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| 1 | 精准医学理念在临床实践中的运用进展显示文摘随着基因组学、功能基因组学及计算机技术的飞速发展,精准医学在继循证医学之后应运而生。精准医学不但引领临床医师从分子生物学本质思考疾病并实现准诊断,同时也要求临床工作者运用患者的遗传信息去寻求最佳的治疗靶点从而实现精准治疗。美国和中国自2015年相继启动精准医学计划,精准医学的时代即将来临。该综述将从基因测序、大数据整合、分子病理、精准无创产前诊断、精准肿瘤医学这几方面,就目前精准医学理念在临床实践中的运用加以阐述。 | 程伟 李幼生 | 2016 | 医学研究生学报2016，29，4： | 14 |
| 2 | Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2/My D88 signaling in THP-1 cells显示文摘AIM: To investigate the role of mi R-125 b in regulating monocyte immune responses induced by hepatitis C virus(HCV) core protein.METHODS: Monocytic THP-1 cells were treated with various concentrations of recombinant HCV core protein, and cytokines and mi R-125 b expression in these cells were analyzed. The requirement of Tolllike receptor 2(TLR2) or My D88 gene for HCV core protein-induced immune responses was determined by the transfection of THP-1 cells with gene knockdown vectors expressing either TLR2 si RNA or My D88 si RNA. The effect of mi R-125 b overexpression on TLR2/My D88 signaling was examined by transfecting THP-1 cells with mi R-125 b mimic RNA oligos.RESULTS: In response to HCV core protein stimulation, cytokine production was up-regulated and mi R-125 b expression was down-regulated in THP-1 cells. The modulatory effect of HCV core protein on cellular events was dose-dependent and required functional TLR2 or My D88 gene. Forced mi R-125 b expression abolished the HCV core protein-induced enhancement of tumor necrosis factor-α, interleukin(IL)-6, and IL-10 expression by 66%, 54%, and 66%, respectively(P < 0.001), by inhibiting My D88-mediated signaling, including phosphorylation of NF-k Bp65, ERK, and P38.CONCLUSION: The inverse correlation between mi R-125 b and cytokine expression after HCV core challenge suggests that mi R-125 b may negatively regulate HCVinduced immune responses by targeting TLR2/My D88 signaling in monocytes. | Cheng Peng Hua Wang Wen-Jing Zhang Sheng-Hua Jie Qiao-Xia Tong Meng-Ji Lu Dong-Liang Yang | 2016 | World Journal of Gastroenterology2016，22，17： | 2 |
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