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| 1 | Significance of serum carcinoembryonic antigen in metastatic breast cancer patients:A prospective study显示文摘BACKGROUND Carcinoembryonic antigen(CEA)is an important serum tumour marker with a substantial role in diagnosis and monitoring of various solid tumours.About 36%-70%of breast cancers have elevated serum CEA.And the available studies show discrepancy in addressing the prognostic significance of CEA in advanced breast cancer.AIM To estimate the serum CEA level in our metastatic breast cancer patients and correlate it with response to treatment and clinical outcome.METHODS This was a prospective clinical study conducted on 50 metastatic breast cancer patients treated at breast clinic,with newly diagnosed metastatic breast cancer planned for palliative chemotherapy,targeted therapy,and hormonal treatment.We estimated the proportion of patients with elevated serum CEA level at baseline and after palliative treatment and also studied the association of serum CEA levels with known prognostic factors.The response to treatment was correlated with the serum CEA levels in the context of responders and nonresponders.RESULTS The median pre-treatment and post-treatment CEA levels were 7.9(1.8-40.7)ng/mL and 4.39(1.4-12.15)ng/mL,respectively,in the whole study population(P=0.032).No statistically significant difference was seen in baseline serum CEA between responders and non-responders.Even in the luminal group,pretreatment serum CEA was not a predictor of response,but post-treatment CEA was a significant predictor of tumour progression.In patients with liver and lung metastases,post-treatment CEA level difference was not statistically significant in both responders and non-responders though the values were higher in nonresponders.Among those with bone metastases,69.5%had elevated post-treatment serum CEA,and only 37.5%had elevated serum CEA in those with no bone metastases.CONCLUSION Elevated post-treatment serum CEA levels are associated with disease progression and poor response to therapy.Persistently elevated post-treatment serum CEA levels are significantly associated with bone metastases.Elevated serum CEA and hormonal status are significant predictors of treatment response. | Thattungal Manoharan Anoop Rona Joseph P Saikumar Soman Steffi Chacko Mintu Mathew | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 2 | Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer显示文摘 | Chacko P Rajan B Joseph T | 2005 | Breast Cancer Research and Treatment2005，89，1： | 1 |
| 3 | Polymorphisms in DNA repair gene XRCC 1 and increased genetic susceptibility to breast cancer显示文摘 | Chacko P Rajan B Joseph T | 2005 | Breast Cancer Res Treat2005，89，1： | 1 |
| 4 | Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children显示文摘 | Joseph T Kusumakumary P Chacko P | 2004 | Pediatr Blood Cancer2004，43，5： | 1 |
| 5 | Development of technologies aiding large-tissue engineering显示文摘 | Eiselt P Kim BS Chacko B | 1998 | Biotechnol Prog1998，14，1： | 1 |
| 6 | Medical tourism in India: issues and challenges 显示文摘 | Chacko P | 2006 | MBA Review ICFAI University Press2006，4，12： | 1 |
| 7 | Apoptosis in epithelial ovarian tumors显示文摘 | Preethi T R Chacko P Kesari A L | 2002 | Pathol Res Pract2002，198，： | 1 |
| 8 | 'Dorgan's' percutaneous lateral cross-wiring of supracondylar fractures of the humerus in children显示文摘 | Shannon F J Mohan P Chacko J | 2004 | J Pediatr Qr- thop2004，24，4： | 1 |
| 9 | Beneficial effects of green tea: a literature review显示文摘 | Chacko S M Thambi P T Kuttan R | 2010 | Chinese Medicine2010，5，13： | 1 |
| 10 | Syringomyelia in sponta neous intracranial hypotension Case report 显示文摘 | Sharma P Sharma A Chacko AG | 2001 | Neurosurg2001，95，5： | 1 |
| 11 | Dynamical behavior of polyethylenes and model composites显示文摘 | Chacko V P Karasz F E Farris R J | 1982 | Polym Eng Sci1982，22，15： | 1 |
| 12 | Further evaluation of the Re - Os geochronometer in organic rich sedimentary rocks:A test of hydrocarbon maturation effects in the Exshaw Formation, Western Canada Sedimentary Basin显示文摘 | Creaser R A Sannigrahi P Chacko T | 2002 | Geochimicaet Cosmochimica Aeta2002，66，： | 1 |
| 13 | Prevalence of helicobacter pylori infection in children with recurrent abdominal pain显示文摘 | Mukerjee P Chacko B Singh T | 2005 | Trop Gastroentrol2005，26，2： | 1 |
| 14 | Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer显示文摘 | Chacko P Rajan B Joseph T | 2005 | Breast Cancer Res Treat2005，89，1： | 1 |
| 15 | Electrospun mesoporous metal oxide fibers显示文摘 | Macias M Chacko A Ferraris J P | 2005 | Microporous and Mesoporous Materials2005，86，13： | 1 |
| 16 | Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer显示文摘 | Chacko P Rajan B Joseph T | 2005 | Breast Cancer Res Treat2005，89，1： | 1 |
| 17 | Long term follow up of nasolacrimal intubation in adults显示文摘 | Connell P P Fulcher T P Chacko E | 2006 | Br J Ophthalomol2006，90，4： | 1 |
| 18 | Expression of folate receptors and heterogeneous nuclear ribonueleopro- tein el in women with human papillomavirus mediated transformation of cervical tissue to cancer 显示文摘 | Pillai MR Chacko P Kesari LA | 2003 | J Clin Patho12003，56，8： | 1 |
| 19 | Uniplanar UWB antenna for diversity applications显示文摘 | CHACKO B P AUGUSTIN G | 2012 | IEEE Antenna Propagation Soc Int Symp2012，，7： | 1 |
| 20 | Role of CYP17 and SULT1A1 gene polymorphisms in breast cancer显示文摘 | Rajan B Chacko P Pillai M | 2004 | European Journal of Cancer Supplements2004，2，： | 1 |
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