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| 1 | Hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis:A multicenter propensity scorematched cohort study显示文摘Objective:Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis(PM)in gastric cancer(GC).Hyperthermic intraperitoneal chemotherapy(HIPEC)combined with complete cytoreductive surgery(CRS)has shown promising outcomes but remains controversial.The present study aimed to evaluate the safety and efficacy of HIPEC without CRS in GC patients with PM.Methods:This retrospective propensity score-matched multicenter cohort study included GC patients with PM treated with either chemotherapy alone(Cx group)or with HIPEC combined with chemotherapy(HIPEC-Cx group)in four Chinese high-volume gastric medical centers between 2010 and 2017.The primary outcomes were median survival time(MST)and 3-year overall survival(OS).Propensity score matching was performed to compensate for controlling potential confounding effects and selection bias.Results:Of 663 eligible patients,498 were matched.The MST in the Cx and HIPEC-Cx groups was 10.8 and 15.9 months,respectively[hazard ratio(HR)=0.71,95%confidence interval(95%CI),0.58-0.88;P=0.002].The 3-year OS rate was 10.1%(95%CI,5.4%-14.8%)and 18.4%(95%CI,12.3%-24.5%)in the Cx and HIPEC-Cx groups,respectively(P=0.017).The complication rates were comparable.The time to first flatus and length of hospital stay for patients undergoing HIPEC combined with chemotherapy was longer than that of chemotherapy alone(4.6±2.4 d vs.2.7±1.8 d,P<0.001;14.2±5.8 d vs.11.4±7.7 d,P<0.001),respectively.The median follow-up period was 33.2 months.Conclusions:Compared with standard systemic chemotherapy,HIPEC combined with chemotherapy revealed a statistically significant survival benefit for GC patients with PM,without compromising patient safety. | Ziying Lei Jiahong Wang Zhi Li Baozhong Li Jiali Luo Xuejun Wang Jin Wang MingchenBa Hongsheng Tang Qingjun He Quanxing Liao Xiansheng Yang Tianpei Guan Han Liang Shuzhong Cui | 2020 | Chinese Journal of Cancer Research2020，32，6： | 11 |
| 2 | Hepatitis C Virus Infection Downregulates the Ligands of the Activating Receptor NKG2D显示文摘Natural killer (NK) cells are a major component of the host innate immune defense against various pathogens. Several viruses, including hepatitis C virus (HCV), have developed strategies to evade the NK-cell response. In our study, we found HCV infection could trigger DNA damage response by both ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) pathways. Recent reports had revealed that NKG2D ligands (NK cell-activating ligands) were upregulated when a major DNA damage checkpoint pathway was activated. However, here we found that DNA damage response was activated but NKG2D ligands were downregulated upon HCV infection. Further studies showed that the protease NS3/4A of HCV which had been shown relation with immune invasion contributed to the reduced expression of NKG2D ligands. These findings provide a novel insight into the mechanisms evolved by HCV to escape from the NK cell response. | Chaoyang Wen Xiang He Hongfang Ma Ningbo Hou Congwen Wei Ting Song Yanhong Zhang Liping Sun Qingjun Ma Hui Zhong | 2008 | Cellular & Molecular Immunology2008，5，6： | 6 |
| 3 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 4 | Effect of fine steel slag powder on the early hydration process of portland cement显示文摘 | Hu Shuguang Ph D He Yongjia Lu Linnu Ding Qingjun | 2006 | Journal of Wuhan University of Technology - Mater Sci Ed2006，，1： | 1 |
| 5 | A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment显示文摘Andrographolide(AG)has favorable anti-inflammatory and antioxidative capacity.However,it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection,leading to low therapeutic efficiency in osteoarthritis(OA).Herein,we designed a nano-sized pH-responsive drug delivery system(DDS)for OA treatment by using modified mesoporous silica nanoparticles(MSNs)with pH-responsive polyacrylic acid(PAA)for loading of AG to form AG@MSNs-PAA nanoplatform.The nanoparticles have uniform size(120 nm),high drug loading efficiency(22.3860.71%)and pH-responsive properties,beneficial to sustained release in OA environment.Compared with AG,AG@MSNs-PAA showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1b-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model,as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss.Therefore,the AG@MSNs-PAA nanoplatform may be developed as a promising OA-specific and on-demand DDS. | Mingwei He Zainen Qin Xiaonan Liang Xixi He Bikang Zhu Zhenhui Lu Qingjun Wei Li Zheng | 2021 | Regenerative Biomaterials2021，8，4： | 1 |
| 6 | Proliferating cell nuclear antigen destabilizes c-Abl tyrosine kinase and regulates cell apoptosis in response to DNA damage显示文摘 | Xiang He Congwen Wei Ting Song Jing Yuan Yanhong Zhang Qingjun Ma Wei Shi Hui Zhong | 2009 | Apoptosis2009，，3： | 1 |
| 7 | SmBaCo2O5+δ double-perovs- kite structure cathode material for intermediate-temperature solid-oxide fuel cells 显示文摘 | ZHOU Qingjun HE Tianmin JI Yuan | 2008 | J Power Sources2008，185，： | 1 |
| 8 | Enantioselective Chlorocyclization of Olefinic Amides with 1,3-Dichloro-5,5-Dimethylhydantoin(DCDMH) Catalyzed by(DHQD)2PHAL显示文摘 | ZHOU Qingjun GUO Chao LI Xiwang HE Pei YANG Guichun DONG Chune | 2018 | Wuhan University Journal of Natural Sciences2018，23，3： | 0 |
| 9 | The mechanism of hydraulic fracturing assisted oil displacement to enhance oil recovery in low and medium permeability reservoirs显示文摘Aiming at the technology of hydraulic fracturing assisted oil displacement which combines hydraulic fracturing,seepage and oil displacement,an experimental system of energy storage and flowback in fracturing assisted oil displacement process has been developed and used to simulate the mechanism of percolation,energy storage,oil displacement and flowback of chemical agents in the whole process.The research shows that in hydraulic fracturing assisted oil displacement,the chemical agent could be directly pushed to the deeper area of the low and medium permeability reservoirs,avoiding the viscosity loss and adhesion retention of chemical agents near the pay zone;in addition,this technology could effectively enlarge the swept volume,improve the oil displacement efficiency,replenish formation energy,gather and exploit the scattered residual oil.For the reservoir with higher permeability,this measure takes effect fast,so to lower cost,and the high pressure hydraulic fracturing assisted oil displacement could be adopted directly.For the reservoir with lower permeability which is difficult to absorb water,hydraulic fracturing assisted oil displacement with surfactant should be adopted to reduce flow resistance of the reservoir and improve the water absorption capacity and development effect of the reservoir.The degree of formation energy deficit was the main factor affecting the effective swept range of chemical agents.Moreover,the larger the formation energy deficit was,the further the seepage distance of chemical agents was,accordingly,the larger the effective swept volume was,and the greater the increase of oil recovery was.Formation energy enhancement was the most important contribution to enhanced oil recovery(EOR),which was the key to EOR by the technology of hydraulic fracturing assisted oil displacement. | LIU Yikun WANG Fengjiao WANG Yumei LI Binhui ZHANG Dong YANG Guang ZHI Jiqiang SUN Shuo WANG Xu DENG Qingjun XU He | 2022 | Petroleum Exploration and Development2022，49，4： | 0 |
| 10 | Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids显示文摘Objective:Organoids have recently been used as in vitro models to screen chemotherapy drugs in combination with hyperthermia treatment in colorectal cancer.Our research aimed to establish a library of patient-derived colorectal cancer organoids to evaluate synergism between chemotherapy drugs and hyperthermia;validate an index of the hyperthermia chemotherapy sensitization enhancement ratio(HCSER)to identify the chemotherapeutics most enhanced by hyperthermia;and recommend chemotherapy drugs for hyperthermic intraperitoneal treatment.Methods:Organoids were grown from cells extracted from colorectal cancer patient samples or colorectal cancer cell lines.Cells from both sources were encapsulated in 3 D Matrigel droplets,which were formulated in microfluidics and phase-transferred into identical cell-laden Matrigel microspheres.The microspheres were seeded in 96-well plates,with each well containing a single microsphere that developed into an organoid after 7 days.The organoids were used to evaluate the efficacy of chemotherapy drugs at both 37℃ as a control and 43℃ for 90 min to examine hyperthermia synergism.Cell viability was counted with 10%CCK8.Results:We successfully established a library of colorectal cancer organoids from 22 patient parental tumors.We examined the hyperthermia synergism of 7 commonly used hyperthermic intraperitoneal chemotherapy drugs.In 11 of the 22 patient organoids,raltitrexed had significant hyperthermia synergism,which was indexed as the highest HCSER score within each patient group.Conclusions:Our results primarily demonstrated the use of patient-derived colorectal cancer organoids as in vitro models to evaluate hyperthermia synergistic chemotherapeutics.We found that hyperthermia enhanced the effect of raltitrexed the most among the common anti-colorectal cancer drugs. | Lisi Zeng Quanxing Liao Haoran Zhao Shengwei Jiang Xianzi Yang Hongsheng Tang Qingjun He Xiansheng Yang Shuxian Fang Jinfu He Weiwen Cui Laiqiang Huang Shaohua Ma Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，3： | 0 |
| 11 | Electrocoagulation coupled with electrooxidation for the simultaneous treatment of multiple pollutants in contaminated sediments显示文摘In situ and simultaneous remediation of a variety of pollutants in sediments remains a challenge.In this study,we report that the combination of electrocoagulation(EC)and electrooxidation(EO)is efficient in the immobilization of phosphorus and heavymetals and in the oxidation of ammonium and toxic organicmatter.The integratedmixed metal oxide(MMO)/Fe anode system allowed the facile removal of ammonium and phosphorus in the overlying water(99% of 10 mg/L NH_(4)^(+)-N and 95% of 10 mg/L P disappeared in 15 and 30 min,respectively).Compared with the controls of the single Fe anode and single MMO anode systems,the dual MMO/Fe anode system significantly improved the removal of phenanthrene and promoted the transition of Pb and Cu from the mobile species to the immobile species.The concentrations of Pb and Cu in the toxicity characteristic leaching procedure extracts were reduced by 99%and 97% after an 8 hr operation.Further tests with four real polluted samples indicated that substantial proportions of acid-soluble fraction Pb and Cu were reduced(30%-31% for Pb and 16%–23% for Cu),and the amounts of total organic carbon and NH_(4)^(+)-N decreased by 56%–71% and 32%–63%,respectively.It was proposed that the in situ electrogenerated Fe(II)at the Fe anode and the active oxygen/chlorine species at the MMO anode are conducive to outstanding performance in the co-treatment of multiple pollutants.The results suggest that the EC/EO method is a powerful technology for the in situ remediation of sediments contaminated with different pollutants. | Qingjun Zeng Yifan Zhang Pingshan Chen Yuting He Congli Yi Chunhua Feng | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 12 | Synergistic effect of vermiculite and submerged plants on lake sediments显示文摘The synergistic effect of vermiculite and the submerged macrophytes Vallisneria spiralis and Hydrilla verticillata on lake sediment was studied using diffusive gradients in thin films(DGT)technology.The dynamics of phosphorus(P)fractions in sediment,the labile-P and labile-S in the water-sediment continuum,and the microbial community in the rhizosphere were studied.Vermiculite effectively promoted reproduction of microorganisms in the sediments Microbial abundance in treatments containing V.spiralis with sediments containing 10%added vermiculite,and H.verticillata containing 50%added vermiculite being 1.7 and 3.5 times higher than the controls which contained no added vermiculite.Acidobacteria and Proteobacteria populations,which are both beneficial for the sediment microenvironment,were higher in treatment groups containing vermiculite.The bioavailable-P in treatment groups containing added vermiculite was lower at the sediment-water interface,with a correlating decrease of TP by between 63%and 91%in the overlying water.This suggests that vermiculite can affect the release of labile P and facilitate the assimilation of nutrients by macrophyte roots.Additionally,vermiculite can improve the Oxidation-Reduction potential and further reduce sulfide toxicity to plants.These results provide theoretical guidance and technical support for the application of vermiculite combined with submerged plants for the remediation of eutrophic lakes. | Rou Wang Yunli Liu Feng Luo Guoliang Bai Yadong Tang Qingjun Fang Jiying Zhu Beining Li Zisen Liu Feng He Qiaohong Zhou Zhenbin Wu Yi Zhang | 2023 | Water Biology and Security2023，2，3： | 0 |
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