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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | Adjuvant sorafenib after heptectomy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma patients显示文摘AIM: To investigate the efficacy and safety of adjuvant sorafenib after curative resection for patients with Barcelona Clinic Liver Cancer(BCLC)-stage C hepatocellular carcinoma(HCC).METHODS: Thirty-four HCC patients, classified as BCLC-stage C, received adjuvant sorafenib for highrisk of tumor recurrence after curative hepatectomy at a tertiary care university hospital. The study group was compared with a case-matched control group of 68 patients who received curative hepatectomy for HCC during the study period in a 1:2 ratio.RESULTS: The tumor recurrence rate was markedly lower in the sorafenib group(15/34, 44.1%) than in the control group(51/68, 75%, P = 0.002). The median disease-free survival was 12 mo in the study group and 10 mo in the control group. Tumor number more than 3, macrovascular invasion, hilar lymph nodes metastasis, and treatment with sorafenib were significant factors of disease-free survival by univariate analysis. Tumor number more than 3 and treatment with sorafenib were significant risk factors of diseasefree survival by multivariate analysis in the Cox proportional hazards model. The disease-free survival and cumulative overall survival in the study group were significantly better than in the control group(P = 0.034 and 0.016, respectively). CONCLUSION: Our study verifies the potential benefit and safety of adjuvant sorafenib for both decreasing HCC recurrence and extending disease-free and overall survival rates for patients with BCLC-stage C HCC after curative resection. | Feng Xia Li-Li Wu Wan-Yee Lau Hong-Bo Huan Xu-Dong Wen Kuan-Sheng Ma Xiao-Wu Li Ping Bie | 2016 | World Journal of Gastroenterology2016，22，23： | 17 |
| 3 | Efficiency and safety of radiofrequency-assisted hepatectomy for hepatocellular carcinoma with cirrhosis:A single-center retrospective cohort study显示文摘AIM: To assess the efficiency and safety of radiofrequencyassisted hepatectomy in patients with hepatocellular carcinoma(HCC) and cirrhosis.METHODS: From January 2010 to December 2013, 179 patients with HCC and cirrhosis were recruited for this retrospective study. Of these, 100 patients who received radiofrequency-assisted hepatectomy(RF+ group) were compared to 79 patients who had hepatectomy without ablation(RF- group). The primary endpoint was intraoperative blood loss. The secondary endpoints included liver function, postoperative complications, mortality, and duration of hospital stay.RESULTS: The characteristics of the two groups were closely matched. The Pringle maneuver was not used in the RF+ group. There was significantly less median intraoperative blood loss in the RF+ group(300 vs 400 m L, P = 0.01). On postoperative days(POD) 1 and 5, median alanine aminotransferase was significantly higher in the RF+ group than in the RF- group(POD 1: 348.5 vs 245.5, P = 0.01; POD 5: 112 vs 82.5, P = 0.00), but there was no significant difference between the two groups on POD 3(260 vs 220, P = 0.24). The median AST was significantly higher in the RF+ group on POD 1(446 vs 268, P = 0.00), but there was no significant difference between the two groups on POD 3 and 5(POD 3: 129.5 vs 125, P = 0.65; POD 5: 52.5vs 50, P = 0.10). Overall, the rate of postoperative complications was roughly the same in these two groups(28.0% vs 17.7%, P = 0.11) except that post hepatectomy liver failure was far more common in the RF+ group than in the RF- group(6% vs 0%, P = 0.04).CONCLUSION: Radiofrequency-assisted hepatectomy can reduce intraoperative blood loss during liver resection effectively. However, this method should be used with caution in patients with concomitant cirrhosis because it may cause severe liver damage and liver failure. | Fan Zhang Jun Yan Xiao-Bin Feng Feng Xia Xiao-Wu Li Kuan-Sheng Ma Ping Bie | 2015 | World Journal of Gastroenterology2015，21，35： | 7 |
| 4 | Complete response to sorafenib in a patient with recurrent hepatocellular carcinoma显示文摘Partial hepatectomy is still the treatment of choice aiming at a cure for patients with hepatocellular carcinoma(HCC), provided that the patient can tolerate the treatment. For patients with multiple recurrent HCC after partial hepatectomy which cannot be treated by re-hepatectomy or local ablative therapy, the prognosis is extremely poor. sorafenib is a molecular-targeted agent which has been demonstrated in two global phase III randomized controlled trials to show survival benefit for advanced HCC. Here, we present a 56-yearold patient with HCC who showed complete clinical response after sorafenib was used for tumor recurrence which developed 3 mo after partial hepatectomy. There was no evidence of progression of disease for 60 mo till now after continuous treatment with sorafenib. | Hong-bo Huan Wan-Yee Lau Feng Xia Kuan-sheng Ma Ping bie | 2014 | World Journal of Gastroenterology2014，20，39： | 6 |
| 5 | A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma显示文摘 | Kai Feng Jun Yan Xiaowu Li Feng Xia Kuansheng Ma Shuguang Wang Ping Bie Jiahong Dong | 2012 | Journal of Hepatology2012，，4： | 5 |
| 6 | Epidermal growth factor receptor mutation analysis in cytological specimens and responsiveness to gefitinib in advanced non-small cell lung cancer patients显示文摘Background: Epidermal growth factor receptor(EGFR) mutation is the key predictor of EGFR tyrosine kinase inhibitors(TKIs) efficacy in non-small cell lung cancer(NSCLC). We conducted this study to verify the feasibility of EGFR mutation analysis in cytological specimens and investigate the responsiveness to gefitinib treatment in patients carrying EGFR mutations.Methods: A total of 210 cytological specimens were collected for EGFR mutation detection by both direct sequencing and amplification refractory mutation system(ARMS). We analyzed EGFR mutation status by both methods and evaluated the responsiveness to gefitinib treatment in patients harboring EGFR mutations by overall response rate(ORR), disease control rate(DCR) and progression free survival(PFS).Results: Of all patients, EGFR mutation rate was 28.6%(60/210) by direct sequencing and 45.2%(95/210) by ARMS(P<0.001) respectively. Among the EGFR wild type patients tested by direct sequencing, 26.7% of them were positive by ARMS. For the 72 EGFR mutation positive patients treated with gefitinib, the ORR, DCR and median PFS were 69.4%, 90.2% and 9.3 months respectively. The patients whose EGFR mutation status was negative by direct sequencing but positive by ARMS had lower ORR(48.0% vs. 80.9%, P=0.004) and shorter median PFS(7.4 vs. 10.5 months, P=0.009) as compared with that of EGFR mutation positive patients by both detection methods. Conclusions: Our study verified the feasibility of EGFR analysis in cytological specimens in advanced NSCLC. ARMS is more sensitive than direct sequencing in EGFR mutation detection. EGFR Mutation status tested on cytological samples is applicable for predicting the response to gefitinib. Abundance of EGFR mutations might have an influence on TKIs efficacy. | Lin Li Zijin Zhang Zhixin Bie Zheng Wang Ping Zhang Xin Nie Yuanming Li Hui Wang Bin Ai Gang Cheng | 2015 | Chinese Journal of Cancer Research2015，27，3： | 5 |
| 7 | Intrahepatic Glissonian approach and outflow vascular occlusion during partial hepatectomy显示文摘Under ultrasound guidance, a blunt suture needle was inserted around the Glissonian pedicle and then sutured. This technique significantly reduced the blood loss and facilitated the procedure of partial hepatectomy. We applied this technique in 182 patients who needed partial hepatectomy. We concluded that this method is simple and easy to occlude the vascular inflow and outflow, and allows an accurate delineation of the anatomic zone and therefore, simplifies the procedure of partial hepatectomy. | Feng Xia Guo Li Wan-Yee Lau Kuan-Sheng Ma Ping Bie | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 3 |
| 8 | A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma显示文摘 | Kai Feng Jun Yan Xiaowu Li Feng Xia Kuansheng Ma Shuguang Wang Ping Bie Jiahong Dong | 2012 | Journal of Hepatology2012，，4： | 2 |
| 9 | The safety and feasibility of reoperation for the treatment of hepatolithiasis by laparoscopic approach显示文摘 | Ju Tian Jian-wei Li Jian Chen Yu-dong Fan Ping Bie Shu-guang Wang Shu-guo Zheng | 2013 | Surgical Endoscopy2013，，4： | 2 |
| 10 | Modified hepatic outflow tract reconstruction in piggyback liver transplantation显示文摘OBJECTIVE: To summarize the experience in modified reconstruction of the hepatic outflow tract duringpiggyback liver transplantation at our hospital.METHODS: The clinical data on 67 patients undergoing piggyback liver transplantation with modifiedhepatic outflow tract reconstruction from January 1999 to October 2002 were analyzed retrospectively.RESULTS: In this group, 7 patients (10. 45%) died perioperatively. Complications included:pulmonary infection (38 patients); multiple organ system failure (10), intraperitoneal bleeding (6), acuterespiratory distress syndrome (14), thrombosis of the hepatie artery (1), and bile leakage (1). Nohepatic outflow occluded. Two recipients survived for over 3 years, 8 over 2 years, and 19 over a year.CONCLUSION: Modified hepatic outflow reconstruction in piggyback live transplantation may increasethe success rate of liver transplantation and decrease technical complications. | Huai-Zhi Wang Jia-Hong Dong Shu-Guang Wang Ping Bie Jing-Xiu Cai Qian Lu the Southurest Hospital and Institute of Hepatobiliary Surgery of PLA. Third Military Medical University, Chongqing 400038, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，2： | 2 |
| 11 | Does Hepatic Ischemia–Reperfusion Injury Induced by Hepatic Pedicle Clamping Affect Survival after Partial Hepatectomy for Hepatocellular Carcinoma?显示文摘 | Feng Xia Wan-Yee Lau Yanmin Xu Lin Wu Cheng Qian Ping Bie | 2013 | World Journal of Surgery2013，，1： | 2 |
| 12 | Numerical Simulation of High-pressure Hydrogen Jet Flames During Bonfire Test 显示文摘 | ZHENG Jinyang BIE Haiyan XU Ping | 2012 | Intemational Journal of Hydrogen Energy2012，37，1： | 1 |
| 13 | A randomized comparison of primary closure and T-tube drainage of the common bile duct after laparoscopic choledochotomy显示文摘 | Zhang Leida Bie Ping Wang Shuguang He Yu | 2008 | Surgical Endoscopy2008，，7： | 1 |
| 14 | Experimental and Numerical Studies on the Bonfire Test of High-pressure Hydrogen Storage Vessels显示文摘 | ZHENG Jinyang BIE Haiyan XU Ping | 2010 | Intemational Journal of Hydrogen Energy2010，35，15： | 1 |
| 15 | A randomized comparison of primary elosure and T-tube drainage of the common bile duct after laparoscopic choledochotomy 显示文摘 | Zhang Leida Bie Ping Wang Shuguang | 2008 | Surg Endosc2008，22，： | 1 |
| 16 | Analysis of cyclin E co-expression genes reveals nuclear transcription factor Y subunit alpha is an oncogene in gastric cancer显示文摘Objective: To explore genes potentially co-expressed with cyclin E in gastric cancer and discover possible targets for gastric cancer treatment. Methods: The Cancer Genome Atlas (TCGA) stomach adenocarcinoma sequencing data were used to predict genes co-expressed with cyclin E. Co-expression genes predicted by cBioPortal online analysis with Pearson correlation coefficient ≥0.4 were analyzed by gene ontology (GO) enrichment annotation using the PANTHER online platform (Ver. 7). Interactions between proteins encoded by these genes were analyzed using the STRING online platform (Ver. 10.5) and Cytoscape software (Ver. 3.5.1). Genes displaying a high degree of connection were analyzed by transcription factor enrichment prediction using FunRich software (Ver. 3). The significant transcription factor and cyclin E expression levels and their impact on gastric cancer progression were analyzed by Western blotting and Kaplan-Meier survival curve analysis. Results: After filtering the co-expression gene prediction results, 78 predicted genes that included 73 protein coding genes and 5 non-coding genes with Pearson correlation coefficient ≥0.4 were selected. The expressions of the genes were considered to be correlated with cyclin E expression. Among the 78 genes co-expressed with cyclin E, 19 genes at the central of the regulatory network associated with cyclin E were discovered. Nuclear transcription factor Y subunit alpha (NF-YA) was identified as a significant transcription factor associated with cyclin E co-expressing genes. Analysis of specimen donors’ clinical records revealed that high expression of NF-YA tended to be associated with increased cyclin E expression. The expression of both was associated with progression of gastric cancer. Western blotting results showed that compared with normal tissues, NF-YA and cyclin E were highly expressed in tumor tissues (P < 0.001). Survival curve analysis clearly demonstrated relatively poor overall survival of gastric cancer patients with high cyclin E or high NF-YA expression level, compared to patients with low cyclin E or NF-YA expression (P < 0.05). Conclusions: NF-YA may promote gastric cancer progression by increasing the transcription of cyclin E and other cell cycle regulatory genes. NF-YA might be a potential therapeutically useful prognostic factor for gastric cancer. | Liang-Yu Bie Dan Li Yu Mu Sheng Wang Bei-Bei Chen Hui-Fang Lyu Li-Li Han Cai-Yun Nie Chang-Cheng Yang Lin Wang Chuan-Chuan Ren Wei-Jie Zhang Ping Guo Feng Shi Qing-Xia Fan Liu-Xing Wang Xiao-Bing Chen Su-Xia Luo | 2019 | Chronic Diseases and Translational Medicine2019，5，1： | 1 |
| 17 | Arangdomized comparison of primary closure and T-tube drainage of the common bile duct after laparoscopic choledochotomy 显示文摘 | Zhao Leida Bie Ping Wang Shu- guang | 2008 | Sury Endosc2008，22，7： | 1 |
| 18 | A randomized comparison of primary closure and T-tube drainage of the common bile duct after laparoscopic choledochotomy显示文摘 | Zhang Lei-da Bie Ping Wang Shu-guang | 2008 | Surg Endosc2008，22，7： | 1 |
| 19 | First Total Synthesis of(±)—Abieta—8,11,13-trien-7β-ol显示文摘The first total synthesis of (?-abieta-8, 11, 13-trien-7?ol (7) was accomplished via a strategy of ACABC, in which the reduction of the ketone 6 with LiAlH4 gave exclusively the title compound. | Cheng Lu ZHANG Ping Yan BIE Xuan Jia PENG Yi YANG Xin Fu PAN | 2003 | Chinese Chemical Letters2003，14，5： | 1 |
| 20 | Surgical Treatment of Giant Liver Hemangiomas: Enucleation with Continuous Occlusion of Hepatic Artery Proper and Intermittent Pringle Maneuver显示文摘 | Feng Xia Wan-Yee Lau Cheng Qian Shuguang Wang Kuansheng Ma Ping Bie | 2010 | World Journal of Surgery2010，，9： | 1 |
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