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| 1 | Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets显示文摘Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity, and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to hepatocellular carcinoma in the absence of liver transplantation. Fibrosis generally results from chronic hepatic injury caused by various factors, mainly viral infection, schistosomiasis, and alcoholism; however, the exact pathological mechanisms are still unknown. Although numerous drugs have been shown to have antifibrotic activity in vitro and in animal models, none of these drugs have been shown to be efficacious in the clinic. Importantly, hepatic stellate cells(HSCs) play a key role in the initiation, progression, and regression of liver fibrosis by secreting fibrogenic factors that encourage portal fibrocytes, fibroblasts, and bone marrow-derived myofibroblasts to produce collagen and thereby propagate fibrosis. These cells are subject to intricate cross-talk with adjacent cells, resulting in scarring and subsequent liver damage. Thus, an understanding of the molecular mechanisms of liver fibrosis and their relationships with HSCs is essential for the discovery of new therapeutic targets. This comprehensive review outlines the role of HSCs in liver fibrosis and details novel strategies to suppress HSC activity, thereby providing new insights into potential treatments for liver fibrosis. | Chong-Yang Zhang Wei-Gang Yuan Pei He Jia-Hui Lei Chun-Xu Wang | 2016 | World Journal of Gastroenterology2016，22，48： | 114 |
| 2 | Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation显示文摘ABSTRACTHuman placenta-derived mononuclear cells (MNC) were isolated by a Percoll density gradient and cultured in mesen-chymal stem cell (MSC) maintenance medium. The homogenous layer of adherent cells exhibited a typical fibroblast-like morphology, a large expansive potential, and cell cycle characteristics including a subset of quiescent cells. In vitrodifferentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic, osteogenic andchondrogenic lineages. Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was ahomogeneous cell population devoid of hematopoietic cells, which uniformly expressed CD29, CD44, CD73, CD105,CD166, laminin, fibronectin and vimentin while being negative for expression of CD31, CD34, CD45 and α-smoothmuscle actin. Most importantly, immuno-phenotypic analyses demonstrated that these cells expressed class I majorhistocompatibility complex (MHC-I), but they did not express MHC-II molecules. Additionally these cells could sup-press umbilical cord blood (UCB) lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli. Thisstrongly implies that they may have potential application in allograft transplantation. Since placenta and UCB arehomogeneous, the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells(HSC) from UCB to reduce the potential graft -versus-host disease (GVHD) in recipients. | Chang Dong LI Wei Yuan ZHANG He Lian LI Xiao Xia JIANG Yi ZHANG Pei Hsien TANG Ning MAO | 2005 | Cell Research2005，15，7： | 36 |
| 3 | Relationship between vascular invasion and microvessel density and micrometastasis显示文摘瞄准:在血评估在脉管的侵略和织物和微转移的微容器密度(MVD ) 之间的关系。方法:脉管的侵略被苏木精并且曙红染色并且 immunohistochemiscal 染色检测。没有脉管的侵略,血样品与脉管的侵略和 29 个病人从 17 个病人被收集并且由反向的 transcriptase 聚合酶为 cytokeratin20 (CK20 ) 检验了表示链反应(RT-PCR ) 分析。织物样品的 Microvessel 密度被免疫组织化学也用抗体决定到 CD105。结果:没有脉管的侵略, CK20 与脉管的侵略并且在 29 个病人中的 9 个在 17 个病人中的 12 个被检测。积极 RT-PCR 显著地与脉管的侵略被相关(70.6% 对 30.0% , P <
0.05 ) 。平均 MVD 比在有否定脉管的侵略的病人在有积极脉管的侵略的病人是显著地更高的(29.2 +/- 3.3 对 25.4 +/- 4.7, P <
0.05 ) 。检测, hematoxylin 曙红染色的脉管的侵略是不到那与免疫组织化学的染色。在二染色法之间有有效差量(19.6% 对 36.9% , P <
0.05 ) 。结论:积极 CK20 RT-PCR,肿瘤侵略的深度,淋巴节点地位,转移和 MVD 显著地与脉管的侵略被相关。染色的 Immunohistochemical 比为检测脉管的侵略染色的 hematoxylin 曙红更敏感。 | Yan-Dong Wang Pei Wu Jia-Ding Mao He Huang Fan Zhang | 2007 | World Journal of Gastroenterology2007，13，46： | 24 |
| 4 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 5 | Curcumin inhibits hepatitis B virus infection by downregulating ccc DNA-bound histone acetylation显示文摘AIM To investigate the potential effect of curcumin on hepatitis B virus(HBV) covalently closed circular DNA(ccc DNA) and the underlying mechanism.METHODS A Hep G2.2.15 cell line stably transfected with HBV was treated with curcumin, and HBV surface antigen(HBs Ag) and e antigen(HBe Ag) expression levels were assessed by ELISA. Intracellular HBV DNA replication intermediates and ccc DNA were detected by Southern blot and real-time PCR, respectively. The acetylation levels of histones H3 and H4 were measured by Western blot. H3/H4-bound ccc DNA was detected by chromatin immunoprecipitation(Ch IP) assays. The deacetylase inhibitors trichostatin A and sodium butyrate were used to study the mechanism of action for curcumin. Additionally, short interfering RNAs(si RNAs) targeting HBV were tested along with curcumin.RESULTS Curcumin treatment led to time-and dose-dependent reductions in HBs Ag and HBe Ag expression and significant reductions in intracellular HBV DNA replication intermediates and HBV ccc DNA. After treatment with 20 μmol/L curcumin for 2 d, HBs Ag and ccc DNA levels in Hep G2.2.15 cells were reduced by up to 57.7%(P < 0.01) and 75.5%(P < 0.01), respectively, compared with levels in non-treated cells. Meanwhile, time-and dose-dependent reductions in the histone H3 acetylation levels were also detected upon treatment with curcumin, accompanied by reductions in H3-and H4-bound ccc DNA. Furthermore, the deacetylase inhibitors trichostatin A and sodium butyrate could block the effects of curcumin. Additionally, transfection of si RNAs targeting HBV enhanced the inhibitory effects of curcumin.CONCLUSION Curcumin inhibits HBV gene replication via downregulation of ccc DNA-bound histone acetylation and has the potential to be developed as a ccc DNA-targeting antiviral agent for hepatitis B. | Zhi-Qiang Wei Yong-Hong Zhang Chang-Zheng Ke Hong-Xia Chen Pan Ren Yu-Lin He Pei Hu De-Qiang Ma Jie Luo Zhong-Ji Meng | 2017 | World Journal of Gastroenterology2017，23，34： | 18 |
| 6 | Intestinal barrier dysfunction in severe burn injury显示文摘Severe burn injury is often accompanied by intestinal barrier dysfunction,which is closely associated with post-burn shock,bacterial translocation,systemic inflammatory response syndrome,hypercatabolism,sepsis,multiple organ dysfunction syndrome,and other complications.The intestinal epithelium forms a physical barrier that separates the intestinal lumen from the internal milieu,in which the tight junction plays a principal role.It has been well documented that after severe burn injury,many factors such as stress,ischemia/hypoxia,proinflammatory cytokines,and endotoxins can induce intestinal barrier dysfunction via multiple signaling pathways.Recent advances have provided new insights into the mechanisms and the therapeutic strategies of intestinal epithelial barrier dysfunction associated with severe burn injury.In this review,we will describe the current knowledge of the mechanisms involved in intestinal barrier dysfunction in response to severe burn injury and the emerging therapies for treating intestinal barrier dysfunction following severe burn injury. | Wen He Yu Wang Pei Wang Fengjun Wang | 2019 | Burns & Trauma2019，7，1： | 17 |
| 7 | Full-thickness tissue engineered skin constructed with autogenic bone marrow mesenchymal stem cells显示文摘To explore the feasibility of repairing clinical cutaneous deficiency, autogenic bone marrow mesen-chymal stem cells (BMSCs) were isolated and differentiated into epidermal cells and fibroblasts in vitro supplemented with different inducing factors and biomaterials to construct functional tissue- engineered skin. The results showed that after 72 h induction, BMSCs displayed morphologic changes such as typical epidermal cell arrangement, from spindle shape to round or oval; tonofibrils, melano-somes and keratohyaline granules were observed under a transmission electronic microscope. The differentiated cells expressed epidermal stem cell surface marker CK19 (59.66% ± 4.2%) and epidermal cells differentiation marker CK10. In addition, the induced epidermal cells acquired the anti-radiation capacity featured by lowered apoptosis following exposure to UVB. On the other hand, the collagen microfibrils deposition was noticed under a transmission electronic microscope after differentiating into dermis fibroblasts; RT-PCR identified collagen type I mRNA expression in differentiated cells; radioimmunoassay detected the secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) (up to 115.06 pg/mL and 0.84 ng/mL, respectively). Further in vivo implanting BMSCs with scaffold material short-ened skin wound repair significantly. In one word, autogenic BMSCs have the potential to differentiate into epidermal cells and fibroblasts in vitro, and show clinical feasibility acting as epidermis-like and dermis-like seed cells in skin engineering. | HE LiJuan, NAN Xue, WANG YunFang, GUAN LiDong, BAI CiXian, SHI ShuangShuang, YUAN HongFeng, CHEN Lin, LIU DaQing & PEI XueTao Laboratory of Stem Cells and Regenerative Medicine, Institute of Blood Transfusion, Academy of Military Medical Sciences, Beijing 100850, China | 2007 | Science China(Life Sciences)2007，50，4： | 16 |
| 8 | Relationship between expression of gastrin, somatostatin,Fas/FasL and caspases in large intestinal carcinoma显示文摘AIM: To explore the correlation between the mRNAs and protein expression of gastrin (GAS), somatostatin (SS) and apoptosis index (AI), apoptosis regulation gene Fas/ FasL and caspases in large intestinal carcinoma (LIC). METHODS: Expression of GAS and SS mRNAs were detected by nested RT-PCR in 79 cases of LIC. Cell apoptosis was detected by molecular biology in situ apoptosis detecting methods (TUNEL). Immunohistochemical staining for GAS, SS, Fas/FasL, caspase-3 and caspase-8 was performed according to the standard streptavidin-biotin-peroxidase (S-P) method. RESULTS: There was a significant positive correlation between mRNA and protein expression of GAS and SS (GASrs=0.99, P < 0.01; SSrs = 0.98, P < 0.01). There was significant difference in positive expression rates of GAS, SS mRNAs and protein among different histological differentiation, histological types and Dukes’ stage of LIC. The AI in GAS high and moderate expression groups was significantly lower than that in low expression groups (3.75 ± 2.38 vs 7.82 ± 2.38, P < 0.01; 5.51 ± 2.66 vs 7.82 ± 2.38, P < 0.01), and the AI in SS high and moderate expression groups was significantly higher than that in low expression groups (9.03 ± 1.76 vs 5.35 ± 3.00, P < 0.01; 7.44 ± 2.67 vs 5.35 ± 3.00, P < 0.01). There was a significant negative correlation between the integral ratio of GAS to SS and the AI (rs = -0.41, P < 0.01). The positive expression rate of FasL in GAS high and moderate expression groups was higher than thatin low expression group (90.9% and 81.0% vs 53.2%, P < 0.05). The positive expression rates of Fas, caspase-8 and caspase-3 in SS high (90.0%, 90.0% and 100%) and moderate (80.0%, 70.0%, 75.0%) expression groups were higher than that in low expression group (53.1%, 42.9%, 49.0%) (90.0% and 80.0% vs 53.1%, P < 0.05; 90.0% and 70.0% vs 42.9%, P < 0.05; 100.0% and 75.0% vs 49.0%, P < 0.05). There was a significant positive correlation between the integral ratio of GAS to SS and the semiquantitative integral of FasL (rs = 0.32, P < 0.01). CONCLUSION: GAS and SS play important roles in the regulation and control of cell apoptosis in LIC, and the mechanism may be directly related to the aberrant expression of Fas/FasL. The GAS and SS will be valuable targets of the biological behavior of LIC. | Jia-Ding Mao Pei Wu Ying-Lin Yang Jian Wu He Huang | 2008 | World Journal of Gastroenterology2008，14，18： | 15 |
| 9 | Treatment of osteoporotic intertrochanteric fractures by zoledronic acid injection combined with proximal femoral nail anti-rotation显示文摘观察在 osteoporotic intertrochanteric 的处理与 zoledronic 酸注射相结合的近似大腿骨的钉子反旋转(PFNA ) 的临床的结果的目的断裂在老。有 osteoporotic intertrochanteric 破裂的 60 个老病人用一台双精力 X 光检查骨头密度仪器被诊断的方法。病人们随机被划分成治疗或控制组(在每个组的 30 个盒子) 。在两个组的病人被关上 / 打开的减小和内部固定用 PFNA 对待。在治疗组,病人们收到了一 zoledronic 5 mg/100 ml 经由的磷的酸注射静脉内滴下,除了 Caltrate D (qd ) 和 alpha 骨化酒精(qd ) 的 0.25 g 的 600 mg。控制组收到了 Caltrate D (qd ) 和 alpha 骨化酒精(qd ) 的 0.25 g 的 600 mg。口头的药被管理 12 个月。骨头疼痛地势在骨头矿物质密度(BMD ) 被观察,并且变化腰部并且健康方面臀部被记录。临床的结果被评估用视觉类似物规模(管) ,哈里斯关节功能分数,和生活优秀的骨质疏松症可伸缩(OQOLS ) 。结果与控制组,相比,骨头疼痛症状显著地被减轻(p 1-4 , 大腿骨的颈和 trochanter (p p = 0.04 ) 。在处理组的盒子在控制组比那些更快速愈合了[(13 景漠瑳潥潰潲楴? 湩整瑲潲档湡整楲? 牦捡畴敲 ? 祢稠汯摥潲楮 ? 捡摩椠橮' 虡 N 湯挠浯楢敮 ? 楷桴瀠潲楸慭? 敦潭慲? 慮汩愠瑮 ? | Yong Li Wen-Bo Zhao De-Li Wang Qing He Qin Li Fu-Xing Pei Lei Liu | 2016 | Chinese Journal of Traumatology2016，19，5： | 15 |
| 10 | A novel CFTR mutation found in a Chinese patient with cystic fibrosis显示文摘Background Cystic fibrosis (CF) is rare in Chinese. We investigated the mutations in the gene of cystic fibrosis transmembrane conductance regulator (CFTR) in a Chinese CF patient and reviewed the clinical features, gene mutations in Chinese CF cases. Methods Blood samples were collected from a previously reported CF girl and her parents. The 24 coding exons of CFTR of the proband were amplified and sequenced. Results A Chinese girl of 16 years old was diagnosed as CF at the age of 14. She had recurrent productive cough with bronchiectasis in bilateral upper lobes, parasinusitis and otitis media, but without pancreatic involvement. Her sweat chloride was (108.9 ±3.3) mmol/L. A heterozygous novel missense mutation of 699 C→ A which results in the amino acid change of N189K was identified in exon 5. In addition, a heterozygous 3821-3823 delT mutation in exon 19 was found in CFTR. The mutation 699C→A was inherited from her father, and the 3821-3823delT mutation was from her mother. Twenty patients with CF in Chinese reported from 1974 to 2004 were also reviewed. DelF508 mutation was not found in the nine cases whose CFTR mutations were analyzed. Conclusions The CF proband carries two heterozygous mutations (699C→A and 3821-3823delT) in CFTR. 699C→A mutation is a novel mutation which is not reported previously. Review of reported Chinese cases suggests that the genotype of Chinese CF may be different from those of white cases. More studies are needed to understand the spectra of CFTR and clinical CF features in Chinese. | LI Nan PEI Pei BU Ding-fang HE Bing WANG Guang-fa | 2006 | Chinese Medical Journal2006，，2： | 14 |
| 11 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 12 | Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota显示文摘Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. | Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 12 |
| 13 | Meta-analysis comparing total hip arthroplasty with hemiarthroplasty in the treatment of displaced femoral neck fractures in patients over 70 years old显示文摘ObjectiveTotal 新潮的关节造形术(THA ) 和 hemiarthroplasty (哈) 有效方法当前被用来在老病人对待大腿骨的颈骨折,但是二种选择超过 70 岁在病人仍然保持争论。我们的学习的主要目的是决定是否 THA 或哈大腿骨的破裂的优异治疗在是超过 70 年 age.MethodsA 的病人正在包含代替的颈 Medline ( 1970-2011 )的基于计算机的联机搜索, PubMed ( 1977-2011 ),并且控制试用( 2002-2011 )的 Cochrane 中央收款机被进行。有 739 个病人的一个总数的六相关使随机化的控制试用为最后的分析被包括。分析与与 THA 相比发现那的软件 RevMan 5.0 .ResultsWe 被执行,哈需要的更短的平均时间和失去的更少血。当时在长期的后续上, THA 病人显著地展出了更少的疼痛和更好的功能并且多半是更少要求一个修订臀部手术。手术后的感染是同等地普通的在之中哈并且在结果的重要差别建议的 THA patients.ConclusionsThe 那 THA 是为 activeelderly 新潮的破裂个人的一种珍贵治疗选择。然而,更老,损害或使制度化的病人得益于哈。 | HE Jun-hui ZHOU Cheng-pei ZHOU Zong-ke SHEN Bin YANG Jing KANG Peng-de PEI Fu-xing | 2012 | Chinese Journal of Traumatology2012，15，4： | 11 |
| 14 | Association of CYP3A polymorphisms with the pharmacokinetics of cyclosporine A in early post- renal transplant recipients in China显示文摘目的: 回顾地评估细胞色素 P450 3A (CYP3A ) 和 ATP 有约束力的盒子亚科 B 的协会成员 1 (ABCB1 ) 有用汉语的 cyclosporine A (CsA ) 的 pharmacokinetics 的基因多型性肾移植病人。 | Xiang-guang MENG Cheng-xian GUO Guo-qing FENG Ying-chun ZHAO Bo-ting ZHOU Jian-le HAN Xin CHEN Yong SHI Hong-yao SHI Ji-ye YIN Xiang-dong PENG Qi PEI Wei ZHANG Guo WANG Meng HE Min LIU Jing-ke YANG Hong-hao ZHOU | 2012 | Acta Pharmacologica Sinica2012，33，12： | 11 |
| 15 | Simultaneous determination of 15 flavonoids from different parts of Scutellaria baicalensis and its chemometrics analysis显示文摘Objective: The aerial parts of Scutellaria baicalensis were used as Huangqin Tea for thousands of years and mainly contain flavonoids which contribute to its bioactivities. However, there is no appropriate quality evaluation method of Huangqin Tea, and three flavanones of isocarthamidin-7-O-β-D-glucuronide,carthamidin-7-O-β-D-glucuronide, and isoscutellarein-8-O-β-D-glucuronide with high contents in the aerial parts have never been defined quantitatively. Here, an HPLC-DAD method for simultaneous determination of 15 flavonoids and systematically compared their contents and distribution in the roots,stems, leaves, and flowers of S. baicalensis was established.Methods: Under the HPLC-DAD chromatographic conditions, 77 batches of samples of S. baicalensis were analyzed. Meanwhile, the chromatographic fingerprint of different parts of S. baicalensis was established.Subsequently, principal component analysis(PCA), orthogonal projections to latent structures discriminant analysis(OPLS-DA), and clustering heat map were performed based on the contents of 15 flavonoids in different parts of S. baicalensis.Results: The results showed significant differences in the contents and distributions of 15 flavonoids among the different parts of S. baicalensis. The chemical composition of stems showed some similarities to leaves, and their contents were all lower than leaves. The contents of isocarthamidin-7-O-β–glucuronide [(106.66 66 ± 22.68) mg/g], carthamidin-7-O-β-D-glucuronide [(19.82 ± 11.17) mg/g],and isoscutellarein-8-O-β-D-glucuronide [(3.10 ± 1.73) mg/g] were the highest in leaves. The content of apigenin-7-O-β-D-glucopyranoside and chrysin-7-O-β-D-glucuronide were the highest in flowers. The contents of baicalin, baicalein, wogonoside, wogonin, alpinetin, and oroxylin A were higher in roots than in other parts.Conclusion: The method was fully validated and could be effectively used to characterize the contents and distributions of main flavonoids in the different parts of S. baicalensis. It may lay a foundation to establish the quality evaluation system for Huangqin Tea. | Jie Shen Pei Li Chun-nian He Hai-tao Liu Yan-ze Liu Xiao-bo Sun Rong Xu Pei-gen Xiao | 2019 | Chinese Herbal Medicines2019，11，1： | 11 |
| 16 | Liquid organic hydrogen carriers显示文摘The development of efficient hydrogen storage materials is one of the biggest technical challenges for the coming 'hydrogen economy'. The liquid organic hydrogen carriers(LOHCs) with high hydrogen contents,reversibilities and moderate dehydrogenation kinetics have been considered as an alternative option supplementing the extensively investigated inorganic hydride systems. In this review, LOHCs for long distance H2 transport and for onboard application will be discussed with the focuses of the design and development of LOHCs and their hydrogenation & dehydrogenation catalyses. | Teng He Qijun Pei Ping Chen | 2015 | Journal of Energy Chemistry2015，24，5： | 11 |
| 17 | Risk factors and outcomes of acute kidney injury after intracoronary stent implantation显示文摘BACKGROUND:Acute kidney injury following percutaneous coronary intervention(PCI) is associated with a worse outcome.However,the risk factors and outcomes of acute kidney injury(AKI) in patients after intracoronary stent implantation are still unknown.METHODS:A retrospective case control study was done in 325 patients who underwent intracoronary stent implantation from January 2010 to March 2011 at the Drum Tower Hospital of Nanjing University School of Medicine.Those were excluded from the study if they had incomplete clinical data.The patients were divided into a normal group and a AKI group according to the standard of post-operation day 7 to identify AKI.The parameters of the patients included:1) pre-operative ones:age,gender,hypertension,diabetes mellitus,cerebrovascular disease,left ventricular insufficiency,peripheral angiopathy,creatinine,urea nitrogen,estimated glomerular filtration rate(eGFR),hyperuricemia,proteinuria,emergency operation,hydration,medications(ACEI/ARBs,statins);2) intraoperative ones:dose of contrast media,operative time,hypotension;and 3) postoperative one:hypotension.The parameters were analyzed with univariate analysis and multivariate logistical regression analysis.RESULTS:Of the 325 patients,51(15.7%) developed AKI.Hospital day and in-hospital mortality were increased significantly in the AKI-group.Univariate analysis showed that age,pre-operative parameters(left ventricular insufficiency,peripheral angiopathy,creatinine,urea nitrogen,estimated glomerular filtration rate,hyperuricemia,proteinuria,hydration),emergency operation,intraoperative parameters(operative time,hypotension) and postoperative hypotension were significantly different.However,multivariate logistic regression analysis revealed that increased age(OR=0.253,95%CI=0.088-0.727),pre-operative proteinuria(OR=5.351,95%CI=2.128-13.459),pre-operative left ventricular insufficiency(OR=8.704,95%CI=3.170-23.898),eGFR<60 ml/min/1.73 m^2(OR=6.677,95%CI = 1.167-38.193),prolonged operative time,intraoperative hypotension(OR=25.245,95%CI=1.001-1.034) were independent risk factors of AKI.CONCLUSIONS:AKI is a common complication and associated with ominous outcome following intracoronary stent implantation.Increased age,pre-operative proteinuria,pre-operative left ventricular insufficiency,pre-operative low estimated glomerular filtration rate,prolonged operative time,intraoperative hypotension were the significant risk factors of AKI. | Fei He Jun Zhang Zhong-qiu Lu Qing-ling Gao Du-juan Sha Li-gang Pei Guo-feng Fan | 2012 | World Journal of Emergency Medicine2012，3，3： | 11 |
| 18 | Signaling pathways and targeted therapy for myocardial infarction显示文摘Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts. | Qing Zhang Lu Wang Shiqi Wang Hongxin Cheng Lin Xu Gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 11 |
| 19 | Interpreting the sea surface temperature warming trend in the Yellow Sea and East China Sea显示文摘Previous studies have demonstrated that the low-frequency sea surface temperature(SST) variability in the Yellow Sea and East China Sea(YECS) is linked to large-scale climate variability, but explanations on the mechanisms vary. This study examines the low-frequency variability and trends of some atmospheric and oceanic variables to discuss their different effects on the YECS warming. The increasing temperature trend is also observed at a hydrographic section transecting the Kuroshio.The increasing rate of ocean temperature decreases with depth, which might result in an increase in vertical stratification and a decrease in vertical mixing, and thus plays a positive role on the YECS warming. The surface net heat flux(downward positive)displays a decreasing trend, which is possibly a result of the YECS warming, and, in turn, inhibits it. Wind speeds show different trends in different datasets, such that its role in the YECS warming is uncertain. The trends in wind stress divergence and curl have large uncertainties, so their effects on SST warming are still unclear. The Kuroshio heat transport calculated in this study,displays no significantly increasing trend, so is an unlikely explanation for the SST warming. Limited by sparse ocean observations,sophisticated assimilative climate models are still needed to unravel the mechanisms behind the YECS warming. | PEI YuHua LIU XiaoHui HE HaiLun | 2017 | Science China Earth Sciences2017，60，8： | 10 |
| 20 | Numerical simulation for determining three zones in the goaf at a fully-mechanized coal face显示文摘According to the theory of ventilation network, a model for a filtration flow field in goaf was built and simulation soft- ware for determining the three zones in goaf has been developed. This software uses no-gap-connection between Visual Basic (VB) and Excel to exchange data, uses Component Object Model (COM) component of MATLAB to plot charts of the three zones and to export the corresponding coordinates of the isolines. An example shows that this software is convenient and simple. By using it, the three zones can be easily determined. The software is convenient in studies and analyses of the three zones in goaf. | HE Xiao-gang ZHANG Ren-wei PEI Xiao-dong SUN Yong TONG Bo-gen HUANG Hua-shan | 2008 | Journal of China University of Mining and Technology2008，18，2： | 10 |
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