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| 1 | Structural basis of SARS-CoV-2 3CL^pro and anti-COVID-19 drug discovery from medicinal plants显示文摘The recent pandemic of coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 has raised global health concerns.The viral 3-chymotrypsin-like cysteine protease(3CL^pro)enzyme controls coronavirus replication and is essential for its life cycle.3CL^pro is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV).Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of SARS-CoV.Therefore,herein,we analysed the 3CL^pro sequence,constructed its 3D homology model,and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal compounds.Our analyses revealed that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules for further optimisation and drug development process to combat COVID-19. | Muhammad Tahir ul Qamar Safar MAlqahtani Mubarak AAlamri Ling-Ling Chen | 2020 | Journal of Pharmaceutical Analysis2020，10，4： | 29 |
| 2 | 基于深度学习的裂缝预测在S区潜山碳酸盐岩储层中的应用显示文摘准确描述并预测裂缝空间分布是裂缝型潜山油藏储层开发的前提条件,裂缝型潜山油藏构造复杂、断层发育、地震反射多表现为空白或杂乱反射,传统的依赖模型的反演方法难以表征复杂的潜山断裂系统。为此,提出了以测井裂缝敏感参数FIC c为训练目标的深度信念网络反演方法。首先基于碳酸盐岩裂缝在测井曲线上的响应特征,综合伽马、井径等曲线,构建敏感性裂缝识别参数FIC c;然后以基于优选井计算的FIC c曲线作为训练目标、以井旁地震数据作为训练特征构成训练样本,通过训练深度信念网络,建立井旁地震数据与FIC c曲线之间的非线性映射关系;最后将训练成熟的网络模型应用到整个地震数据体,反演得到裂缝识别参数FIC c,进而预测裂缝空间分布。S区潜山裂缝预测的应用结果表明,测井裂缝识别参数FIC c识别结果与成像测井裂缝识别结果基本吻合,FIC c作为训练目标在S区裂缝预测中具有较好的可靠性;应用深度信念网络反演的解释结果表明S区潜山主要发育北东向裂缝,呈带状沿断层大面积发育,与熵属性刻画的裂缝发育带一致性较好,钻井吻合率达71%。 | 丁燕 杜启振 Qamar Yasin 张强 刘力辉 | 2020 | 石油物探2020，59，2： | 22 |
| 3 | Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains显示文摘Objective:To investigate the antibacterial potential of the polar and non-polar extracts of the seeds of Melia azedarach(M.azedarach) L.(Meliaceae) against eighteen hospital isolated human pathogenic bacterial strains.Methods:Petrol,benzene,ethyl acetate,methanol,and aqueous extracts at five different concentrations(1,2,5,10 and 15 mg/mL) were evaluated.Disk diffusion method was followed to evaluate the antibacterial efficacy.Results:All extracts of the seeds demonstrated significant antibacterial activity against tested pathogens.Among all extracts,ethyl acetate extract revealed the highest inhibition comparatively.The present study also favored the traditional uses reported earlier.Conclusions:Results of this study strongly confirm that the seed extracts of M.azedarach could be effective antibiotics,both in controlling gram-positive and gram-negative human pathogenic infections. | Abdul Viqar Khan Qamar Uddin Ahmed M Ramzan Mir Indu Shukla Athar Ali Khan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 4 | Carbon/carbon supercapacitors显示文摘Supercapacitors, or electrochemical capacitors, are a power storage system applied for harvesting energy and delivering pulses during short periods of time. The commercially available technology is based on charging an electrical double-layer (EDL), and using high surface area carbon electrodes in an organic electrolyte. This review first presents the state-of-the-art on EDL capacitors, with the objective to better understand their operating principles and to improve their performance. In particular, it is shown that capacitance might be enhanced for carbons having subnanometric pores where ions of the electrolyte are distorted and partly desolvated. Then, strategies for using environment friendly aqueous electrolytes are presented. In this case, the capacitance can be enhanced through pseudo-faradaic contributions involving i) surface functional groups on carbons, ii) hydrogen electrosorption, and iii) redox reactions at the electrode/electrolyte interface. The most promising system is based on the use of aqueous alkali sulfate as electrolyte allowing voltages as high as 2 V to be reached, due to the high overpotential for di-hydrogen evolution at the negative electrode. | Elzbieta Frackowiak Qamar Abbas Franois Bguin | 2013 | Journal of Energy Chemistry2013，22，2： | 10 |
| 5 | 多电平变换器PWM控制技术研究现状综述及最新进展显示文摘近年来,多电平变换器成为高压、大功率电力电子系统应用领域的一个研究热点,而多电平脉宽调制PWM(pulse width modulation)控制方法是多电平变换器研究领域的核心问题之一。首先,阐述了3种载波PWM控制方法,并根据不同的控制指标介绍了各类优化载波PWM控制方法;其次,介绍了传统空间矢量脉宽调制SVPWM(space vector pulse width modulation)算法,并根据算法优化及控制指标详细介绍了不同坐标变换下的SVPWM,着重阐述了虚拟SVPWM及在其基础上衍生的各类优化虚拟空间矢量PWM在中点电压平衡控制中的应用;最后,介绍了n电平任意段多电平SVPWM与SPWM之间的本质联系,以及根据其统一性提出的优化PWM算法。 | 朱宏 李永东 王奎 QAMAR Muhammad Attique 徐晓娜 | 2021 | 电源学报2021，19，4： | 8 |
| 6 | Genome editing opens a new era of genetic improvement in polyploid crops显示文摘Sequence-specific nucleases(SSN) that generate double-stranded DNA breaks(DSBs) in genes of interest are the key to site-specific genome editing in plants. Genome editing has developed into one method of reducing undesirable traits in crops by the induction of knockout mutations. Different SSN-mediated genome-editing systems, including LAGLIDADG homing endonucleases or meganucleases, zinc-finger nucleases, transcription activator-like effector nucleases and clustered regularly interspaced short palindromic repeats, are emerging as robust tools for introducing functional mutations in polyploid crops including citrus, wheat, cotton, soybean, rapeseed, potato, grapes, Camelina sativa,dandelion, and tobacco. The approach utilizes knowledge of biological mechanisms for targeted induction of DSBs and their error-prone repair, allowing highly specific changes at designated genome loci. In this review, we briefly describe genome-editing technologies and their application to genetic improvement of polyploid crops. | Qamar U.Zaman Chao Li Hongtao Cheng Qiong Hu | 2019 | The Crop Journal2019，7，2： | 7 |
| 7 | Three Tier Fog Networks: Enabling IoT/5G for Latency Sensitive Applications显示文摘Following the progression in Internet of Things(IoT) and 5G communication networks, the traditional cloud computing model have shifted to fog computing. Fog computing provides mobile computing, network control and storage to the network edges to assist latency critical and computation-intensive applications. Moreover, security features are improved in fog paradigm by processing critical data on edge devices instead of data centres outside the control plane of users. However, fog network deployment imposes many challenges including resource allocation, privacy of users, non-availability of programming model and testing software and support for the heterogenous networks. This article highlights these challenges and their potential solutions in detail. This article also discusses threetier fog network architecture, its standardization and benefits in detail. The proposed resource allocation mechanism for three tier fog networks based on swap matching is described. Results show that by practicing the proposed resource allocation mechanism, maximum throughput with reduced latency is achieved. | Romana Shahzadi Ambreen Niaz Mudassar Ali Muhammad Naeem Joel J.P.C.Rodrigues Farhan Qamar Syed Muhammad Anwar | 2019 | China Communications2019，16，3： | 6 |
| 8 | 单源双能CT成像碘(水)浓度值评估脂肪肝和肝岛血供的价值显示文摘目的:探讨单源双能CT能谱成像的碘(水)浓度值评估脂肪肝和肝岛血供的价值。方法:搜集行能谱CT扫描且诊断为脂肪肝及肝岛的20例患者。由两位放射科医生分别测量同一患者脂肪肝背景和肝岛的平扫及三期增强扫描的混合能量CT值及碘(水)浓度值,计算混合能量CT值及碘(水)浓度值的三期增强率。使用Bland-Altman图、直线回归分析及组内相关系数(ICC)检验两位观察者所测数据的一致性。比较脂肪肝与肝岛平扫、三期增强扫描的混合能量CT值及碘(水)浓度值的差异,比较脂肪肝与肝岛混合能量CT值及碘(水)浓度值三期增强率的差异。结果:两位观察者所测数据的一致性很好(ICC>0.75)。平扫及三期增强扫描中,肝岛的混合能量CT值和碘(水)浓度值均高于脂肪肝背景(P值均<0.001);脂肪肝与肝岛的混合能量CT值三期增强率差异均有统计学意义(P=0.006、P<0.001、P<0.001);脂肪肝与肝岛的碘(水)浓度值三期增强率差异均无统计学意义(P=0.455、P=0.279、P=0.279)。结论:单源双能CT能谱成像碘(水)值增强率评估脂肪肝与肝岛血供更可靠,证实肝岛与脂肪肝血供状态一致,为临床上鉴别肝岛与不典型乏血供肝脏肿瘤提供了相关依据。 | 赵莹 刘爱连 李烨 陈安良 王逸敏 孙美玉 刘义军 徐明哲 Sahrish Qamar | 2017 | 放射学实践2017，32，5： | 5 |
| 9 | 3D Printed Integrated Gradient-Conductive MXene/CNT/Polyimide Aerogel Frames for Electromagnetic Interference Shielding with Ultra-Low Reflection显示文摘Construction of advanced electromagnetic interference(EMI)shielding materials with miniaturized,programmable structure and low reflection are promising but challenging.Herein,an integrated transition-metal carbides/carbon nanotube/polyimide(gradient-conductive MXene/CNT/PI,GCMCP)aerogel frame with hierarchical porous structure and gradient-conductivity has been constructed to achieve EMI shielding with ultra-low reflection.The gradient-conductive structures are obtained by continuous 3D printing of MXene/CNT/poly(amic acid)inks with different CNT contents,where the slightly conductive top layer serves as EM absorption layer and the highly conductive bottom layer as reflection layer.In addition,the hierarchical porous structure could extend the EM dissipation path and dissipate EM by multiple reflections.Consequently,the GCMCP aerogel frames exhibit an excellent average EMI shielding efficiency(68.2 dB)and low reflection(R=0.23).Furthermore,the GCMCP aerogel frames with miniaturized and programmable structures can be used as EMI shielding gaskets and effectively block wireless power transmission,which shows a prosperous application prospect in defense industry and aerospace. | Tiantian Xue Yi Yang Dingyi Yu Qamar Wali Zhenyu Wang Xuesong Cao Wei Fan Tianxi Liu | 2023 | Nano-Micro Letters2023，15，3： | 5 |
| 10 | 基于UHPLC-QTOF-MS/MS技术的骆驼蓬化学成分分析及其神经保护活性显示文摘目的 基于UHPLC-QTOF-MS/MS技术对骆驼蓬Pegannum harmala化学成分进行分析,并探讨其神经保护活性。方法 色谱柱为ACQUITY UPLC BEH C_(18)(100 mm×2.1 mm,1.6μm),流动相为0.1%甲酸水溶液(A)-0.1%甲酸乙腈溶液(B),梯度洗脱;体积流量0.3 mL/min;进样体积2μL;柱温35℃。质谱系统采用电喷雾离子源(ESI),正离子模式下检测。利用过氧化氢(H_(2)O_(2))和6-羟基多巴胺(6-hydroxydopamine,6-OHDA)诱导的PC12细胞氧化损伤模型和脂多糖(lipopolysaccharide,LPS)诱导的BV2细胞神经炎症模型,探讨骆驼蓬全草和种子的甲醇提取物以及去氢骆驼蓬碱、骆驼蓬碱、哈尔满和去甲哈尔满4种骆驼蓬中主要生物碱的神经保护活性。结果 从骆驼蓬中共鉴别32个化学成分,全草中主要含有脱氧鸭嘴花碱、鸭嘴花醇等喹唑酮类生物碱,而种子中主要含有去氢骆驼蓬碱、骆驼蓬碱等β-咔啉类生物碱。骆驼蓬全草、种子甲醇提取物和4种生物碱对LPS刺激诱导BV2细胞一氧化氮(NO)生成具有一定的抑制活性,并对H_(2)O_(2)和6-OHDA诱导的PC12细胞损伤均具有明显的保护作用(P<0.01)。结论 骆驼蓬全草和种子中的生物碱成分存在差异,而且其所含的生物碱类化合物具有一定的神经保护作用,为骆驼蓬的质量控制及药效物质基础研究提供了参考。 | 王宁宁 魏冠华 张智军 房建国 Mohammad Umar Farooq Imtiaz Ahmad Qamar 刘映前 杨志刚 | 2022 | 中草药2022，53，6： | 3 |
| 11 | Antibacterial activity of leaves extracts of Trifolium alexandrinum Linn,against pathogenic bacteria causing tropical diseases显示文摘Objective:To investigate antibacterial potential of Trifolium alexandrinum(T.alexandrinum) Linn,against seven gram positive and eleven gram negative hospital isolated human pathogenic bacterial strains responsible for many tropical diseases.Methods:Non-polar and polar extracts of the leaves of T.alexandrinum i.e.,hexane,dichloromethane(DCM),ethyl acetate(EtOAc), methanol(MeOH) and aqueous(AQ) extracts at five different concentrations(1,2,5,10 and 15 mg/ mL) were prepared to evaluate their antibacterial value.NCCL standards were strictly followed to perform antimicrobial disc susceptibility test using disc diffusion method.Results:Polar extracts demonstrated significant antibacterial activity against tested pathogens.EtOAc and MeOH extracts showed maximum antibacterial activity with higher inhibition zone and were found effective against seventeen of the tested pathogens.While AQ plant extract inhibited the growth of sixteen of the test strains.EtOAc and MeOH plant extracts inhibited the growth of all seven gram positive and ten of the gram negative bacterial strains.Conclusions:The present study strongly confirms the effectiveness of crude leaves extracts against tested human pathogenic bacterial strains causing several tropical diseases.Since Egyptian clover is used as a fodder plant,it could be helpful in controlling various infectious diseases associated with cattle as well. | Abdul Viqar Khan Qamar Uddin Ahmed Indu Shukla Athar Ali Khan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，3： | 3 |
| 12 | Effect of accelerated ageing on the performance of high voltage carbon/carbon electrochemical capacitors in salt aqueous electrolyte显示文摘 | Paula Ratajczak Krzysztof Jurewicz Piotr Skowron Qamar Abbas Francois Béguin | 2014 | Electrochimica Acta2014，，： | 3 |
| 13 | Citrus Pan-Genome to Breeding Database(CPBD):A comprehensive genome database for citrus breeding显示文摘Dear Editor,The genus Citrus comprises more than 30 species worldwide(Swingle,1943).However,citrus genetics and traditional breeding are hindered due to asexual reproduction,long generation time,and empirical utilization of the germplasm.The whole-genome information of different citrus species accelerates the genetic studies and improves the breeding efficiency by high-density markers. | Hanmingzi Liu Xia Wang Shengjun Liu Yue Huang Yi-Xiong Guo Wen-Zhao Xie Hao Liu Muhammad Tahir ul Qamar Qiang Xu Ling-Ling Chen | 2022 | Molecular Plant2022，15，10： | 3 |
| 14 | Effect of gravistimulation on amino acid profile of pea,rice,corn,wheat during early growth stages显示文摘The amino acids are one of the major cellular components of plants,which are involved in different metabolic pathways.In present study,effect of artificial gravistimulation on amino acid profiles of pea,rice,corn,wheat during early growth stages was investigated.One-axis clinostat was used for gravistimulation application,which was applied at embryonic stage.Amino acid profile was measured in 10-days old seedlings of pea,rice,corn and wheat cultivars.The effect of clinostat rotation was also evaluated under salt stress and MS medium supplement.Germinated pea,rice,corn and wheat seedlings were grown under the gravity condition for specific time interval.Corn and wheat seeds showed slowgermination as compared to pea and rice cultivars.The rate of amino acid formation under gravity condition was significantly higher than control(un-treated seedling).The variation in amino acid profile of pea,rice,corn and wheat cultivars vary deferentially.Results revealed that gravistimulation applied through clinostat has positive effect on amino acid profile in plant tissue and future studies should be focused on growth,biochemical,physiological at lateral stages of growth. | Raghad S.Mouhamad Munawar Iqbal MAfzal Qamar Lamiaa A.Mutlag Ibrahim B.Razaq Mazhar Abbas Fida Hussain | 2016 | Information Processing in Agriculture2016，3，4： | 2 |
| 15 | Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats显示文摘 | Abdulrashid Umar Qamar U. Ahmed Bala Y. Muhammad Bashar Bello S. Dogarai Siti Zaiton Bt. Mat Soad | 2010 | Journal of Ethnopharmacology2010，，1： | 2 |
| 16 | Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats显示文摘 | Abdulrashid Umar Qamar U. Ahmed Bala Y. Muhammad Bashar Bello S. Dogarai Siti Zaiton Bt. Mat Soad | 2010 | Journal of Ethnopharmacology2010，，1： | 2 |
| 17 | Synthesis of yttrium and cerium doped ZnO nanoparticles as highly inexpensive and stable photocatalysts for hydrogen evolution显示文摘Yttrium and cerium co-doped ZnO nanoparticles were synthesized by combustion route and characterized using X-ray diffraction(XRD),scanning electron microscopy(SEM),Brunauer-Emmett-Teller(BET),energy dispersive spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS),UV-visible diffuse reflectance spectroscopy(UV-vis DRS),photoluminescence(PL)and electrochemical impedance spectroscopy(EIS)techniques.The introduction of yttrium ions has efficiently increased the relative percentage of Ce^(3+)ions in ZnO.Yttrium and cerium co-doped ZnO shows efficient photo activity for hydrogen evolution(10.61 mmol/((g·h))higher than previously reported optimal value for rare earth codoped ZnO photocatalysts.This remarkably increased hydrogen evolution can be ascribed to the synergy between electronic anchoring effect of Y^(3+)/Y^(2+)and Ce^(4+)/Ce^(3+)redox couples.This report presents new idea for the synthesis of efficient photocatalyst using economical route and ion anchoring effect.The hydrogen evolution was also tested using Na_(2)S and Na_(2)SO_(3)as electron donors under visible light illumination.The synthesized photocatalysts also exhibit high stability. | Irshad Ahmad Muhammad Shoaib Akhtar Mian Faisal Manzoor Muhammad Wajid Muhammad Noman Ejaz Ahmed Mukhtar Ahmad Waheed Qamar Khan Anwar M.Rana | 2021 | Journal of Rare Earths2021，39，4： | 2 |
| 18 | Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases显示文摘Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer’s disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes(e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA-and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging. | Syed Aoun Mehmood Sherazi Asim Abbasi Abdullah Jamil Mohammad Uzair Ayesha Ikram Shanzay Qamar Adediji Ayomide Olamide Muhammad Arshad Peter J.Fried Milos Ljubisavljevic Ran Wang Shahid Bashir | 2023 | Neural Regeneration Research2023，18，5： | 2 |
| 19 | Total phenolic,chromium contents and antioxidant activity of raw and processed sugars显示文摘Processing improves the visual quality of food;however,the ingredient and nutritional values may alter.In present study,the sugar samples(refined,raw,gur(Jaggery/jaggeree)and molasses)were collected from 20 different agro-climatic regions of Pakistan and analyzed for the chromium concentration,total phenolic and antioxidant activity,in order to evaluate the processing effect.The concentration of Cr was determined by digestion method using atomic absorption spectrophotometer,while antioxidant activity was determined by DPPH(1,1-diphenyl-2-picrylhydrazyl)and reducing power.It was observed that chromium content in Jaggery was 74%higher than raw sugar,while molasses showed 21.27%higher concentration versus jaggery.The total phenolic contents were found considerably higher in molasses(3751 lg GAE/g)followed by Jaggery(3285 lg GAE/g),raw sugar(27.75 lg GAE/g)and refined sugar(23.81 lg GAE/g).The DPPH scavenging activity and reducing power was also found dependent to sugar type.Form results,it can be concluded that processing significantly affected the chromium contents,total phenolics and antioxidant activity. | Munawar Iqbal MAfzal Qamar Tanveer H.Bokhari Mazhar Abbas Fida Hussain Nasir Masood Ali Keshavarzi Naseem Qureshih Arif Nazir | 2017 | Information Processing in Agriculture2017，4，1： | 2 |
| 20 | Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2显示文摘Background:Coronavirus disease 2019(COVID-19)linked with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)cause severe illness and life-threatening pneumonia in humans.The current COVID-19 pandemic demands an effective vaccine to acquire protection against the infection.Therefore,the present study was aimed to design a multiepitope-based subunit vaccine(MESV)against COVID-19.Methods:Structural proteins(Surface glycoprotein,Envelope protein,and Membrane glycoprotein)of SARS-CoV-2 are responsible for its prime functions.Sequences of proteins were downloaded from GenBank and several immunoinformatics coupled with computational approaches were employed to forecast B-and T-cell epitopes from the SARS-CoV-2 highly antigenic structural proteins to design an effective MESV.Results:Predicted epitopes suggested high antigenicity,conserveness,substantial interactions with the human leukocyte antigen(HLA)binding alleles,and collective global population coverage of 88.40%.Taken together,276 amino acids long MESV was designed by connecting 3 cytotoxic T lymphocytes(CTL),6 helper T lymphocyte(HTL)and 4 B-cell epitopes with suitable adjuvant and linkers.The MESV construct was non-allergenic,stable,and highly antigenic.Molecular docking showed a stable and high binding affinity of MESV with human pathogenic toll-like receptors-3(TLR3).Furthermore,in silico immune simulation revealed significant immunogenic response of MESV.Finally,MEV codons were optimized for its in silico cloning into the Escherichia coli K-12 system,to ensure its increased expression.Conclusion:The MESV developed in this study is capable of generating immune response against COVID-19.Therefore,if designed MESV further investigated experimentally,it would be an effective vaccine candidate against SARS-CoV-2 to control and prevent COVID-19. | Muhammad Tahir ul Qamar Farah Shahid Sadia Aslam Usman Ali Ashfaq Sidra Aslam Israr Fatima Muhammad Mazhar Fareed Ali Zohaib Ling-Ling Chen | 2020 | Infectious Diseases of Poverty2020，9，5： | 2 |
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