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| 1 | Early precut sphincterotomy and the risk of endoscopic retrograde cholangiopancreatography related complications: An updated meta-analysis显示文摘AIM: To study the cannulation and complication rates of early pre-cut sphincterotomy vs persistent attempts at cannulation by standard approach.METHODS: Systematic search of PubMed, EMBASE, Web of Science, and the Cochrane Library for relevant studies published up to February 2013. The main outcome measurements were cannulation rates and postendoscopic retrograde cholangiopancreatography(ERCP) complications. A comprehensive systematic search of the Cochrane library, PubMed, Google scholar, Scopus, National Institutes of Health, meta-register of controlled trials and published proceedings from major Gastroenterology journals and meetings until February 2013 was conducted using keywords. All Prospective randomized controlled trials(RCT) studies whichmet our inclusion criteria were included in the analysis. Prospective non-randomized studies and retrospective studies were excluded from our meta-analysis. The main outcomes of interest were post-ERCP pancreatitis, overall complication rates including cholangitis, ERCPrelated bleeding, perforation and cannulation success rates. RESULTS: Seven RCTs with a total of 1039 patients were included in the meta-analysis based on selection criteria. The overall cannulation rate was 90% in the pre-cut sphincterotomy vs 86.3% in the persistent attempts group(OR = 1.98; 95%CI: 0.70-5.65). The risk of post-ERCP pancreatitis(PEP) was not different between the two groups(3.9% in the pre-cut sphincterotomy vs 6.1% in the persistent attempts group, OR = 0.58, 95%CI: 0.32-1.05). Similarly, there was no statistically significant difference between the groups for overall complication rate including PEP, cholangitis, bleeding, and perforation(6.2% vs 6.9%, OR = 0.85, 95%CI: 0.51-1.41). CONCLUSION: This meta-analysis suggests that precut sphincterotomy and persistent attempts at cannulation are comparable in terms of overall complication rates. Early pre-cut implementation does not increase PEP complications. | Udayakumar Navaneethan Rajesh Konjeti Preethi GK Venkatesh Madhusudhan R Sanaka Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，5： | 12 |
| 2 | Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP: A single center experience显示文摘AIM: To identify potential factors that can predict adverse short-term outcomes in patients with acute cholangitis undergoing endoscopic retrograde cholangiopancreatography(ERCP). METHODS: Retrospective analysis of consecutive patients admitted to our center for acute cholangitis and underwent ERCP from 2001 to 2012. Involvement of two or more organ systems was termed as organ failure(OF). Cardiovascular failure was defined based on a systolic blood pressure of < 90 mmHg despite fluid replacement and/or requiring vasopressor treatment; respiratory failure if the Pa02 /Fi02 ratio was < 300 mmHg and/or required mechanical ventilation; coagulopathy if the platelet count was < 80; and renal insufficiency if serum creatinine was > 1.9 mg/dL. Variables associated with short term adverse clinical outcomes defined as persistent OF and/or 30-d mortality was determined. RESULTS: A total of 172 patients(median age 62 years, 56.4% female) were included. The median door to ERCP time was 17 h. Bile duct stones were the most common etiology(n = 67, 39.2%). In multivariate analysis, factors that were independently associated with persistent OF and/or 30-d mortality included American Society of Anesthesiology(ASA) physical classification score > 3(OR = 7.70; 95%CI: 2.73-24.40), presence of systemic inflammatory response syndrome(OR = 3.67; 95%CI: 1.34-10.3) and door to ERCP time greater than 72 h(OR = 3.36; 95%CI: 1.12-10.20). Door to ERCP time greater than 72 h was also associated with 70% increase in the mean length of stay(P < 0.001). Every one point increase in the ASA physical classification and every 1 mg/dL increase in the preERCP bilirubin level was associated with a 34% and 2% increase in the mean length of hospital stay, respectively. Transfer status did not impact clinical outcomes. CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergoing ERCP. | Udayakumar Navaneethan Norma G Gutierrez Ramprasad Jegadeesan Preethi GK Venkatesh Madhusudhan R Sanaka John J Vargo Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 3 | Toxicity profile of lutein and lutein ester isolated from marigold flowers( Tagetes erecta)显示文摘 | Harikumar KB Nimita CV Preethi KC Kuttan R Shankaranarayaria ML Deshpande J | 2008 | Int J Toxicol2008，27，1： | 1 |
| 4 | Reprint of “influence of chitosan-PEG binary template on the crystallite characteristics of sol-gel synthesised mesoporous nanotitania photocatalyst”显示文摘 | PREETHI T ABARNA B RAJARAJESWARI G R | 2014 | Applied Surface Science2014，319，： | 1 |
| 5 | Killing of Enteric Bacteria in Drinking Water by a Copper Device for Use in the Home:Laboratory Evidence显示文摘 | Preethi Sudha V B Ojit Singh K Prasad S R | 2009 | Transactions of the Royal Society of Tropical Medicine and Hygiene2009，103，8： | 1 |
| 6 | Apoptosis in epithelial ovarian tumors显示文摘 | Preethi T R Chacko P Kesari A L | 2002 | Pathol Res Pract2002，198，： | 1 |
| 7 | Antitumor activity of Ruta graveolens extract 显示文摘 | Preethi K C Kuttan G Kuttan R | 2006 | Asian Pae J Cancer Prey2006，7，3： | 1 |
| 8 | Antioxidant activity of carotenoid lutein in vitro and in vivo显示文摘 | Sindhu ER Preethi KC Kuttan R | 2010 | Indian J Experimental Biology2010，48，8： | 1 |
| 9 | Human serum albumin binding and eytotoxicity studies of surfactant - cobalt (Ⅲ) complex containing 1,10 -phenanthroline ligand 显示文摘 | SENTHIL K R PAULB PREETHY RIYASDEENB A | 2011 | Colloids Surf B: Biointerfaces2011，86，： | 1 |
| 10 | MLH1 ‐silenced and non‐silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes显示文摘 | Lawrence A Donehower Chad J Creighton Nikolaus Schultz Eve Shinbrot Kyle Chang Preethi H Gunaratne Donna Muzny Chris Sander Stanley R Hamilton Richard A Gibbs David Wheeler | 2012 | J Pathol2012，，1： | 1 |
| 11 | Determinants of ventilator associated pneumonia and its impact on prognosis:A tertiary care experience显示文摘 | Saravu K Preethi V Kumar R | 2013 | Indian J Crit Care Med2013，17，6： | 1 |
| 12 | Endoscopic ultrasound in the diagnosis of cholangiocarcinoma as the etiology of biliary strictures:a systematic review and meta-analysis显示文摘Background and aim:Extrahepatic cholangiocarcinoma(CCA)typically presents as biliary strictures.Endoscopic ultrasound(EUS)-fine needle aspiration(FNA)may contribute to the diagnosis of CCA as the etiology of extrahepatic biliary strictures.Our aim was to study the uselfulness of EUS-FNA in diagnosing CCA as the etiology of biliary strictures.Patients and methods:In this meta-analysis,PUBMED and EMBASE databases were examined to find studies published to April 2014 where diagnostic correlation of CCA was available.Studies reporting only‘‘positive for malignancy’’were included in our analysis.The main outcome measurements were sensitivity,specificity and likelihood ratio.Results:Six studies were included,covering 196 patients.The overall pooled sensitivity and negative likelihood ratio(LR-)of EUS-FNA for diagnosis of CCA were 66%[95%confidence interval(CI)57-74%]and 0.34(95%CI 0.26-0.43),respectively.In five studies(146 patients),where a mass lesion was detected during EUS,the pooled sensitivity and LR-of EUS-FNA for diagnosis of CCA were 80%[95%CI 72-87%]and 0.20(95%CI 0.13-0.28),respectively.In the 49 patients with a negative brush cytology,the pooled sensitivity and LR-of EUS-FNA for diagnosis of CCA were 59%[95%CI 44-73%]and 0.41(95%CI 0.27-0.56),respectively.Conclusions:Our study suggests that EUS-FNA is useful in the evaluation of CCA as the etiology of biliary strictures.EUS-FNA may improve the diagnosis of CCA in patients with negative cytology and no mass on cross-sectional imaging. | Udayakumar Navaneethan Basile Njei Preethi G.K Venkatesh Vennisvasanth Lourdusamy Madhusudhan R Sanaka | 2015 | Gastroenterology Report2015，3，3： | 1 |
| 13 | Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of calendula officinalis L flowers显示文摘 | Preethi KG Siveen KS Kuttan R | | 0，，： | 1 |
| 14 | Antioxidant activity of carotenoid lutein in vitro and in vivo显示文摘 | Sindhu ER Preethi KC Kuttan R | 2010 | Indian J Exp Biol2010，48，8： | 1 |
| 15 | L-DOPA and total phenolic stimulation in dark germinated lava bean in response to pep- tide and phytochemical elicitors 显示文摘 | Reena R Preethi S Kalidas S | 2002 | Process Biochemistry2002，37，： | 1 |
| 16 | Determinants of ventilator associated pneumonia and its impact on prognosis:a tertiary care experience显示文摘 | Saravu K Preethi V Kumar R | 2013 | Indian J Crit Care Med2013，17，6： | 1 |
| 17 | Apoptosis in epithelial ovarian tumors显示文摘 | Preethi T R Chacko P Kesari A L | 2002 | Pathol Res Pract2002，198，： | 1 |
| 18 | Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species 显示文摘 | Michael W R Preethi R Beth A N | 2004 | Genome Biol2004，5，10： | 1 |
| 19 | Loop-Mediated Isothermal Amplification Compared to RealTime PCR and Enzyme Immunoassay for Toxigenic Clostridium difficile Detection显示文摘 | Bobby L Boyanton Jr Preethi Sural Caroline R Loomis | 2012 | Journal of Clinical Microbiology2012，50，3： | 1 |
| 20 | Bile proteomics for differentiation of malignant from benign biliary strictures:a pilot study显示文摘Background:Determining the etiology of biliary strictures is challenging,and the sensitivities of the current tests to diagnose them are low.Protein biomarkers in bile,in combination with other tests,may improve sensitivity in diagnosing biliary strictures.Objective:To analyse the differential abundance of proteins in benign and malignant biliary strictures through proteomic analysis of bile.Methods:In this prospective,cross-sectional study,bile was aspirated in 24 patients undergoing endoscopic retrograde cholangiopancreatography(ERCP)including six patients with primary sclerosing cholangitis(PSC),three with cholangiocarcinoma(CCA),ten with pancreatic cancer,and five with benign biliary conditions.Liquid chromatography/mass spectrometry was used to examine the bile for differential abundance of protein biomarkers.The relative abundance of various proteins was compared in the malignant vs.benign groups and in CCA vs.PSC.Results:The majority of the proteins identified in bile were similar to those of the plasma(plasma proteins)and certain proteins were differentially expressed among the different groups(CCA,pancreatic cancer,PSC or benign).A total of 18 proteins were identified as being more abundant in the malignant group(CCA and pancreatic cancer)than in the benign strictures group,including myeloperoxidase,complement C3,inter-alpha-trypsin inhibitor heavy chain H4,apolipoprotein B-100,and kininogen-1 isoform 2.A total of 30 proteins were identified to be less abundant in the malignant group than in the benign group,including trefoil factor 2,superoxide dismutase[Cu-Zn],kallikrein-1,carboxypeptidase B and trefoil factor 1.Conclusions:Protein biomarkers in bile may differentiate malignant from benign biliary strictures.Larger studies are warranted to validate these observations. | Udayakumar Navaneethan Vennisvasanth Lourdusamy Preethi GK Venkatesh Belinda Willard Madhusudhan R Sanaka Mansour A Parsi | 2015 | Gastroenterology Report2015，3，2： | 0 |
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