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| 1 | Hepatitis C virus syndrome: A constellation of organ-and non-organ specific autoimmune disorders, B-cell nonHodgkin's lymphoma, and cancer显示文摘The clinical course of chronic hepatitis C virus(HCV)infection is characterized by possible development of both liver and extrahepatic disorders. The tropism of HCV for the lymphoid tissue is responsible for several immune-mediated disorders; a poly-oligoclonal B-lymphocyte expansion, commonly observed in a high proportion of patients with HCV infection, are responsible for the production of different autoantibodies and immune-complexes, such as mixed cryoglobulins. These serological alterations may characterize a variety of autoimmune or neoplastic diseases. Cryoglobulinemic vasculitis due to small-vessel deposition of circulating mixed cryoglobulins is the prototype of HCV-driven immune-mediated and lymphoproliferative disorders; interestingly, in some cases the disease may evolve to frank malignant lymphoma. In addition, HCV shows an oncogenic potential as suggested by several clinicoepidemiological and laboratory studies; in addition to hepatocellular carcinoma that represents the most frequent HCV-related malignancy, a causative role of HCV has been largely demonstrated in a significant percentage of patients with isolated B-cells nonHodgkin's lymphomas. The same virus may be also involved in the pathogenesis of papillary thyroid cancer, a rare neoplastic condition that may complicate HCVrelated thyroid involvement. Patients with HCV infection are frequently asymptomatic or may develop only hepatic alteration, while a limited but clinically relevant number can develop one or more autoimmune and/or neoplastic disorders. Given the large variability of their prevalence among patients' populations from different countries, it is possible to hypothesize a potential role of other co-factors, i.e., genetic and/or environmental, in the pathogenesis of HCV-related extra-hepatic diseases. | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Michele Colaci Poupak Fallahi Alessia Piluso Alessandro Antonelli Anna Linda Zignego | 2015 | World Journal of Hepatology2015，7，3： | 11 |
| 2 | Micro RNA expression in hepatitis C virus-related malignancies: A brief review显示文摘Not only is chronic hepatitis C virus(HCV) infection a major public health problem,but also it can cause hepatocellular carcinoma and,more rarely,nonHodgkin's lymphoma.These characteristics mean that HCV is the only virus infecting humans that is able to cause two different cancers.The fine pathogenetic and molecular mechanisms by which HCV induces these two malignancies are not completely clear.In the last decade,it has been shown that microRNAs(miRNAs),a class of 21-23-nucleotide molecules modulating posttranscriptional gene expression,make an important contribution to the pathogenesis of several cancers and are also considered highly promising biomarkers.Here,we briefly describe the current knowledge about microRNAs' involvement in HCV-related molecular oncogenesis.We decided to focus our attention on studies fully conducted on ex vivo samples with this specific etiology,and on cultured cell lines partially or completely expressing the HCV genome.Some of the results reported in this review are controversial,possibly because of methodological issues,differences in sampling size and features,and ethnicity of patients.What is certain is that miRNAs play a remarkable role in regulating gene expression during oncogenetic processes and in viral infection.A clear understanding of their effects is fundamental to elucidating the mechanisms underlying virus-induced malignancies. | Laura Gragnani Alessia Piluso Elisa Fognani Anna Linda Zignego | 2015 | World Journal of Gastroenterology2015，21，28： | 2 |
| 3 | Status of the OECD-SERENA Project for the Resolution of Ex-vessel Steam Explosion Risks显示文摘 | Seong-Wan Hong Pascal Piluso Matjazu Leskovar | 2013 | Journal of Energy and Power Engineering2013，7，3： | 2 |
| 4 | Plastic design of seismic resistant steel frames 显示文摘 | Mazzolani FM Piluso V | 1997 | Earthquake Engineering and Structural Dynamics1997，26，2： | 1 |
| 5 | Mullitization and Densification of (3Al2O3 + 2SiO2 ) Powder Compacts by Microwave Sintering 显示文摘 | Piluso P | 1996 | J European Ceramic Soc1996，16，： | 1 |
| 6 | Experimental Analysis and Modeling of Bolted T-Stubs Under Cyclic Loads显示文摘 | Vincenzo Piluso Gianvittorio Rizzano | 2008 | Jour- nal of Constructional Steel Research2008，64，： | 1 |
| 7 | Theory of plastic mechanism control for eccentrically braced fames with inverted y-scheme 显示文摘 | Montuor R Nastri E Piluso V | 2014 | Journal of Constrn- cional Steel Resareh2014，，92： | 1 |
| 8 | Structural Steel Semirigid Connections显示文摘 | Piluso V Rizzano G | 1987 | Journal of Constructional Steel Research1987，16，6： | 1 |
| 9 | Multiscale Characterization of Automotive Surface Coating Formation for Sustainable Manufacturing显示文摘汽车的表面涂层生产是在汽车的汇编的最复杂、昂贵的步之一。这步涉及通过油漆水花在车辆表面上产生聚合涂层的多重薄层并且在多级式的、动态地变化的环境治好。传统地,质量管理是基于的完全过程以后的检查,并且处理运作的调整仅仅经验被基于,这样生产不能是(高度) 持续。在这篇文章,当模特儿的一个多尺度的系统和分析方法论为通过在汽车的表面涂层生产治好的油漆水花和电影完成聚合材料的持续应用被介绍。由这方法论,在油漆材料之中的关联,应用程序进程和涂层,性能能被识别。基于模型的分析在大量长度和时间允许材料,进程,和产品的动态行为的全面、深的研究。案例研究为持续生产说明方法论的功效。 | Jie XIAO Jia LI Cristina Piluso Yinlun HUANG | 2008 | Chinese Journal of Chemical Engineering2008，16，3： | 1 |
| 10 | Local Buckling of Aluminum Alloy Angles under Uniform Compression显示文摘 | Mazzolani F M Piluso V Rizzano G | 2011 | Journal of Structural Engineering2011，137，2： | 1 |
| 11 | Rigid-plastic analysis and moment-shear interaction for hierarchy criteria of inverted Y EB-Frames 显示文摘 | Montuori R Nastri E Piluso V | 2014 | Journal of Constructional Steel Research2014，95，： | 1 |
| 12 | p53 acetylation is crucial for its transcription-independent proapoptotic functions显示文摘 | Yamaguchi H Woods NT Piluso LG | 2009 | J Biol Chem2009，284，11： | 1 |
| 13 | Experimental Analysis of Bolted Connections:Snug Versus Preloaded Bolts显示文摘 | Ciro Faella Vincenzo Piluso Gianvittorio Rizzano | 1998 | Journal of Structural Engineering1998，，： | 1 |
| 14 | Mechanistic insights into maintenance of high p53 acetylation by PTEN显示文摘 | Li AG Piluso LG Cai X | 2006 | Mol Cell2006，23，4： | 1 |
| 15 | Value of IL28B genotyping in patients with HCV-related mixed cryoglobulinemia:results of a large,prospective study显示文摘 | Piluso A Giarmini C Fognani E | | 0，，4： | 1 |
| 16 | Purification of acetyl- p53 using p300 co-infection and the baculovirus expression system显示文摘 | Piluso L G Wei G Li A G | 2005 | Protein Expres Purif2005，40，： | 1 |
| 17 | Ecological input-output analysis-based sustainability analysis of industrial systems显示文摘 | Piluso C Huang Y Lou H H | 2008 | Industrial & Engineering Chemistry Research2008，47，6： | 1 |
| 18 | A phase II, single-arm multicenter study of low-dose rituximab for refractory mixed cryoglobulinemia secondary to hepatitis C virus infection显示文摘 | Marcella Visentini Serena Ludovisi Antonio Petrarca Federica Pulvirenti Marco Zaramella Monica Monti Valentina Conti Jessica Ranieri Stefania Colantuono Elisa Fognani Alessia Piluso Carmine Tinelli Anna Linda Zignego Mario U. Mondelli Massimo Fiorilli Mil | 2011 | Autoimmunity Reviews2011，，11： | 1 |
| 19 | Sustainability assessment of industrial systems under uncertainty:a fuzzy logic based approach to short-term to midterm predictions显示文摘 | Piluso C Huang J Liu Z Huang Y | 2010 | Industrial & Engineering Chemistry Research2010，49，18： | 1 |
| 20 | Experimental Analysis of Bolted Connections: Snug Versus Preloaded Bolts显示文摘 | Ciro Faella Vincenzo Piluso Gianvittorio Rizzano | 1998 | Journal of Structural Engineering1998，124，7： | 1 |
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