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| 1 | Performance of liver stiffness measurements by transient elastography in chronic hepatitis显示文摘AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published meta-analysis.METHODS:This was a single center cross-sectional study.Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled.TE was carried out by using FibroScan(Echosens,Paris,France).Liver biopsy was performed on the same day as TE,as day case procedure.Fibrosis was staged according to the Metavir scoring system.The diagnostic performance of TE was assessed by using receiver operating characteristic(ROC) curves and the area under the ROC curve analysis.RESULTS:Two hundred and fifty-two patients met the inclusion criteria.Six(2%) patients were excluded due to unreliable TE measurements.Thus,246(171 men and 75 women) patients were analyzed.One hundred and ninety-five(79.3%) patients had chronic hepatitis C,41(16.7%) had chronic hepatitis B,and 10(4.0%) were coinfected with human immunodeficiency virus.ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa forF ≥ 2;7.9 kPa forF ≥ 3;9.6 kPa for F = 4 in all patients(n = 246),and as high as 6.9 kPa for F ≥ 2;7.3 kPa for F ≥ 3;9.3 kPa for F = 4 in patients with hepatitis C(n = 195).Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2;9.6 kPa for F ≥ 3;12.2 kPa for F = 4 in all patients(n = 246),and as high as 7.0 kPa forF ≥ 2;9.3 kPa forF ≥ 3;12.3 kPa forF = 4 in patients with hepatitis C(n = 195).CONCLUSION:The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies. | Giovanna Ferraioli Carmine Tinelli Barbara Dal Bello Mabel Zicchetti Raffaella Lissandrin Gaetano Filice Carlo Filice Elisabetta Above Giorgio Barbarini Enrico Brunetti Willy Calderon Marta Di Gregorio Roberto Gulminetti Paolo Lanzarini Serena Ludovisi Laura Maiocchi Antonello Malfitano Giuseppe Michelone Lorenzo Minoli Mario Mondelli Stefano Novati Savino FA Patruno Alessandro Perretti Gianluigi Poma Paolo Sacchi Domenico Zanaboni Marco Zaramella | 2013 | World Journal of Gastroenterology2013，19，1： | 18 |
| 2 | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients显示文摘The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant.However,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense debate.The start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body.This variability seems to be correlated with the presence of genetic polymorphisms.Genotyping is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given gene.However,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that medication.At present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of tacrolimus.However,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and toxicity.For these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing. | Alessio Provenzani Andrew Santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra Provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 3 | Determinant-Based Classification of Acute Pancreatitis Severity: An International Multidisciplinary Consultation显示文摘 | E. Patchen Dellinger Christopher E. Forsmark Peter Layer Philippe Lévy Enrique Maraví-Poma Maxim S. Petrov Tooru Shimosegawa Ajith K. Siriwardena Generoso Uomo David C. Whitcomb John A. Windsor | 2012 | Annals of Surgery2012，，6： | 7 |
| 4 | Development of an analytical method based on solid-phase extraction and LC-MS/MS for the monitoring of current-use pesticides and their metabolites in human urine显示文摘Pyrethroids,organophosphorus pesticides and fipronil have been listed as priority chemicals in human biomonitoring studies because of their wide use and potential health effects in humans.The determination of 13 pesticides,including pyrethroids(deltamethrin,cypermethrin,permethrin,cyfluthrin,bifenthrin),organophosphorus(chlorpyrifos,chlorpyrifosmethyl,and malathion),fipronil,neonicotinoids(imidacloprid,acetamiprid and thiacloprid)and triazole(prothioconazole),together with 13 corresponding metabolites in human urine samples was achieved by solid-phase extraction and analysis by liquid chromatography coupled to tandem mass spectrometry.All targeted compounds,except malathion dicarboxylic acid,were measured with a mean within-accuracy(n=5)of 71%–114%(RSD:1%–14%)and between-run(n=15)accuracy of 80%–118%(RSD:2%–14%).Limits of quantitation of the targeted analytes ranged from 0.1 to 16 pg/m L.The detection result of urine samples from 25 volunteers indicated that the detection frequencies of 3,5,6-trichloro-2-pyridinol(median:448 pg/m L),6-chloropyridine-3-carboxylic acid(median:193 pg/m L),2-methyl-3-phenylbenzoic acid(median:181 pg/m L),3-phenoxybenzoic acid(median:99 pg/m L),2-isopropyl-6-methyl-4-pyrimidinol(median:77 pg/m L),cyfluthrin(median:59 pg/m L),cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid(cis-DCCA,median:53 pg/m L),trans-DCCA(median:25 pg/m L),prothioconazole(median:21 pg/m L),imidacloprid(median:7 pg/m L),and prothioconazole-desthio(median:1 pg/m L)were>50%.The obtained results show that the validated method is suitable for the human biomonitoring of these currentuse pesticides and their metabolites. | Beibei Gao Giulia Poma Govindan Malarvannan Catalina Dumitrascu Michiel Bastiaensen Minghua Wang Adrian Covaci | 2022 | Journal of Environmental Sciences2022，34，1： | 3 |
| 5 | Multifactorial nature of hepatocellular carcinoma drug resistance: Could plant polyphenols be helpful?显示文摘主要肝细胞癌(HCC ) 是导致高死亡并且最经常展出差的回答介绍药治疗的一个相当经常的肿瘤。清楚地,这恶意的生物的底的彻底的理解可能为它的治疗建议新策略。这里,我们检验证据两“药理学”机制(例如药 transporter 或 detoxification 酶在表示上) 并且在另外的关键因素的改变,包括国际机场(Apoptosis 蛋白质禁止) ,在房间幸存和增长的改进包含了可以决定 HCC 的治疗学的抵抗;我们也在抄写因素的激活的过程加重可能的角色,象 NF-kappaB 一样,能够同时起来调整讨论的机制。在这个基础上,我们最后评论象植物多酚一样的自然多指向的 antitumoral 代理人的可能的使用在 HCC 完成促进感受性到处理。 | Natale D'Alessandro Paola Poma Giuseppe Montalto | 2007 | World Journal of Gastroenterology2007，13，14： | 3 |
| 6 | Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: A case report and a review of literature显示文摘肾的房间癌(RCC ) 是最普通的肾的肿瘤,为所有恶意的 2%-3% 的财务。尽管 RCC 被知道造血地传播,到胃的孤立的 RCC 转移是一个稀罕事件。在这篇文章,我们描述 RCC 的胃的复发 10 年以前与切除术和 interleukin-2 (IL-2 ) 对待的以后开发了 RCC 和 1 年的胰腺的复发的一个病人的临床的功课。积累的证据显示胰和胃的那变形参与应该与 RCC 的历史在任何病人被怀疑在 RCC 切除术和免疫疗法以后与胃肠的症状介绍甚至 10 年。 | Chiara Riviello Ilaria Tanini Greta Cipriani Pietro Pantaleo Carlo Nozzoli Alberto Poma Viligiardi Riccardo Andrea Valeri | 2006 | World Journal of Gastroenterology2006，12，32： | 2 |
| 7 | Isoprene and its degradation products as strong ozone precursors in Insubria, Northern Italy显示文摘 | M Duane B Poma D Rembges C Astorga B.R Larsen | 2002 | Atmospheric Environment2002，，24： | 2 |
| 8 | Accumulation of Pb and Zn in Bidens triplinervia and Senecio sp. spontaneous species from mine spoils in Peru and their potential use in phytoremediation显示文摘 | Jaume Bech Paola Duran Núria Roca Wilfredo Poma Isidoro Sánchez Luis Roca-Pérez Rafael Boluda Juan Barceló Charlotte Poschenrieder | 2012 | Journal of Geochemical Exploration2012，，： | 2 |
| 9 | Effects of obsterician characteristics on cesarean delivery rates:A community hospital experience显示文摘 | Pedro A Poma MD | 1999 | Am J Obstet Gynecol1999，180，6： | 1 |
| 10 | Curcumin as a possi- ble lead compound against hormone-independent multidrug-resistant breast cancer显示文摘 | Labbozzetta M Notarbartolo M Poma P | 2009 | Ann N Y Acad Sci2009，1155，： | 1 |
| 11 | Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin显示文摘 | Poma A Marcozzi G Cesare P | 1999 | Biochim Biophys Acta1999，1472，12： | 1 |
| 12 | Differential response of human melanoma and Ehrlich ascites cells in vitro to the ribosome-inactivating protein luffin显示文摘 | Poma A Miranda M Spano L | 1998 | Melanoma Res1998，8，5： | 1 |
| 13 | The spleen pigment cells in some amphibian显示文摘 | Scalia M Di Pietro C Poma M | | 0，，02： | 1 |
| 14 | Erythropoietin therapy and prooperative autologous blood donation in children显示文摘 | Sonzogni V Crupi G Poma R | 2001 | Br J Anaesth2001，87，3： | 1 |
| 15 | Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin显示文摘 | Poma A Marcozzi G Cesare P | 1999 | Biochim Biophys Acta1999，1472，12： | 1 |
| 16 | Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression显示文摘 | Notarbartolo M Poma P Perri D | 2005 | Cancer Lett2005，224，1： | 1 |
| 17 | Kininergic system and arterial hypertension following chronic exposure to inorganic lead显示文摘 | Boscolo P Poma A | 1999 | Immunpharmacology1999，44，12： | 1 |
| 18 | Toxicogenomics to improve comprehension of the mechanisms underlying responses of in vitro and in vivo systems to nanomaterials: a review显示文摘 | Poma A Giorgio ML | 2008 | Curr Genomics2008，9，8： | 1 |
| 19 | Differential response of human melanoma and Ehrlich ascites cells in vitro to the ribosome-inactivating protein luffin显示文摘 | Poma A Miranda M Spano L | 1998 | Melanoma Res1998，8，5： | 1 |
| 20 | Anti-tumor ef- fects of the novel NF-KB inhibitor dehydroxyme-thyl-e- poxyquinomicin on human hepatic cancer cells: Analysis of synergy with cisplatin and of possible correlation with inhibition of pro-survival genes and IL-6 production 显示文摘 | Poma P Notarbartolo M Labboz M | 2006 | Int J Onco12006，28，4： | 1 |
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