Shu Guo Bowen Yu Lihong Wang Min He Tingwen Liu Hongbo Xu | 2021 | Data Intelligence2021，3，3： | 4 |
| 20 | Novel scheduling strategy for downlink multiuser MIMO system: Particle swarm optimization显示文摘In this paper the scheduling problem in downlink multiuser MIMO system is described as an optimization problem and particle swarm optimization (PSO) algorithm is introduced to address such problem. Two PSO scheduling methods with different objective functions applicable to different requirements on capacity and complexity are investigated. One is the capacity based PSO(C-PSO) scheduling method aiming at achieving the near optimal capacity; and the other is the lower bound of eigenvalue based PSO (LBE-PSO) scheduling method with the purpose of reducing computational complexity and at the same time achieving as large as possible capacity gain. Furthermore, convergence analysis of PSO from both the particle and the velocity aspects is also presented to derive the convergent condition, which is validated by several examples of different parameter values. Simulation results reveal that the C-PSO can obtain nearly the same capacity as the exhaustive search method with lower complexity, while the LBE-PSO provides a viable approach by striking a better tradeoff between capacity and computational complexity. | HEI YongQiang LI XiaoHui YI KeChu YANG Hong | 2009 | Science in China(Series F)2009，52，12： | 4 |
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