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| 1 | Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape显示文摘在 2006,鈥渨a ll 沿限制了区分的房间的试验性的变换进 pluripotent 状态的鈥 ? 下来。在一份里程碑报告, Shinya Yamanaka 的组描述了那抄写因素(Oct4, Sox2, Klf4 和 c-Myc ) 的一把能在一些星期的功课上变换一个区分的房间回到 pluripotency,这样 reprograming 他们进导致的 pluripotent 茎(iPS ) 房间。 iPS 房间的出生在研究人员之中启动了匆忙增加 reprogramming 过程的效率,到揭示内在的机械学的事件,并且允许病人特定、疾病特定的人的 iPS 房间的产生,它有潜力为代替治疗并且疾病建模被变换成相关专业化房间类型。这评论探讨涉及在 reprogramming 期间重设 epigenetic 风景的步。显然,定义事件发生在 reprogramming 过程的功课期间。在 reprogramming 因素的表示之上,立即,一些房间开始更快划分并且开始快速与体的基因的柔韧的 downregulation 失去他们的区分的房间特征。仅仅细胞的一个子集继续胚胎的表示节目到 upregulate,并且最后, pluripotency 基因是建立胚胎的茎的 upregulated 有 pluripotent 能力的像房间的 transcriptome 和 epigenome。到 pluripotency 的理解 reprogramming 将通知机械学的研究系切换,在哪个从一个系的区分的房间能是直接 reprogrammed 进没有通过 pluripotent 中介的另外一个。 | Bemadett Papp Kathrin Plath | 2011 | Cell Research2011，21，3： | 9 |
| 2 | Revisiting the thermal ageing on the metallised polypropylene film capacitor:from device to dielectric film显示文摘Metallised polypropylene film capacitors(MPPFCs)are widely used in power electronics and are generally degraded by elevated temperatures.This work aims to determine the relationships between the structural changes of MPPFC and the microstructural variations of the PP film during the thermal ageing of MPPFC at 100℃ for 38 days.The capacitance of MPPFC has a slight decrease during thermal ageing.However,the breakdown voltage of the MPPFC decreases by 39.4%by the ageing.The partial discharge(PD)number of MPPFC increases linearly with ageing time.The tear-down analysis of the MPPFC reveals that the molecular structure of the PP film has not been altered but has led to molecular chain scission and the generation of some polar fragments/groups.Meanwhile,the relative permittivity of the PP films rises as the ageing time increases.Moreover,thermal ageing causes the conversion of aluminum to alumina in the metallised electrode,which is hydrophilic for polar groups and leads to an adhesion effect between the metallised electrodes and the PP film.Contact angle measurements prove that the surface hydrophilicity of the PP sample increased after thermal ageing.Therefore,the PD/breakdown voltage in the MPPFC increases/decreases due to the uneven adhesion of the metallised PP film. | Yushuang He Feipeng Wang Guoqiang Du Lei Pan Kaizheng Wang Reimund Gerhard Ronald Plath Pawel Rozga Pavel Trnka | 2023 | High Voltage2023，8，2： | 2 |
| 3 | Expression of transforming growth factors alpha and beta-1 messenger RNA in the bovine mammary gland during different stages of development and lactation 显示文摘 | Plath A Einspanier R Peters F | 1997 | J Endocrinol1997，155，： | 1 |
| 4 | Loosening pattern in a cementless custom-made hip stem:X-ray analysis,finiteelements and photoelasticity measurements显示文摘 | Plath J Schuhr T Fethke K | 2000 | Arch Orthop Trauma Surg2000，120，1： | 1 |
| 5 | Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution显示文摘 | Nimet Maherali Rupa Sridharan Wei Xie Jochen Utikal Sarah Eminli Katrin Arnold Matthias Stadtfeld Robin Yachechko Jason Tchieu Rudolf Jaenisch Kathrin Plath Konrad Hochedlinger | 2007 | Cell Stem Cell2007，，1： | 1 |
| 6 | Role of histone H3 lysine 27 methylation in X inactivation 显示文摘 | PLATH K FANG J MLYNARCZYK - EVANS S K | 2003 | Science2003，300，5616： | 1 |
| 7 | Role of histone H3 lysine 27 methylation in X inactivation显示文摘 | PLATH K FANG J MLYNARCZYK-EVANS S K | 2003 | Science2003，300，5616： | 1 |
| 8 | The three sorCS genes are differentially expressed and regulated by synaptic activity显示文摘 | Hermey G Plath N Hubner C A | 2004 | J Neuro- chem2004，88，6： | 1 |
| 9 | Post-Translational Reg-ulation of Oct4Transcriptional显示文摘 | Saxe J P Tomilin A Plath K | 2009 | Activit PLoS ONE2009，4，2： | 1 |
| 10 | Regulation of mediator secretionin human basophils by p38 mitogen-activated protein kinase:phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization显示文摘 | Gibbs BF Plath KE Wolff HH | | 0，，2： | 1 |
| 11 | De novo expression of vascular endothelial growth factor and its receptors in human pancreatic cancer: Evidence for a novel autocrine mitogenic loop显示文摘 | Zofia Marschall Thorten Cramer Michael Hoecker Rahel Burde Thomas Plath Michael Schirner Regina Heindenreich Georg Breier Ernst-Otto Riecken Bertram Wiedenmann Stefan Rosewicz | 2000 | Gastroenterology2000，，： | 1 |
| 12 | Endoscopic laser surgery versus serial aminocenteses in the treatment of severe twin-twin transfusion syndrome显示文摘 | Plath H Bregenzer T | 1999 | Am J Obstet Gynecol1999，180，31： | 1 |
| 13 | Developmental regulation of Suz 12 localization显示文摘 | de la Cruz CC Fang J Plath K | | 0，，03： | 1 |
| 14 | Pluripoteney re-centered around Esrrb 显示文摘 | Papp B Plath K | 2012 | EMBO J2012，22，31： | 1 |
| 15 | Friction torque of a rotary shaft lip type seal-a comparison between test results and finite element simulation显示文摘 | Plath S Meyer S Wollesen V M | 2005 | Mechanika2005，4，54： | 1 |
| 16 | A novel function for the tumor suppressor p16(INK4a) : induction of anoikis via upregulation of the alpha (5) beta( 1 ) fibronectin receptor显示文摘 | Plath T Detjen K Welzel M | 2000 | J Cell Biol2000，150，6： | 1 |
| 17 | Role of histone H3 lysine 27 methylation in X inactivation 显示文摘 | Plath K Fang J Mlynarczyk-Evans SK | 2003 | Science2003，300，5616： | 1 |
| 18 | Communication,social capital and workplace health management as determinants of the innova tive climate in German banks显示文摘 | Kohler T Janssen C Plath SC etal | 2010 | Int J Public Health2010，55，6： | 1 |
| 19 | Role of histone H3 lysine 27 methylation in X inactivation显示文摘 | PLATH K FANG J MLYNARCZYK-EVANS S K | 2003 | Science2003，300，5616： | 1 |
| 20 | Sporting Activity After Arthroscopic Bankart Repair for Chronic Glenohumeral Instability显示文摘 | Plath JE Fieucht MJ Saier T | 2015 | Arthroscopy2015，31，10： | 1 |
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