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| 1 | Analyses of Lattice Traffic Flow Model on a Gradient Highway显示文摘The optimal current difference lattice hydrodynamic model is extended to investigate the traffic flow dynamics on a unidirectional single lane gradient highway. The effect of slope on uphill/downhill highway is examined through linear stability analysis and shown that the slope significantly affects the stability region on the phase diagram.Using nonlinear stability analysis, the Burgers, Korteweg-deVries(KdV) and modified Korteweg-deVries(mKdV) equations are derived in stable, metastable and unstable region, respectively. The effect of reaction coefficient is examined and concluded that it plays an important role in suppressing the traffic jams on a gradient highway. The theoretical findings have been verified through numerical simulation which confirm that the slope on a gradient highway significantly influence the traffic dynamics and traffic jam can be suppressed efficiently by considering the optimal current difference effect in the new lattice model. | Arvind Kumar Gupta Sapna Sharma Poonam Redhu | 2014 | Communications in Theoretical Physics2014，61，9： | 5 |
| 2 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 3 | Evaluation of the rela-tive efficacy of an alloplast used alone and in conjunction with an os-teoclast inhibitor in the treatment of human periodontal infrabony de-fects :a clinical and radiological study 显示文摘 | Jyoti Gupta Amarjit Singh Gill Poonam Sikri | 2011 | Original Research2011，22，2： | 1 |
| 4 | Rotenone-induced apoptosis and role of calcium: a study on Neuro-2a cells显示文摘 | Supriya Swarnkar Poonam Goswami Pradeep Kamat Sonam Gupta Ishan Patro Sarika Singh Chandishwar Nath | 2012 | Archives of Toxicology2012，，： | 1 |
| 5 | Effects of couple ,stresses on the flow through a porous medium with variable permeability in slip flow regime显示文摘 | Khandelwal K Anti Gupta Poonam Jain N C | 2003 | Ganita2003，54，2： | 1 |
| 6 | Foreign Banks in Poor Countries: Theory and Evidence 显示文摘 | Enrica Detragiache Thierry Tressel Poonam Gupta | 2008 | The Journal of Finance2008，，5： | 1 |
| 7 | Jamming transition of a two-dimensional traffic dynamics with consideration of optimal current difference显示文摘 | Arvind Kumar Gupta Poonam Redhu | 2013 | Physics Letters A (-)2013，，34： | 1 |
| 8 | Physio-chemical properties of banana fiber显示文摘 | Poonam Bhatia Gupta K C | 1991 | India Textile Journal1991，，10： | 1 |
| 9 | Heat capacity and phonon dispersion in poly(L-methionine)显示文摘 | Poonam Tandon Gupta V D Prasad O | 1997 | Journal of Polymer Science:Part B:Polymer Physics1997，35，14： | 1 |
| 10 | Efficacy of three doses of Ketamine with Bupivacaine for caudal analgesia in pediatric inguinal herniotomy显示文摘 | Neelambary Panjabi Smita Prakash Poonam Gupta | 2013 | Regional Anesthesia and Pain Medicine2013，29，1： | 1 |
| 11 | Co-inoculation of indigenous Pseudomonas oryzihabitans and Bradyrhizobium sp.modulates the growth,symbiotic efficacy,nutrient acquisition,and grain yield of soybean显示文摘Soil microbes play a vital role in improving plant growth,crop productivity,and soil health through solubilization of essential nutrients.Present investigation was conducted to access the efficacy of Bradyrhizobium sp.LSBR-3 and the indigenous phosphate-solubilizing Pseudomonas oryzihabitans LSE-3 in improving the symbiosis,nutrient accumulation,and yield of soybean.The isolate LSE-3,selected on the basis of phosphate solubilization,was screened for beneficial traits,antagonistic activities,and pathogenicity.The levels of indole acetic acid production(50.34±2.35μg mL^(-1)),phosphate solubilization(184.4±7.4 mg L^(-1)),biofilm formation(optical density at 560 mm,1.3896±0.04),siderophore production(121.46±1.61μg mL^(-1)),and 1-aminocyclopropane-1-carboxylate deaminase activity(0.51±0.07 mmolα-ketobutyrateμg^(-1) protein h^(-1))were significantly higher with the dual inoculants(LSBR-3 and LSE-3)than with the single inoculant LSBR-3.The plant growth-promoting traits of single and dual inoculants were evaluated for the synergistic effects on soybean under field conditions.Soybean plots treated with LSBR-3+LSE-3 exhibited improvement in seed germination,plant height,plant biomass,and chlorophyll content compared with the uninoculated control.Dual inoculant treatments resulted in significantly higher symbiotic efficacy evidenced by increased nodulation(40.0±0.75 plant^(-1)),nodule biomass(188.52±6.29 mg plant^(-1)),and leghemoglobin content(11.02±0.83 mg g^(-1) fresh nodule),and significantly increased activities of phosphatase(75.16±3.17 and 58.77±6.08μg p-nitrophenol g^(-1) h^(-1) for alkaline and acid phosphatase,respectively)and dehydrogenase(32.66±1.92μg triphenylformazan g^(-1) h^(-1))compared with the control.Dual inoculation with LSBR-3 and LSE-3 enhanced the uptake of macro-and micronutrients,reduced Na content in shoots,and resulted in 10.85%higher grain yield and ca.US$96.80 ha^(-1) higher profit compared with the control.This is the first report on the effectiveness of combined inoculation of LSE-3 and LSBR-3 in promoting the growth,symbiotic efficacy,and yield of soybean for sustainable agriculture. | Kailash Chand KUMAWAT Inderjeet SINGH Sharon NAGPAL Poonam SHARMA Rajeev Kumar GUPTA Asmita SIRARI | 2022 | Pedosphere2022，32，3： | 0 |
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