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| 1 | New technologies to investigate the brain-gut axis显示文摘Functional gastrointestinal disorders are commonly encountered in clinical practice, and pain is their commonest presenting symptom. In addition, patients with these disorders often demonstrate a heightened sensitivity to experimental visceral stimulation, termed visceral pain hypersensitivity that is likely to be important in their pathophysiology. Knowledge of how the brain processes sensory information from visceral structures is still in its infancy. However, our understanding has been propelled by technological imaging advances such as functional Magnetic Resonance Imaging, Positron Emission To-mography, Magnetoencephalography, and Electroen-cephalography (EEG). Numerous human studies have non-invasively demonstrated the complexity involved in functional pain processing, and highlighted a number of subcortical and cortical regions involved. This review will focus on the neurophysiological pathways (primary afferents, spinal and supraspinal transmission), brain- imaging techniques and the influence of endogenous and psychological processes in healthy controls and patients suffering from functional gastrointestinal dis- orders. Special attention will be paid to the newer EEG source analysis techniques. Understanding the pheno- typic differences that determine an individual's response to injurious stimuli could be the key to understanding why some patients develop pain and hyperalgesia in response to inflammation/injury while others do not. For future studies, an integrated approach is required incorporating an individual's psychological, autonomic, neuroendocrine, neurophysiological, and genetic prof ile to def ine phenotypic traits that may be at greater risk of developing sensitised states in response to gut in? am- mation or injury. | Abhishek Sharma Dina Lelic Christina Brock Peter Paine Qasim Aziz | 2009 | World Journal of Gastroenterology2009，15，2： | 15 |
| 2 | Functional brain imaging of gastrointestinal sensation in health and disease显示文摘It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function. More specifi cally, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the (neurobiological) mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective & cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut (brain- gut axis) will be briefky outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorderpatients will be highlighted. | Lukas Van Oudenhove Steven J Coen Qasim Aziz | 2007 | World Journal of Gastroenterology2007，13，25： | 9 |
| 3 | Metabolic investigations in patients with hepatitis B and C显示文摘AIM:To investigate the similarities and dissimilarities in patients with hepatitis B and hepatitis C,clinically and metabolically. METHODS:Fifty patients with hepatitis B virus and hepatitis C virus infection were included in this study, along with fifty healthy controls for comparison purposes.Intravenous blood(10 mL)samples from patients and healthy subjects were collected and made to clot before serum was separated and immediately levels of the enzymes,alkaline phosphatase(ALK),creatinine phosphokinase(CPK),lactate dehydrogenase (LDH),serum glutamate oxaloacetate transaminase(sGOT)and serum glutamate pyruvate transaminase(sGPT)were determined by a kit method.For total con-tent of each metal the serum samples were analyzed using atomic absorption spectrophotometry.Levels of cholesterol,triglycerides,urea,creatinine and uric acid were determined using a kit method on Microlab 300. RESULTS:Serum magnesium and copper levels remained unchanged,whereas the concentration of zinc decreased and iron increased significantly in both groups of patients.Total antioxidant activity was significantly decreased in both hepatitis B and C.Among the enzymes analyzed,ALK,s-GPT,LDH and s-GOT were all significantly increased in both patients with hepatitis B and C whereas CPK was significantly decreased in patients with hepatitis B and remained unchanged in patients with hepatitis C. CONCLUSION:The information accumulated by this study will help provide a better understanding of involved metabolic processes in order to design appropriate therapeutic approaches for treating these patients,so they can recover and lead normal lives. | Abdul Aziz Mastoi Bikha Ram Devrajani Syed Zulfiquar Ali Shah Qasim Rohopoto Sikander Ali Memon Marya Baloch Ghulam Ali Qureshi Waqas Sami | 2010 | World Journal of Gastroenterology2010，16，5： | 2 |
| 4 | Translational aspects of rectal evoked potentials: a comparative study in rats and humans显示文摘 | Thomas Dahl Nissen Christina Brock Carina Graversen Steven J. Coen Leif Hultin Qasim Aziz Jens Lykkesfeldt Asbj?rn Mohr Drewes | 2013 | AJP: Gastrointestinal and Liver Physiology2013，，2： | 1 |
| 5 | Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus显示文摘 | Philip J Matthews Qasim Aziz Paul Facer John B Davis David G Thompson Praveen Anand | 2004 | European Journal of Gastroenterology & Hepatology2004，，9： | 1 |
| 6 | Brain imaging of visceral functions in healthy volunteers and IBS patients显示文摘 | Nora Rapps Lukas van Oudenhove Paul Enck Qasim Aziz | 2008 | Journal of Psychosomatic Research2008，，6： | 1 |
| 7 | Role of vitamin D receptor(VDR) polymorphisms in susceptibility to multiple myeloma in ethnic Kashmiri population显示文摘 | Shafia S Qasim I Aziz SA | 2013 | Blood Cells Mol Dis2013，51，1： | 1 |
| 8 | Modulation of Activity in Swallowing Motor Cortex Following Esophageal Acidification: A Functional Magnetic Resonance Imaging Study显示文摘 | Peter A. Paine Shaheen Hamdy Xavier Chitnis Lloyd J. Gregory Vincent Giampietro Mick Brammer Steve Williams Qasim Aziz | 2008 | Dysphagia2008，，2： | 1 |
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