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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Antioxidant potential,tannin and polyphenol contents of seed and pericarp of three Coffea species显示文摘Objective:To investigate the antioxidant activity,total phenolic and total tannin content of the pericarp and the seed of Coffea benghalensis(C.benghalensis) and Coffea liberica compared to Coffea arabica(C.arabica).Methods:The antioxidant potential,total tannin and polyphenol contents of the immature and mature seed and pericarp of C.benghalensis and Coffea liberica were quantified and compared to C.arabica.Enhanced chemiluminescence(ECL).2,2-diphenyl-1-picrylhydruzyl(DPPH).oxygen radical absorbance capacity,Folin-Ciocaltcau method and total tannin content assays were used.Results:Trolox equivalent(TE/g plant material) values obtained by ECL and DPPH methods showed loose correlation(r^2=0.587)while those measured by oxygen radical absorbance capacity assay were higher without correlation in each plant.A closer correlation was detected between the ECL method and the percentage antioxidant activity of the DPPH technique(r^2=0.610 7) in each species,however the immature pericarp of C.benghalensis showed much higher DPPH scavenging potential than was seen in the ECL assay.The immature pericarp of C.benghalensis expressed the highest tannin and polyphenol content,and a high polyphenol level was also detected in the immature seed of C.arabica.The immature pericarp of Bengal and Liberian coffees showed the largest amount of phenolic contents.Conclusions:The obtained data highlight the potential role of C.benghalensis as a new source of natural antioxidants and polyphenols compared to C.arabica. | va Brigitta Patay Nikolett Sali Tams Kszegi Rita Csepregi Viktória Lilla Blaz Tibor Sebastian Németh Tibor Németh Nóra Papp | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 3 |
| 3 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 4 | Determination of aliatoxins in food by overpressured-layer chromatographic显示文摘 | Otta K H Papp E Bagocsi B | 2000 | Journal of Chromatography A2000，882，： | 1 |
| 5 | Efficacy and safety of tofacitinib,an oral Janus kinase inhibitor,in the treatment of psoriasis:a Phase 2b randomized placebo-controlled dose-ranging study显示文摘 | Papp K Menter A Strober B | 2012 | Br J Dermatol2012，167，3： | 1 |
| 6 | Determination of aflatoxins in food by overpressured-layer Chromatography显示文摘 | Otta K H Papp E Bagoesi B | 2000 | Journal of Chromatography A2000，882，： | 1 |
| 7 | Comparison of the cellular electrophysiological characteristics of canine left ventricular epicardium,M cells,endocardium and Purkinje fibers显示文摘 | Balati B Varro A Papp JC | 1998 | Acta Physiol Scand1998，164，： | 1 |
| 8 | mieroRNA modulation of circadian-clock period and entrainment显示文摘 | Cheng H Y Papp J W Varlamova O Dziema H Russell B Cur- fman J P | 2007 | Neuron2007，54，： | 1 |
| 9 | High frequency of methylenetetrahydr-ofolate reductase 677TT genotype in Hungarian HELLP syndromepatients determined by quantitative real-time PCR显示文摘 | Nagy B’Hupuczi P Papp Z | 2007 | J HumHypertens2007，21，2： | 1 |
| 10 | Screening of Catalysts in the Oxidative Dehydrogenation with Carbon Dioxide 显示文摘 | Badstube T Papp H Dziembaj B | 2000 | Appl Catal A2000，204，： | 1 |
| 11 | Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure 显示文摘 | Schoket B Papp G Levay K | 2001 | Murat Res2001，482，： | 1 |
| 12 | Prenatal sonographic findings in 207 fetuses with trisomy 21显示文摘 | Papp C Bn Z Szigeti Z | 2007 | Eur J Obstet Gynecol Reprod Biol2007，133，2： | 1 |
| 13 | Echodense spinal subarachnoid space in neonates with progressive vertricular dilatation: a marker of noncommucating hydrocephalus显示文摘 | Ahnassy Z Papp B | 1998 | AJR Am J Roentgenol1998，171，4： | 1 |
| 14 | Pluripoteney re-centered around Esrrb 显示文摘 | Papp B Plath K | 2012 | EMBO J2012，22，31： | 1 |
| 15 | P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus 显示文摘 | Papp L Vizi ES Sperlagh B | 2007 | Biochem and Bioph Res Co2007，355，2： | 1 |
| 16 | Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure显示文摘 | SCHOKET B PAPP G LIVAY K | 2001 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis2001，482，12： | 1 |
| 17 | Prenatal sonographic findings in 207 fetuses with trisomy 21显示文摘 | Papp C Bán Z Szigeti Z | 2007 | Eur J Obstet Gynecol Reprod Biol2007，133，2： | 1 |
| 18 | The effect of increased fibre content fed in a previ- ous week on the parturition of sows显示文摘 | Papp B G | 1990 | Magyar Allatorvokok Lap- ja1990，45，： | 1 |
| 19 | Efficacy of methylprednisolone in children with severe community acquired pneumonia 显示文摘 | NagyJr B Gaspar 5 Papp A | 2013 | Pediatric Pulmonology2013，48，2： | 1 |
| 20 | The effects of noradrenergic re-uptake inhibition on memory encoding in man显示文摘 | Papps B P Shajahan P M Ebmeier K P | 2002 | Psychopharmacology (Berl)2002，159，： | 1 |
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